Allele Symbol Stock Number Strain Name
B4galt1tm1Shur 006941Under Development for Production
B6.129S7-B4galt1tm1Shur /J
These mutant mice do not express the long or short isoforms of Beta 1,4-galactosyltransferase enzyme. 90% of homozygotes die soon after birth or within 2-3 weeks of birth. This mutant mouse strain may be useful in studies of glycosidic molecular interactions and function, and polyglandular endocrine insufficiency.
B4galt1tm2Shur 006943Under Development for Production
B6.129S7-B4galt1tm2Shur /J
These mutant mice do not express the long isoform of the beta 1,4-galactosyltransferase enzyme. Homozygotes exhibit abnormal acrosomal exocytosis and mammary gland morphogenesis. This mutant mouse strain may be useful in studies of glycosidic molecular interactions and function, and cell-to-extracellular matrix (ECM) interactions.
Dicer1tm1Bdh 006366Under Development for Production
B6.Cg-Dicer1tm1Bdh /J
These mice contain loxP sites on either side of exon 23 of the Dicer1 (Dicer1, Dcr-1 homolog (Drosophila)) gene. Cre-mediated recombination (resulting in deletion of exon 23) in the germline leads to developmental arrest at embryonic day 7.5 (E7.5). Mutant mice can be used to generate cell/tissue-specific deletions of the endogenous gene for applications in embryonic development, translation, protein processing and miRNA/siRNA regulation of gene expression.
Eif2ak4tm1.1Dron 008452Under Development for Production
B6;129-Eif2ak4tm1.1Dron /J
Mice homozygous for the GCN2.KO4conditional allele (also called GCN2.KO4c) have loxP sites flanking exon XII of the eukaryotic translation initiation factor 2 alpha kinase 4 (Eif2ak4 or GCN2) targeted gene, and may be useful in generating conditional mutations for studying eIF2 (eukaryotic initiation factor 2) phosphorylation in response to environmental stresses (amino acid starvation, proteasome inhibition and UV irradiation).
Eif2ak4tm1.2Dron 008240Under Development for Production
B6.129S6-Eif2ak4tm1.2Dron /J
Mice homozygous for the GCN2.KO4 mutant locus (also called GCN2.KO4- , GCN2- , GCN2.KO4ex , or GCN2-KO) have a deletion of exon XII of the eukaryotic translation initiation factor 2 alpha kinase 4 (Eif2ak4 or GCN2) gene, and may be useful in studying eIF2 (eukaryotic initiation factor 2) phosphorylation in response to environmental stresses (amino acid starvation, proteasome inhibition and UV irradiation).
Foxp3sf 006775On Hold
NOD.Cg-Foxp3sf /DoiJ
Gt(ROSA)26Sortm4(Ikbkb)Rsky 008242Under Development for Production
C57BL/6-Gt(ROSA)26Sortm1(Ikbkb)Rsky /J
These R26StopFL ikk2ca mice allow inducible expression of an activated form of Ikbkb (IKK2ca) and subsequent activation of the NF-kappaB transcription factor pathways.
Leprtm1Mgmj 008518Under Development for Production
B6.129-Leprtm1Mgmj /J
Mice homozygous for the LeprS1138 mutant allele (or s/s mice) have a Tyr->Ser replacement at amino acid residue 1138 of the leptin receptor long form (LRb)-specific exon 18b that specifically disrupts LRb-STAT3 transcription factor signaling, and may be useful for studying LRb-STAT3 signaling in the physiological and metabolic function of leptin; specifically body energy homeostasis and neuroendocrine function, glucose homeostasis, melanocortin production, neuropeptide Y, obesity, diabetes, fertility and growth.
Leprtm2Mgmj 008385Under Development for Production
B6.129-Leprtm2Mgmj /J
Mice homozygous for the LeprLeu985 mutant allele (or l/l mice) have a Tyr->Leu replacement at amino acid residue 985 of the leptin receptor long form (LRb)-specific exon 18b that specifically disrupts LRb-SHP2 and LRb-SOCS3 transcription factor signaling, and may be useful for studying the influence of LRb-SHP2 and LRb-SOCS3 signaling in the physiological and metabolic function of leptin; specifically body energy homeostasis and neuroendocrine function, glucose homeostasis, melanocortin production, neuropeptide Y, obesity, diabetes, fertility and growth.
