Arthritis Models in the Mouse

JAX® NOTES Issue 432, October 1988

Arthritis Models

Arthritis in the mouse can be induced, spontaneous in some inbred strains, or related to single gene mutations. Induced murine arthritis models include treatment with type II collagen (DBA/1LacJ), pristane (BALB/c), thymocytes (C3H/He), Mycoplasma (CBA), and high fat diet (C57BL). Inbred strains that have been reported to develop spontaneously arthritis-like symptoms include MRL/1, C57BL, and NZB. Three mutations have been associated with arthritis, lpr (lymphoproliferation), ank (progressive ankylosis), and Moblo (mottled-blotchy). Selected articles for these arthritis models in the mouse are listed below. A Medline search through the National Library of Medicine computerized reference database will provide additional reference material.

References for Induced Arthritis in Mice

Induced arthritis in mice

Silberberg M, Silberberg R. 1960. Osteoarthritis in mice fed diets enriched with animal or vegetable fat. Arch Pathol 70:385.

Harwick HJ, et al. 1973. Arthritis in mice due to infection with Mycoplasma
pulmonis. I. Clinical and microbiologic features. J Infect Diseases 128:533.

Cole BC, et al. 1976. Arthritis of mice induced by Mycoplasma arthritidis. Humoral antibody and lymphocyte responses of CBA mice. Ann Rheum Dis 35:14.

Holmdahl R, et al. 1986. Homologous type II collagen induces chronic and progressive arthritis in mice. Arthritis Rheum 29:106.

Courtenay JS, et al. 1980. Immunization against heterologous type II collagen induces arthritis in mice. Nature 283:666.

Paska W, et al. 1986. Studies on type II collagen induced arthritis in mice. Agents Actions 18:413.

Hopkins  SJ, et al. 1985. Pristane-induced arthritis in BALB/c mice. Curr Top Microbiol Immunol 122:213.

Tanabe S, et al. 1981. Chronic polyarthritis in inbred C3H/He mice after systemic administration of allogeneic thymocytes. J. Rheumatol 8:895.

Brackertz D, et al. 1977. Antigen-induced arthritis in mice. I. Induction of arthritis in various strains of mice. Arthritis Rheum 20:841.

References for Inbred Strains with Arthritis

Arthritis in inbred strains

Hang L, et al. 1982. A spontaneous rheumatoid arthritis-like disease in MRL/1 mice. J Exp Med 155:1690.

Pataki A, et al. 1980. Age-related histochemical and histological changes in the knee-joint cartilage of C57BL mice and their significance for the pathogenesis of osteoarthrosis. I. Oxidative enzymes. Exp Cell Biol 48:329.

Wilhelmi G, Faust R. 1976. Suitability of the C57 black mouse as an experimental animal for the study of skeletal changes due to aging, with special reference to osteo-arthrosis and its response to tribenoside. Pharmacol 14:289.

Wigley RD, et al. 1977. Degenerative arthritis in mice. Study of age and sex frequency in various strains with a genetic study of NZB/B1, NZY/B1, and hybrid mice. Ann Rheum Dis 36:249.

References for Single Gene Mutations

Single gene mutations causing arthritis

Theofilopoulos AN, et al. 1983. Monoclonal IgM rheumatoid factors derived from arthritic MRL/MP-lpr/lpr mice. J Exp Med 158:901.

Pataki A, Rordorf-Adam C. 1985. Polyarthritis in MRL/MpJ-lpr/lpr mice. Rheumatol Int 5:113.

Sweet HO, Green MC. 1981. Progressive ankylosis, a new skeletal mutation in the mouse.  J Hered 72:87.

Silberberg R. 1977. Epiphyseal growth and osteoarthrosis in blotchy mice. Exp Cell Biol 45:1.