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Internal/Organ Research

 
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Internal/Organ Research

Allele Symbol
 
Strain Description		 Stock Number Strain Name
   (link to Data Sheet)
Atxn1ltm2.1Hzo 017942
Awaiting Transfer from the Donor		 B6.129S7-Atxn1ltm2.1Hzo/J
Approximatley 50% of homozygous Atxn1l (ataxin 1-like) KO mice die before postnatal day 21. Hydrocephalus, omphalocele, and lung alveolar deficits are observed. This strain may be helpful in studies related to extracellular matrix remodeling and lung alveolarization.
Cmahtm1Avrk 017588
In Progress		 B6.129X1-Cmahtm1Avrk/J
These CMAH KO mice may be useful for studying the hydroxylation of sialic acids required for protein/lipid synthesis and pancreatic beta cell function. In combination with other alleles, they may also have applications in studies realted to Duchenne muscular dystrophy.
Dmdmdx 018018
Awaiting Transfer from the Donor		 B10ScSn.Cg-Prkdcscid Dmdmdx/J
MDX/SCID mice exhibit necrosis, centrally located nuclei and and the muscle degeneration characteristic of DMD and may be used a dystrophic model for the transplantation of human donor cells to evaluate skeletal muscle regeneration.
Gnmttm1Cwa 018066
In Progress		 B6.129-Gnmttm1Cwa/J
In this strain a NEO cassette replaces exon1 and the promoter region of the Gnmt gene. This strain is a model for Glycine N-Methyltransferase Deficiency and has applications in studies of methionine metabolism, methylation and molecular markers for hepatocellular carcinoma.
H2-Ab1tm1Doi 004606
On Hold		 NOD.Cg-Prkdcscid H2-Ab1tm1Doi Tg(HLA-DQA1,HLA-DQB1)1Dv/SzJ
This strain which is MHC II deficient and has no functional T or B cells expresses a humanized transgenic HLA-DQ8 molecule that has been linked to IDDM development. This model is a valuable genetic tool for identifying the role of HLA-DQ8 in Type 1 Diabetes.
Hfe2tm1Nca 017788
In Progress		 129S-Hfe2tm1Nca/J
These Hfe2 knockout mice exhibit iron loading and have applications in studies of juvenile or Type2A hemochromatosis, iron homeostasis and iron-induced oxidative damage.
Hfetm2Nca 017785
In Progress		 129S-Hfetm2Nca/J
These mice carry a targeted mutation of Hfe, hemochromatosis, exhibit iron loading, and have applications in studies of hereditary hemochromatosis, iron homeostasis and innate immune response
Hfetm2Nca 017784
Under Development for Cryo		 B6.129S6-Hfetm2Nca/J
These mice carry a targeted mutation of Hfe, hemochromatosis, exhibit iron loading, and have applications in studies of hereditary hemochromatosis, iron homeostasis and innate immune response.
Impad1Gt(RST634)Byg 012921
In Progress		 B6;129P2-Impad1Gt(RST634)Byg/J
Homozyous Impad1 (inositol monophosphatase domain containing 1; also called gPAPP) mutant mice die within 10 minutes of birth due to severe respiratory insufficiency and chondrodysplasia. Mutants have shortened limbs due to defects in endochondral ossification which are hypothesized to be due to an undersulfonation of chondroitin and heparin sulfate. This strain may be useful in studies of skeletal development and sulfation.
Kitltm1.1Sjm 017860
Awaiting Transfer from the Donor		 STOCK Kitltm1.1Sjm/J
An EGFP reporter disrupts expression of the Kitl gene in this targeted mutation strain. EGFP is primarily expressed by perivascular endothelial and stromal cells throughout the bone marrow in heterozygotes.
Lattm6(DTR)Mal 016937
In Progress		 B6.129S2-Lattm6(DTR)Mal/J
Latfl-dtr mutant mice contain a loxP site downstream from exon 1, and an internal ribosome entry site (IRES), a human diphtheria toxin receptor, and an enhanced green fluorescent protein (EGFP) followed by a second loxP site downstream of the internal stop codon of the linker for activation of T cells (Lat) gene. These mice may be useful for studying the TCR signaling cascade and T cell homeostasis.
Nkx3-1tm2Mms 016541
Awaiting Transfer from the Donor		 B6N;129S6-Nkx3-1tm2Mms/J
In this Nkx3-1lacZ mutant strain a β-galactosidase (lacZ) cassette disrupts the NK-3 transcription factor, locus 1 (Nkx3-1) gene, abolishing gene function. This strain may be useful for visualizing the differentiating prostate and the development of prostate tumors.
Nlrp3tm3Hhf 017971
In Progress		 B6N.129-Nlrp3tm3Hhf/J
These Nlrp3D301NneoR mice serve as a constitutive knockout of the Nlrp3 gene. In the presence of cre recombinase however, a transcript encoding a D301N mutation is produced. This line may be useful in studying the role of cryopyrin in the regulation of autoinflammatory diseases.
Pax7tm1(cre/ERT2)Gaka 017763
Awaiting Transfer from the Donor		 B6.Cg-Pax7tm1(cre/ERT2)Gaka/J
A CreERT2 fusion protein sequence inserted downstream of the Pax7 stop codon allows endogenous PAX7 expression in these mice while permitting specific conditional labeling, manipulation, and deletion of satellite cells.
Pitx2tm1.1Dmm 018054
Awaiting Transfer from the Donor		 B6.129P2(Cg)-Pitx2tm1.1Dmm/J
In this mutant strain, an IRES Tau-lacZ cassette abolishes expression of all three PITX2 isoforms. TaulacZ is expressed in neurons projecting from the mammillary tract of the hypothalamus.
