In Vivo Imaging Capabilities Expanded With Xenogen’s IVIS® Lumina Imaging System
JAX® NOTES Issue 510, Summer 2008
Imagine having the ability to monitor cellular events such as tumor progression and metastasis in live mice! Well, thanks to a newly installed image monitoring system at The Jackson Laboratory — West, that concept is now a reality. The Jackson Laboratory's In Vivo Services group has recently purchased and installed the IVIS® Lumina Imaging System from Xenogen, now part of Caliper Life Sciences. Located in Sacramento, California, JAX® In Vivo Services deliver target validation and efficacy testing in the context of mouse models of human disease. The addition of the IVIS® Lumina imaging system to the In Vivo Services group allows monitoring of cellular activity through bioluminescent or fluorescent reporters in live mice. The IVIS® Imaging System is physically calibrated and measures absolute light emitted from an animal. This enables meaningful comparisons of results obtained from different mice, experiments, or labs over the course of time.
By leveraging our cancer research experience and the extensive collection of immunodeficient mouse strains available at JAX, we have developed orthotopic transplant models of human cancer incorporating the IVIS® Lumina imaging system. These models allow longitudinal evaluation of tumor development before, during and after treatment as well as the detection of small tumor and micrometastases, offering an excellent preclinical strategy to assess tumor response and recurrence. Our service is very customizable. We have the flexibility to import client-provided cancer cell lines to develop new orthotopic models. We can perform standard protocols, modify our routine procedures to match clients’ requirements, and/or transfer protocols from the literature.
Still have questions? Want to get started? Contact JAX® Services at jaxservices@jax.org, 1-800-422-6423, or 1-207-288-5845.
