List of agents monitored and policy for communication of changes in health status
We monitor for the same agents in all of our Production, Repository and Research barriers. However, exclusion policies and policies related to shipping and notification of customers differ depending on the facility (Production and Repository vs. Research) and on the barrier level as noted below.
EX = Excluded agents: If we were to find any of these agents in a barrier, we would suspend all shipments from the barrier and notify customers.
N = Non-tolerated agents: If we were to find one of these agents in a barrier, we would undertake an investigation to identify and eliminate all infected mice from the barrier. Positive results - including results from investigations - would be noted in the Health Report for the barrier, but shipping from the barrier would not be suspended.
T = Tolerated agents: The presence of these agents is tolerated. Positive results are noted in the Health Report for the barrier, but specific efforts are not taken to eliminate the agent(s), and shipping from the barrier is not stopped.
Any concern about agents for which we monitor, but do not stop shipments should be communicated to us in advance or at the time orders are placed (see below).
| Organism | Production & Repository Barriers | Research Barriers | ||||
|---|---|---|---|---|---|---|
| Maximum | High | Standard | Elevated | Intermediate | Low | |
|
Viruses |
|
|
|
|
|
|
|
Ectromelia virus (agent causing mouse pox) |
EX |
EX |
EX |
EX |
EX |
EX |
|
GDVII (Theiler’s mouse encephalomyelitis) virus |
EX |
EX |
EX |
EX |
EX |
EX |
|
Hantaan virus ( hantavirus) |
EX |
EX |
EX |
EX |
EX |
EX |
|
K virus |
EX |
EX |
EX |
EX |
EX |
EX |
|
Lactic dehydrogenase elevating virus |
EX |
EX |
EX |
EX |
EX |
EX |
|
Lymphocytic choriomeningitis (LCMV) |
EX |
EX |
EX |
EX |
EX |
EX |
|
Mouse adenovirus (MAV) |
EX |
EX |
EX |
EX |
EX |
EX |
|
Mouse cytomegalovirus (MCMV) |
EX |
EX |
EX |
EX |
EX |
EX |
|
Mouse hepatitis virus (MHV) |
EX |
EX |
EX |
EX |
EX |
EX |
|
Mouse minute virus (MMV) |
EX |
EX |
EX |
EX |
EX |
EX |
|
Mouse norovirus (MNV) |
EX |
EX |
EX |
N |
N |
T |
|
Mouse parvovirus (MPV) |
EX |
EX |
EX |
EX |
EX |
EX |
|
Mouse thymic virus (MTV) |
EX |
EX |
EX |
EX |
EX |
EX |
|
Pneumonia virus of mice (PVM) |
EX |
EX |
EX |
EX |
EX |
EX |
|
Polyoma virus |
EX |
EX |
EX |
EX |
EX |
EX |
|
Reovirus 3 (REO 3) |
EX |
EX |
EX |
EX |
EX |
EX |
|
Rotavirus (Epizootic diarrhea of infant mice [EDIM]) |
EX |
EX |
EX |
EX |
EX |
EX |
|
Sendai virus |
EX |
EX |
EX |
EX |
EX |
EX |
|
Bacteria, Mycoplasma, and Fungi |
|
|
|
|
|
|
|
Bordetella bronchiseptica |
EX |
EX |
EX |
EX |
EX |
EX |
|
CAR bacillus |
EX |
EX |
EX |
EX |
EX |
EX |
|
Citrobacter rodentium (Citrobacter freundii 4280) |
EX |
EX |
EX |
EX |
EX |
EX |
|
Clostridium piliforme |
EX |
EX |
EX |
EX |
EX |
EX |
|
Cornebacterium kutscheri |
EX |
EX |
EX |
EX |
EX |
EX |
|
Cornebacterium bovis |
EX |
EX |
EX |
EX |
EX |
EX |
|
Heliocobacter spp. |
EX |
EX |
EX |
N |
N |
T |
|
Klebsiella pneumoniae |
N |
N |
N |
N |
N |
N |
|
Klebsiella spp. other than K. pneumoniae |
N, T† |
N |
T |
N |
T |
T |
|
Mycoplasma pulmonis |
EX |
EX |
EX |
EX |
EX |
EX |
|
Pasteurella pneumotropica |
EX |
EX |
EX |
N |
N |
T |
|
Pneumocystis murina* |
N |
- |
- |
N |
T |
T |
|
Pseudomonas spp. |
N |
N |
N |
N |
N |
N |
|
Salmonella spp. |
EX |
EX |
EX |
EX |
EX |
EX |
|
Staphylococcus aureus |
N |
N |
N |
N |
N |
N |
|
Streptobacillus moniliformis |
EX |
EX |
EX |
EX |
EX |
EX |
|
Streptococcus spp. |
N |
N |
N |
N |
N |
N |
|
Parasites and Protozoa |
|
|
|
|
|
|
|
Encephalitozoon cuniculi |
EX |
EX |
EX |
EX |
EX |
EX |
|
Fleas, fur mites, lice |
EX |
EX |
EX |
EX |
EX |
EX |
|
Follicle mites |
EX |
EX |
EX |
EX |
EX |
EX |
|
Nonpathogenic protozoa (e.g., trichomonads) |
N |
N |
T |
N |
T |
T |
|
