Erratum to "Alzheimer's Disease-Related Strain" JAX® Notes No. 488, Winter 2002
JAX® NOTES Issue 491, Fall 2003
The JAX® Notes No. 488, Winter 2002 "Alzheimer's Disease-Related Strain" article indicates that JAX® Mice strain B6C3-Tg(APP695)85Dbo Tg(PSEN1)85Dbo (Stock Number 004462) carries the A246E PSEN1 mutation, when in fact, it actually bears the DeltaE9 PSEN1 mutation. The DeltaE9 mutation results in a misplicing event involving exon 9, while the A246E mutation is a difference in a single amino acid1. Although both are associated with Alzheimer's disease, the article describes the wrong mutation.
To view the corrected article in its entirety, go to: www.jaxmice.jax.org/library/notes/488g.html
Reference
1. Jankowsky JL, Slunt HH, Ratovitski T, Jenkins NA, Copeland NG, and Borchelt DR. Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng 2001; 17:157-165.
