Our complimentary March webinar focus on maximizing the productivity of your mouse breeding colonies by understanding mouse reproductive biology and minimizing naturally occurring genetic drift. We are also proud to present two new webinars focusing on Huntington's Disease and Advances in Genetic Research.
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JAX® Mice and Services newsFollow us:
Improved Nanogel-Based Delivery System for Treating
Systemic Lupus Erythematosus in Mice
Systemic Lupus Erythematosus (SLE) is an autoimmune inflammatory disease of the connective tissues. A nanogel-based delivery system for drug treatment is shown to more directly target immune cells responsible to the autoimmune disease and slow disease progression in mice.
Reduced prices on JAX® Mice strains—Special J offers
Save 25% off select strains of JAX® Mice, while supplies last
Desktop Wallpaper Calendars for March/April 2014
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Protection from HIV using VIP in BLT NSG!
An intriguing new publication in Nature Medicine (Balazs et al. 2014) provides preclinical evidence supporting the use of Vectored Immunoprophylaxis (VIP) to prevent transmission of HIV. BLT NSG mice with human mucosal immunity were infected with HIV intravaginally, establishing a model of human heterosexual transmission. Humanized mice pretreated with VIP produced blocking antibodies that prevented HIV infection despite multiple viral exposures through the vaginal mucosa.
Antibody Directed Against TNFRSF21 is Neuroprotective in the SOD1*G93A Model of ALS
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons in the brain and spinal cord. In a recent study published in Cell Death and Disease (Huang et al. 2013), inhibition of TNFRSF21 leads to motor neuron survival and functional improvement in a transgenic mouse model of ALS.
Join us for our latest webinars as we share valuable information on the innovative approaches to preclinical research and discovery using NSG mice, practical considerations for the care and housing of immune deficient mic, maximizing the productivity of your mouse breeding colonies, and minimizing naturally occurring genetic drift. We are also proud to present two new webinars focusing on Huntington's Disease and Advances in Genetic Research.
Humanized Mouse Model of Muscular Dystrophy
A new publication in Human Molecular Genetics (Zhang et al. 2014) describes a new mouse model of human skeletal muscle xenoengraftment in NRG immunodeficient mice. These researchers demonstrated long term functional engraftment of skeletal muscle from normal and affected patients with Facioscapulohumeral Muscular Dystrophy (FSHD).