Alopecia (loss of hair) in C57BL/6J and Related Strains

JAX® NOTES Issue 431, October 1987

Overgrooming Behavior

Hair loss due to overgrooming (hair nibbling, whisker-eating) has been observed at The Jackson Laboratory for many years among mice in the C57BL/6J and related strains, i.e., C57BL/10J, C58/J, C57BR/cdJ, C57L/J and the congenic histocompatibility lines based on the genetic background of C57BL/10 and C57BL/6. These include the various B10.A lines, the B10.D2 lines, B10.LP lines, B10.129, B6.C, etc. The overgrooming behavior is seen in other strains, but the frequency is usually very low.

Occurrence of Hair Loss

In every case where overgrooming occurs the hair will grow back again if the mice are separated into individually occupied cages. If only one whisker-eating mouse is present in a cage, it can be readily identified by its own full set of whiskers (Fig.1).

If there is more than one whisker eater or if the hair loss is diffuse and involves areas other than the muzzle, the whisker eater cannot be as readily identified (Fig.2 and 3).

The occurrence of hair loss, the size and shape of the affected area, and the frequency of a particular pattern are variable. Mice of the C57BL substrains are much more prone to hair loss than other strains and certain congenic histocompatibility strains are especially susceptible.

Normal Characteristic

At The Jackson Laboratory the type of alopecia resulting from social interaction of the mice - overgrooming - is considered a normal characteristic of C57BL/6J and related mouse strains and no attempt is made to prevent distribution of such mice. In some instances mice with no evidence of hair loss at the time of shipping will arrive at the consignee's facility with alopecia on the body. In such cases the hair grows back after one or two weeks in the animal room environment.

Alopecia Bibliography

Hair loss caused by overgrooming is not a problem in our colonies. We are aware of the situation, the cause in not clearly understood, and the method of prevention (other than isolating the mice) is not known.

For additional literature see the following Bibliography:

Clark, L.H. and M. W. Schein. 1966. Activities associated with conflict behavior in mice. Animal Behavior 14:44-49.

Hauschka, T. S. 1952. Whisker-eating mice. J. Hered. 43:77-80.

Litterst, C. L. 1974. Mechanically self-induced muzzle alopecia in mice. Lab Animal Science 24:806-809.

Long, S. Y. 1972. Hair-nibbling and whisker-trimming as indicators of social hierarchy in mice. Animal Behavior 20:10-12.

Militzer, K. And E. Wecker. 1986. Behavior associated alopecia areata in mice. Laboratory Animals 20:9-13.

Strozik, E. And M. R. W. Festing. 1981. Whisker trimming in mice. Laboratory Animals 15:309-312.

Thornburg, L. P., H. D. Stowe and J. R. Pick. 1973. The pathogenesis of the alopecia due to hair chewing in mice. Lab. Animal Sciences 23:843-850.