Allele Symbol Stock Number Strain Name
Braftm1Mmcm 017837Awaiting Transfer from the Donor
B6.129P2(Cg)-Braftm1Mmcm /J
These Cre-activated BRaf mutant mice (BRafCA ) have expression of physiological normal BRaf prior to Cre recombinase exposure. Following Cre-mediated excision of the floxed sequences, Braf expression is replaced by that of the constitutively active BRafV600E mutation (BRafVE ) associated with sustained activation of the MEK1/2-ERK1/2 pathway and human malignancies such as melanoma, colorectal, papillary thyroid, ovarian, and non-small-cell lung cancers. These mice may be useful in such studies, as well as for studying the RAS-activated RAF/MEK/ERK mitogen-activated protein (MAP) kinase signaling pathway and pleiotropic regulators of the aberrant cancer cell physiology.
Brca1tm1Aash 017835In Progress
STOCK Brca1tm1Aash /J
The Brca1F22-24/F22-24 allele has loxP sites flanking exons 22-24 of the Brca1 gene. These mice may be useful in generating tissue-specific BRCA1 deletions for studying basal-like cancer and breast cancer.
Cacna1ftm1.2Sdie 017762Under Development for Cryo
B6(Cg)-Cacna1ftm1.2Sdie /J
These mice carry the I756T point mutation in exon 17, and loxP sites flanking exons 14 through 17, of the Cacna1f (calcium channel, voltage-dependent, alpha 1F subunit). This mutant mouse strain may be useful in studies of calcium channelopathies, an inherited retinal disorder, photoreceptor electrophysiology, and the role of the Cav1.4 channel in survival of naive T cells.
Cacna1ftm1Sdie 017760Under Development for Cryo
B6(Cg)-Cacna1ftm1Sdie /J
These I756T+neo mice carry the I756T point mutation in exon 17 of the Cacna1f , calcium channel, voltage-dependent, alpha 1F subunit, (756 is the mouse equivalent to residue 745 in human CACNA1F ) as well as a FRT flanked NEO selection cassette and loxP sites flanking exons 14 through 17. This mutant mouse strain may be useful in studies of calcium channelopathies, incomplete congenital stationary night blindness, photoreceptor electrophysiology, and the role of the Cav1.4 channel in survival of naive T cells.
Ccktm1Lcs 017710In Progress
B6.129-Ccktm1Lcs /J
The cholecystokinin gene is disrupted by the insertion of a β-geo fusion cassette in these knockin/knockout mice. LacZ is detected in the gut and brain, and homozygotes exhibit a range of metabolic and behavioral defects.
Ccl2 016849Awaiting Transfer from the Donor
B6.Cg-Ccl2tm1.1Pame /J
These Ccl2-RFPlox/lox mice contain loxP sites flanking exons 2-3 of the Ccl2 gene which has been modified with a red fluorescent protein gene (mcherry).
Fluorescence is seen in all Ccl2 -expressing cells. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exons 2-3, as well as RFP, deleted in the cre-expressing tissue.
Cd207tm2Mal 016939In Progress
B6.129S2-Cd207tm2Mal /J
Lang-EGFP mutant mice express enhanced green fluorescent protein downstream of the internal stop codon of the CD207 antigen gene. These mice may be useful for visualizing Langerhans cells and monitoring their movement during inflammation.
Cd207tm3Mal 016940In Progress
B6.129S2-Cd207tm3Mal /J
Lang-DTREGFP mutant mice express human diphtheria toxin receptor and EGFP genes downstream of the internal stop codon of the Cd207 gene. These mice may be useful for both visualizing and specifically ablating Langerhans cells.
Cfl2tm1Itl 018135Awaiting Transfer from the Donor
C57BL/6-Cfl2tm1Itl /J
These Cofi/Cofi mice possess loxP sites flanking exons 2-4 of the Cfl2 gene. They may be useful in applications studying the maintenance.
and development of skeletal and cardiac muscles.
Clec9atm1.1Crs 017696Awaiting Transfer from the Donor
B6(Cg)-Clec9atm1.1Crs /J
A membrane-bound form of enhanced green fluorescent protein (EGFP) replaces the coding region of Clec9a and abolishes gene expression.
Cln3tm1.1Mem 017895In Progress
B6.129(Cg)-Cln3tm1.1Mem /J
These Cln3Δex7/8 knock in mice exhibit sensorimotor deficits, retinal degeneration, metabolic, hematological abnormalities, and accumulate mitochondrial ATPase subunit c, and may be useful in studies of juvenile onset neuronal ceroid lipofuscinosis (JNCL), also known as Batten or Spielmeyer-Vogt disease.
Col1a1tm9(tetO-Dnmt3b_i1)Jae 017983In Progress
B6.Cg-Col1a1tm9(tetO-Dnmt3b1_i1)Jae /J
These mice may be used to regulate expression of Dnmt3b1 via a tetracycline-controlled transactivator protein system. They may applications in studies related to the regulation of tumorigenesis.
Csktm1Tara 018320Awaiting Transfer from the Donor
B6.129P2-Csktm1Tara /J
Exons 9 and 10 of these Csk mutant mice are flanked by loxP sites. When crossed with a cre recombinase-expressing strain, these mice are useful for creating tissue-specific knockouts of the gene. They may have applications in studies related to antigen receptor-mediated development and the regulation of T-lineage cell selection.
