Health statement for mice from The Jackson Laboratory surgical service
Peggy J. Danneman, VMD, MS, DACLAM
Director, Laboratory Animal Health Services
Surgically altered JAX® Mice may originate from any of several areas in The Jackson Laboratory's Production Facility. Areas that may provide mice include AX2, AX3, AX4, AX5, AX6, AX7, AX8, AX9, AX10, AX1l, AX12, MP13, MP14, MP15, MP16, MP24, MP25, and MP27. Mice are brought to the Surgical Suite in cages that are placed immediately into an IVC rack, where the mice are held until surgery. Animals are surgically manipulated using aseptic technique in a laminar flow hood, transferred to another laminar flow hood for recovery, placed in a clean cage within the recovery hood, and transferred back to the IVC holding rack. Once fully recovered from surgery, they are packed for shipping in the recovery hood.
All areas sending mice to the Surgical Suite participate in the regular Jackson Laboratory health monitoring program. They are monitored at least quarterly for the following organisms.
| Viruses | ||
| Ectromelia virus | Mouse minute virus | Polyoma virus |
| GDVII (Theiler's) virus | Mouse adenovirus | Reovirus 3 |
| K virus | Mouse cytomegalovirus | Rotavirus (EDIM) |
| Hantaan virus | Mouse hepatitis virus | Sendai virus |
| Lactic Dehydrogenase Elevating virus | Mouse parvovirus | |
| Lymphocytic choriomeningitis virus | Pneumonia virus of mice | |
| Bacteria and Mycoplasmas | ||
| Bordetella bronchiseptica | Helicobacter spp. | Salmonella spp. |
| CAR bacillus | Klebsiella spp. | Staphylococcus aureus |
| Citrobacter rodentium | Mycoplasma spp. | Streptobacillus moniliformis |
| Clostridium piliforme | Pasteurella multocida | Streptococcus spp. |
| Cornebacterium kutscheri | Pseudomonas spp. | |
| Parasites, Protozoa and Fungi | ||
| Fleas, fur mites, lice | Tapeworms | Amoebae |
| Psorergates simplex | Trichomonads | Encephalitzoon cuniculi |
| Pinworms, e.g., Syphacia spp. | Spironucleus muris | Pneumocystis carinii |
| Helminths | Giardia muris | |
There are minor differences in health status among the different areas sending mice to the Surgical Suite. Depending on the room of origin, mice coming to the Surgical Suite may be positive for Klebsiella spp. and/or trichomonads. Immunodeficient mice may be positive for Pneumocystis carinii. The occasional identification of other bacteria, e.g., Staphylococcus aureus, provokes a clinical investigation to identify and eliminate all infected mice.
To check the most recent health information from these or any other housing area(s) within The Jackson Laboratory, please consult The Jackson Laboratory web site or Customer Service (800-422-6423; 207-288-5845).
