Search Criteria: Strain Type is "Insertion"
| Stock Number |
Strain Name Strain Description |
Standard Supply |
| 013128 | B6129S-Del(7Slx1b-Sept1)4Aam/J | Repository- Live |
| These mutant mice possess an engineered deletion spanning approximately 0.39 Mb on mouse Chromosome 7. The region involved encompasses a chromosomal segment, between the GIY-YIG domain containing 2 (Giyd2) gene and the septin 1(Sept1) loci, that shares conserved synteny with the Autism spectrum disorders critical interval on human Chromosome 16 (the 16p11.2 region). Mice carrying one copy of the deletion prove to be viable while mice homozygous for the deletion are embryonic lethal. These mice exhibit neuroanatomical and behavioral phenotypes reminiscent of human autism. This mutant mouse may be useful in studying Autism and other associated disorders.
(Mice bearing the reciprocal duplication are also available (see Stock No. 013129)) | ||
| 002027 | 129S8/SvEv-Gpi1c Hprtb-m2/J | Cryopreserved - Ready for recovery |
| 005383 | B6.129S6-Dp(16Cbr1-ORF9)1Rhr/J | Cryopreserved - Ready for recovery |
| These mice are trisomic for the mouse chromosome segment orthologus to the human chromosome 21 Down syndrome critical region (DSCR). The borders of the 3.9 Mb region are defined by the carbonyl reductase 1 gene and a site adjacent to the myxovirus (influenza virus) resistance 2 locus. Trisomic mice are viable, fertile and are significantly larger than euploid littermates. Mandible size is enlarged as is skull size, with an overall elongation of the rostrocaudal aspect in comparison to euploid littermates. This mouse may be useful in studies exploring the consequences of polyploidy involving the DSCR. | ||
| 001914 | B6.Cg-Is(HSR;1)1Lub/J | Cryopreserved - Ready for recovery |
| Is(HSR;1)1Lub does not appear to impact viability or impart any other outward phenotype. | ||
| 002460 | C3H/HeJ-Oca2p-J Is(7;1)40H/J | Cryopreserved - Ready for recovery |
| 008131 | C57BL/6J-Celf4Ff/Frk | Cryopreserved - Ready for recovery |
| 017359 | B6;129S2-Cxadrtm1.1Ics/J | Under Development - Now Accepting Orders |
| These mice possess loxP sites on either side of exon 2 of the coxsackie virus and adenovirus receptor gene (Cxadr), a cell adhesion molecule critical in early embryogenesis. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exon 2 deleted in the cre-expressing tissues.
When bred to a strain with widespread cre/Esr1 expression (Stock No. 00 4682), this mutant mouse strain may be useful in studies of cardiac, gastrointestinal, pancreatic, and thymic development and physiology. | ||
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How to Register Interest
Please indicate your interest in purchasing any of the strains listed below when they become available for distribution by checking the box next to the strain(s) of interest and then selecting the "Continue" button which leads to an Interest Form.View a Data sheet for New Strains Awaiting Transfer
Select the strain name to link to the strain data sheet.
New Strains Awaiting TransferThe Jackson Laboratory serves as a worldwide distributor and national repository for common and rare strains of inbred mice and mice carrying spontaneous mutations or induced mutations (i.e., transgenic, targeted/"knockout", or chemically induced mutations). At any one time, we have over 100 strains at various stages of development and colony expansion.
- Receive periodic updates on the status of the colony AWAITING TRANSFER
- Obtain advance notification of strain availability and opportunity to order prior to the strain being published as available
- Provide input affecting speed and quantity of availability
It is VERY IMPORTANT that you register interest in strains Awaiting Transfer. The anticipated demand for a strain enables us to determine effectively the distribution plan for each strain. Registering interest also provides benefits to you (including advance notification of pending availability). Whether a strain is made available from a live colony OR from our cryopreservation repository, you may want to consider the option of Dedicated Supply. To learn more about Dedicated Supply, go to Services.
Send questions to our Technical Support team using the Express Technical Support Form.
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