Allele Symbol Stock Number Strain Name
Atxn1ltm2.1Hzo 017942Awaiting Transfer from the Donor
B6.129S7-Atxn1ltm2.1Hzo /J
Approximatley 50% of homozygous Atxn1l (ataxin 1-like) KO mice die before postnatal day 21. Hydrocephalus, omphalocele, and lung alveolar deficits are observed. This strain may be helpful in studies related to extracellular matrix remodeling and lung alveolarization.
Braftm1Mmcm 017837Awaiting Transfer from the Donor
B6.129P2(Cg)-Braftm1Mmcm /J
These Cre-activated BRaf mutant mice (BRafCA ) have expression of physiological normal BRaf prior to Cre recombinase exposure. Following Cre-mediated excision of the floxed sequences, Braf expression is replaced by that of the constitutively active BRafV600E mutation (BRafVE ) associated with sustained activation of the MEK1/2-ERK1/2 pathway and human malignancies such as melanoma, colorectal, papillary thyroid, ovarian, and non-small-cell lung cancers. These mice may be useful in such studies, as well as for studying the RAS-activated RAF/MEK/ERK mitogen-activated protein (MAP) kinase signaling pathway and pleiotropic regulators of the aberrant cancer cell physiology.
Cacna1ftm1.2Sdie 017762Under Development for Cryo
B6(Cg)-Cacna1ftm1.2Sdie /J
These mice carry the I756T point mutation in exon 17, and loxP sites flanking exons 14 through 17, of the Cacna1f (calcium channel, voltage-dependent, alpha 1F subunit). This mutant mouse strain may be useful in studies of calcium channelopathies, an inherited retinal disorder, photoreceptor electrophysiology, and the role of the Cav1.4 channel in survival of naive T cells.
Cacna1ftm1Sdie 017760Under Development for Cryo
B6(Cg)-Cacna1ftm1Sdie /J
These I756T+neo mice carry the I756T point mutation in exon 17 of the Cacna1f , calcium channel, voltage-dependent, alpha 1F subunit, (756 is the mouse equivalent to residue 745 in human CACNA1F ) as well as a FRT flanked NEO selection cassette and loxP sites flanking exons 14 through 17. This mutant mouse strain may be useful in studies of calcium channelopathies, incomplete congenital stationary night blindness, photoreceptor electrophysiology, and the role of the Cav1.4 channel in survival of naive T cells.
Catsper1tm1Clph 018311Awaiting Transfer from the Donor
B6.129S4-Catsper1tm1Clph /J
Catsper1 homozygous knockout mice show male-specific infertility due to a lack of sperm hyperactivation.
Clec9atm1.1Crs 017696Awaiting Transfer from the Donor
B6(Cg)-Clec9atm1.1Crs /J
A membrane-bound form of enhanced green fluorescent protein (EGFP) replaces the coding region of Clec9a and abolishes gene expression.
Cmahtm1Avrk 017929Awaiting Transfer from the Donor
B10.Cg-Cmahtm1Avrk Dmdmdx /PtmJ
These Cmah-mdx mice are useful for studying how human-like CMAH-deficiency accelerates the onset and severity of the Duchenne muscular dystrophy (DMD) seen in Dmdmdx mice. These mice are useful for studying the metabolic accumulation of dietary N -glycolylneuraminic acid (Neu5Gc; a foreign sialyl-containing glycan in humans and Cmah-deficient mice), the subsequent generation of Neu5Gc-specific antibodies and the deposition of activated (C5b-9) complement on muscle fibers. These Cmah-mdx mice represent a new small animal model for DMD that better approximates the human glycome and its contributions to muscular dystrophy.
Dmdmdx 017929Awaiting Transfer from the Donor
B10.Cg-Cmahtm1Avrk Dmdmdx /PtmJ
These Cmah-mdx mice are useful for studying how human-like CMAH-deficiency accelerates the onset and severity of the Duchenne muscular dystrophy (DMD) seen in Dmdmdx mice. These mice are useful for studying the metabolic accumulation of dietary N -glycolylneuraminic acid (Neu5Gc; a foreign sialyl-containing glycan in humans and Cmah-deficient mice), the subsequent generation of Neu5Gc-specific antibodies and the deposition of activated (C5b-9) complement on muscle fibers. These Cmah-mdx mice represent a new small animal model for DMD that better approximates the human glycome and its contributions to muscular dystrophy.
