JAX Mice Database - Robertsonian

Search Criteria: Strain Type is "Robertsonian"

JAX^® Mice Strains

Stock Number	Strain Name Strain Description	Standard Supply
004850	B6EiC3Sn-Rb(12.Ts17¹⁶65Dn)2Cje/CjeDnJ	Repository- Live
	The trisomic segment in the Rb(12.Ts171665Dn)2Cje strain is genetically identical to the Ts65Dn strains, Stock No. 001924 and Stock No. 005252, with trisomy of the Chr 16 genes, from Mrpl39 to the distal telomere. Quantitative PCR confirmed the triplication of Chr 16 genes from App to Mx1. Transmission of the chromosome 16 segmental trisomy through the female germline is significantly improved over Ts65Dn (43% versus 24%). Dendritic spines on granule cells in the fascia dentata are enlarged in size and decreased in density (Villar AJ, et al. 2005). Unlike Ts65Dn, males are fertile. Trisomic mice are 20% smaller in size than controls. This strain serves a model for Down syndrome.
001802	CByJ.RBF-Rb(8.12)5Bnr/J	Repository- Live
	Hybridomas are produced by fusing mouse meloma cells that are deficient in adenosine phosphoribosyltransferase (APRT) with spleen cells from mice immunized with specific antigens. A selection system using AAT (adenosine, aminopterin, and thymidine) medium eliminates all but the fusion cells that are APRT⁺ . Successful hybridomas must also retain the Igh heavy chain locus on chromosome 12 and one of the Igh light chain loci. The Robertsonian chromosome Rb(8.12)5Bnr can be used to produce hybridomas at a high frequency. Selecting for the Aprt locus on chromosome 8 also selects for the Igh locus on chromosome 12 because the two loci are "genetically linked" by the Robertsonian fusion chromosome. This chromosomal aberration congenic was created by backcrossing the Robertsonian chromosome Rb(8.12)5Bnr on the BALB/cByJ genetic background by Dr. Muriel Davisson at The Jackson Laboratory.
000726	RBF/DnJ	Repository- Live
	The RBF inbred strain arose from crosses with wild mice, originally known as "tobacco mouse", captured in Valle di Poschiavo in S.E. Switzerland. The wild mice originally known as 'tobacco mouse' because of the coat colour. The strain was transferred to Dr. M. Davisson (Dn) in 1981 and subsequently to the production colony of The Jackson Laborotory (J). Mice are homozygous for Robertsonian translocation Rb(1.3)1Bnr, Rb(8.12)5Bnr and Rb(9.14)6Bnr.
001392	ZALENDE/EiJ	Repository- Live
	This wild-derived inbred strain is homozygous for 7 Robertsonian translocations: Rb(1.3)1Bnr, Rb(4.6)2Bnr, Rb(5.15)3Bnr, Rb(11.13)4Bnr, Rb(8.12)5Bnr, Rb(9.14)6Bnr, and Rb(16.17)7Bnr (abbreviated Rb1Bnr - Rb7Bnr, respectively)(LL Washburn, pers. comm.).
001099	AEJ/GnRk-Rb(11.14)1Dn/J	Cryopreserved - Ready for recovery

