JAX® Genetic Stability Program
Our Genetic Stability Program (GSP) arrests genetic drift, including that caused by copy number variation, in our most popular strains.
Initiated in 2003, our GSP nearly stops genetic drift by refreshing our foundation stocks with cryopreserved pedigree embryos or gametes approximately every five generations (Fig. 1)
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| Figure 1: Foundation stocks of several broadly-used strains are refreshed with cryo-recovered embryos about every five generations. |
So far, we have cryopreserved germplasm from the following strains:
- 129S1/SvlmJ (002448)
- C3H/HeJ (000659)
- C57BL/6J (000664)
- C57BL/6NJ (005304)
- DBA/2J (000671)
- FVB/NJ (001800)
- NOD/ShiLtJ (001976)
- NOD.CB17-Prkdcscid/J (001303)
- BALB/cByJ (001026)
- CBA/J (000656)
- DBA/1J (000670)
Limiting genetic drift in these strains is particularly important because they have been either completely or partly sequenced: the C57BL/6J strain was completely sequenced by the Mouse Genome Sequencing Consortium; the DBA/2J strain was partly sequenced by Celera Genomics; and the FVB/NJ, BALB/cByJ, and 13 other JAX® Mice strains have been sequenced by the National Institute of Environmental Health Sciences Resequencing Project.