Cyp46a1tm1Rus 017759In Progress
B6;129S7-Cyp46a1tm1Rus /J
Expression of Cyp46a1 is disrupted in this tau-β-lacZ fusion protein knockin strain. These mice may be useful for studying cholesterol turnover in brain tissues.
D13Mit314 006061Under Development for Cryo
B6.D2-(D13Mit314 -D13Mit35 )/1LusJ
This strain is one of a set of overlapping congenic strains called genome-tagged mice (GTM). Each member of the panel carries an average of a 23 cM segment (range 8 to 58 cM) from DBA/2J introgressed on to a C57BL/6J background. GTM are a valuable resource for mapping and confirmation of loci contributing to complex traits.
D13Mit35 006061Under Development for Cryo
B6.D2-(D13Mit314 -D13Mit35 )/1LusJ
This strain is one of a set of overlapping congenic strains called genome-tagged mice (GTM). Each member of the panel carries an average of a 23 cM segment (range 8 to 58 cM) from DBA/2J introgressed on to a C57BL/6J background. GTM are a valuable resource for mapping and confirmation of loci contributing to complex traits.
Dmdmdx 018018Awaiting Transfer from the Donor
B10ScSn.Cg-Prkdcscid Dmdmdx /J
MDX/SCID mice exhibit necrosis, centrally located nuclei and and the muscle degeneration characteristic of DMD and may be used a dystrophic model for the transplantation of human donor cells to evaluate skeletal muscle regeneration.
En2tm6Alj 008872Awaiting Transfer from the Donor
STOCK En2tm6Alj /J
These En2lox mice have loxP sites flanking the engrailed homeodomain portion in exon 2 of the engrailed 2 gene (En2 ). When bred to mice that express Cre recombinase, the resulting offspring will have this region deleted in the cre -expressing tissues. As such, these En2lox mice may be useful in generating conditional mutations for studying engrailed protein function in the developing mesencephalon, rhombomere 1, and jaw muscles, as well as the embryonic and adult cerebellum.
Fat3tm1.1Good 017839In Progress
B6;129P-Fat3tm1.1Good /J
These FAT3 mutant mice possess loxP sites flanking exon 23 (transmembrane domain) of the FAT tumor suppressor homolog 3 gene, and may be useful for studying dendrite development.
Fbxw7tm1Iaai 017563Awaiting Transfer from the Donor
B6;129-Fbxw7tm1Iaai /J
This mutation of the ubiquitin ligase, F-box and WD-40 domain protein 7 (Fbxw7 ), may be useful in generating conditional mutants to study hematopoietic stem cell self-renewal/differentiation and tumor suppression.
Flnatm1.1Caw 010907In Progress
STOCK Flnatm1.1Caw /J
These mice harbor a conditional knockout allele of the Flna gene. When bred to mice expressing cre recombinase, the floxed exons are deleted in the tissues expressing cre in the offspring. This strain may be useful in mechanistic studies of neuronal and cardiovascular development.
Foxp3tm3Ayr 016958Awaiting Transfer from the Donor
B6N.129(Cg)-Foxp3tm3Ayr /J
Foxp3DTR mutant mice express knocked-in human diphtheria toxin receptor and EGFP genes from the Foxp3 locus--without disrupting expression of the endogenous Foxp3 gene. These mice may be useful for regulatory T cell visualizing and ablation.
Foxp3tm4(YFP/cre)Ayr 016959Awaiting Transfer from the Donor
B6.129(Cg)-Foxp3tm4(YFP/cre)Ayr /J
Foxp3YFP/cre mutant mice express a knocked-in yellow fluorescent protein/Cre-recombinase fusion protein from the Foxp3 locus--without disrupting expression of the endogenous Foxp3 gene. These mice may be useful for studying regulatory T cells suppression of autoimmunity and immune dysfunction.
Foxp3tm9(EGFP/cre/ERT2)Ayr 016961Awaiting Transfer from the Donor
STOCK Foxp3tm9(EGFP/cre/ERT2)Ayr /J
Foxp3EGFP-cre-ERT2 mutant mice contain an internal ribosome entry site (IRES) and an enhanced green fluorescent protein (EGFP) fused to a CreERT2 fusion gene downstream of the internal stop codon of the forkhead box P3 (Foxp3 ) gene. These mice may be useful for studying lineage stability and genetic mapping of regulatory T cells.
Gata4tm3.1Wtp 018121Awaiting Transfer from the Donor
STOCK Gata4tm3.1Wtp Gt(ROSA)26Sortm1(birA)Mejr /J
In these double mutant mice, GATA4 is biotinylated, allowing for specific imunoprecipitation of both GATA4 and the proteins GATA4 interacts with.
Gnmttm1Cwa 018066In Progress
B6.129-Gnmttm1Cwa /J
In this strain a NEO cassette replaces exon1 and the promoter region of the Gnmt gene. This strain is a model for Glycine N-Methyltransferase Deficiency and has applications in studies of methionine metabolism, methylation and molecular markers for hepatocellular carcinoma.
