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JAX® Mice and Services news

November 17

Reduced prices on JAX® Mice strains—Special J offers
Save 25% off select strains of JAX® Mice, while supplies last

November 10

Tumor-Stromal Cell Turnover in PDX Mice
Stromal cells found within epithelial tumors can have a significant impact on the growth, vascularization, invasiveness, and metastatic potential of the cancer.  These features make stromal cell populations potential therapeutic targets.  A new publication in the journal Digestive Diseases and Sciences (Maykel et al., 2014) demonstrates the importance of immunodeficient host mouse selection for efficient propagation of primary human tumors referred to as patient derived xenografts (PDX), maintenance of tumor microenvironment, and in establishing a platform for in vivo therapy testing.

October 28

Novel Inhibitor Targets Vascular and Cognitive Defects in AD Mice
A new study in Journal of Experimental Medicine (Ahn et al. 2014) describes a novel molecule that targets Aβ-fibrinogen interactions in the 5XFAD mouse model of Alzheimer’s disease.  The novel inhibitor, RU-505, demonstrates efficacy in improving cerebrovascular and cognitive deficits in this model.

October 28

Desktop Wallpaper Calendars for November/December 2014
Free downloadable image for your desktop or phone

October 26

Intestinal cell modifications aid gut microbiota during infection, helps host
A recent article in Nature reveals an exciting mechanism by which a host can select beneficial micro-biota to improve its own fitness during systemic infection.  The studies provide novel insights into host-gut microbiota mutualistic relationships.

October 9

Cas9 Knock-in Mice for Efficient Genome Editing In Vivo and Ex Vivo
Two novel Cas9-expressing mouse models are described in a recent Cell publication from the laboratory of Dr. Feng Zhang at MIT.  The Cre-dependent LSL-Cas9 (024857) and constitutive Cas9 (024858) mice offer numerous and exciting possibilities for genome editing in vivo and ex vivo.

October 9

Complete Life Cycle of Malaria Parasite in Humanized DRAG Mice
A very import new advance towards the development of Malaria therapy has been reported in Malaria Journal (Wijayalath et al., 2014).  The work presented by Wijayalath et al. demonstrates, for the first time, a mouse model that enables all components of the malaria parasite life cycle. This new model supports human immune functions that will allow a greater understanding of the immunobiology of malaria, which in turn may allow for the development of new treatment strategies.

September 30

Humanized Mice for Tumor Antibody Production
An exciting publication in the journal mAbs (Wege et al. 2014) describes a new method for making human B cell-derived antibodies specific for novel antigens present on human cancer cells.  These researchers accomplished this in vivo by co-injecting human hematopoietic stem cells and human breast cancer cells into immunodeficient NSG mice.  The mice developed a human immune system, including antibodies in serum that were specific for antigens on the engrafted tumor cells.

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