Prkdcscid 018018
Awaiting Transfer from the Donor		 B10ScSn.Cg-Prkdcscid Dmdmdx/J
MDX/SCID mice exhibit necrosis, centrally located nuclei and and the muscle degeneration characteristic of DMD and may be used a dystrophic model for the transplantation of human donor cells to evaluate skeletal muscle regeneration.
Prkdcscid 017620
Awaiting Transfer from the Donor		 NOD.Cg-Prkdcscid Tg(CAG-DsRed*MST)1Nagy/KupwJ
This compound mutant strain combines the immunodeficiency features of the Prkdcscid mutation and widespread fluorescent cell labeling capabilities of CAG-DsRed on the NOD genetic background. These mice are effective recipients of allogeneic and xenogenic grafts, and are an excellent source of fluorescent-labeled cells for transfer experiments.
Prkdcscid 004606
On Hold		 NOD.Cg-Prkdcscid H2-Ab1tm1Doi Tg(HLA-DQA1,HLA-DQB1)1Dv/SzJ
This strain which is MHC II deficient and has no functional T or B cells expresses a humanized transgenic HLA-DQ8 molecule that has been linked to IDDM development. This model is a valuable genetic tool for identifying the role of HLA-DQ8 in Type 1 Diabetes.
Prom1tm1(cre/ERT2)Gilb 017743
In Progress		 B6N;129S-Prom1tm1(cre/ERT2)Gilb/J
A CreERT2 fusion protein and β-galactosidase (lacZ) gene knocked into the ATG start codon of Prom1 abolishes gene function in these mice. Useful applications include visualizing and tracking adult stem cell lineages.
Reg3gtm1.1Lvh 017480
In Progress		 B6.129-Reg3gtm1.1Lvh/J
Reg3g (regenerating islet-derived 3 gamma) is a bactericidal C-type lectin that specifically targets Gram-positive bacteria. This knockout strain has been useful in studies of bacterial colonization of the small intestine and host intestinal-microbial homeostasis.
Slc19a3tm1Said 017343
In Progress		 STOCK Slc19a3tm1Said/J
This THTR-2- knockout mouse line has a deletion of exons 1-2 of the Slc19a3 gene. These mice may be useful in studying the role of thiamin transporters in regulating thiamin homeostasis in different cells; including liver and kidney cells.
Tardbptm1.1Pcw 017591
Awaiting Transfer from the Donor		 B6(SJL)-Tardbptm1.1Pcw/J
These floxed mice possess loxP sites flanking exon 3 of the Tardbp gene. Deletion results in premature death due to increased fat metabolism and leanness associated with ALS.
Thy1a 014550
Under Development for Cryo		 B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J
These Bd 1807 TCR transgenic mice feature a CD4+ T cell repertoire that are reactive to several types of dimorphic fungi that cause major systemic mycoses found in North America.
Tg(ACTB-UPF1*R844C)581Hcd 010939
Under Development for Cryo		 B6.Cg-Tg(ACTB-UPF1*R844C)581Hcd/J
Human beta actin drives expression of the dominant negative R844C form of the human (UPF1)cDNA in these transgenic mice resulting in T cell-related defects.
Tg(CAG-CYP27A1)23Etl 009109
On Hold		 B6.CBA-Tg(CAG-CYP27A1)23Etl/J
These CYP27 overexpressor transgenic mice (or CYP27overexp mice) have widespread expression of human cytochrome P450, family 27, subfamily A, polypeptide 1 directed by the CAG promoter. These mice may be useful in studying the conversion of cholesterol to bile acids (bile acid synthesis) by both the classical and alternate pathways, as well as lipid and cholesterol homeostasis research.
Tg(CAG-DsRed*MST)1Nagy 017620
Awaiting Transfer from the Donor		 NOD.Cg-Prkdcscid Tg(CAG-DsRed*MST)1Nagy/KupwJ
This compound mutant strain combines the immunodeficiency features of the Prkdcscid mutation and widespread fluorescent cell labeling capabilities of CAG-DsRed on the NOD genetic background. These mice are effective recipients of allogeneic and xenogenic grafts, and are an excellent source of fluorescent-labeled cells for transfer experiments.
Tg(HLA-DQA1,HLA-DQB1)1Dv 004606
On Hold		 NOD.Cg-Prkdcscid H2-Ab1tm1Doi Tg(HLA-DQA1,HLA-DQB1)1Dv/SzJ
This strain which is MHC II deficient and has no functional T or B cells expresses a humanized transgenic HLA-DQ8 molecule that has been linked to IDDM development. This model is a valuable genetic tool for identifying the role of HLA-DQ8 in Type 1 Diabetes.
Tg(TcraCWM5,TcrbCWM5)1807Wuth 014550
Under Development for Cryo		 B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J
These Bd 1807 TCR transgenic mice feature a CD4+ T cell repertoire that are reactive to several types of dimorphic fungi that cause major systemic mycoses found in North America.
Tg(Vil1-Myd88)1Lvh 017481
In Progress		 C57BL/6-Tg(Vil1-Myd88)1Lvh/J
This Myd88 (myeloid differentiation primary response gene 88) transgene is expressed exclusively in the epithelium of the small intestine via a mouse Vil1 (villin 1) promoter. It has been useful in studies of bacterial colonization.
017606
Awaiting Transfer from the Donor		 STOCK Hopxtm2.1(cre/ERT2)Joe/J
These knockin mice harbor a tamoxifen-inducible CreERT2 fusion gene in the 3' UTR of the Hopx gene. Cre activity is observed in intestinal epithelial stem cells.

(30 stocks)

 

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