Allele Symbol Stock Number Strain Name
Adipoqtm1Chan 008195Under Development for Production
B6.129-Adipoqtm1Chan /J
These adiponectin-deficient (Adipoq -/- or Adipo -/- ) mice may be useful in studying obesity, diabetes, insulin resistance, metabolism, inflammation, leukocyte-endothelium interactions, and colitis.
Art2atm1Fkn 008252Under Development for Production
NOD.129S4(B6)-Art2atm1Fkn Art2btm1Fkn /LtJ
This Art2a and Art2b targeted mutant strain becomes diabetic at a similar onset and rate as NOD/Lt mice. The absence of ART2 expression on T cells from thymus and lymph nodes was confirmed by RT-PCR and FACS analysis. Cd4 + and CD8 + T cells from ART2 deficient NOD mice are completely resistant to NAD induced apoptosis at all concentrations in vitro. This ART2 deficient stock provides a tool to further dissect the interplay of ADP rybosylation and NAD-catabolizing enzymes and their effect on Tregs and iNKT involved in autoimmune diseases specifically, Type 1 Diabetes.
Art2btm1Fkn 008252Under Development for Production
NOD.129S4(B6)-Art2atm1Fkn Art2btm1Fkn /LtJ
This Art2a and Art2b targeted mutant strain becomes diabetic at a similar onset and rate as NOD/Lt mice. The absence of ART2 expression on T cells from thymus and lymph nodes was confirmed by RT-PCR and FACS analysis. Cd4 + and CD8 + T cells from ART2 deficient NOD mice are completely resistant to NAD induced apoptosis at all concentrations in vitro. This ART2 deficient stock provides a tool to further dissect the interplay of ADP rybosylation and NAD-catabolizing enzymes and their effect on Tregs and iNKT involved in autoimmune diseases specifically, Type 1 Diabetes.
Cd19tm1(cre)Cgn 008242Under Development for Production
C57BL/6-Gt(ROSA)26Sortm1(Ikbkb)Rsky /J
These R26StopFL ikk2ca mice allow inducible expression of an activated form of Ikbkb (IKK2ca) and subsequent activation of the NF-kappaB transcription factor pathways.
Cd4tm1Mak 006483Under Development for Production
CBy.129S2(B6)-Cd4tm1Mak /J
Cell surface expression of CD4 protein is not detected on thymocytes and lymph node cells from mice homozygous for this Cd4 (CD4 antigen) targeted mutation. Homozygous mutant mice also show a Class II restricted deficit in helper T-cell activity and other T-cell responses. This mutant mouse strain may be useful in studies of T cell development, susceptibility to viral infection and inflammation.
Cdh23ahl 000668On Hold
C57L/J
D11Mit314 008059Under Development for Production
NOD.L-(D11Mit314-D11Mit339 )(D11Mit325-D11Mit42 )/McdfJ
Stock No.'s 008053 , 008054 , 008055, 008056 , 008057 , 008058 , 008059 and 008060 , are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
D11Mit314 008054Under Development for Production
NOD.L-(D11Mit314-D11Mit339 )/McdfJ
Stock No.'s 008053 , 008054, 008055, 008056 , 008057 , 008058 , 008059 and 008060 , are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
D11Mit314 008057Under Development for Production
NOD.L-(D11Mit314-D11Mit33 )/McdfJ
Stock No.'s 008053 , 008054 , 008055, 008056 , 008057, 008058 , 008059 and 008060 , are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
D11Mit325 008059Under Development for Production
NOD.L-(D11Mit314-D11Mit339 )(D11Mit325-D11Mit42 )/McdfJ
Stock No.'s 008053 , 008054 , 008055, 008056 , 008057 , 008058 , 008059 and 008060 , are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
D11Mit339 008059Under Development for Production
NOD.L-(D11Mit314-D11Mit339 )(D11Mit325-D11Mit42 )/McdfJ
Stock No.'s 008053 , 008054 , 008055, 008056 , 008057 , 008058 , 008059 and 008060 , are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
D11Mit339 008054Under Development for Production
NOD.L-(D11Mit314-D11Mit339 )/McdfJ
Stock No.'s 008053 , 008054, 008055, 008056 , 008057 , 008058 , 008059 and 008060 , are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
D11Mit33 008057Under Development for Production
NOD.L-(D11Mit314-D11Mit33 )/McdfJ
Stock No.'s 008053 , 008054 , 008055, 008056 , 008057, 008058 , 008059 and 008060 , are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
D11Mit42 008059Under Development for Production
NOD.L-(D11Mit314-D11Mit339 )(D11Mit325-D11Mit42 )/McdfJ
Stock No.'s 008053 , 008054 , 008055, 008056 , 008057 , 008058 , 008059 and 008060 , are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
D4Mit59 008065Under Development for Production
NOD.NZM2328-(D4Mit76-D4Mit59 )/McdfJ
This NOD congenic strain may be useful to identify candidate genes on Chromosome 4 associated with diabetes resistance and to identify genes with common roots in multiple autoimmune diseases.
