•  The elevated blood glucose characteristic of these mice is related to their body weight. Differences in housing density can affect food intake and energy expenditure which affect body weight. We recommend group housing in density of 3 to 5 per pen. Over time, mice housed individually can be expected to weigh less than mice housed in groups.

•  Changes in diet (macronutrient content of diet as well as hardness) can affect body weight and non-fasted blood glucose. When the cages are changed, we recommend sprinkling some food on the bottom of the mouse cage to make it more accessible for these mice.

•  These mice become polyuric by 8 to 10 weeks of age. Bedding should be changed once per week. More frequent bedding changes are not normally necessary and could cause the rate of body weight gain to decline. We recommend that mice be provided nesting materials (we use Nestpacks) for enrichment.

If you have questions about working with the NONNZO Male, please contact our Technical Support group at 1-800-422-MICE (6423) or e-mail them at micetech@jax.org .