002545	B6 x RBA/DnJ	Cryopreserved - Ready for recovery

000610	B6 x STOCK Rb(6.15)1Ald/J	Cryopreserved - Ready for recovery

000861	B6.Cg-Rb(1.3)1Lub/J	Cryopreserved - Ready for recovery

000952	B6.Cg-Rb(10.11)8Bnr/J	Cryopreserved - Ready for recovery

000960	B6.Cg-Rb(2.8)2Lub/J	Cryopreserved - Ready for recovery

001733	B6.WMP-Rb(10.17)9Mpl/J	Cryopreserved - Ready for recovery

001734	B6.WMP-Rb(13.15)10Mpl/J	Cryopreserved - Ready for recovery

001727	B6.WMP-Rb(2.16)3Mpl/J	Cryopreserved - Ready for recovery

001728	B6.WMP-Rb(3.12)4Mpl/J	Cryopreserved - Ready for recovery

001729	B6.WMP-Rb(4.6)5Mpl/J	Cryopreserved - Ready for recovery

001732	B6.WMP-Rb(8.9)8Mpl/J	Cryopreserved - Ready for recovery

001796	B6Ei.Cg-Rb(1.2)18Lub/J	Cryopreserved - Ready for recovery

001921	B6Ei.Cg-Rb(1.7)1Rma/J	Cryopreserved - Ready for recovery

001386	B6Ei.Cg-Rb(10.12)5Lub/J	Cryopreserved - Ready for recovery

001617	B6Ei.Cg-Rb(10.15)23Lub/J	Cryopreserved - Ready for recovery

001795	B6Ei.Cg-Rb(11.13)4Bnr/J	Cryopreserved - Ready for recovery

000150	B6Ei.Cg-Rb(11.16)2H/J	Cryopreserved - Ready for recovery

000906	B6Ei.Cg-Rb(16.17)8Lub t^w3Lub/+ +/J	Cryopreserved - Ready for recovery

001387	B6Ei.Cg-Rb(2.17)11Rma/J	Cryopreserved - Ready for recovery

001613	B6Ei.Cg-Rb(5.14)21Lub/J	Cryopreserved - Ready for recovery

001616	B6Ei.Cg-Rb(5.15)4Lub/J	Cryopreserved - Ready for recovery

001791	B6Ei.Cg-Rb(5.19)1Wh/J	Cryopreserved - Ready for recovery

000762	B6Ei.Cg-Rb(6.15)1Ald/J	Cryopreserved - Ready for recovery

001798	B6Ei.Cg-Rb(6.16)24Lub/J	Cryopreserved - Ready for recovery

001389	B6Ei.Cg-Rb(6.7)13Rma/J	Cryopreserved - Ready for recovery

001615	B6Ei.Cg-Rb(7.18)9Lub/J	Cryopreserved - Ready for recovery

001797	B6Ei.Cg-Rb(8.12)22Lub/J	Cryopreserved - Ready for recovery

000888	B6Ei.Cg-Rb(8.14)16Rma/J	Cryopreserved - Ready for recovery

001792	B6Ei.Cg-Rb(9.19)163H/J	Cryopreserved - Ready for recovery

001794	B6Ei.WMP-Rb(13.16)1Mpl/J	Cryopreserved - Ready for recovery

002470	B6EiC3Sn x B6-Rb(5.8)3Dn/J	Cryopreserved - Ready for recovery

000975	C57BL/6J x STOCK Rb(1.3)1Ei/J	Cryopreserved - Ready for recovery
	Robertsonian chromosomes are bi-armed (metacentric) chromosomes formed by the joining of two single-armed (acrocentric) chromosomes at the centromere ends. Rb(1.3)1Ei is a Robertsonian chromosome composed of Chromosomes 1 and 3.
001391	C57BL/6J-Rb(4.15)1Rk/J	Cryopreserved - Ready for recovery

001390	C57BL/6J-Rb(6.18)2Dn/J	Cryopreserved - Ready for recovery

001793	C57BL/6JEi-Rb(X.2)2Ad/J	Cryopreserved - Ready for recovery

000714	CByJ.RBF-Rb(8.12)5Bnr	Cryopreserved - Ready for recovery

002040	RB126Bnr/EiJ	Cryopreserved - Ready for recovery

002041	RB16Bnr/EiJ	Cryopreserved - Ready for recovery

000609	RBB/DnJ	Cryopreserved - Ready for recovery

000889	RBC/DnJ	Cryopreserved - Ready for recovery

001000	RBD/DnJ	Cryopreserved - Ready for recovery

000807	RBJ/DnJ	Cryopreserved - Ready for recovery

000862	STOCK Rb(1.7)1Rma/J	Cryopreserved - Ready for recovery

000891	STOCK Rb(10.11)5Rma/J	Cryopreserved - Ready for recovery

000614	STOCK Rb(10.11)8Bnr/J	Cryopreserved - Ready for recovery

000892	STOCK Rb(10.12)5Lub/J	Cryopreserved - Ready for recovery

000895	STOCK Rb(11.13)6Lub/J	Cryopreserved - Ready for recovery

001100	STOCK Rb(13.16)1Mpl/J	Cryopreserved - Ready for recovery

000615	STOCK Rb(16.17)7Bnr	Cryopreserved - Ready for recovery
	Rb(16.17)7Bnr carries a Robertsonian chromosome containing mouse chromosomes 16 and 17. These mice can be used to generate embryos trisomic for all of mouse Chr 16 by mating to Rb(6.16)24Bnr (Stock No. 000885) to produce (Rb(6.16)24Lub x Rb(16.17)7Bnr)F1 hybrid mice. The F1 hybrid mice are typically mated to C57BL/6J (Stock No. 000664) mice to produce the aneuploid embryos. Please see the Down Syndrome and Cytogenetics Models Resource for information on other chromosomal aberration strains.
003304	STOCK Rb(16.17)7Bnr-Myo15^sh2-2J/J	Cryopreserved - Ready for recovery