D4Mit76 008065Under Development for Production
NOD.NZM2328-(D4Mit76-D4Mit59 )/McdfJ
This NOD congenic strain may be useful to identify candidate genes on Chromosome 4 associated with diabetes resistance and to identify genes with common roots in multiple autoimmune diseases.
Edardl-J 000255On Hold
GL/Le Edardl-J +/+ Ostm1gl /J
Eif2ak4tm1Munn 008240Under Development for Production
B6.129S6-Eif2ak4tm1Munn /J
Mice homozygous for the GCN2-KO allele have a deletion of exon XII of the eukaryotic translation initiation factor 2 alpha kinase 4 (Eif2ak4 or GCN2) gene, and may be useful in studying eIF2 (eukaryotic initiation factor 2) phosphorylation in response to environmental stresses (amino acid starvation, proteasome inhibition and UV irradiation).
Foxp3sf 006775On Hold
NOD.Cg-Foxp3sf /DoiJ
Gt(ROSA)26Sortm4(Ikbkb)Rsky 008242Under Development for Production
C57BL/6-Gt(ROSA)26Sortm1(Ikbkb)Rsky /J
These R26StopFL ikk2ca mice allow inducible expression of an activated form of Ikbkb (IKK2ca) and subsequent activation of the NF-kappaB transcription factor pathways.
H2d 000359On Hold
B6.C-H2d /bByJ
H2g7 001627Under Development for Cryo
NON.NOD-H2g7 /LtJ
This histocompatibiity congenic strain carries the diabetogenic MHC from NOD/ShiLtJ mice. These mice exhibit some but not all of the immune dysfunctions of NOD/ShiLtJ mice. These mice are useful for dissecting the role of MHC versus non-MHC genes in producing aberrant immunophenotypes.
Hlxtm1Rph 008313Under Development for Production
B6.129P2-Hlxtm1Rph /J
Mice homozygous for this Hlx targeted mutation have an embryonic or perinatal lethal phenotype, failing to develop past ED15.5 or dying at birth. Homozygotes exhibit defective fetal hematopoiesis with abnormal liver and gut development. Naive CD4 T cells from heterozygotes on the FVB/NJ background exhibit increased responsiveness to IL-4, resulting in differentiation of more Th2 cells. This mutant mouse strain may be useful in studies of liver and gastrointestinal development and T helper 2 cell differentiation.
Hlxtm1Rph 008315Under Development for Production
FVB.129P2(Cg)-Hlxtm1Rph /J
Mice homozygous for this Hlx targeted mutation have an embryonic or perinatal lethal phenotype, failing to develop past ED15.5 or dying at birth. Homozygotes exhibit defective fetal hematopoiesis with abnormal liver and gut development. Naive CD4 T cells from heterozygotes on the FVB/NJ background exhibit increased responsiveness to IL-4, resulting in differentiation of more Th2 cells. This mutant mouse strain may be useful in studies of liver and gastrointestinal development and T helper 2 cell differentiation.