Dmdmdx 018018Awaiting Transfer from the Donor
B10ScSn.Cg-Prkdcscid Dmdmdx /J
MDX/SCID mice exhibit necrosis, centrally located nuclei and and the muscle degeneration characteristic of DMD and may be used a dystrophic model for the transplantation of human donor cells to evaluate skeletal muscle regeneration.
Dmdmdx 013141Awaiting Transfer from the Donor
D2.B10-Dmdmdx /J
These Dmdmdx mutant mice may be useful for studying Duchenne muscular dystrophy (DMD).
Ifngtm3.1Lky 017580Awaiting Transfer from the Donor
C.129S4(B6)-Ifngtm3.1Lky /J
The "interferon-g amma r eporter with e ndogenous polyA t ranscript" (GREAT) allele has an IRES-eYFP reporter cassette inserted between the translational stop codon and 3' UTR/polyA tail of the interferon gamma (Ifng ) gene. Thus, the bicistronic IFNγ-IRES-eYFP mRNA is under control of the endogenous IFNγ promoter/enhancer regions with proper regulation defined by the endogenous 3' UTR and polyA tail. These GREAT mice are a fluorescent reporter strain for studying innate immunity/adaptive immunity against viral and intracellular bacterial infections, for studying anti-tumor biology, as well for studying aberrant IFN-γ expression associated with autoinflammatory/autoimmune diseases.
Itga7tm1Burk 016857In Progress
B6;129-Itga7tm1Burk /J
The α7- (or α7βgal- ) mutant allele is designed to both abolish endogenous gene expression and place β-galactosidase under transcriptional control of the α7 integrin promoter/enhancer region.
Lattm6(DTR)Mal 016937In Progress
B6.129S2-Lattm6(DTR)Mal /J
Latfl-dtr mutant mice contain a loxP site downstream from exon 1, and an internal ribosome entry site (IRES), a human diphtheria toxin receptor, and an enhanced green fluorescent protein (EGFP) followed by a second loxP site downstream of the internal stop codon of the linker for activation of T cells (Lat ) gene. These mice may be useful for studying the TCR signaling cascade and T cell homeostasis.
Mcm2tm1(cre/ERT2)Scpr 017611Awaiting Transfer from the Donor
129-Mcm2tm1(cre/ERT2)Scpr /J
In this strain Cre-ERT2 is knocked into the minichromosome maintenance deficient 2 mitotin (Mcm2 ) gene. Expression of Mcm2 is reduced, but not abolished. This strain may be useful for mediating inducible cre recombination in Mcm2 -expressing tissues, as well as for studying the regulation of core DNA replication machinery.
Mcm2tm2Scpr 017612Awaiting Transfer from the Donor
129-Mcm2tm2Scpr /J
Mcm2IRES-EGFP mice have an enhanced green fluorescent protein (EGFP) sequence inserted downstream of the stop codon of the minichromosome maintenance deficient 2 mitotin (Mcm2 ) gene. These mice may be useful for visualizing and recovering proliferation competent cells.
Mir22tm1.1Arod 018155Awaiting Transfer from the Donor
129S-Mir22tm1.1Arod /J
These mice carry a targeted mutation of Mir22 (microRNA 22) and exhibit impaired cardiac intracellular calcium homeostasis and increased sensitivity to hemodynamic stress.
Naip1tm1Dgen 005778On Hold
B6.129P2-Naip1tm1Dgen /J
This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen.
Nanogtm1Hoch 016233Awaiting Transfer from the Donor
129S;B6-Nanogtm1Hoch /J
A GFP-IRES-puro-cassette replaces the coding region of the Nanog gene in these mice. Mouse embryonic fibroblasts containing this mutation may be useful for identifying induced pluripotent stem cells.
Pak6tm1Amin 015826Awaiting Transfer from the Donor
B6.129-Pak6tm1Amin /J
These Pak6 knock-out mice may be useful for studying learning, memory, and locomotion.
Pak7tm1Amin 015827In Progress
B6;129P2-Pak7tm1Amin /J
These Pak7 knock-out mice may be useful for studying learning, memory, and locomotion.
Pax7tm1(cre/ERT2)Gaka 017763Awaiting Transfer from the Donor
B6.Cg-Pax7tm1(cre/ERT2)Gaka /J
A CreERT2 fusion protein sequence inserted downstream of the Pax7 stop codon allows endogenous PAX7 expression in these mice while permitting specific conditional labeling, manipulation, and deletion of satellite cells.
