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JAX® Mice and Services news

December 10

Safer Gene Therapy for Immuno-Oncology
An important advance in developing safer gene therapies for immune-mediated cancer treatments has been reported in Cancer Research (Gschweng et al. 2014).  The safety of gene delivery by viral vectors into human hematopoietic stem cells (HSCs) is a legitimate concern based on adverse events observed in early clinical trials. Gschweng et al. have addresses this issue by creating a vector engineered to co-deliver a suicide gene along with a therapeutic anti-tumor T cell receptor (TCR).

December 9

Essential airway stem cells for lung generation
An exciting article in Nature reveals a mechanism by which a population of distal airway stem cells contributes to lung regeneration following acute viral infection and lung injury.  The studies highlight the potential for stem-cell based therapeutic strategies for treating patients with acute and chronic lung disease.

November 24

In Vivo Optogenetic Modulation of Cerebellar Networks
A recent article in PLoS One demonstrates a new device to precisely control and simultaneously record from specific neuronal circuits and cell-types in vivo using optogenetic tools. 

November 24

Replacement of Embryo-derived Cardiac Macrophages with Age May Affect Heart Tissue Homeostasis
A recent study (Molawi et al., 2014) describes how resident, embryo-derived macrophages in the heart slowly lose their capacity for self-renewal, and are replaced gradually by less proliferative, monocyte-derived macrophages.   This transition is associated with decreased capacity to repair cardiac tissue, and might explain the increased prevalence of cardiac disease as we age.

November 17

Reduced prices on JAX® Mice strains—Special J offers
Save 25% off select strains of JAX® Mice, while supplies last

November 10

Tumor-Stromal Cell Turnover in PDX Mice
Stromal cells found within epithelial tumors can have a significant impact on the growth, vascularization, invasiveness, and metastatic potential of the cancer.  These features make stromal cell populations potential therapeutic targets.  A new publication in the journal Digestive Diseases and Sciences (Maykel et al., 2014) demonstrates the importance of immunodeficient host mouse selection for efficient propagation of primary human tumors referred to as patient derived xenografts (PDX), maintenance of tumor microenvironment, and in establishing a platform for in vivo therapy testing.

October 28

Novel Inhibitor Targets Vascular and Cognitive Defects in AD Mice
A new study in Journal of Experimental Medicine (Ahn et al. 2014) describes a novel molecule that targets Aβ-fibrinogen interactions in the 5XFAD mouse model of Alzheimer’s disease.  The novel inhibitor, RU-505, demonstrates efficacy in improving cerebrovascular and cognitive deficits in this model.

October 28

Desktop Wallpaper Calendars for November/December 2014
Free downloadable image for your desktop or phone

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