Hmox1tm1Poss 008311Under Development for Production
FVB.129S2(B6)-Hmox1tm1Poss /J
Mice that are homozygous for this Hmox1 (heme oxygenase (decycling) 1) targeted mutation develop anemia with diminished serum iron, increased serum ferritin, iron accumulation in kidney and liver and progressive chronic inflammatory disease. Homozygotes occur at a lower than expected frequency, or are not produced, from heterozygous crosses and have decreased postnatal survival. This mutant mouse strain may be useful in studies of hemochromatosis, inflammation and iron metabolism.
Idd4 008059Under Development for Production
NOD.L-(D11Mit314-D11Mit339 )(D11Mit325-D11Mit42 )/McdfJ
Stock No.'s 008053 , 008054 , 008055, 008056 , 008057 , 008058 , 008059 and 008060 , are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
Idd4 008054Under Development for Production
NOD.L-(D11Mit314-D11Mit339 )/McdfJ
Stock No.'s 008053 , 008054, 008055, 008056 , 008057 , 008058 , 008059 and 008060 , are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
Idd4 008057Under Development for Production
NOD.L-(D11Mit314-D11Mit33 )/McdfJ
Stock No.'s 008053 , 008054 , 008055, 008056 , 008057, 008058 , 008059 and 008060 , are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
Ightm1Janz 008332Under Development for Production
C.129S1-Ightm1Janz /J
These mutant mice carry a His6 -tagged myelocytomatosis oncogene (Myc ) gene (cDNA) sequence inserted in the endogenous immunoglobulin heavy chain complex (Igh ) locus, which mimics the human endemic Burkitt lymphoma t(8;14)(q24;q32) translocation and mouse plasmacytoma T(12;15) translocation. This mutant mouse strain may be useful in studies of Burkitt Lymphoma and plasma cell and B-cell neoplasia.
Ltb4r1tm1Adl 008102Under Development for Production
B6.129S4-Ltb4r1tm1Adl /J
As the G protein-coupled receptor BLTR/BLT1 is expressed on myeloid leukocytes (including neutrophils, macrophages, eosinophils, T cell lymphomas, and effector T cells (TH1 CD4+ cells, TH2 CD4+ cells, and effector memory CD8+ cells) during CD4+ migration/recruitment from the lymphoid compartment into peripheral tissues), these BLTR/BLT1 mutant mice may be useful for studying leukocyte function in inflammation, as well as the role of the LTB4-BLT1 pathway linking early immune system activation and multiple classes of acquired immune effector cells.
Mgat5tm1Jwd 006335Under Development for Production
B6.129-Mgat5tm1Jwd /J
Mgat5 (mannoside acetylglucosaminyltransferase 5) deficient mice exhibit increased responses to induced immune challenges and delayed tumor progression when bred with oncomice. This mutant mouse strain may be useful in studies of glycosidic molecular interactions and function, autoimmunity and antitumor immunity.
Mirn150tm1Rsky 007750Under Development for Production
B6;C-Mirn150tm1Rsky /J
These miR150-/- mice may be useful in mircoRNA biology, specifically to study the role of miR-150 and its target genes (including c-Myb) in lymphocyte development and function.
Mirn155tm1.1Rsky 007745Under Development for Production
B6.Cg-Mirn155tm1.1Rsky /J
These bic /mir-155 mutant mice may be useful in mircoRNA biology, specifically to study the role of miR-155 and its target genes (including cytokines, chemokines, and transcription factors) in homeostasis and function of the immune system.
Mlphln 000668On Hold
C57L/J
Mmp9tm1Tvu 007084Under Development for Production
B6.FVB(Cg)-Mmp9tm1Tvu /J
This targeted mutation of the Mmp9 (matrix metalloproteinase 9) gene may be used to study injury response and repair, angiogenesis and inflammatory response.