Pitx2tm1.1Dmm 018054Awaiting Transfer from the Donor
B6.129P2(Cg)-Pitx2tm1.1Dmm /J
In this mutant strain, an IRES Tau-lacZ cassette abolishes expression of all three PITX2 isoforms. TaulacZ is expressed in neurons projecting from the mammillary tract of the hypothalamus.
Prkdcscid 018018Awaiting Transfer from the Donor
B10ScSn.Cg-Prkdcscid Dmdmdx /J
MDX/SCID mice exhibit necrosis, centrally located nuclei and and the muscle degeneration characteristic of DMD and may be used a dystrophic model for the transplantation of human donor cells to evaluate skeletal muscle regeneration.
Prnptm1Cwe 018122Awaiting Transfer from the Donor
FVB.129S7(B6)-Prnptm1Cwe /J
These prion protein-deficient mice are resistant to prion disease and serve as a PrP-deficient background for mouse models of spongiform encephalopathies and neurologic prion disorders.
Rac3tm1Hkp 017832In Progress
B6.129-Rac3tm1Hkp /J
These RAC3 KO mice are useful for studying cancer, leukemia, and programmed cell death.
Ror1tm1.1Meg 018353Awaiting Transfer from the Donor
B6;129S-Ror1tm1.1Meg /J
These Ror1f/f conditional mutant mice may have applications in studies related to Wnt5a -mediated signaling during embryonic development.
Ror2tm1.1Meg 018354Awaiting Transfer from the Donor
B6;129S-Ror2tm1.1Meg /J
These Ror1f/f conditional mutant mice may have applications in studies related to Wnt5a -mediated signaling during embryonic development.
Sept4tm1Hs 018160Awaiting Transfer from the Donor
129-Sept4tm1Hs /J
Septin 4 (Sept4 ) homozygous knockout males are sterile due to immotile and structurally defective sperm. Mice also exhibit increased incidence of hematopoietic malignancies having increased numbers of hematopoietic stem and progenitor cells (HSPCs).
Sept4tm1Hs 018159Awaiting Transfer from the Donor
B6.129P2-Sept4tm1Hs /J
Septin 4 (Sept4 ) homozygous knockout males are sterile due to immotile and structurally defective sperm. Mice also exhibit increased incidence of hematopoietic malignancies having increased numbers of hematopoietic stem and progenitor cells (HSPCs).
Sept4tm1Hs 018161Awaiting Transfer from the Donor
FVB.129P2-Sept4tm1Hs /J
Septin 4 (Sept4 ) homozygous knockout males are sterile due to immotile and structurally defective sperm. Mice also exhibit increased incidence of hematopoietic malignancies having increased numbers of hematopoietic stem and progenitor cells (HSPCs).
Shank3tm1.1Bux 017889Awaiting Transfer from the Donor
B6(Cg)-Shank3tm1.1Bux /J
These mice possess loxP sites flanking exons 4-9 of the Shank3 gene and are suitable for use in making tissue-specific conditional mutations when used in conjunction with a Cre-expressing strain.
Shank3tm1.2Bux 017890Awaiting Transfer from the Donor
B6(Cg)-Shank3tm1.2Bux /J
These mutant mice harbor a deletion of the SH3/ankyrin domain gene 3 (Shank3 ) ankyrin repeat domains (exons 4-9); this deletion prevents full-length Shank3 expression. As Shank3 is necessary for forming functional glutamatergic synapses between receptors and cytoskeletal/scaffolding elements, these mice may be useful for studying synaptic glutamate receptor development/function, transmission and plasticity, as well as Shank3 haploinsufficiency, neurobehavioral manifestations of 22q13 deletion syndrome and/or autism spectrum disorders.
Slc19a3tm1Said 017343In Progress
STOCK Slc19a3tm1Said /J
This THTR-2- knockout mouse line has a deletion of exons 1-2 of the Slc19a3 gene. These mice may be useful in studying the role of thiamin transporters in regulating thiamin homeostasis in different cells; including liver and kidney cells.
Slc26a4tm1Egr 018424Awaiting Transfer from the Donor
129S-Slc26a4tm1Egr /AjgJ
Pds-/- mice are useful for studying deafness and vestibular dysfunction associtated with Pendred syndrome.
