Search Criteria: Strain Type is "Conplastic"
| Stock Number |
Strain Name Phenotype |
Standard Supply |
| 005761 | C57BL/6J-mtPWD/Ph/ForeJ | Repository- Live |
| This strain represents one of a panel of inter-species chromosome substitution (or consomic) strains (IC-ISS). Each strain carries a chromosome from the Mus musculus musculus wild-derived strain PWD/Ph introgressed into a Mus musculus domesticus C57BL/6J background. The two species are believed to have diverged 350,000 to one million years ago and exhibit multiple genetic and phenotypic differences. The strain set also includes a conplastic strain (mtPWD/Ph) created by sequential backcrossing of the donor female to the host male. A conplastic strain carries the mitochondrial genome of the donor strain. The IC-ISS strains represent a tool for dissection of quantitative trait loci. | ||
| 001393 | SKIVE/EiJ | Repository- Live |
| 005333 | ALR/Lt-mtNOD/ShiLtDvs/MxLt | Repository-Cryopreserved |
| ALR mice are resistant to chemically induced and autoimmune type 1 diabetes and encode the mitochondrial mt-Nd2a allele which is associated with resistance to type 1 diabetes. NOD mice are susceptible to type 1 diabetes and encode the mt-Nd2c allele. Although basal mitchondrial respiration is unchanged, mitochondria from this conplastic produce more reactive oxygen species than either parent or the reciprocal conplastic. | ||
| 005545 | C57BL/6J-mtA/J/NaJ | Repository-Cryopreserved |
| A chromosome substitution or consomic strain is an inbred strain with one of its chromosomes replaced by the homologous chromosome of another inbred strain. The C57BL/6J and A/J strains in this set were chosen because they differ in their susceptibility to diseases such as arthritis, asthma, atherosclerosis, cancer, several infectious diseases, inflammatory responses, and physiological, behavioral and sensory phenotypes. Chromosome substitution strain nomenclature is designated as Host Strain - Chromosome #<Donor Strain>/Laboratory code. For example, C57BL/6J-Chr1A/NaJ carries chromosome 1 for strain A/J (A) on a C57BL/6J background, was constructed in the laboratory of Joseph Nadeau (Na) and is maintained at The Jackson Laboratory (J). Chromosome substitution strains or consomic strains can accelerate quantitative trait loci identification and mapping. | ||
| 005332 | NOD/ShiLt-mtALR/Lt/MxLt | Repository-Cryopreserved |
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