000898	STOCK Rb(16.17)8Lub/J	Cryopreserved - Ready for recovery

000865	STOCK Rb(2.17)11Rma/J	Cryopreserved - Ready for recovery

000896	STOCK Rb(2.18)6Rma Rb(12.14)8Rma/J	Cryopreserved - Ready for recovery

000867	STOCK Rb(2.18)6Rma/J	Cryopreserved - Ready for recovery

000864	STOCK Rb(2.8)2Lub Rb(7.18)9Lub/J	Cryopreserved - Ready for recovery

000871	STOCK Rb(3.15)2Rk/J	Cryopreserved - Ready for recovery

000980	STOCK Rb(3.8)2Ei/J	Cryopreserved - Ready for recovery

000869	STOCK Rb(3.8)2Rma/J	Cryopreserved - Ready for recovery

000870	STOCK Rb(3.9)12Lub/J	Cryopreserved - Ready for recovery

000873	STOCK Rb(4.11)12Rma/J	Cryopreserved - Ready for recovery

000876	STOCK Rb(4.15)4Rma/J	Cryopreserved - Ready for recovery

000720	STOCK Rb(4.6)2Bnr/J	Cryopreserved - Ready for recovery

000878	STOCK Rb(5.14)21Lub/J	Cryopreserved - Ready for recovery

000880	STOCK Rb(5.15)15Rma/J	Cryopreserved - Ready for recovery

000881	STOCK Rb(5.17)7Rma/J	Cryopreserved - Ready for recovery

000882	STOCK Rb(5.19)1Wh/J	Cryopreserved - Ready for recovery

001884	STOCK Rb(5.6)1Ty/J	Cryopreserved - Ready for recovery

000885	STOCK Rb(6.16)24Lub	Cryopreserved - Ready for recovery
	Rb(6.16)24Bnr carries a Robertsonian chromosome containing mouse chromosomes 6 and 16. These mice can be used to generate embryos trisomic for all of mouse Chr 16 by mating to Rb(16.17)7Bnr (Stock No. 000615) to produce (Rb(6.16)24Lub x Rb(16.17)7Bnr)F1 hybrid mice. The F1 hybrid mice are typically mated to C57BL/6J (Stock No. 000664) mice to produce the aneuploid embryos. Please see the Down Syndrome and Cytogenetics Models Resource for information on other chromosomal aberration strains.
000887	STOCK Rb(8.12)22Lub/J	Cryopreserved - Ready for recovery

000929	TIRANO/EiJ	Cryopreserved - Ready for recovery
	This wild-derived inbred strain is homozygous for 8 Robertsonian translocations: Rb(1.3)1Bnr, Rb(4.6)2Bnr, Rb(5.15)3Bnr, Rb(11.13)4Bnr, Rb(9.14)6Bnr, Rb(16.17)7Bnr, Rb(2.8)2Lub and Rb(10.12)5Lub (abbreviated Rb1Bnr - Rb7Bnr, Rb2Lub and Rb5Lub, respectively)(LL Washburn, pers. comm.).
001746	WMP/PasDnJ	Cryopreserved - Ready for recovery

000729	STOCK Rb(11.13)4Bnr/J	Research Strain
	This inbred strain bears a Robertsonian translocation, Rb(11.13)4Bnr, and a spontaneous eye mutation, Rd3^rd3, and was derived from the sibling inbreeding of an F1 cross between a female from the outbred NMRI stock and a wild trapped Mus poschiavinus male from Val Poschiavo, Switzerland. It may be useful for studies of retinal degeneration, cancer, reproduction/meiosis, birth defects, aneuploidy generation, other genomic studies or genetic mapping.

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Additional Register Interest Strains

Please indicate your interest in purchasing any of the strains listed below when they become available for distribution by checking the box next to the strain(s) of interest and then selecting the "Continue" button which leads to an Interest Form.
View a Data sheet for a Strain
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Stock Number	Strain Name Strain Description	Standard Supply
005354	RB156Bnr/Ei rul-Gulo^sfx-2J/GrsrJ	On Hold
The phenotype of the sfx^2J remutation is identifiable at 4-5 weeks of age when the mutants appear smaller than their control littermates and begin to hobble about their cage. Between 5 and 8 weeks of age the mutants develop rear limb paralysis and many die by 8 weeks of age. The phenotypic characteristics of this mutation are similar to the original mutation spontaneous fracture (Gulo^sfx) except for the eye phenotype described below that is inherent in the background strain on which the sfx^2J mutation arose. Mice homozygous for the sfx^2J remutation also had cataracts and rosettes and wavy outer nuclear layer of retinas. The eyes of a female mutant were checked using an opthalmascope and it was found to have cataracts on both eyes (as the strain background has characteristically). It has not yet been determined if the rosettes and wavy outer nuclear layer of the retinas is also characteristic of the background s ..... For more information please see the full phenotype on the strain data sheet
000613	STOCK Rb(9.19)163H/J	On Hold

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