Search Criteria: Strain Type is "Duplication"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 005383 | B6.129S6-Dp(16Cbr1-ORF9)1Rhr/J | Cryopreserved - Ready for recovery |
| These mice are trisomic for the mouse chromosome segment orthologus to the human chromosome 21 Down syndrome critical region (DSCR). The borders of the 3.9 Mb region are defined by the carbonyl reductase 1 gene and a site adjacent to the myxovirus (influenza virus) resistance 2 locus. Trisomic mice are viable, fertile and are significantly larger than euploid littermates. Mandible size is enlarged as is skull size, with an overall elongation of the rostrocaudal aspect in comparison to euploid littermates. This mouse may be useful in studies exploring the consequences of polyploidy involving the DSCR. | ||
| 005536 | B6.129S7-Dp(11Cops3-Rnf112)1Jrl/J | Cryopreserved - Ready for recovery |
| Homozygous mutant mice are viable and fertile. Studies employing heterozygous mutant mice (where the duplication exists only on one chromosome) indicate that mutant mice weigh less than their wildtype litter mates. Spleens are noted to be slightly smaller than those from wild type mice. Mutant mice also exhibit impaired contextual fear conditioning. Male heterozygotes have been shown to be hyperactive in open field analysis. This mutant mouse may be useful in studies exploring the consequences of duplications involving the SMS critical interval. (Mice bearing the reciprocal deficiency mutation are also available; see Stock: 005535) | ||
| 013129 | B6129S-Dp(7Slx1b-Sept1)5Aam/J | Under Development - Now Accepting Orders |
| These mutant mice possess an engineered duplication of approximately 0.39 Mb of mouse Chromosome 7. The region involved encompasses a chromosomal segment, between the GIY-YIG domain containing 2 (Giyd2) gene and the septin 1(Sept1) loci, that shares conserved synteny with Autism spectrum disorders (ASD) critical interval on human Chromosome 16, specifically the 16p11.2 region. Homozygous mutant mice are viable and fertile. These mice exhibit neuroanatomical and behavioral phenotypes. This mutant mouse may be useful in studying Autism and other associated disorders.
(Mice bearing the reciprocal deficiency mutation are also available (see Stock No. 013128) | ||
| 013529 | B6;129S7-Dp(10Prmt2-Pdxk)2Yey/J | Under Development - Now Accepting Orders |
| This Dp(10)2Yey/+ mutant strain contains one copy of mouse Chromosome 10 with the targeted sequence duplicated between, and including, the protein arginine N-methyltransferase 2 (Prmt2) gene and the pyridoxal (pyridoxine, vitamin B6) kinase (Pdxk) gene. Hemizygous mice are viable and fertile. This duplicated region on the mouse chromosome is one of three regions orthologous to an extra copy of human Chromosome 21 (Hsa21) which has been implicated in developmental cognitive disabilities like Down Syndrome (DS). Dp(10)1Yey/+ contains a duplication syntenic to the distal part of human 21q22.3, and carries 41 genes orthologous to genes on Hsa21. When mice carrying this duplication are bred to B6;129-Dp(16Lipi-Zfp295)1Yey/J mice (Stock No. 013530) and B6;129-Dp(17Abcg1-Rrp1b)3Yey/J mice (Stock No. 013531) to create a triple duplication ..... For more information please see the full phenotype on the strain data sheet | ||
| 013530 | B6;129S7-Dp(16Lipi-Zfp295)1Yey/J | Under Development - Now Accepting Orders |
| This Dp(16)1Yey/+ mutant strain contains one copy of mouse Chromosome 16 with the targeted sequence between, and including, the lipase, member I (Lipi) gene and the zinc finger protein 295 (Zfp295) gene. Hemizygous mice are fertile. The donating investigator recently observed that 30% of offspring die shortly after birth due to heart defects. This duplicated region on the mouse chromosome is one of three regions orthologous to an extra copy of human Chromosome 21 (Hsa21) which has been implicated in developmental cognitive disabilities associated with Down Syndrome (DS). Dp(16)1Yey/+ contains a duplication orthologous to human 21q11-q22.3 and carries 113 genes orthologous to genes on Hsa21. These mice exhibit heart defects including cleft of the mitral valve, atrial and ventricular defects, and coarcation of the aorta. Some mice also display annular pancreas and malrotation of the intestines. When mice carrying this duplication are bred ..... For more information please see the full phenotype on the strain data sheet | ||
| 013531 | B6;129S7-Dp(17Abcg1-Rrp1b)3Yey/J | Under Development - Now Accepting Orders |
| This Dp(17)3Yey/+ mutant strain contains one copy of mouse Chromosome 17 with the targeted sequence duplicated between, and including, the ATP-binding cassette, sub-family G (WHITE), member 1 (Abcg1) gene and ribosomal RNA processing 1 homolog B (S. cerevisiae) (Rrp1b) gene. Hemizygous mice are viable and fertile. This duplicated region on the mouse chromosome is one of three regions orthologous to an extra copy of human Chromosome 21 (Hsa21) which has been implicated in developmental cognitive disabilities associated with Down Syndrome (DS). Dp(17)1Yey/+ contains a duplication syntenic to the proximal part of human 21q22.3, and carries 19 genes orthologous to genes on Hsa21. When mice carrying this transgene are bred to B6;129-Dp(10Prmt2-Pdxk)2Yey/J mice (Stock No. 013529) and B6;129-Dp(16Lipi-Zfp295)1Yey/J mice (Stock No. 013530 ..... For more information please see the full phenotype on the strain data sheet | ||
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