Gt(ROSA)26Sortm1(CAG-Brainbow2.1)Cle 017492In Progress
B6.129P2-Gt(ROSA)26Sortm1(CAG-Brainbow2.1)Cle /J
The R26R-Confetti conditional allele has a CAG promoter followed by a floxed-STOP cassette and the Brainbow 2.1 construct all targeted into the Gt(ROSA)26Sor locus. The R26R-Confetti allele functions as a stochastic multicolor Cre recombinase reporter of multiple fluorescent proteins from a single genomic locus. These R26R-Confetti mice allow a way to label and distinguish individual / adjacent cells with nuclear localized, membrane-targeted, or cytoplasmic fluorescent proteins in cre recombined cells.
H2-Ab1tm1Doi 004606On Hold
NOD.Cg-Prkdcscid H2-Ab1tm1Doi Tg(HLA-DQA1,HLA-DQB1)1Dv/SzJ
This strain which is MHC II deficient and has no functional T or B cells expresses a humanized transgenic HLA-DQ8 molecule that has been linked to IDDM development. This model is a valuable genetic tool for identifying the role of HLA-DQ8 in Type 1 Diabetes.
Hfe2tm1Nca 017788In Progress
129S-Hfe2tm1Nca /J
These Hfe2 knockout mice exhibit iron loading and have applications in studies of juvenile or Type2A hemochromatosis, iron homeostasis and iron-induced oxidative damage.
Hfetm2Nca 017785In Progress
129S-Hfetm2Nca /J
These mice carry a targeted mutation of Hfe , hemochromatosis, exhibit iron loading, and have applications in studies of hereditary hemochromatosis, iron homeostasis and innate immune response
Hfetm2Nca 017784Under Development for Cryo
B6.129S6-Hfetm2Nca /J
These mice carry a targeted mutation of Hfe , hemochromatosis, exhibit iron loading, and have applications in studies of hereditary hemochromatosis, iron homeostasis and innate immune response.
Ifngtm3.1Lky 017580Awaiting Transfer from the Donor
C.129S4(B6)-Ifngtm3.1Lky /J
The "interferon-g amma r eporter with e ndogenous polyA t ranscript" (GREAT) allele has an IRES-eYFP reporter cassette inserted between the translational stop codon and 3' UTR/polyA tail of the interferon gamma (Ifng ) gene. Thus, the bicistronic IFNγ-IRES-eYFP mRNA is under control of the endogenous IFNγ promoter/enhancer regions with proper regulation defined by the endogenous 3' UTR and polyA tail. These GREAT mice are a fluorescent reporter strain for studying innate immunity/adaptive immunity against viral and intracellular bacterial infections, for studying anti-tumor biology, as well for studying aberrant IFN-γ expression associated with autoinflammatory/autoimmune diseases.
Il4ratm2Fbb 012713Awaiting Transfer from the Donor
BALB/c-Il4ratm2Fbb /J
These IL-4Rα floxed mutant mice may be useful for studying inflammation and the pathology of Type 2 immune responses to infection.
Itga7tm1Burk 016857In Progress
B6;129-Itga7tm1Burk /J
The α7- (or α7βgal- ) mutant allele is designed to both abolish endogenous gene expression and place β-galactosidase under transcriptional control of the α7 integrin promoter/enhancer region.
Itm2btm1Ldad 018132In Progress
B6.129(Cg)-Itm2btm1Ldad /J
These BRI2f/f mice possess loxP sites flanking exon 2 of the Itm2b gene and may have applications in studies related to dementia and Alzheimers Disease.
Kiss1tm1.1(cre/EGFP)Stei 017701In Progress
STOCK Kiss1tm1.1(cre/EGFP)Stei /J
The Kiss1-CreGFP allele expresses a CreGFP fusion protein from the Kiss1 promoter/enhancer elements. These mice may be useful for visualizing KISS1 secreting neurons and for studying their role in fertility.
Kitltm1.1Sjm 017860Awaiting Transfer from the Donor
STOCK Kitltm1.1Sjm /J
An EGFP reporter disrupts expression of the Kitl gene in this targeted mutation strain. EGFP is primarily expressed by perivascular endothelial and stromal cells throughout the bone marrow in heterozygotes.
Kitltm2.1Sjm 017861Awaiting Transfer from the Donor
STOCK Kitltm2.1Sjm /J
These Kitl mutant mice carry a floxed exon which, when excised through a cross with a cre strain, enables tissue-specific disruption of gene expression.
Lattm6(DTR)Mal 016937In Progress
B6.129S2-Lattm6(DTR)Mal /J
Latfl-dtr mutant mice contain a loxP site downstream from exon 1, and an internal ribosome entry site (IRES), a human diphtheria toxin receptor, and an enhanced green fluorescent protein (EGFP) followed by a second loxP site downstream of the internal stop codon of the linker for activation of T cells (Lat ) gene. These mice may be useful for studying the TCR signaling cascade and T cell homeostasis.
Mc3rtm1Butl 017866In Progress
B6(Cg)-Mc3rtm1Butl /J
When these Mc3r-/- floxed-STOP mice are bred to mice that express Cre recombinase, resulting bi-allelic offspring will have a floxed-STOP sequence deleted in cre -expressing tissues, allowing Mc3r expression. These mice may be useful when studying metabolism and obesity.
Mcm2tm1(cre/ERT2)Scpr 017611Awaiting Transfer from the Donor
129-Mcm2tm1(cre/ERT2)Scpr /J
In this strain Cre-ERT2 is knocked into the minichromosome maintenance deficient 2 mitotin (Mcm2 ) gene. Expression of Mcm2 is reduced, but not abolished. This strain may be useful for mediating inducible cre recombination in Mcm2 -expressing tissues, as well as for studying the regulation of core DNA replication machinery.
