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JAX® Mice and Services news

March 23

Reduced prices on JAX® Mice strains—Special J offers
Save 25% off select strains of JAX® Mice, while supplies last

March 17

Normalizing CD4+ T Cell Metabolism Reverses Systemic Lupus
An exciting new study in Science Translational Medicine(Yin et al. 2015) demonstrates that normalizing CD4+ T cell metabolism effectively reverses disease phenotypes in multiple mouse models of lupus, offering a novel therapeutic approach for treating this autoimmune disease in humans.

March 3

JAX® Mice Help Unravel Cannabinoid-induced Munchies
It has been commonly observed that smoking marijuana (Cannabis sativa) induces the "munchies". Indeed, the neural circuits in the hypothalamus that regulate satiety can be disrupted by cannabinoids derived from marijuana. New research published in Nature (Koch et al. 2015) reveals a key role for pro-opiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (ARC) in regulating food intake. Stimulating cannabinoid receptor 1 (CB1R) in the ARC activates POMC neurons and increases food consumption in fed mice. These findings describe an important new mechanism in controlling feeding behavior.

March 3

New NSGTM-variant model does not require irradiation for engraftment of HSCs
NSGTM mice (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ, Stock# 005557) have revolutionized human disease modeling by providing a platform with which to create new and valuable models to study human hematopoiesis, cancer, infectious and many other diseases. With their severely immunodeficient phenotype, NSGTM mice support higher levels of engraftment with many kinds of human cells and tissues than traditional immunocompromised host strains

February 18

Desktop Wallpaper Calendars for March 2015
Free downloadable image for your desktop or phone

February 17

Time-Restricted Feeding:  The Latest Diet Craze?
An exciting study in Cell Metabolism (Chaix et al. 2014) illustrates the pleiotropic beneficial effects of time-restricted feeding on the development of obesity and related disease risk factors that does not rely on caloric restriction.

February 16

Cellular senescence: an unexpected advantage in wound healing
A 2014 publication demonstrates that senescent cells at a wound edge promote tissue repair.  The study uncovered secreted factors that may have clinical applications in improving wound closure and reducing scar tissue. 

February 4

Thirsty? Specific Neural Populations Drive the Instinct
The instinct to drink or stop drinking has been mapped to a distinct group of neurons in the mouse brain in a recent study (Oka et al., 2015). Optogenetic activation or inhibition of these neurons led water-satiated mice to drink or water-deprived mice to stop drinking, respectively. The identification of this control center in the brain points toward progress in mapping and understanding the specific circuits that regulate innate urges and motivations.

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