JAX® NOTES Winter 2006, No. 504

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In this issue...

Reliable New Sperm Cryopreservation Service Developed at The Jackson Laboratory

The Jackson Laboratory recently developed the first truly reliable and cost-effective sperm cryopreservation and recovery service for transgenic and knockout mice.

New Alopecia Areata Service Developed at The Jackson Laboratory

The Jackson Laboratory is offering a new service to alopecia areata researchers. Alopecia areata (AA) is a T cell-mediated autoimmune skin disease resulting in hair loss from the scalp and elsewhere.

JAX® Mice: the Gold Standard Just Got Better

One of the most important reasons why biomedical researchers use JAX® Mice is that they are the most well-characterized laboratory mice in the world.

JAX® Ready StrainsTM: Ready When You Are

Some mouse strains are so critical to biomedical research that they must be available in large quantities at virtually a moment's notice.

AXB and BXA RI Strains Reclassified

After analyzing AXB and BXA recombinant inbred (RI) strains with high-density single nucleotide polymorphic (SNP) markers, Jackson Laboratory staff concluded that some of the strains were genetically similar.

JAX® Mice Strain Sleeps While Standing

At the very moment when Jackson Laboratory biologist Peter Reifsnyder was in the doctor's office being diagnosed with sleep apnea, a sleep disorder that troubles roughly 12 million Americans, some animal technicians in one of the Laboratory's mouse rooms were curiously observing a very odd behavior by individuals of a mouse strain called New Zealand Obese (NZO/HILtJ, 002105).

Clarification: Are C57BL/6J Male Mice Really Glucose Intolerant?

Many of our customers use C57BL/6J (B6, 000664) mice as normoglycemic and glucose tolerant controls for certain obesity/diabesity and genetically engineered mouse mutants with a B6 background.

Newly Available JAX® GEMM® Strains

Newly Available JAX® GEMM® Strains

Discovery Strategies Conference

The Laboratory Mouse in the Development of New Therapeutic Approaches to the Treatment of Neurological Disease

Surgical Services Tissue Order Forms Revised

In addition to performing over 60 types of standard and custom surgical procedures, our Surgical Services group distributes biological specimens such as serum, plasma, whole blood, tissues, and organs.

MGI Releases Version 3.51

Mouse Genome Informatics (MGI, www.informatics.jax.org) is pleased to announce its release of version 3.51.

The Jackson Laboratory to Play a Key Role in the Knockout Mouse Project

In early September, the National Institutes of Health (NIH) formally launched its Knockout Mouse Project (KOMP).

Jackson Laboratory Scientists Help Crack the Egg's Secrets

Drs. Alexei Evsikov, Barbara Knowles, and colleagues at The Jackson Laboratory recently published the results of their extensive investigation of the genetic mechanisms governing the development of a fully-grown oocyte into an embryo (Evsikov et al. 2006).

Jackson Laboratory Scientists Discover Mutation Causing Charcot-Marie-Tooth-Like Disease in Mice

Drs. Robert Burgess, Kevin Seburn, and Gregory Cox (all at The Jackson Laboratory) and colleagues recently identified a dominantly inherited mutation that causes overt neuromuscular dysfunction and dramatically shortens lifespan in mice (Seburn et al. 2006).

New Jackson Laboratory Research Building Opens

In mid-August, The Jackson Laboratory celebrated the opening of its new $26 million three-story, 50,000 square-foot, East Research Building.

Revised Resource Manuals Available

The Jackson Laboratory is pleased to announce that revised editions of the Cancer Resources Manual and the Genetic Background (formerly Genetic Resources) Resource Manual are now available.