Mcm2tm2Scpr 017612Awaiting Transfer from the Donor
129-Mcm2tm2Scpr /J
Mcm2IRES-EGFP mice have an enhanced green fluorescent protein (EGFP) sequence inserted downstream of the stop codon of the minichromosome maintenance deficient 2 mitotin (Mcm2 ) gene. These mice may be useful for visualizing and recovering proliferation competent cells.
Mir22tm1.1Arod 018155Awaiting Transfer from the Donor
129S-Mir22tm1.1Arod /J
These mice carry a targeted mutation of Mir22 (microRNA 22) and exhibit impaired cardiac intracellular calcium homeostasis and increased sensitivity to hemodynamic stress.
Mll1tm2(MLLT3)Thr 009079On Hold
STOCK Mll1tm2(MLLT3)Thr /KsyJ
Beginning around six months of age, these Mll-AF9 knock-in mice recapitulate the acute myeloid leukemia (AML) phenotype associated with the t(9;11)(p22;q23) translocation in humans and may be useful for studying hematopoietic development, cancer, and acute myeloid leukemia.
Naip1tm1Dgen 005778On Hold
B6.129P2-Naip1tm1Dgen /J
This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen.
Nanogtm1Hoch 016233Awaiting Transfer from the Donor
129S;B6-Nanogtm1Hoch /J
A GFP-IRES-puro-cassette replaces the coding region of the Nanog gene in these mice. Mouse embryonic fibroblasts containing this mutation may be useful for identifying induced pluripotent stem cells.
Nf1tm1Par 017639In Progress
STOCK Nf1tm1Par /J
These mice possess loxP sites flanking exons 31-32 of the neurofibromatosis 1 (Nf1 ) gene and have applications in studies of cancer, neural crest development and neurofibromatosis type I.
Nkx3-1tm2Mms 016541Awaiting Transfer from the Donor
B6N;129S6-Nkx3-1tm2Mms /J
In this Nkx3-1lacZ mutant strain a β-galactosidase (lacZ ) cassette disrupts the NK-3 transcription factor, locus 1 (Nkx3-1 ) gene, abolishing gene function. This strain may be useful for visualizing the differentiating prostate and the development of prostate tumors.
Nlrp3tm1Hhf 017969In Progress
B6N.129-Nlrp3tm1Hhf /J
These Nlrp3A350VneoR mice serve as a constitutive knockout of the Nlrp3 gene. In the presence of cre recombinase however, a transcript encoding a A350V mutation is produced. This line may be useful in studying the role of cryopyrin in the regulation of autoinflammatory diseases.
Nlrp3tm2Hhf 017970In Progress
B6N.129-Nlrp3tm2Hhf /J
These Nlrp3L351PneoR mice serve as a constitutive knockout of the Nlrp3 gene. In the presence of cre recombinase however, a transcript encoding a L351P mutation is produced. This line may be useful in studying the role of cryopyrin in the regulation of autoinflammatory diseases.
Nlrp3tm3Hhf 017971In Progress
B6N.129-Nlrp3tm3Hhf /J
These Nlrp3D301NneoR mice serve as a constitutive knockout of the Nlrp3 gene. In the presence of cre recombinase however, a transcript encoding a D301N mutation is produced. This line may be useful in studying the role of cryopyrin in the regulation of autoinflammatory diseases.
Nr3c1tm2.1Ljm 012914Awaiting Transfer from the Donor
B6.129S6-Nr3c1tm2.1Ljm /J
These Grflox mutant mice may be useful in generating conditional mutations for studies of the hypothalamic-pituitary-adrenal axis and physiological adaptations to stress.
Pasktm1Weng 017709In Progress
B6.129S6-Pasktm1Weng /J
The Pask gene is disrupted by the insertion of an IRES-β-geo fusion cassette in these knockin/knockout mice. LacZ is detected in testis and homozygotes exhibit a range of metabolic traits.
Pax7tm1(cre/ERT2)Gaka 017763Awaiting Transfer from the Donor
B6.Cg-Pax7tm1(cre/ERT2)Gaka /J
A CreERT2 fusion protein sequence inserted downstream of the Pax7 stop codon allows endogenous PAX7 expression in these mice while permitting specific conditional labeling, manipulation, and deletion of satellite cells.
Pik3catm1Jjz 017704Awaiting Transfer from the Donor
B6N.129-Pik3catm1Jjz /J
These p110αflox mice possess loxP sites flanking exon 1 of the phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (Pik3ca ) gene. This strain may be useful for studying insulin signaling, and hepatic glucose and lipid metabolism.
Pik3cbtm1Jjz 017705Awaiting Transfer from the Donor
B6N.129S(Cg)-Pik3cbtm1Jjz /J
These p110βflox mice possess loxP sites flanking exon 2 of the phosphatidylinositol 3-kinase, catalytic, beta polypeptide (Pik3cb ) gene. These mice may be useful for studying insulin signaling and cell proliferation.
Pitx2tm1.1Dmm 018054Awaiting Transfer from the Donor
B6.129P2(Cg)-Pitx2tm1.1Dmm /J
In this mutant strain, an IRES Tau-lacZ cassette abolishes expression of all three PITX2 isoforms. TaulacZ is expressed in neurons projecting from the mammillary tract of the hypothalamus.