Ncf1m1J 004742On Hold
B6(Cg)-Ncf1m1J /J
Obq3C57L/J 000668On Hold
C57L/J
Obq4C57L/J 000668On Hold
C57L/J
Ostm1gl 000255On Hold
GL/Le Edardl-J +/+ Ostm1gl /J
Pepc 006259Under Development for Production
B6.Cg-Pepcb Ptprca Tg(UBC-scFv)2Nemz/J
These "kappa-macroself Ag#2" transgenic mice may be useful to study B cell receptor editing, B cell tolerance in polyclonal immune systems, and for the rapid screening of mutants of interest for potential defects in B cell tolerance.
Ptgs2tm2.1(Ptgs1)Fun 008104Under Development for Production
B6.129(FVB)-Ptgs2tm2.1(Ptgs1)Fun /J
These mutant mice develop chronic peritonitis and progressive kidney deterioration. COX1 protein (Ptgs1 gene product) is increased 5 fold in LPS-stimulated macrophages from homozygotes.
This mutant mouse strain may be useful in studies of prostaglandin synthesis and inflammation.
Ptprc 006259Under Development for Production
B6.Cg-Pepcb Ptprca Tg(UBC-scFv)2Nemz/J
These "kappa-macroself Ag#2" transgenic mice may be useful to study B cell receptor editing, B cell tolerance in polyclonal immune systems, and for the rapid screening of mutants of interest for potential defects in B cell tolerance.
Rag1tm1Mom 006770Under Development for Production
STOCK Rag1tm1Mom Tg(TIE2GFP)287Sato/J
To generate this double mutant strain, B6.Cg-Tg(TIE2GFP)287Sato/1J (Stock No. 004659 ) was crossed to C.129S7(B6)-Rag1tm1Mom /J (Stock No. 003145 ). This mutant mouse strain may be useful in studies examining angiogenesis in transplanted tissues.
Rag2tm1.1Cgn 008309Under Development for Production
C57BL/6-Rag2tm1Cgn /J
These RAG-2fl mice harbor loxP sites flanking the entire coding region of the Rag2 (recombination activating gene 2) locus. When bred to mice that express Cre recombinase, the resulting offspring will have exon 3 deleted in the cre -expressing tissue(s). These RAG-2fl mice may be useful in generating conditional mutations for studying the role of RAG-2 in B and T cell development (including cancer and toxicology research as a xenograft/transplant host), T and B cell receptor (V(D)J) recombination, hematopoiesis, hematology, immunology, and inflammation research.
Rag2tm1Cgn 008309Under Development for Production
C57BL/6-Rag2tm1Cgn /J
These RAG-2fl mice harbor loxP sites flanking the entire coding region of the Rag2 (recombination activating gene 2) locus. When bred to mice that express Cre recombinase, the resulting offspring will have exon 3 deleted in the cre -expressing tissue(s). These RAG-2fl mice may be useful in generating conditional mutations for studying the role of RAG-2 in B and T cell development (including cancer and toxicology research as a xenograft/transplant host), T and B cell receptor (V(D)J) recombination, hematopoiesis, hematology, immunology, and inflammation research.
Rmcfs 000668On Hold
C57L/J
Seletm1Dmil 008238Under Development for Production
129S-Seletm1Dmil /J
These E-selectin mutant mice may be useful in studying inflammation, leukocyte rolling, leukocyte-endothelial adhesion, angiogenesis, and cancer.
Seletm1Dmil 008236Under Development for Production
B6.129S4-Seletm1Dmil /J
These E-selectin mutant mice may be useful in studying inflammation, leukocyte rolling, leukocyte-endothelial adhesion, angiogenesis, and cancer.
Seletm1Dmil 008237Under Development for Production
C.129S4-Seletm1Dmil /J
These E-selectin mutant mice may be useful in studying inflammation, leukocyte rolling, leukocyte-endothelial adhesion, angiogenesis, and cancer.
Serpinb9tm1Arp 008158Under Development for Production
C57BL/6-Serpinb9tm1Arp /J
These Serpinb9-deficient (Spi6-/-) mutant mice have impaired cytotoxic T lymphocyte (CTL) immunity to viruses and may be useful in studies of viral immune response and inflammation, and the exocytosis pathway in CTL apoptosis.
