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JAX® Mice and Services news

August 20

Desktop Wallpaper Calendars for September/October 2014
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August 19

Transgenic Parasites to Dissect Host-Pathogen Interactions During Toxoplasmosis
A new report in Infection and Immunity (Christian et al.  2014) describes a powerful new T. gondii cre-lox based fluorescent reporter system for tracking host-pathogen cell interactions which can provide new insights into how host cells respond in vivo to toxoplasmosis infection.

August 19

Transparent Mice for Connectome Phenotyping
A highly innovative new technique has been published in Cell (Yang et al. 2014) that renders whole organs, and even an entire mouse, optically transparent. This amazing new development allows creation of enhanced three dimensional imaging of fluorescently labeled cells within multiple organs.  Yang et al. demonstrated imaging from cells expressing fluorescent transgenes as well as labeling by viral transduction, small molecules, mRNA probes, and antibodies. Using this approach, researchers will be able to build a “connectome” to understand the structural relationships between cell populations in both normal and pathological conditions.

August 18

Reduced prices on JAX® Mice strains—Special J offers
Save 25% off select strains of JAX® Mice, while supplies last

August 4

Inhibition of Bromodomain Proteins for Human Diffuse Large B-cell Lymphoma
A recent article in Clinical Cancer Research revealed a broad anti-tumor effect of the small molecule JQ1, an inhibitor of BET family of bromodomain proteins (including Myc), on human DLBCL cell lines or DLBCL tumor-engrafted mice, providing novel potential therapeutic strategies for therapy-resistant or recurrent human DLBCL.

July 23

Enhancer Hijacking in Medulloblastoma
New research published in Nature (Northcott et al. 2014) describes previously unreported mechanisms of activation of oncogenes leading to medulloblastoma. Using a combination of genomic and RNA sequencing data, the authors identified chromosomal structural variants (SV) that led to changes in proximity of oncogenes, GFI1 and GFI1B,  to enhancer elements that ultimately up-regulated gene expression. Transduction of mouse neuronal stem cells with GFI1 or GFI1B in combination with Myc stimulated development of tumors in orthotopically transplanted NSG host mice, establishing a new mouse platform for medulloblastomas. The new mechanisms described in this research may help to provide new insight into the development of other heterogeneous cancers and provide new targets for molecular therapy.

July 9

Induction of Autoimmunity in Humanized NSG Mice
A new publication in the Journal of Immunology (Vudattu, N. et al. 2014) provides evidence that treatment of “humanized” NSG mice with ipilimumab (CTLA-4 Ig) can disrupt immune tolerance and initiate features of autoimmune disease, making this the first small animal model of human specific autoimmunity. This research establishes humanized NSG mice as a new therapeutic platform to study pathogenesis of human autoimmunity and develop new therapeutic interventions with greater potential to translate to human patients suffering from a wide range of autoimmune diseases (ex. Type 1 diabetes, Lupus, Multiple Sclerosis, etc.).

July 8

One-Step Generation of Genetically Engineered Mice by CRISPR/Cas Systems
Two exciting articles in Cell revealed how the revolutionary CRISPR/Cas system can be used to generate multiple gene mutations, reporter alleles and conditional alleles in mice in one step. The power of this system will undoubtedly transform genetic and biological research and facilitate the development of novel molecular therapeutics for complex human diseases.

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