Pitx3tm1.1Jae 017941Awaiting Transfer from the Donor
B6;129-Pitx3tm1.1Jae /J
In these KI mice, the Pitx3 promoter drives expression of EGFP in midbrain dopaminergic neurons.
Plxnd1tm1.1Tmj 018319Awaiting Transfer from the Donor
B6;129-Plxnd1tm1.1Tmj /J
These plexinD1flox mice may have applications in studies related to cardiac and vascular development and maintenance.
Pmltm1(PML/RARA)Ley 017959In Progress
C57BL/6-Pmltm1(PML/RARA)Ley /J
These mPML-PRflox mice express a Cre recombinase mediated PML-PARA fusion protein and may be useful in studies of acute promyelocytic leukemia.
Polr2atm1(cre/ERT2)Bbd 017585In Progress
STOCK Polr2atm1(cre/ERT2)Bbd /J
These RERT mutant mice express the inducible Cre-ERT2 from the endogenous Polr2a locus.
Pomt2tm1.1Hhu 017880Awaiting Transfer from the Donor
129S;B6-Pomt2tm1.1Hhu /J
These floxed-POMT2 mice may be useful for studying central nervous system malformations such as Walker-Warburg syndrome and muscle-eye-brain disease.
Prkdcscid 018018Awaiting Transfer from the Donor
B10ScSn.Cg-Prkdcscid Dmdmdx /J
MDX/SCID mice exhibit necrosis, centrally located nuclei and and the muscle degeneration characteristic of DMD and may be used a dystrophic model for the transplantation of human donor cells to evaluate skeletal muscle regeneration.
Prkdcscid 017620Awaiting Transfer from the Donor
NOD.Cg-Prkdcscid Tg(CAG-DsRed*MST)1Nagy/KupwJ
This compound mutant strain combines the immunodeficiency features of the Prkdcscid mutation and widespread fluorescent cell labeling capabilities of CAG-DsRed on the NOD genetic background. These mice are effective recipients of allogeneic and xenogenic grafts, and are an excellent source of fluorescent-labeled cells for transfer experiments.
Prkdcscid 004606On Hold
NOD.Cg-Prkdcscid H2-Ab1tm1Doi Tg(HLA-DQA1,HLA-DQB1)1Dv/SzJ
This strain which is MHC II deficient and has no functional T or B cells expresses a humanized transgenic HLA-DQ8 molecule that has been linked to IDDM development. This model is a valuable genetic tool for identifying the role of HLA-DQ8 in Type 1 Diabetes.
Prom1tm1(cre/ERT2)Gilb 017743In Progress
B6N;129S-Prom1tm1(cre/ERT2)Gilb /J
A CreERT2 fusion protein and β-galactosidase (lacZ ) gene knocked into the ATG start codon of Prom1 abolishes gene function in these mice. Useful applications include visualizing and tracking adult stem cell lineages.
Ror1tm1.1Meg 018353Awaiting Transfer from the Donor
B6;129S-Ror1tm1.1Meg /J
These Ror1f/f conditional mutant mice may have applications in studies related to Wnt5a -mediated signaling during embryonic development.
Ror2tm1.1Meg 018354Awaiting Transfer from the Donor
B6;129S-Ror2tm1.1Meg /J
These Ror1f/f conditional mutant mice may have applications in studies related to Wnt5a -mediated signaling during embryonic development.
Sarm1tm1Aidi 018069Awaiting Transfer from the Donor
B6.129X1-Sarm1tm1Aidi /J
In this strain exons 3-6 of the Sarm1 gene are disrupted. These mice exhibit enhanced resistance to oxygen and glucose deprivation induced neuronal death and have applications in studies of neurodegeneration.
Scgb1a1tm1(cre/ERT)Blh 016225In Progress
B6N.129S6(Cg)-Scgb1a1tm1(cre/ERT)Blh /J
Theses mice express a tamoxifen-inducible form of cre recombinase from the Scgb1a1 locus (secretoglobin). This strain may useful for inducing cre recombinase activity in bronchiolar non-ciliated Clara cells.
Shank3tm1.1Bux 017889Awaiting Transfer from the Donor
B6(Cg)-Shank3tm1.1Bux /J
These mice possess loxP sites flanking exons 4-9 of the Shank3 gene and are suitable for use in making tissue-specific conditional mutations when used in conjunction with a Cre-expressing strain.
Shank3tm1.2Bux 017890Awaiting Transfer from the Donor
B6(Cg)-Shank3tm1.2Bux /J
These mutant mice harbor a deletion of the SH3/ankyrin domain gene 3 (Shank3 ) ankyrin repeat domains (exons 4-9); this deletion prevents full-length Shank3 expression. As Shank3 is necessary for forming functional glutamatergic synapses between receptors and cytoskeletal/scaffolding elements, these mice may be useful for studying synaptic glutamate receptor development/function, transmission and plasticity, as well as Shank3 haploinsufficiency, neurobehavioral manifestations of 22q13 deletion syndrome and/or autism spectrum disorders.
Siaetm1.2Avrk 012339Awaiting Transfer from the Donor
B6.129-Siaetm1.2Avrk /J
These Siaeexon2del mutant mice lack exon 2 of the sialic acid acetylesterase gene. This strain may be useful for studying the regulation of B cell receptor activity and B cell fate decisions.
