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| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 002693 | B6.129S1-Il12btm1Jm/J | Level 4 |
| Mice homozygous for the Il12btm1Jmtargeted mutation have a severely restricted ability to mount a TH1 response to in vivo endotoxin administration as evidenced by decreased interferon-gamma production although IL2 (IL-2) production is not compromised. The TH2 response is enhanced as evidenced by increased secretion of IL4 (IL-4). Delayed type hypersensitivity (DTH) responses are reduced. Also see the Il12a-deficient strains (Stock No. 002691 & 002692). | ||
| 006412 | B6.129-Il12btm1Lky/J | Repository- Live |
| Mice homozygous for this bicistronic "yet40" allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. The IRES-EYFP is inserted downstream of the endogenous stop codon, allowing for normal expression of the endogenous gene and simultaneous EYFP reporter expression. ELISA assays confirm that p40 protein is expressed at similar levels in homozygous mutant and wildtype mice. The EYFP reporter marks dendritic cell (DC) and macrophage lineage cells that produce p40 following stimulation with toll-like receptor (TLR) ligands both in vivo and in vitro. These mice may be useful for labeling activated IL12/23 p40 expressing cells in studies of immunology and immunity, TLR signal cascades, cancer immunity, and vaccine development. | ||
| 002694 | C.129S1-Il12btm1Jm/J | Repository- Live |
| Mice homozygous for the Il12btm1Jm targeted mutation have a severely restricted ability to mount a TH1 response to in vivo endotoxin administration as evidenced by decreased interferon-gamma production although IL2 (IL-2) production is not compromised. The TH2 response is enhanced as evidenced by increased secretion of IL4 (IL-4). Delayed type hypersensitivity (DTH) responses are reduced. Also see the Il12a-deficient strains (002691 & 002692). | ||
| 015864 | C.129S4(B6)-Il12btm1Lky/J | Repository- Live |
| A targeting vector was designed to insert an internal ribosome entry site (IRES)-enhanced yellow fluorescent protein (eYFP) fusion protein, followed by a floxed neomycin (neo) resistance cassette, downstream of the endogenous translational stop codon of the interleukin 12b (Il12b) gene. These homozygous YET40 mice are viable, fertile, and normal in size. IL-12b, or p40, binds with p35 to form the heterodimeric cytokine IL-12, after induction by toll like receptors (TLRs), in macrophages and dendritic cells (DC). YET40 mice show p40 and YFP expression in DC in draining lymph nodes, after inoculation with Listeria monocytogenes or lipopolysaccharide (LPS), and promote Th1 differentiation. These mice may be useful for visualizing active IL-12 in DCs and macrophages during immune response. | ||
| 015863 | C.129S4(B6)-Il12btm2Lky/J | Repository- Live |
| A targeting vector was designed to insert an internal ribosome entry site (IRES)-enhanced green fluorescent protein (eGFP) fusion protein, followed by a floxed neomycin (neo) resistance cassette, downstream of the endogenous translational stop codon of the interleukin 12b (Il12b) gene. These homozygous GET40 mice are viable, fertile, and normal in size. IL-12b, or p40, binds with p35 to form the heterodimeric cytokine IL-12, after induction by toll like receptors (TLRs), in macrophages and dendritic cells (DC). GET40 mice show p40 and GFP expression in DC in draining lymph nodes, after inoculation with Listeria monocytogenes or lipopolysaccharide (LPS), and promote Th1 differentiation. These mice may be useful for visualizing active IL-12 in DCs and macrophages during immune response. | ||
| 009618 | NOD.129(B6)-Il12btm1Lky/JbsJ | Cryopreserved - Ready for recovery |
| Mice homozygous for this bicistronic "yet40" allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. The IRES-EYFP is inserted downstream of the endogenous stop codon, allowing for normal expression of the endogenous gene and simultaneous EYFP reporter expression. ELISA assays confirm that p40 protein is expressed at similar levels in homozygous mutant and wildtype mice. The EYFP reporter marks dendritic cell (DC) and macrophage lineage cells that produce p40 following stimulation with toll-like receptor (TLR) ligands both in vivo and in vitro. NOD congenic female mice carrying this bicistronic "yet40" allele experience slightly accelerated diabetes. These mice may be useful for labeling activated IL12/23 p40 expressing cells in studies of immunology and immunity, TLR signal cascades, cancer immunity, vaccine development and diabetes. | ||
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