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JAX® Mice and Services news

July 21

Cellular Architecture from the Outside-In
In a 2015 EMBO Journal study, the powerful interconnectedness between extracellular matrix homeostasis and internal cellular architecture is described.  Mice with a deficit in a remodeling collagenase exhibit profound cellular disorganization and induction of senescence, leading to dwarfism and premature death.  This study highlights the underlying mechanisms of diseases attributed to matrix metalloproteinase mutations, such as progeria, and may lead toward development of therapies for these patients.  

July 20

Reduced prices on JAX® Mice strains—Special J offers
Save 25% off select strains of JAX® Mice, while supplies last

July 6

Not feeling the love? That makes scents.
Neuroscientists investigate fluctuations in female attraction to and sensory perception of male pheromones throughout the estrous cycle (Dey et al 2015).

July 6

Diversity Outbred Mice Identify Exposure Thresholds and Genetic Factors That Influence Benzene-Induced Genotoxicity
A 2015 study demonstrates that the J:DO mice display a reproducible response to benzene inhalation that more accurately reflects the range of responses observed in human populations. Further, genetic mapping linked variation in benzene-induced genotoxicity to two sulfotransferase candidate genes.

June 24

The XactMice You Need For a Tumor Microenvironment
A new publication in Oncogene (Morton et al., 2015) demonstrates the importance of human immune cells in maintaining the microenvironment of a patient derived xenograft (PDX).   The human immune cells infiltrate the tumor, stimulate lymphangiogenesis, and help maintain the original genetic expression profile of the PDX.  These observations highlight the complex interactions between tumors and the immune system and their importance in maintaining original tumor fidelity.  Humanized, tumor-bearing mice are clearly an important and relevant platform for studying human tumor biology, and will be an important tool for future preclinical efficacy testing.

June 24

Lymphatic Vessels Discovered within the Mouse Central Nervous System
A recent Nature study (Louveau et al. 2015) describes the discovery and characterization of lymphatic vessels in the dura of the central nervous system.  These long-elusive structures answer many neuroanatomical questions regarding how immune cells enter and exit the brain, and may improve our understanding of neural disease etiology and suggest novel treatment paradigms. 

June 24

Desktop Wallpaper Calendars for July 2015
Free downloadable image for your desktop or phone

June 10

Sperm Counts: A Father’s Influence Is Far-Reaching
Researchers at Emory University School of Medicine demonstrate that environmental experience is transmitted through epigenetic modifications in the male germline and physically shapes neuroanatomy (Dias and Ressler 2014).

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