Sirt4tm1Fwa 012756Awaiting Transfer from the Donor
129-Sirt4tm1Fwa /J
The targeted mutation replace exon 1-3 of the mouse sirtuin (silent information regulator 2 (Sir2 )) homolog 4, Sirt4 , gene with a β-galactosidase (lacZ ) cassette, abolishing gene function. These mice may be useful in studying life span and the effects of sirtuin and calorie restriction on amino acid-stimulated insulin secretion and mitochondrial regulation.
Sirt5tm1Fwa 012757Awaiting Transfer from the Donor
129-Sirt5tm1Fwa /J
The targeted mutation replace exon 2-5 of the mouse sirtuin (silent information regulator 2 (Sir2 )) homolog 5, Sirt5 , gene with a β-galactosidase (lacZ ) cassette, abolishing gene function. These mice may be useful in studying life span and the effects of sirtuin and food restriction on ammonia detoxification and disposal though CPS1 activation.
Slc11a2tm2Nca 017789In Progress
129S-Slc11a2tm2Nca /J
These Dmt1fl mice possess loxP sites flanking exons 6-8 of the solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (Slc11a2 ) gene and have applications in studies related to anemia, iron homeostasis and micronutrient and drug absorption in the intestine.
Slc19a3tm1Said 017343In Progress
STOCK Slc19a3tm1Said /J
This THTR-2- knockout mouse line has a deletion of exons 1-2 of the Slc19a3 gene. These mice may be useful in studying the role of thiamin transporters in regulating thiamin homeostasis in different cells; including liver and kidney cells.
Slc29a1tm1Msg 017739Awaiting Transfer from the Donor
B6.129X1-Slc29a1tm1Msg /J
These ENT-/- mice are deficient for Slc29a1 and exhibit decreased sensitivity to the effects of ethanol intoxication, decreased anxiety-like behavior and increased alcohol consumption. They have applications in studies related to alcohol dependence.
Slc29a1tm2Msg 017792Awaiting Transfer from the Donor
129X1/SvJ-Slc29a1tm2Msg /J
These ENT1 flox mice have loxP sites flanking exons 2 through 4 of the Slc29a1 gene and have applications in studies related to anxiety and alcohol dependence.
Slc40a1tm2Nca 017790In Progress
129S-Slc40a1tm2Nca /J
These ferroportinfl mice possess loxP sites flanking exons 6 and 7 of the solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1 ) gene and have applications in studies related to type 4 hemochromatosis, anemia, and iron homeostasis.
Tardbptm1.1Pcw 017591Awaiting Transfer from the Donor
B6(SJL)-Tardbptm1.1Pcw /J
These floxed mice possess loxP sites flanking exon 3 of the Tardbp gene. Deletion results in premature death due to increased fat metabolism and leanness associated with ALS.
Tdgf1tm2.2Mms 016539Awaiting Transfer from the Donor
STOCK Tdgf1tm2.2Mms /J
These Cripto2loxP mice possess a loxP -sites flanking exons 3-5 of the teratocarcinoma-derived growth factor 1 (Tdgf1 ) gene. This strain may be useful for studying embryonic development and tumor growth.
Tet2tm1.1Iaai 017573Awaiting Transfer from the Donor
B6;129S-Tet2tm1.1Iaai /J
This mutation of the tet oncogene family member 2 (Tet2 )gene, may be useful in generating conditional mutants to in studying hematopoietic stem cell self-renewal myeloid transformation.
Thtm1(cre/Esr1)Nat 008532In Progress
B6;129-Thtm1(cre/Esr1)Nat /J
This creER knock-in line can be used to produce target gene recombination specifically in dopaminergic neurons following 4-hydroxytamoxifen treatment. Heterozygotes and homozygotes are normal in size and viability.
Thy1a 014550Under Development for Cryo
B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J
These Bd 1807 TCR transgenic mice feature a CD4+ T cell repertoire that are reactive to several types of dimorphic fungi that cause major systemic mycoses found in North America.
Wisp3tm1(cre)Mawa 017685Awaiting Transfer from the Donor
B6;129S-Wisp3tm1(cre)Mawa /J
Male mice express Cre recombinase from the Wisp3 promoter in spermatocytes at the pachytene stage of meiosis I. When crossed with a floxed allele strain, Cre-mediated recombination of the floxed fragment may be observed in 100% of offspring.
Rb(9.19)163H
000613On Hold
STOCK Rb(9.19)163H/J
Tg(Aicda-cre)1Rcas
018421Awaiting Transfer from the Donor
B6;FVB-Tg(Aicda-cre)1Rcas/J
These AID-GFP mice may be useful for visualizing active germinal center B cells.
