Both cryopreserved and live Repository strains can be quickly and efficiently expanded to deliver cohorts directly into your discovery program. With JAX® Dedicated Supply Service and JAX® Speed Expansion Service you'll get the mice you need when you need them — fast.
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 004434 | B6.129S4-Ccl2tm1Rol/J | Level 4 |
| Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. No gene product is detected in lipopolysaccharide (LPS) -stimulated peritoneal macrophages isolated from homozygous mice. The numbers of peritoneal macrophages, Kupffer cell and alveolar macrophages were similar to levels found in wildtype mice. Thioglycollate induced peritonitis results in impaired recruitment of monocytes and macrophages to peritoneal cavity. Cellular recruitment to delayed-type hypersensitivity challenges and secondary granulomata is reduced. This mutant mouse strain represents a model that may be useful in studies related to leukocyte trafficking. | ||
| 014095 | B6.Cg-Tg(GFAP-Ccl2)JE95Rmra/J | Repository- Live |
| Mice homozygous for the huGFAP-MCP-1 transgene are viable and fertile, with expression of mouse monocyte chemoattractant protein-1 (MCP-1 or Ccl2) directed primarily to astrocytes of the CNS by the human glial fibrillary acidic protein (GFAP) promoter. Transgene-directed mRNA and protein expression is observed in CNS lysates and astrocyte cultures, as well as in peripheral nerve (such as sciatic; because GFAP is expressed by nonmyelinating Schwann cells). Mice derived from the high-expressing founder line 95 (also called huGFAP-MCP-1hi tg+, huGFAP-CCL2hi tg+, or JE-95 mice) overexpress CCL2 in an astroglial activation-dependent manner. Levels of CCL2 expression in the CNS of huGFAP-CCL2hi tg+ mice were comparable with those observed in CNS tissues from mice with experimental autoimmune encephalomyelitis (EAE). With chronic overexpression of CCL2, aged huGFAP-CCL2hi tg+ mice develop D ..... For more information please see the full phenotype on the strain data sheet | ||
| 016849 | B6.Cg-Ccl2tm1.1Pame/J | Awaiting Transfer from the Donor |
| These Ccl2-RFPlox/lox mice contain loxP sites flanking exons 2-3 of the Ccl2 gene which has been modified with a red fluorescent protein gene (mcherry). Fluorescence is seen in all Ccl2-expressing cells. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exons 2-3, as well as RFP, deleted in the cre-expressing tissue. | ||
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