Ssttm1Ute 008117Under Development for Production
B6.129S4(129S6)-Ssttm1Ute /J
Somatostatin deficient mice exhibit increased baseline plasma growth hormone, corticosterone and total ghrelin levels and impaired motor performance. Hippocampal amyloid beta 42 peptides levels are elevated. This mutant mouse strain may be useful in studies of gastric homeostasis, learning and memory and endocrinology.
Tcfe2atm5Zhu 008078Under Development for Production
B6;129S4-Tcfe2atm5Zhu /J
These mice contain an Enhanced Green Fluorescent Protein (EGFP) gene inserted into the endogenous Tcfe2a , transcription factor E2a, locus. This strain serves as a reporter strain, with functional Tcfe2a , transcription factor E2a, expression indicated by EGFP expression.
Tff3tm1Dkpy 008243Under Development for Production
129-Tff3tm1Dkpy /J
These intestinal trefoil factor (ITF or Tff3 ) mutant mice may be useful in studying gastrointestinal tract injury (including inflammatory bowel diseases), maintenance of the mucosal barrier, migration and turnover of the intestinal epithelium, and therapies for colon cancer.
Tlr4lps-del 007227Under Development for Production
B6.B10ScN-Tlr4lps-del /JthJ
This spontaneous mutation is a 7 kb deletion in the Tlr4 gene, which results in absence of both mRNA and protein and thus exhibits a defective response to LPS stimulation. This strain may be used to study the Toll signalling pathway and susceptibility to Gram-negative bacterial infection.
Traf1tm1Tsi 008074Under Development for Production
C.129S4-Traf1tm1Tsi /J
These TRAF1 mutant mice may be useful in studying negative regulation of tumor necrosis factor (TNF) signaling, NF-kB and AP-1 signaling, T cell receptor (TCR)-induced proliferation of T cells, Th2 responses, TRAF1/Bim function in CD8 memory T cell survival, allergic airway diseases and Rheumatoid arthritis, as well as the role of TRAF1 activation in the pathogenesis of lymphomas. Of note, TRAF1 mutant mice are available on either a BALB/c congenic (Stock No. 008074 ) or C57BL/6 congenic (Stock No. 008076 ) background.
Trp53tm2Xu 007218Under Development for Production
B6.129S6-Trp53tm2Xu /J
This targeted mutation of Trp53 (transformation related protein 53) contains two phosphorylation site disruptions: Ser18 to Ala (S18A), and Ser23 to Ala (S23A). Trp53-dependent apoptosis is essentially abolished in thymocytes from mice homozygous for this allele. This mutant mouse strain may be useful in studies of phosphorylation events, cancer development and apoptosis.
Usp18tm1Dzh 007225Under Development for Production
FVB.129(B6)-Usp18tm1Dzh /J
These Usp18 (or Ubp43)-mutant mice may be useful in studying interferons and their receptors, cellular function, signal transduction, and the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway.
Tg(Ins1-EGFP)1Hara
008173Under Development for Production
NOD.Cg-Tg(Ins1-EGFP)1Hara/QtngJ
Congenic NOD mice hemizygous for Enhanced Green Florescent Protein, EGFP , under the control of the Mouse Insulin I promoter, InsI , (MIP-GFP) express green florescence in tissues where insulin I is normally detected, specifically in pancreatic beta-cells. Transgenic mice are reported to develop diabetes at a similar or higher rate and kenetics as wildtype controls. Transgenic mice may be useful in studies of diabetes and pancreatic beta islet cell biology.
Tg(Itgax-DTR/EGFP)57Lan
008549Under Development for Production
NOD.FVB-Tg(Itgax-DTR/EGFP)57Lan/JdkJ
Congenic NOD mice hemizygous for a simian diphtheria toxin receptor - green fluorescent protein fusion protein under the control of mouse integrin alpha X, Itgax , promoter (CD11c ). These transgenic mice provide a diphtheria toxin inducible system that transiently depletes dendritic cell populations. This congenic NOD, transgenic strain is useful for studying the specific role of dendritic cells in the immune response, specifically type 1 diabetes.
