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Apoptosis Research

 
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Apoptosis Research

	Allele Symbol   Strain Description	Stock Number	Strain Name    (link to Data Sheet)
	Trp53bp2tm1Cdlo	017615 In Progress	C.129(B6)-Trp53bp2tm1Cdlo/J
	Exons 10-17 of the Trp53bp2 gene are disrupted in this strain, abolishing gene function. These mice may be useful for studying tumor development and treatment.
	Tg(BCL2)22Wehi	002318 On Hold	C.Cg-Tg(BCL2)22Wehi/J
	Expression of the human BCL2 transgene is restricted to B cell lineage (no T cell expression) in which it enhances cell survival. Hemizygotes show increased numbers of B lymphocytes, Ig-secreting cells and serum Ig, as well as a heightened and prolonged antibody response to immunization. This phenotype is somewhat greater on the BALB/c than on the C57BL/6 background. Hemizygotes on a mixed B6,SJL background (but not on the BALB/c background) develop autoimmune disease characterized by immune complex glomerulonephritis, anti-nuclear antibodies, lymphadenopathy and myocardial infarction. These mice serve as a robust source for the production of B cells and antibodies. Although mice bearing this allele exhibit a mild increase in spontaneous lymphoma and plasmacytoma occurrence (<10% to 18 months) on a (C57BL/6 x SJL)F2 background, on the BALB/c and C57BL/6 backgrounds tumor incidence is insignificant. When this transgene is crossed with an Emu-myc transgene bearing strain (Stock ..... For more information please see the full phenotype on the strain data sheet
	Tg(CAG-Tfb1m)AGsha	018021 Awaiting Transfer from the Donor	B6.Cg-Tg(CAG-Tfb1m)AGsha/J
	In these trangenic mice, widespread overexpression of the mitochondrial ribosomal RNA methyltransferase, mtTFB1, results in maternally inherited deafness.
	Tg(tetO-TAg)1Efr	017719 Awaiting Transfer from the Donor	C3HeB/FeJ-Tg(tetO-TAg)1Efr/J
	These tet-Tag transgenic mice express the SV40 large T antigen under the direction of the tetracycline operator. These mice may be useful for studying tumorigenesis and cancer progression.

(4 stocks)

 

Select another Research Area Application:

• Apoptosis Research
• Cancer Research
• Cardiovascular Research
• Cell Biology Research
• Dermatology Research
• Developmental Biology Research
• Diabetes and Obesity Research
• Endocrine Deficiency Research
• Hematological Research
• Immunology and Inflammation Research
• Internal/Organ Research
• Metabolism Research
• Mouse/Human Gene Homologs
• Neurobiology Research
• Reproductive Biology Research
• Research Tools
• Sensorineural Research
• Virology Research
• Under Review

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