Slc29a1tm2Msg 017792Awaiting Transfer from the Donor
129X1/SvJ-Slc29a1tm2Msg /J
These ENT1 flox mice have loxP sites flanking exons 2 through 4 of the Slc29a1 gene and have applications in studies related to anxiety and alcohol dependence.
Tdgf1tm2.2Mms 016539Awaiting Transfer from the Donor
STOCK Tdgf1tm2.2Mms /J
These Cripto2loxP mice possess a loxP -sites flanking exons 3-5 of the teratocarcinoma-derived growth factor 1 (Tdgf1 ) gene. This strain may be useful for studying embryonic development and tumor growth.
Thy1a 014550Under Development for Cryo
B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J
These Bd 1807 TCR transgenic mice feature a CD4+ T cell repertoire that are reactive to several types of dimorphic fungi that cause major systemic mycoses found in North America.
Ulk2tm1Thsn 017977Awaiting Transfer from the Donor
B6.129-Ulk2tm1Thsn /J
These floxed Ulk2FL mice may be useful for studying the mechanisms of autophagy.
Tg(CRKL*)8746Hkp
017834In Progress
STOCK Tg(CRKL*)8746Hkp/J
These transgenic mice express human CRKL and exhibit an increase in lymphoma and osteomyelosclerosis.
Tg(Cp-EGFP)25Gaia
005854On Hold
STOCK Tg(Cp-EGFP)25Gaia/J
Mice homozygous for the Notch reporter transgene are viable, fertile, normal in size, and do not display any behavioral abnormalities. Enhanced green fluorescent protein (EGFP) expression is present in a wide variety of hemizygous cell/tissue types during development and in the adult, including enriched hematopoietic stem cell (HSC) populations. The location of EGFP expression is consistent with Notch signaling pathway elements/genes and appears to faithfully reflect canonical (CBF1-mediated) Notch activity. With respect to hematopoiesis, low expression is shown in fully differentiated cells of the peripheral lymphoid organs (blood and spleen). Isolated HSC retain their ability to differentiate. Mice expressing this Notch reporter transgene may be useful in studying HSC populations and other cell types utilizing the Notch, CBF1, or Wnt signaling pathways. As immature (double negative [DN]) thymocytes have differential expression patterns as they progress from DN1-DN4, these mice may al ..... For more information please see the full phenotype on the strain data sheet
Tg(TcraCWM5,TcrbCWM5)1807Wuth
014550Under Development for Cryo
B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J
These Bd 1807 TCR transgenic mice feature a CD4+ T cell repertoire that are reactive to several types of dimorphic fungi that cause major systemic mycoses found in North America.
Tg(tetO-Cdkn1b)1Scpr
017613Awaiting Transfer from the Donor
C57BL/6-Tg(tetO-Cdkn1b)1Scpr/J
These mice express a cyclin-dependent kinase inhibitor 1B (Cdkn1b ) cDNA under the direction of the tetracycline operator. These mice may be useful for studying cellular replication and aging.
Tg(tetO-Gnai2*,-lacZ)382Kndl
017333In Progress
FVB-Tg(tetO-Gnai2*,-lacZ)382Kndl/J
A constitutively active R179C mutant form of Gnai2 (also called G-alpha-i2) was cointegrated with lacZ under the control of the tetO promoter in this transgenic strain. This strain may be useful in a variety of studies involving G-protein coupled signaling.
018064Awaiting Transfer from the Donor
B6.129S1-Plcb2tm1Dwu /J
Plcb2 (phospholipase C, beta 2) knockout mice show enhanced resistance to viral and bacterial infection, and lack sweet and bitter taste reception.
018322Awaiting Transfer from the Donor
STOCK Tg(Cp-EGFP)25Gaia/ReyaJ
These Notch reporter mice are useful in studying hematopoietic stem cell populations utilizing the Notch or Wnt signaling pathways, as well as in thymocyte maturation studies.
017761Under Development for Cryo
C57BL/6-Cacna1ftm1.1Sdie /J
These mice carry a targeted mutation with exons 14 through 17 of the Cacna1f (calcium channel, voltage-dependent, alpha 1F subunit) gene deleted. This mutant mouse strain may be useful in studies of calcium channelopathies, incomplete congenital stationary night blindness, photoreceptor electrophysiology, and the role of the Cav1.4 channel in survival of naive T cells.
View Strains Newly Available for all Cell Biology Research models.