Mouse Phenome Project: Priority Strains List Revised
JAX® NOTES Issue 507, Fall 2007
The Mouse Phenome Project (MPP) Priority Strains has been reviewed and revised based on strain availability, research trends, community input, and new resources, especially the recent release of the NIEHS-Perlegen SNPs for 8.27 million genome-wide locations in a set of inbred strains (Frazer et al. 2007). The strains in the revised MPP list (plus C57BL/6J) will receive top phenotyping priority. Phenotypic data for these strains can now be correlated to the densest SNP dataset available in the world.
The revised MPP list groups 36 strains into three priority tiers (Fig. 1, see pdf document for this figure): tier 1 contains the 16 NIEHS-Perlegen strains; tiers 2 and 3 each contain 10 strains. These strains are well-distributed in the Mouse Family Tree. Strains C57BL/10J, CE/J, I/LnJ, JF1/Ms, NZB/BlNJ, PERA/EiJ, SEA/GnJ, and SPRET/EiJ were dropped from the previous list because they are difficult to breed (and therefore sometimes unavailable), hard to handle, or redundant to other priority strains. Because considerable amounts of phenotypic data already exist for these strains, they will be listed as retired strains and may be used if other strains are not suitable or available. Strains BPL/1J, DDY/JclSidSeyFrkJ, MRL/MpJ, and NZL/LtJ were added to the list to ensure that analyses of MPP strains can be performed with sufficient statistical power. The new strains breed well, are widely used, and/or have unique phenotypes.
You can order MPP strains from Customer Service at 1-800-422-6423 or 1-207-288-5845. MPP strain characteristics data and SNPs are available from the Mouse Phenome Database.
References
(Authors in bold are Jackson Laboratory scientists.)
Petkov PM, Ding Y, Cassell MA, Zhang W, Wagner G, Sargent EE, Asquith S, Crew V, Johnson KA, Robinson P, Scott VE, Wiles MV. 2004. An efficient SNP system for mouse genome scanning and elucidating strain relationships. Genome Res 14:1806-11.
Frazer KA, Eskin E, Kang HM, Bogue MA, Hinds DA, Beilharz EJ, Gupta RV, Montogomery J, Morenzoni MM, Nilsen GB, Pethiyagoda CL, Stuve LL, Johnson FM, Daly MJ, Wade CM, Cox DR. 2007. A sequence-based variation map of 8.27 million SNPs in inbred mouse strains. Nature Advance online publication 29 July 2007.
