AXB and BXA RI Strains Reclassified
JAX® NOTES Issue 504, Winter 2006
After analyzing AXB and BXA recombinant inbred (RI) strains with high-density single nucleotide polymorphic (SNP) markers, Jackson Laboratory staff concluded that some of the strains were genetically similar. Thus, the following strains have been reclassified:
BXA8/PgnJ (001697) and BXA17/PgnJ (001704).
Strain BXA17/PgnJ, shown to be a replica of BXA8/PgnJ, was discarded and is now listed as extinct. The original and unique BXA17/PgnJ strain was lost between 1989 and 1990. Literature before then refers to the original strain; literature since then refers to strain BXA8/PgnJ.
AXB13/PgnJ (001826) and AXB14/PgnJ (001684).
These strains were shown to be "sister" strains: isogenic except for large regions of chromosomes 11, 12, and 13, and smaller regions of a few other chromosomes. They are therefore "near congenics." Thus, AXB13/PgnJ retained its name, and AXB14/PgnJ was renamed AXB13a/PgnJ.
AXB18/PgnJ (001686), AXB19/PgnJ (001687), and AXB20/PgnJ (001688).
These three strains were also shown to be sister strains, but with significant regions of some chromosomes differing between them. Two of these strains were renamed: AXB18/PgnJ is now AXB19a/PgnJ; AXB20/PgnJ is now AXB19b/PgnJ. AXB19/PgnJ was considered the primary strain because it has the best traceable history, and its name was retained.
In general, the sister strains should not be used for primary screening or QTL mapping. However, if a QTL is located in a region of difference between sister RI strains, the strains may be used as near congenics for additional analysis.
