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JAX® Mice and Services news

April 16

The Cancer Arms Race: Targeting Multiple Immune Pathways to Match Cancer Evolution
In a new, reverse translational study, a team of investigators from the University of Pennsylvania report that a three-pronged, combination therapy using radiation and two checkpoint inhibitors boosts T cell responses against metastatic melanoma.

April 14

Reduced prices on JAX® Mice strains—Special J offers
Save 25% off select strains of JAX® Mice, while supplies last

March 31

Desktop Wallpaper Calendars for April 2015
Free downloadable image for your desktop or phone

March 31

Enhancement of Antibody Production in Humanized Mice
A newly published approach to humanizing NSG mice demonstrates improved B cell development and IgG antibody production following immunization.  The new method addresses an important limitation in immune cell responses that develop in mice humanized using other protocols. The new technique improves follicular lymphoid structure development and splenic germinal center formation, which are necessary and critical for B cell maturation, immunoglobulin class switching, and the development of IgG-producing plasma cells.

March 31

Mecp2 Mutations Underlie Decreased Bone Mass in Rett Syndrome
Previously, the early-onset osteoporosis experienced by many Rett syndrome patients has been attributed to drug side effects or to patient behavior.  New research suggests that the same MECP2 mutations that underlie the neurological disorder also affect bone remodeling by osteoblasts.

March 17

Normalizing CD4+ T Cell Metabolism Reverses Systemic Lupus
An exciting new study in Science Translational Medicine(Yin et al. 2015) demonstrates that normalizing CD4+ T cell metabolism effectively reverses disease phenotypes in multiple mouse models of lupus, offering a novel therapeutic approach for treating this autoimmune disease in humans.

March 3

JAX® Mice Help Unravel Cannabinoid-induced Munchies
It has been commonly observed that smoking marijuana (Cannabis sativa) induces the "munchies". Indeed, the neural circuits in the hypothalamus that regulate satiety can be disrupted by cannabinoids derived from marijuana. New research published in Nature (Koch et al. 2015) reveals a key role for pro-opiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (ARC) in regulating food intake. Stimulating cannabinoid receptor 1 (CB1R) in the ARC activates POMC neurons and increases food consumption in fed mice. These findings describe an important new mechanism in controlling feeding behavior.

March 3

New NSGTM-variant model does not require irradiation for engraftment of HSCs
NSGTM mice (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ, Stock# 005557) have revolutionized human disease modeling by providing a platform with which to create new and valuable models to study human hematopoiesis, cancer, infectious and many other diseases. With their severely immunodeficient phenotype, NSGTM mice support higher levels of engraftment with many kinds of human cells and tissues than traditional immunocompromised host strains

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