Mgat5tm1Jwd 006335Under Development for Production
B6.129-Mgat5tm1Jwd /J
Mgat5 (mannoside acetylglucosaminyltransferase 5) deficient mice exhibit increased responses to induced immune challenges and delayed tumor progression when bred with oncomice. This mutant mouse strain may be useful in studies of glycosidic molecular interactions and function, autoimmunity and antitumor immunity.
Mirn150tm1Rsky 007750Under Development for Production
B6;C-Mirn150tm1Rsky /J
These miR150-/- mice may be useful in mircoRNA biology, specifically to study the role of miR-150 and its target genes (including c-Myb) in lymphocyte development and function.
Mirn155tm1.1Rsky 007745Under Development for Production
B6.Cg-Mirn155tm1.1Rsky /J
These bic /mir-155 mutant mice may be useful in mircoRNA biology, specifically to study the role of miR-155 and its target genes (including cytokines, chemokines, and transcription factors) in homeostasis and function of the immune system.
Nrgntm1Kph 008233Under Development for Production
B6.129-Nrgntm1Kph /J
These neurogranin mutant mice may be useful for neurological studies involving memory and learning, neuronal signaling pathways (including calmodulin, alpha-CaMKII, protein kinase A, protein kinase C, MAPK, and CREB), attention deficit-hyperactivity disorder (ADHD), and schizophrenia.
Pde10atm1Pfi 008210Under Development for Production
B6.D1-Pde10atm1Pfi /J
These PDE10AC57 mutant mice are deficient in phosphodiesterase 10A activity, and may be useful in neurobiological studies including metabolic inactivation of intracellular signal transduction pathways by cyclic phosphodiesterases (PDEs), regulation of information processing by basal ganglia circuitry, and striatal hypofunction or psychotic disease.
Per1tm1Brd 008530Under Development for Production
B6;129S7-Per1tm1Brd Per2tm1Brd /J
Mice that are double homozygous mutants for the Per1tm1Brd (period homolog 1 (Drosophila)) and Per2tm1Brd (period homolog 2 (Drosophila)) alleles do not exhibit circadian rhythm when kept in constant darkness. A light pulse does not reestablish circadian rhythm. This mutant mouse strain may be useful in studies of circadian rhythm.
Per2tm1Brd 008530Under Development for Production
B6;129S7-Per1tm1Brd Per2tm1Brd /J
Mice that are double homozygous mutants for the Per1tm1Brd (period homolog 1 (Drosophila)) and Per2tm1Brd (period homolog 2 (Drosophila)) alleles do not exhibit circadian rhythm when kept in constant darkness. A light pulse does not reestablish circadian rhythm. This mutant mouse strain may be useful in studies of circadian rhythm.
Seletm1Dmil 008238Under Development for Production
129S-Seletm1Dmil /J
These E-selectin mutant mice may be useful in studying inflammation, leukocyte rolling, leukocyte-endothelial adhesion, angiogenesis, and cancer.
Seletm1Dmil 008236Under Development for Production
B6.129S4-Seletm1Dmil /J
These E-selectin mutant mice may be useful in studying inflammation, leukocyte rolling, leukocyte-endothelial adhesion, angiogenesis, and cancer.
Seletm1Dmil 008237Under Development for Production
C.129S4-Seletm1Dmil /J
These E-selectin mutant mice may be useful in studying inflammation, leukocyte rolling, leukocyte-endothelial adhesion, angiogenesis, and cancer.
