JAX Mice Database - Radiation Induced Mutation

Search Criteria: Strain Type is "Radiation Induced Mutation"

JAX^® Mice Strains

Stock Number	Strain Name Strain Description	Standard Supply
000199	AEJ/GnLeJ	Repository- Live

000655	CBA/CaH-T(14;15)6Ca/J	Repository- Live
	This strain carries the T(14;15)6Ca translocation which results in nondisjunction at a rate of 4.4% in males and 22.2% in females. CBA/CaH-T6 mice have been used in tandem with the CBA/H strain in foreign body tumorigenesis studies in which the T6 chromosome was used as a marker to distinguish donor cells from host.
002283	B6.Cg-Kit^W-19H/EiJ	Repository-Cryopreserved
	This deletion is a dominant mutation causing white spotting on the feet, tail, belly, and occasionally elsewhere. Homozygosity is embryonic lethal. On the C57BL/6 background approximately 60% of heterozygous females have a closed vagina. The ovaries from these heterozygotes are normal and fine for transplantation. On the C57BL/6 background in the presence of the Y^AKR/J Chromosome (available from Stock No. 007250), Kit^W-19H heterozygosity results in sex reversed XY females.
002993	B6.Cg-Kitl^Sl-18H/EiJ	Repository-Cryopreserved

002306	B6.Cg-an/BrkJ	Repository-Cryopreserved

001378	B6;D2-In(3)55Rk Uoxⁱⁿ/J	Repository-Cryopreserved
	The Uoxⁱⁿ homozygous phenotype has incomplete penetrance. While 63% of Uoxⁱⁿ homozygotes die by 12-14 days of age, those that live to adulthood generally live a normal breeding life span. Homozygous adults display chronic polyuria, increased serum BUN and creatinine levels, and hydronephrosis with a concomitant inflammatory response that is followed by glomerular and tubular dilation. (Cook et al., 2001.)
000125	B6By.Cg-Sox18^Ra Pt Os/J	Repository-Cryopreserved
	The Sox18^Ra and Sox18^Ra-J alleles cause a less severe phenotype than the Sox18^Ra-Op allele. The Sox18^Ra and Sox18^Ra-J alleles are similar mutations and give a very similar phenotype. The Sox18^Ra allele has been more broadly described in the literature and will be covered here. Heterozygotes are viable and fertile. Heterozygotes have developmentally retarded sinus hair growth apparent at embryonic day 16.5 and retarded development of pelage follicles apparent by embryonic day 17.5. Thus, heterozygotes have slightly shorter vibrissae evident at birth, and can be distinguished at three days of age by their pink skin which, due to the abnormally sparse development of the coat, fails to darken like that of wildtype siblings. A paucity of fur is apparent by nine days of age and persists throughout life. Compared with the wild type pelage, Sox18^Ra/+ coats have longer g ..... For more information please see the full phenotype on the strain data sheet
000288	B6CBACa A^w-J/A-we a Mafb^kr/J	Repository-Cryopreserved

001906	C3Ga.Cg-Cat^b/J	Repository-Cryopreserved

000269	SB/LeJ	Repository-Cryopreserved
	The SB/Le inbred strain is homozygous for both the satin (Foxq1^sa) and beige (Lyst^bg) mutations. Most of the immunological phenotype is due to the beige mutation. Homozygous mutant beige mice are characterized by a condition that closely resembles Chediak-Higashi disease in man and similar conditions in mink and cattle. Abnormal giant lysosomal granules occur in all tissues with granule-containing cells, including granulocytes, lymphocytes, cells of the liver, kidney, central nervous system, pancreas, and thyroid, and the ducts of most glands; in type II pneumocytes; in mast cells; and in retinal pigment epithelium. Granulocytes from beige mice show defective chemotaxis and reduced bactericidal activity. Beige mice are more susceptible than controls to pneumonitis and to various viral, bacterial, and parasitic infections. They have a severe deficiency of natural killer (NK) cells. Beige mice also have a defective cytotoxic T-cell and cytotoxic antibo ..... For more information please see the full phenotype on the strain data sheet
000306	STOCK Dll3^pu + Tyr^c-ch/+ Oca2^p Tyr^c-ch/J	Repository-Cryopreserved

