Unique Collaboration Results in Mouse Endocrine System Book
JAX® NOTES Issue 514, Summer 2009
In a unique collaboration, a new book on the embryology of the mouse endocrine system "Histologic basis of mouse endocrine system development: a comparative analysis" is authored by Drs. Matthew H. Kaufman at the University of Edinburgh Medical School, Edinburgh, Scotland, Alexander Yu Nikitin at the Department of Biosciences, Cornell University College of Veterinary Medicine, Ithaca, NY, and John Sundberg, a professor at The Jackson Laboratory, Bar Harbor, ME, and published by CRC Press in Boca Raton, FL.
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JAX Professor John Sundberg, one of the authors of the new book |
Although the book focuses on comparative embryology of the endocrine organs, the images contain many other organs. Low magnification images of mouse embryos were previously published in black and white in Dr. Kaufman's classic textbooks on mouse embryology. However, the authors used new digital 'virtual slide' technology to generate color images of mouse embryos at various magnifications and developmental stages. They can be examined in two formats: 1) on the text pages themselves (for orientation and reference) and 2) on an accompanying DVD as 'virtual slides'. The ImageScopeª software (Aperio Technologies, Inc.) on the DVD turns a computer into a 'virtual microscope': the DVD's images can be moved across the screen, and areas of interest can be enlarged and evaluated in more detail. This technology can help an investigator identify structures in normal mouse embryos and compare them with embryos being investigated.
The text discusses how the embryogenesis of the mouse endocrine system relates to that in humans (primarily) and to many other species. On the other hand, because the book is intended to help investigators examine genetically engineered mice with embryonic abnormalities, the digital images focus entirely on the mouse.
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