Strains of JAX® Mice available from The Jackson Laboratory—West

Our Sacramento, CA facility maintains the following popular strains:

Inbred Strains

BALB/cJ
(Stock Number 000651)

BALB/cJ is a commonly used inbred. Key traits include a resistance to experimental autoimmune encephalomyelitis (EAE), and a susceptibility to developing the demyelinating disease upon infection with Theiler's murine encephalomyelitis virus. The BALB/cJ substrain is susceptible to Listeria, all species of Leishmania, and several species of Trypanosoma, but is resistant to experimental allergic orchitis (EAO).

C57BL/6J
(Stock Number 000664)

C57BL/6J is the most widely used inbred strain and the first to have its genome sequenced. Although this strain is refractory to many tumors, it is a permissive background for maximal expression of most mutations. C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss. They are also susceptible to diet-induced obesity, type 2 diabetes, and atherosclerosis. Macrophages from this strain are resistant to the effects of anthrax lethal toxin.

DBA/2J
(Stock Number 000671)

DBA/2J mice show low voluntary consumption of ethanol or morphine and a low susceptibility to diet induced development of atherosclerotic aortic lesions. Young DBA/2J mice are prone to audiogenic seizures. They also exhibit high-frequency hearing loss beginning around the time of weaning/adolescence and it becomes severe by two to three months of age. Aging DBA/2J mice develop progressive eye abnormalities that closely mimic human hereditary glaucoma.

FVB/NJ
(Stock Number 001800)

Due to the prominent pronuclei in their fertilized eggs and the large litter size, FVB/NJ are commonly used for transgenic injection. FVB/NJ mice are homozygous for the retinal degeneration 1 allele of Pde6brd1, resulting in blindness by wean age.

F1 Hybrid

B6D2F1/J
(Stock Number 100006)

Cross between C57BL/6J (B6) female x DBA/2J (D2) male. B6D2F1/J mice are heterozygous for B6 and D2 alleles at all loci in their genome. Useful as a genetic background for transgenic/knockout creation, as well as other deleterious mutations. Research applications include radiation and behavioral research, and safety and efficacy testing, bioassays of nutrients, drugs, pathogens, and hormones.

JAX® GEMM® Strains

B6.129P2-Apoetm1Unc/J
(Stock Number 002052)

Mice homozygous for the Apoetm1Unc mutation show a marked increase in total plasma cholesterol levels that are unaffected by age or gender. Fatty streaks in the proximal aorta are found at 3 months of age. The lesions increase with age and progress to lesions with less lipid but more elongated cells, typical of a more advanced stage of pre-atherosclerotic lesion.

C3Bir.129P2(B6)-Il10tm1Cgn/Lt
(Stock Number 004326)

This strain represents a genetic mouse model of inflammatory bowel disease (IBD) where stable inflammatory lesions in the cecum and colon are present by six to seven weeks of ages. The mice carry a targeted mutation of the interleukin 10 gene, one of several genes whose disruption induces IBD. Evidence from several publications suggests that the enteric flora of the mice contributes significantly to the presentation of the IBD-like phenotype. Our colony is maintained in isolators under conditions which preserve the presence of potentially strain-unique enteric flora required for the development of IBD.

CBySmn.CB17-Prkdcscid/J
(Stock Number 001803)

Commonly referred to as BALB/c scid, these animals carry the severe combined immune deficiency mutation (scid) on the BALB/c background. This strain is very similar to the original BALB/c-Ighb scid (C.B-17 scid) strain maintained at the Institute for Cancer Research in Philadelphia, PA. Compared with our most popular scid mutant strain (NOD-scid, Stock #001303), the BALB/c scid does not carry the C5 complement deficient mutation, thus enabling Complement-Dependent Cytotoxicity (CDC), a major pharmacological effect of therapeutic antibodies. This is the strain of choice for efficacy testing of therapeutic antibodies in the context of transplantable tumor host.

MRL/MpJ-Faslpr/J
(Stock Number 000485)

Commonly referred to as lpr mutants. Mice are homozygous for the lymphoproliferation spontaneous mutation (Faslpr), and show systemic autoimmunity, massive lymphadenopathy associated with proliferation of aberrant T cells, arthritis, and immune complex glomerulonephrosis. Mice are useful as a model for systemic lupus erythematosus and Sjorgren syndrome.

NOD.CB17-Prkdcscid/J
(Stock Number 001303)

Mice homozygous for the severe combined immune deficiency spontaneous mutation Prkdcscid, commonly referred to as scid, are characterized by an absence of functional T cells and B cells, lymphopenia, hypogammaglobulinemia, and a normal hematopoietic microenvironment. Prkdcscid mice accept allogeneic and xenogeneic grafts making them an ideal model for cell transfer experiments. In general, Prkdcscid leakiness is low on the NOD/ShiLtSz genetic background.

NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(Stock Number 005557)

These mutant mice combine the features of the NOD/ShiLtJ background, the severe combined immune deficiency mutation (scid) and IL2 receptor gamma chain deficiency. As a result, the NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ mice lack mature T cells, B cells, or functional NK cells, and are deficient in cytokine signaling, leading to better engraftment of human hematopoietic stem cells and peripheral-blood mononuclear cells than any other published mouse strain. Recent publications have demonstrated this strain's outstanding utility in the studies of islet transplantation, hematopoietic stem cells and cancer stem cells.