004711	STOCK Ednrb^s-52Pub	Repository-Cryopreserved

001610	STOCK Krt27^Re-wc/J	Repository-Cryopreserved

001584	STOCK Oca2^p-J/Oca2^p-bs/J	Repository-Cryopreserved
	Oca2^p-J/Oca2^p-J mice exhibit significant dilution of coat color with pink eyes, a phenotype similar to that produced by Oca2^p/Oca2^p. The Oca2^p-J mutation is a partial deletion of the gene that completely ablates Oca2^p function (Oakey et al. 1996). Oca2^p-bs/Oca2^p-bs mice show a less extreme coat color dilution and have black eyes from birth; the phenotype of Oca2^p-bs homozygotes also includes stunted growth, jerky gait, male sterility, female semisterility, and impaired maternal behavior, and the smaller-than-expected proportion of Oca2^p-bs homozygous intercross offspring implies reduced prenatal viability (Lyon et al. 1992). The Oca2^p-bs mutation comprises a deletion that begins about 10 kb 5' of the Oca2^p locus and extends for about 8 kb in the proximal direc ..... For more information please see the full phenotype on the strain data sheet
001585	STOCK Oca2^p-d/Oca2^p-25H/J	Repository-Cryopreserved
	Oca2^p-25H/Oca2^p-25H mice exhibit significant dilution of coat color with pink eyes, similar in appearance to Oca2^p/Oca2^p mice. The Oca2^p-25H phenotype also includes a slightly jerky gait with some tremor, small body size compared to control littermates, male sterility, female semisterility, and impaired maternal behavior, and the smaller-than-expected proportion of Oca2^p-25H homozygous intercross offspring implies reduced prenatal viability (Lyon et al. 1992, Phillips et al. 1977). The Oca2^p-25H mutation comprises an inversion of a segment of Chromsome 7 that alters the 5' end of the Oca2^p gene so that no detectable ptranscript is produced, accounting for the pigment-dilution phenotype (Gardner et al. 1992). The deletion also disrupts the Herc2/rjs gene proximal to Oca2^p so the transcript seq ..... For more information please see the full phenotype on the strain data sheet
000823	STOCK Oca2^p-d/Oca2^p-6H/J	Repository-Cryopreserved

001747	STOCK Oca2^p-d/Oca2^p-cp/J	Repository-Cryopreserved
	Mice homozygous for Oca2^p-d (dark pink-eye) are born with lightly pigmented eyes, darker than those of Oca2^p/Oca2^p mice, which darken by weaning and a coat color "considerably darker than that of Oca2^p/Oca2^p mice, somewhat resembling that of brown [Tyrp1^b/Tyrp1^b] mice"; both sexes are fertile (Gardner et al. 1977, Lyon et al. 1992). A normal-sized Oca2^p transcript is present in eyes of Oca2^p-d/Oca2^p-d mice (Gardner et al. 1992), and Southern blot analysis revealed no gross alteration of the Oca2^p gene (Gardner et al. 1992, Lyon et al. 1992); thus, the molecular nature of the defect is unknown. Most Oca2^p-cp (p-cleft palate, formerly p^11H) homozygotes die soon after birth with cleft palate; the few that survive to adulthood exhibit significant dilution of coat co ..... For more information please see the full phenotype on the strain data sheet
002307	WB.Cg-an/BrkJ	Repository-Cryopreserved

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New Strains Under Development

(See informational text following listing of strains)

How to Register Interest
Please indicate your interest in purchasing any of the strains listed below when they become available for distribution by checking the box next to the strain(s) of interest and then selecting the "Continue" button which leads to an Interest Form.
View a Data sheet for New Strains Under Development
Select the strain name to link to the strain data sheet.

Stock Number	Strain Name Strain Description	Standard Supply
008393	C3H;101-Dync1h1^Swl/PopJ	Under Development for Production
These mice harbor the radiation-induced Sprawling mutation of the cytoplasmic dynein heavy chain 1 gene (Dync1h1^Swl) and may be useful in studying microtubule motor protein function in sensory neuron degeneration, specifically in proprioceptive sensory neurons.

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New Strains Under Development
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The Jackson Laboratory serves as a worldwide distributor and national repository for common and rare strains of inbred mice and mice carrying spontaneous mutations or induced mutations (i.e., transgenic, targeted/"knockout", or chemically induced mutations). At any one time, we have over 100 strains at various stages of development and colony expansion. Strains "Under Development" fall into two categories depending on the anticipated demand from the scientific community.
Strains that will be made available from a live distribution colony at The Jackson Laboratory.
These strains are designated as: "Under Development for Distribution Colony"

Strains that will be made available through the Cryopreservation Repository.
These strains are designated as: "Under Development for Cryopreservation Repository"
It is VERY IMPORTANT that you register interest in strains Under Development. The anticipated demand for a strain enables us to determine effectively the distribution plan for each strain Under Development. Registering interest also provides benefits to you (including advance notification of pending availability). Whether a strain is made available from a live colony OR from our cryopreservation repository, you may want to consider the option of Dedicated Supply. To learn more about Dedicated Supply, go to Services.
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JAX® Mice Strains

New Strains Under Development

JAX^® Mice Strains