Tg(BCL2)22Wehi
002318On Hold
C.Cg-Tg(BCL2)22Wehi/J
Expression of the human BCL2 transgene is restricted to B cell lineage (no T cell expression) in which it enhances cell survival. Hemizygotes show increased numbers of B lymphocytes, Ig-secreting cells and serum Ig, as well as a heightened and prolonged antibody response to immunization. This phenotype is somewhat greater on the BALB/c than on the C57BL/6 background. Hemizygotes on a mixed B6,SJL background (but not on the BALB/c background) develop autoimmune disease characterized by immune complex glomerulonephritis, anti-nuclear antibodies, lymphadenopathy and myocardial infarction. These mice serve as a robust source for the production of B cells and antibodies. Although mice bearing this allele exhibit a mild increase in spontaneous lymphoma and plasmacytoma occurrence (<10% to 18 months) on a (C57BL/6 x SJL)F2 background, on the BALB/c and C57BL/6 backgrounds tumor incidence is insignificant. When this transgene is crossed with an Emu-myc transgene bearing strain (Stock ..... For more information please see the full phenotype on the strain data sheet
Tg(BCR/ABL)623Hkp
017833In Progress
B6.Cg-Tg(BCR/ABL)623Hkp/J
These transgenic mice express the BCR/ABL p190 fusion protein from the MT1 promoter, making them useful for studying acute lymphoblastic leukemia.
Tg(CAG-CYP27A1)23Etl
009109On Hold
B6.CBA-Tg(CAG-CYP27A1)23Etl/J
These CYP27 overexpressor transgenic mice (or CYP27overexp mice) have widespread expression of human cytochrome P450, family 27, subfamily A, polypeptide 1 directed by the CAG promoter. These mice may be useful in studying the conversion of cholesterol to bile acids (bile acid synthesis) by both the classical and alternate pathways, as well as lipid and cholesterol homeostasis research.
Tg(CAG-DsRed*MST)1Nagy
017620Awaiting Transfer from the Donor
NOD.Cg-Prkdcscid Tg(CAG-DsRed*MST)1Nagy/KupwJ
This compound mutant strain combines the immunodeficiency features of the Prkdcscid mutation and widespread fluorescent cell labeling capabilities of CAG-DsRed on the NOD genetic background. These mice are effective recipients of allogeneic and xenogenic grafts, and are an excellent source of fluorescent-labeled cells for transfer experiments.
Tg(CD4-Il17re)#Cdon
017943In Progress
C57BL/6-Tg(CD4-Il17re)#Cdon/J
These mice contain a transgene utilizing a human CD4 promoter driving expression of IL-17RE in Th17 cells. They exhibit a susceptibility to EAE.
Tg(Cdh5-cre)1Spe
017968Awaiting Transfer from the Donor
B6;129-Tg(Cdh5-cre)1Spe/J
These VEC-cre transgenic mice express Cre recombinase under the control of a Cdh5 promoter with greater efficiency than other similar lines. They may have applications related to the study of hematopoietic stem cell lineages derived from vascular endothelial cells.
Tg(Cp-EGFP)25Gaia
005854On Hold
STOCK Tg(Cp-EGFP)25Gaia/J
Mice homozygous for the Notch reporter transgene are viable, fertile, normal in size, and do not display any behavioral abnormalities. Enhanced green fluorescent protein (EGFP) expression is present in a wide variety of hemizygous cell/tissue types during development and in the adult, including enriched hematopoietic stem cell (HSC) populations. The location of EGFP expression is consistent with Notch signaling pathway elements/genes and appears to faithfully reflect canonical (CBF1-mediated) Notch activity. With respect to hematopoiesis, low expression is shown in fully differentiated cells of the peripheral lymphoid organs (blood and spleen). Isolated HSC retain their ability to differentiate. Mice expressing this Notch reporter transgene may be useful in studying HSC populations and other cell types utilizing the Notch, CBF1, or Wnt signaling pathways. As immature (double negative [DN]) thymocytes have differential expression patterns as they progress from DN1-DN4, these mice may al ..... For more information please see the full phenotype on the strain data sheet
Tg(Crh-cre)1Kres
011087In Progress
B6.FVB-Tg(Crh-cre)1Kres/J
This strain expresses Cre recombinase from a truncated mouse Crh (corticotropin releasing hormone) promoter. When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination results in tissue-specific deletion of the target. Recombination occurs in more than 90% of neurons that express Crh , such as the CRH (CRF) neurons in the lateral division of the central nucleus of the amygdala, the bed nucleus of the stria terminalis and paraventricular nucleus (PVN).
Tg(Cspg4-cre)1Akik
008533On Hold
B6;FVB-Tg(Cspg4-cre)1Akik/J
Mice hemizygous for the NG2creBAC transgene are viable and fertile, normal in size and do not display any gross physical or behavioral abnormalities. These transgenic mice express the Cre recombinase under the control of the mouse NG2 (Cspg4 ) promoter/enhancer. Cre recombinase expression is detected in NG2 expressing glial cells and vasculature throughout the brain as well as in NG2-expressing cells in other tissues from late embryonic stages (~embryonic day 14) throughout adulthood. The efficiency of Cre-mediated recombination is less than 100% (86% in forebrain and 70-75% in spinal cord). Immunoreactive Cre was not detected in S100beta+ or GFAP+ astrocytes or APC+ oligodendrocytes. These NG2creBAC transgenic mice may be may be crossed to various floxed mutants to delete floxed sequences specifically in NG2-expressing cells. The donating investigator reports that there appears to be transient Cre expression in some projection neurons and interneurons scattered throughout the ce ..... For more information please see the full phenotype on the strain data sheet
Tg(Drd1a-rtTA)ARgmk
018156Awaiting Transfer from the Donor
STOCK Tg(Drd1a-rtTA)ARgmk/J
These transgenic mice express the reverse tetracycline-controlled transactivator (rtTA) protein under the control of the mouse Drd1a promoter. These Drd1BAC-rtTA mice provide a Tet-On tool that allows the inducible expression of genes in D1A dopamine receptor subtype-expressing neurons, and may be useful for studying dopamine-sensitive behaviors such as addiction.