Tg(Itgax-cre,-EGFP)4097Ach
007567Under Development for Production
C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
These CD11c-Cre-GFP transgenic mice may be useful in immunological studies utilizing Cre-lox technology or fluorescent protein expression in dendritic cells.
Tg(MMTV-neu/OT-I/OT-II)CBnel
007962Under Development for Production
B6.FVB-Tg(MMTV-neu/OT-I/OT-II)CBnel Tg(Trp53R172H)8512Jmr/J
Approximately 85% of the compound mutant females develop focal mammary tumors at 6-10 months of age. Both virgin and breeder mice develop tumors. Approximately 37% of tumor-bearing mice develop metastatic disease to the lung. High expression of neu is detected in tumor tissue while very low levels are found in lung and ovary.
Female mice carrying only the neuOT-I/OT-II mutation develop focal mammary tumors at approximately 18 months of age.
Tg(Mx1-cre)1Cgn
008309Under Development for Production
C57BL/6-Rag2tm1Cgn /J
These RAG-2fl mice harbor loxP sites flanking the entire coding region of the Rag2 (recombination activating gene 2) locus. When bred to mice that express Cre recombinase, the resulting offspring will have exon 3 deleted in the cre -expressing tissue(s). These RAG-2fl mice may be useful in generating conditional mutations for studying the role of RAG-2 in B and T cell development (including cancer and toxicology research as a xenograft/transplant host), T and B cell receptor (V(D)J) recombination, hematopoiesis, hematology, immunology, and inflammation research.
Tg(Nlrp1b)1Die
006840Under Development for Production
B6.Cg-Tg(Nlrp1b)1Die/DieJ
The transgenic line expresses the mouse NLR family pyrin domain (Nlrp1b ). Bone marrow-derived macrophages from these transgenic mice are highly susceptible to necrosis induced by anthrax lethal toxin. This mouse strain may be useful in studies of inflammatory autoimmune and infectious diseases, and of anthrax in particular.
Tg(TIE2GFP)287Sato
006770Under Development for Production
STOCK Rag1tm1Mom Tg(TIE2GFP)287Sato/J
To generate this double mutant strain, B6.Cg-Tg(TIE2GFP)287Sato/1J (Stock No. 004659 ) was crossed to C.129S7(B6)-Rag1tm1Mom /J (Stock No. 003145 ). This mutant mouse strain may be useful in studies examining angiogenesis in transplanted tissues.
Tg(Trp53R172H)8512Jmr
007962Under Development for Production
B6.FVB-Tg(MMTV-neu/OT-I/OT-II)CBnel Tg(Trp53R172H)8512Jmr/J
Approximately 85% of the compound mutant females develop focal mammary tumors at 6-10 months of age. Both virgin and breeder mice develop tumors. Approximately 37% of tumor-bearing mice develop metastatic disease to the lung. High expression of neu is detected in tumor tissue while very low levels are found in lung and ovary.
Female mice carrying only the neuOT-I/OT-II mutation develop focal mammary tumors at approximately 18 months of age.
Tg(UBC-scFv)2Nemz
006259Under Development for Production
B6.Cg-Pepcb Ptprca Tg(UBC-scFv)2Nemz/J
These "kappa-macroself Ag#2" transgenic mice may be useful to study B cell receptor editing, B cell tolerance in polyclonal immune systems, and for the rapid screening of mutants of interest for potential defects in B cell tolerance.
008452Under Development for Production
STOCK Eif2ak4tm1Dron /J
Mice homozygous for the GCN2.KO4conditional allele have loxP sites flanking exon XII of the eukaryotic translation initiation factor 2 alpha kinase 4 (Eif2ak4 or GCN2) targeted gene, and may be useful in generating conditional mutations for studying eIF2 (eukaryotic initiation factor 2) phosphorylation in response to environmental stresses (amino acid starvation, proteasome inhibition and UV irradiation).
Strains Newly Available for all Immunology and Inflammation Research models.