CBA Substrains Maintained at The Jackson Laboratory

JAX® NOTES Issue 432b, January 1988

Characteristics of CBA Substrains

All CBA substrains originated from Strong (1920) in a cross of a Bagg albino female and a DBA male. The following characteristics distinguish CBA substrains maintained at The Jackson Laboratory:

CBA/J. Inbreeding F200. Differs from CBA/CaJ at a number of loci (see Inbred Strains of Mice 14:7, 1986). Some incidence of hepatomas and mammary tumors (Smith, G S, et al, J Natl Canc Inst 50:1195-1213, 1973). Carries retinal degeneration (rd). Not histocompatible with CBA/CaJ or CBA/CaH-T6J;

CBA/CaJ. Inbreeding F123. Histocompatible with CBA/CaH-T6J;

CBA/CaH-T6J. Inbreeding N13F93. The reciprocal translocation, T(14;15)6Ca was introduced into this substrain by M.F. Lyon followed by 13 generations of backcrossing to CBA/Ca and subsequent inbreeding. It is histocompatible with CBA/CaJ;

CBA/NJ. Inbreeding F75. Originated from CBA/H. The CBA/NJ substrain carries the X-linked mutation, xid (X-linked immune deficiency), which causes a defective immune response to thymus-independent antigens (Cohen, P L, et al, J Immunol 116:301-304, 1976).

References

References for further information on CBA substrains:

Pedigree history

  • Handbook on Genetically Standardized JAX Mice, Third Edition, Heiniger HJ, Dorey JL (ed.), The Jackson Laboratory, Bar Harbor, Maine, 1980.
  • Origins of Inbred Mice, Morse III HC, ed, Academic Press, NY, 1978.

Strain characteristics

  • Inbred Strains in Biomedical Research, Festing MFW, Oxford University Press, NY 1978.
  • Staats J. J Nat Canc Inst 45:945-977, 1985.
  • Inbred Strains of Mice, 14:7, 1986.

Subline divergence

  • Whitmore AC, Whitmore SP. Immunogenet 21:407-428, 1985.
  • Green MC, Kaufer KA. Transplant 3:767-768, 1965.