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JAX® Mice and Services news

February 23

Reduced prices on JAX® Mice strains—Special J offers
Save 25% off select strains of JAX® Mice, while supplies last

February 18

Desktop Wallpaper Calendars for March 2015
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February 17

Time-Restricted Feeding:  The Latest Diet Craze?
An exciting study in Cell Metabolism (Chaix et al. 2014) illustrates the pleiotropic beneficial effects of time-restricted feeding on the development of obesity and related disease risk factors that does not rely on caloric restriction.

February 16

Cellular senescence: an unexpected advantage in wound healing
A 2014 publication demonstrates that senescent cells at a wound edge promote tissue repair.  The study uncovered secreted factors that may have clinical applications in improving wound closure and reducing scar tissue. 

February 4

Thirsty? Specific Neural Populations Drive the Instinct
The instinct to drink or stop drinking has been mapped to a distinct group of neurons in the mouse brain in a recent study (Oka et al., 2015). Optogenetic activation or inhibition of these neurons led water-satiated mice to drink or water-deprived mice to stop drinking, respectively. The identification of this control center in the brain points toward progress in mapping and understanding the specific circuits that regulate innate urges and motivations.

February 4

Inhibition of Diabetes Onset by an ROR Inverse Agonist
TH17 cells are a T cell subpopulation that plays a significant role in autoimmune diseases, including type 1 diabetes. Exciting new data published in Endocrinology (Solt et al. 2015) demonstrates that TH17 cell differentiation can be blocked in vivo by an RORα and RORγt antagonist. Treating NOD/ShiLtJ mice, a model of human type 1 diabetes, with the antagonist significantly diminished insulitis and prevented the onset and progression of diabetes.

January 21

Desktop Wallpaper Calendars for February 2015
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January 20

Breast Cancer Stem Cell Self-Promotion Occurs through Extracellular Matrix Modification
A compelling 2015 study by Chang et al. demonstrates that a specialized population of breast cancer stem cells promotes its own “stemness” and influences its microenvironment through a TAZ transcriptional positive feedback loop. 

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