JAX Mice Database - Internal/Organ Research

New strains under development - Research area: Internal/Organ Research

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Internal/Organ Research

Allele Symbol Strain Description	Stock Number	Strain Name (link to Data Sheet)
Adipoq^tm1Chan	008195 Under Development for Production	B6.129-Adipoq^tm1Chan/J
These adiponectin-deficient (Adipoq^-/- or Adipo^-/-) mice may be useful in studying obesity, diabetes, insulin resistance, metabolism, inflammation, leukocyte-endothelium interactions, and colitis.
Foxp3^sf	006775 On Hold	NOD.Cg-Foxp3^sf/DoiJ

Gpi1^b	005730 Under Development for Cryo	129S6.CB(B6)-Del(1)1Brk Gpi1^b/Gpi1^c/BrkMdfJ

Hmox1^tm1Poss	008311 Under Development for Production	FVB.129S2(B6)-Hmox1^tm1Poss/J
Mice that are homozygous for this Hmox1 (heme oxygenase (decycling) 1) targeted mutation develop anemia with diminished serum iron, increased serum ferritin, iron accumulation in kidney and liver and progressive chronic inflammatory disease. Homozygotes occur at a lower than expected frequency, or are not produced, from heterozygous crosses and have decreased postnatal survival. This mutant mouse strain may be useful in studies of hemochromatosis, inflammation and iron metabolism.
Il2rg^tm1Wjl	007799 Under Development for Production	NOD.Cg-Rag1^tm1Mom Il2rg^tm1Wjl/SzJ
These NOD-Rag1^null IL2rg^null double mutant mice may be useful for cell or tissue transplantation studies, particularly as a model for human lymphohematopoietic cell engraftment studies that require a radioresistant host.
Kras^tm4Tyj	008180 Under Development for Production	129S/Sv-Kras^tm4Tyj/J
This strain carries a point mutation (G12D) in the Kras (v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) gene whose expression is blocked by the presence of a loxP-flanked stop codon. Homozygotes die in utero. Cre-mediated recombination can excise the stop codon and permit the oncogenic protein to be expressed. Intranasal infection with an adenovirus encoding Cre results in a very high frequency of lung tumors and permits controlled timing of tumor initiation and tumor multiplicity. This strain may be useful in studies of cancer and development.
Ldlr^tm1Her	007070 Under Development for Production	AKR.129S7(B6)-Ldlr^tm1Her/J
Mice homozygous for this Ldlr (low density lipoprotein receptor) targeted mutation, Ldlr^tm1Her, may be useful for studying lipid and leptin homeostasis, hyperglycemia, hypercholesterolemia, atherosclerosis, and the effects of diet on skin and coat.
Mirn150^tm1Rsky	007750 Under Development for Production	B6;C-Mirn150^tm1Rsky/J
These miR150^-/- mice may be useful in mircoRNA biology, specifically to study the role of miR-150 and its target genes (including c-Myb) in lymphocyte development and function.
Mirn155^tm1.1Rsky	007745 Under Development for Production	B6.Cg-Mirn155^tm1.1Rsky/J
These bic/mir-155 mutant mice may be useful in mircoRNA biology, specifically to study the role of miR-155 and its target genes (including cytokines, chemokines, and transcription factors) in homeostasis and function of the immune system.
Rag1^tm1Mom	007799 Under Development for Production	NOD.Cg-Rag1^tm1Mom Il2rg^tm1Wjl/SzJ
These NOD-Rag1^null IL2rg^null double mutant mice may be useful for cell or tissue transplantation studies, particularly as a model for human lymphohematopoietic cell engraftment studies that require a radioresistant host.
Rag2^tm1Cgn	008309 Under Development for Production	C57BL/6-Rag2^tm1Cgn/J
These RAG-2^fl mice harbor loxP sites flanking the entire coding region of the Rag2 (recombination activating gene 2) locus. When bred to mice that express Cre recombinase, the resulting offspring will have exon 3 deleted in the cre-expressing tissue(s). These RAG-2^fl mice may be useful in generating conditional mutations for studying the role of RAG-2 in B and T cell development (including cancer and toxicology research as a xenograft/transplant host), T and B cell receptor (V(D)J) recombination, hematopoiesis, hematology, immunology, and inflammation research.
Sele^tm1Dmil	008238 Under Development for Production	129S-Sele^tm1Dmil/J
These E-selectin mutant mice may be useful in studying inflammation, leukocyte rolling, leukocyte-endothelial adhesion, angiogenesis, and cancer.
Sele^tm1Dmil	008236 Under Development for Production	B6.129S4-Sele^tm1Dmil/J
These E-selectin mutant mice may be useful in studying inflammation, leukocyte rolling, leukocyte-endothelial adhesion, angiogenesis, and cancer.
Sele^tm1Dmil	008237 Under Development for Production	C.129S4-Sele^tm1Dmil/J
These E-selectin mutant mice may be useful in studying inflammation, leukocyte rolling, leukocyte-endothelial adhesion, angiogenesis, and cancer.
Sox10^Dom	000290 On Hold	B6C3Fe a/a-Sox10^Dom/J