Opportunistic protozoa (e.g., Giardia, Spironucleus) |
EX |
EX |
EX |
N |
N |
T |
|
Pinworms |
EX |
EX |
EX |
EX |
EX |
EX |
|
Roundworms and other helminths |
EX |
EX |
EX |
EX |
EX |
EX |
|
Tapeworms |
EX |
EX |
EX |
EX |
EX |
EX |
† Klebsiella oxytoca is excluded from most Maximum barriers, but is currently tolerated in one such barrier (AX11).
* Pneumocystis murina is monitored in severely immunodeficient mice only, and only if these mice are housed in the room. All severely immunodeficient mice in our Production colonies are housed in Maximum barriers, and all Maximum barriers are monitored for Pneumocystis murina.
Notification of outbreaks and shipping policy
Actions taken for excluded agents (EX)
- Containment procedures will be initiated to effectively isolate the area where the agent was found from all other Jackson Laboratory animal areas and support facilities.
- Shipment of mice involved in the contamination (i.e., all mice housed in the animal room(s) where the contamination occurred) will be suspended immediately.
- Within 2 business days of definitive diagnosis, a notice will be placed on our Web site, and notifications will be sent by first class mail or by fax to all institutions on our general JAX® Mice mailing list. Institutions which received mice from the affected area(s) during the previous three months will receive additional notifications to the Purchasing Contact on record by first class mail or by fax as soon as possible.
- Any customer placing a new order for mice in the area affected by the contamination will be informed, at the time of order placement, of any shipping hold due to a contamination.
- The agent will be eliminated from the affected area by one or more of the following methods: depopulation followed by repopulation from another animal area or recovery from cryopreservation; depopulation followed by rederivation; or test and cull. The method used will depend on the microbial contaminant (infectivity and biological or environmental persistence) and on the degree of spread within the affected area.
- Following elimination of the contamination, the housing area will be thoroughly cleaned and disinfected prior to redeployment for animal housing.
Actions taken for non-tolerated agents (N)
These agents are generally recognized as opportunistic pathogens that may complicate disease or interfere with research under certain circumstances, e.g., immunodeficient mice.
If any of these organisms are detected the following procedures are followed:
- Positive results trigger a clinical investigation designed to eliminate all infected mice.
- Shipping from the area is not stopped.
- The presence of the organism is reported on the Animal Health Report from the barrier.
Actions taken for tolerated agents (T)
These agents may be viewed as normal flora of mice or as exogenous microorganisms with little or no potential to cause disease or interfere with research. If any of these organisms are found the following actions are taken:
- No special efforts will made to eliminate the agent
- Mice from the area will continue to be shipped.
- The presence of the agent will be reported on the Animal Health Status Report from the area.
Important: if there are concerns about agents that we include in the N or T categories and your institution will NOT accept animals with agents in these categories please inform us at the time of order placement.
General communication activities associated with animal health notices
- Mailings related to animal health notices will go to the general JAX® Mice mailing list.
- Information related to animal health notices will remain posted on our website for at least 6 months from the original date of the notice.
- In some cases, we will provide additional information or updates to the original notice by mail, by fax, and/or by postings on our website.
