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JAX® Mice and Services news

October 12

Reduced prices on JAX® Mice strains—Special J offers
Save 25% off select strains of JAX® Mice, while supplies last

October 9

Cas9 Knock-in Mice for Efficient Genome Editing In Vivo and Ex Vivo
Two novel Cas9-expressing mouse models are described in a recent Cell publication from the laboratory of Dr. Feng Zhang at MIT.  The Cre-dependent LSL-Cas9 (024857) and constitutive Cas9 (024858) mice offer numerous and exciting possibilities for genome editing in vivo and ex vivo.

October 9

Complete Life Cycle of Malaria Parasite in Humanized DRAG Mice
A very import new advance towards the development of Malaria therapy has been reported in Malaria Journal (Wijayalath et al., 2014).  The work presented by Wijayalath et al. demonstrates, for the first time, a mouse model that enables all components of the malaria parasite life cycle. This new model supports human immune functions that will allow a greater understanding of the immunobiology of malaria, which in turn may allow for the development of new treatment strategies.

September 30

Humanized Mice for Tumor Antibody Production
An exciting publication in the journal mAbs (Wege et al. 2014) describes a new method for making human B cell-derived antibodies specific for novel antigens present on human cancer cells.  These researchers accomplished this in vivo by co-injecting human hematopoietic stem cells and human breast cancer cells into immunodeficient NSG mice.  The mice developed a human immune system, including antibodies in serum that were specific for antigens on the engrafted tumor cells.

September 30

 Potential New Therapeutic Target for Treating Down Syndrome
A new study in PLoS One (Garcia-Cerro, S. et al. 2014) identifies a potential therapeutic target to ameliorate learning disabilities in Down syndrome (DS).  Normalization of Dyrk1a (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A) gene dosage in B6EiCSN.BLiA-TS(1716)65Dn/J (Ts65Dn, 005252)rescues many, but not all, of the cognitive and neuromorphological phenotypes observed in trisomic (TS) mice.  Drug or genetic targeting of Dyrk1a, therefore, may be a novel therapeutic target to improve memory and learning for DS patients. 

September 16

Targeting Endothelin and Complement Pathways is Effective in Preventing Glaucoma in Mice
A recent article in Neurobiology of Disease revealed an exciting and robust therapeutic strategy to prevent glaucoma development in mice using combinatorial inhibition of both the endothelin system and the classical complement cascade. Their studies offer great potential to transform the treatment of glaucoma.

September 16

Inhibition of Obesity by Manipulation of Gut Microbiota
A new study in Journal of Clinical Investigation (Chen, et al. 2014) describes genetic engineering and therapeutic delivery of gut bacteria, which provide long-lasting inhibition of obesity and improved insulin response in both induced and polygenic mouse models of obesity.

September 3

Validated Therapeutic Target for ALS
A new publication in Science Translational Medicine (de Boer, A. S. et al. 2014) uncovers and validates a new mechanism of disease in Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease). These researchers show that microglia from ALS mice (B6SJL-Tg(SOD1*G93A)1Gur/J 002726) are toxic to normal human motor neurons in vitro. The researchers also found that blockage of signaling through the prostaglandin D receptor (Ptgdr, or DP1) could restore motor neuron survival and extend lifespan.  These findings suggest inhibiting the DPI receptor could be a viable therapeutic strategy in the future. 

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