Sst^tm1Ute	008117 Under Development for Production	B6.129S4(129S6)-Sst^tm1Ute/J
Somatostatin deficient mice exhibit increased baseline plasma growth hormone, corticosterone and total ghrelin levels and impaired motor performance. Hippocampal amyloid beta 42 peptides levels are elevated. This mutant mouse strain may be useful in studies of gastric homeostasis, learning and memory and endocrinology.
Tff3^tm1Dkpy	008243 Under Development for Production	129-Tff3^tm1Dkpy/J
These intestinal trefoil factor (ITF or Tff3) mutant mice may be useful in studying gastrointestinal tract injury (including inflammatory bowel diseases), maintenance of the mucosal barrier, migration and turnover of the intestinal epithelium, and therapies for colon cancer.
Tnf^tm1Gkl	007082 Under Development for Production	CByJ.129S(B6)-Tnf^tm1Gkl/J
Mice homozygous for the Tnf^tm1Gkl targeted mutation may be useful in studies of susceptibility to parasitic amd bacterial infection, endotoxin sensitivity and immune response.
Traf1^tm1Tsi	008074 Under Development for Production	C.129S4-Traf1^tm1Tsi/J
These TRAF1 mutant mice may be useful in studying negative regulation of tumor necrosis factor (TNF) signaling, NF-kB and AP-1 signaling, T cell receptor (TCR)-induced proliferation of T cells, Th2 responses, TRAF1/Bim function in CD8 memory T cell survival, allergic airway diseases and Rheumatoid arthritis, as well as the role of TRAF1 activation in the pathogenesis of lymphomas. Of note, TRAF1 mutant mice are available on either a BALB/c congenic (Stock No. 008074) or C57BL/6 congenic (Stock No. 008076) background.
a	000290 On Hold	B6C3Fe a/a-Sox10^Dom/J

Del(1)1Brk	005730 Under Development for Cryo	129S6.CB(B6)-Del(1)1Brk Gpi1^b/Gpi1^c/BrkMdfJ

Tg(APOE-DGAT2)24Far	007744 Under Development for Production	C57BL/6-Tg(APOE-DGAT2)24Far/J
These Liv-DGAT2-low transgenic mice may be useful in studying hepatic steatosis, lipid, glucose, and insulin metabolism, as well as obesity and diabetes.
Tg(APOE-NPC1L1)20Lqyu	008408 Under Development for Production	B6;D2-Tg(APOE-NPC1L1)20Lqyu/J
These transgenic mice express the human NPC1 (Niemann-Pick disease, type C1, gene)-like 1 (NPC1L1) gene under the control of the human apolipoprotein E (APOE) promoter and hepatic control region. This mutant mouse strain exhibits decreased biliary cholesterol levels, which is associated with increased plasma cholesterol levels, and may be useful in studies related to lipid metabolism and cholesterol transport.
Tg(Alb1-Ren)1Unc	007853 Under Development for Production	129S/SvEv-Tg(Alb1-Ren)1Unc/CofJ
These RenTgMK mice may be useful in studying the effects of genetically clamped renin (and angiotensin II) on hypertension, diabetic nephropathy, albuninurea, nephrosclerosis, and other aspects of the renin–angiotensin system (RAS).

(24 stocks)

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