Both cryopreserved and live Repository strains can be quickly and efficiently expanded to deliver cohorts directly into your discovery program. With JAX® Dedicated Supply Service and JAX® Speed Expansion Service you'll get the mice you need when you need them — fast.
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 010714 | B6.FVB-Tg(Pomc-cre)1Stl/J | Repository- Live |
| In this strain, the mouse pro-opiomelanocortin-alpha (Pomc) promoter drives expression of cre in the central nervous system, primarily the hippocampus. Cre expression is strongest and most restricted to the granule cells of the dentate gyrus subregion. Weaker, scattered expression can also be detected in other regions including the arcuate nucleus of the hypothalamus and the habenular nucleus. When crossed with a strain carrying a loxP-flanked genomic segment of interest, tissue-specific excision of that segment may be achieved. | ||
| 009593 | C57BL/6J-Tg(Pomc-EGFP)1Low/J | Repository- Live |
| Mice hemizygous for this POMC-EGFP transgene are viable and fertile, with EGFP expression directed to POMC-expressing neurons by the mouse Pomc (pro-opiomelanocortin-alpha) promoter/enhancer regions. The donating investigator reports that transcripts from the transgene encode EGFP but do not express any POMC prohormone or peptides. Direct EGFP fluorescence is observed in the arcuate nucleus of the hypothalamus (ARC), in melanotrophs/corticotrophs of the pituitary gland, and (unlike other POMC promoter-driven fluorescent mice) in a subpopulation of newly born granule neurons of the dentate gyrus of the hippocampus. EGFP expression is also observed in the nucleus of the solitary tract of the medulla. EGFP expression is downregulated as neurons mature and migrate deeper into the granule cell layer. These POMC-EGFP mice may be useful in studying neuronal signaling pathways, energy metabolism, leptin activity, obesity, seizures, depression, and epilepsy. | ||
| 006421 | FVB-Tg(Pomc1-hrGFP)1Lowl/J | Repository- Live |
| Hemizygous mice are viable and express humanized Renilla Green Fluorescent Protein (hrGFP, Stratagene) under control of the mouse pro-opiomelanocortin-alpha (Pomc1) promoter. As such, UV light-exposed transgenic brain tissues show GFP fluorescence patterns consistent with the endogenous Pomc1 gene, specifically POMC expressing neurons. The donating investigator reports that hrGFP is more stable and resistant to signal fading compared to other GFP's. The donating investigator reports that transgenic males have smaller seminal vesicles, and breeding transgenic males results in infrequent and very small (<2 pups) litter sizes. When non-transgenic males are crossed with transgenic females, fertility is normal. These POMC-GFP transgenic mice may be useful for studies of neurobiology, energy metabolism, obesity, seizures, and epilepsy. | ||
| 003191 | B6.129S2-Pomctm1Low/J | Cryopreserved - Ready for recovery |
| Mice homozygous for the Pomctm1Low targeted mutation are viable and fertile. Homozygous mutant mice display no overt developmental or behavioral abnormalities. The hypothalmic-pituitary-adrenal axis functions normally. Homozygotes do display significantly greater nonopioid analgesia in response to cold water swim stress compared with controls and display paradoxical naloxone-induced analgesia. Male mice show an altered growth curve during puberty resulting in increased body mass and white fat. This phenotype is present in both the homozygous mutant males and in wildtype males reared by homozygous parents. This strain is useful for looking at response to pain. | ||
| 008115 | B6.129X1-Pomctm2Ute/J | Cryopreserved - Ready for recovery |
| Mice that are heterozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. 60 to 75% of homozygotes die perinatally. Surviving homozygotes have decreased fertility and homozygous females produce milk that does not allow pups to survive past 14 days of age. No serum adrenocorticotropic hormone (ACTH) or corticosterone was detected by radioimmunoassay (RIA) of homozygotes. Serum epinephrine and aldosterone levels are reduced. Although homozygotes are born with adrenal glands or normal size, adrenal glands fail to grow postnatally and become almost undetectable with age. By 3 months of age, mice homozygous for the mutation are twice the weight of wildtype controls and increased serum leptin levels. Heterozygotes exhibit elevated serum leptin levels, but not increased weight and reduced levels of serum adrenocorticotropic hormone (ACTH), corticosterone, and aldosterone levels. Both heterozygotes and homozygote ..... For more information please see the full phenotype on the strain data sheet | ||
| 008322 | B6.Cg-Tg(Pomc-MAPT/Topaz)1Rck/J | Cryopreserved - Ready for recovery |
| These mice express a tau (MAPT)-sapphire green fluorescent protein (GFP) under the transcriptional control of the mouse pro-opiomelanocortin-alpha (Pomc) promoter. Immunohistochemistry for POMC in colchicine-treated animals demonstrated greater than 99% colocalization of POMC with the GFP-expressing neurons in the hypothalamic arcuate nucleus. This strain has been useful in studying the role of Pomc and leptin in food intake and may be useful in further understanding the function of the associated neurons. Hemizygotes are viable and fertile and do not display any gross physical or behavioral abnormalities. | ||
| 008326 | FVB-Tg(Pomc-rtTA)1Rck/J | Cryopreserved - Ready for recovery |
| The mouse pro-opiomelanocortin-alpha (Pomc) promoter drives expression of a modified reverse tetracycline regulatable transactivator (rtTA2S-M2F86Y A209T) in this Tet-On transgenic strain. When these mice are mated to a second transgenic strain carrying a target gene regulated by the tetO responsive elements, expression of the target gene is turned on in POMC-expressing neurons by the tetracycline analog doxycycline (dox). Dox can be administered orally in the food or water. Hemizygous mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. | ||
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