Slc6a3tm1.1(cre)Bkmn 006660Under Development for Production
B6.SJL-Slc6a3tm1.1(cre)Bkmn /J
These dopamine transporter IRES-cre (DATIREScre ) mutant mice exhibit co-localization of Cre recombinase and endogenous Slc6a3 (solute carrier family 6 (neurotransmitter transporter, dopamine), member 3) gene expression and may be useful in neurobiological studies to facilitate the analysis of gene function in dopaminergic neurons, such as drug addiction or Parkinson's disease.
Timp2tm1Pds 008120Under Development for Production
B6.129S4-Timp2tm1Pds /J
These mice are deficient in TIMP-2, tissue inhibitor of metalloproteinase 2, and exhibit locomotor impairment, abnormal fear conditioning behavior, and defective neuronal differentiation. This mutant mouse strain may be useful in studies of extracellular matrix homeostasis, synaptic plasticity in behavior, learning and memory, neuronal differentiation and development of neuromuscular junctions.
Traf1tm1Tsi 008074Under Development for Production
C.129S4-Traf1tm1Tsi /J
These TRAF1 mutant mice may be useful in studying negative regulation of tumor necrosis factor (TNF) signaling, NF-kB and AP-1 signaling, T cell receptor (TCR)-induced proliferation of T cells, Th2 responses, TRAF1/Bim function in CD8 memory T cell survival, allergic airway diseases and Rheumatoid arthritis, as well as the role of TRAF1 activation in the pathogenesis of lymphomas. Of note, TRAF1 mutant mice are available on either a BALB/c congenic (Stock No. 008074 ) or C57BL/6 congenic (Stock No. 008076 ) background.
Usp18tm1Dzh 007225Under Development for Production
FVB.129(B6)-Usp18tm1Dzh /J
These Usp18 (or Ubp43)-mutant mice may be useful in studying interferons and their receptors, cellular function, signal transduction, and the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway.
Tg(CAG-EGFP/CETN2)3-4Jgg
008234Under Development for Production
CB6-Tg(CAG-EGFP/CETN2)3-4Jgg/J
Transgenic GFP-CETN2 mice express an enhanced green fluorescent protein-labeled human Centrin-2 (EGFP-CETN2) under the control of the chicken beta-actin promoter (with cytomegalovirus immediate early enhancer). These GFP-CETN2 mice allow fluorescent staining of the centrioles of the centrosome, and may be useful for studying mitosis, microtubule organization, cell-cycle regulation, signal transduction, transcription activation, cell migration, DNA damage repair, and cancer.
Tg(CAG-SAC/EGFP)35Rang
008080Under Development for Production
B6;C3-Tg(CAG-SAC/EGFP)35Rang/J
These SAC-GFP transgenic mice may be useful as a cancer-resistant model; evading oncogene-mediated tumorigenesis by expressing an archetypical anticancer therapeutic agent (SAC) that is well tolerated in vivo , does not compromise the normal tissue function or life span of the host, and is potent enough at physiologically innocuous levels to concomitantly suppress the NF-kappaB pro-cell survival pathway and induce tumor suppression via apoptosis.
Tg(CAG-Ub*G76V/GFP)1Dant
008111Under Development for Production
B6.Cg-Tg(CAG-Ub*G76V/GFP)1Dant/J
Both ubiquitin/proteasome system reporter (UPS reporter) founder lines, UbG76V -GFP/1 (Stock No. 008111) and UbG76V -GFP/2 (Stock No. 008112), may be useful for monitoring the role of ubiquitin/proteasome-dependent proteolysis in diverse disorders, and for efficacy trials testing the effect of compounds on the ubiquitin/proteasome system (including the effect of proteasome inhibitors as novel anticancer drugs).
Tg(tetO-DTA)1Gfi
008168Under Development for Production
STOCK Tg(tetO-DTA)1Gfi/J
These tet-DTA mice express diphtheria toxin A (DTA) under the control of a tetracycline operator (tetO ; also called tetracycline-responsive element (TRE) or tet-operator) and a cytomegalovirus minimal promoter, and may be useful in generating bi-transgenic mutant mice for the reversible, inducible deletion of specific groups of cells.
Strains Newly Available for all Cell Biology Research models.