Tg(Eno2-YFP/Cox8a)ZRwb
007860Awaiting Transfer from the Donor
C57BL/6J-Tg(Eno2-YFP/Cox8a)ZRwb/J
These transgenic mice express Yellow Fluorescent Protein (YFP ) under the control of the neuron-specific rat, enolase 2, gamma, Eno2 , promoter. YFP is specifically localized to the mitochondria by a mouse cytochrome c oxidase, subunit VIIIa, gene targeting signal fused to the N-terminus. This mutant mouse strain may be useful in studies of mitochondrial transport.
Tg(Fev-cre)1Esd
012712Awaiting Transfer from the Donor
B6.Cg-Tg(Fev-cre)1Esd/J
These mice express cre under the direction of the Fev promoter. They may be useful for inducing cre-mediated recombination in serotonergic neurons.
Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan
017955In Progress
C57BL/6-Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan/J
These transgenic mice allow inducible astroglia-specific expression of human MAOB (monoamine oxidase B) and lacZ (beta-galactosidase). With induction, they exhibit neurodegeneration, decreased locomotor activity, mitochondrial dysfunction, astrogliosis, and microglial activation.
This strain may have applications in studies related to the initiation and progression of Parkinson's disease.
Tg(H2-K-S100a9,GFP)1Gabr
018055Awaiting Transfer from the Donor
B6.FVB-Tg(H2-K-S100a9,GFP)1Gabr/J
These transgenic mice express S100a9 (S100 calcium binding protein A9 (calgranulin B)), a myeloid-related protein, and GFP under the control of the hematopoietic cell-specific H2-K promoter. Overexpression of S100a9 inhibits the differentiation of dendritic cells and macrophages while inducing an accumulation of myeloid-derived suppressor cells.
Tg(HLA-DQA1,HLA-DQB1)1Dv
004606On Hold
NOD.Cg-Prkdcscid H2-Ab1tm1Doi Tg(HLA-DQA1,HLA-DQB1)1Dv/SzJ
This strain which is MHC II deficient and has no functional T or B cells expresses a humanized transgenic HLA-DQ8 molecule that has been linked to IDDM development. This model is a valuable genetic tool for identifying the role of HLA-DQ8 in Type 1 Diabetes.
Tg(Isl1-EGFP*)1Slp
017952Awaiting Transfer from the Donor
STOCK Tg(Isl1-EGFP*)1Slp/J
These transgenic mice express EGFP in all somatic motor neurons and provide an excellent comprehensive view of axon projections during their development.
Tg(LGB-cre)74Acl
017836In Progress
STOCK Tg(LGB-cre)74Acl/J
BLG-Cre transgenic mice have the beta-lactoglobulin (BLG) promoter directing Cre recombinase expression to mammary gland during lactation.
This strain may be useful for studying basal-like cancer and breast cancer, as well as providing a useful tool for testing new therapeutics.
Tg(MMTV-neu/OT-I/OT-II)CBnel
007962On Hold
B6.FVB-Tg(MMTV-neu/OT-I/OT-II)CBnel Tg(Trp53R172H)8512Jmr/J
Approximately 85% of the compound mutant females develop focal mammary tumors at 6-10 months of age. Both virgin and breeder mice develop tumors. Approximately 37% of tumor-bearing mice develop metastatic disease to the lung. High expression of neu is detected in tumor tissue while very low levels are found in lung and ovary. Female mice carrying only the neuOT-I/OT-II mutation develop focal mammary tumors at approximately 18 months of age.
Tg(Mpz-cre)26Mes
017927Awaiting Transfer from the Donor
B6N.FVB-Tg(Mpz-cre)26Mes/J
These transgenic mice contain the myelin protein zero (P0 ) (Mpz ) promoter driving expression of Cre recombinase in Schwann cell. These mice may be useful for studying the myelination of peripheral nerve cells.
Tg(Msx2-cre/ERT)27Alj
008847Awaiting Transfer from the Donor
STOCK Tg(Msx2-cre/ERT)27Alj/J
These Msx2-CreERT transgenic mice have expression of a tamoxifen-inducible cre (Cre-ERT ) directed to apical ectodermal ridge (AER) of the developing limb by the -0.5 kbp promoter region from mouse homeobox msh-like 2 locus (Msx2 ). When these Msx2-CreERT transgenic mice are bred with mice containing a loxP -flanked sequences, tamoxifen-inducible Cre-mediated recombination is expected to result in deletion of the floxed sequences in AER of the developing limb.
Tg(PGK2-sb10)1780Ove
017610In Progress
FVB/N-Tg(PGK2-sb10)1780Ove/J
PGK2-SB10 transgenic line OVE1780 have testes-specific expression of the SB10 Sleeping Beauty transposase. When bred to mice harboring a Sleeping Beauty transposon (IR/DR site-flanked sequences), the resulting double mutant male offspring have the ability to mobilize the transposon in their germline. These PGK2-SB10 transgenic mice allow the mobilization of transposons to generate new integration sites or genomic rearrangements depending upon the design of the transposon.
Tg(Pdgfra-cre/ERT)467Dbe
018280Awaiting Transfer from the Donor
B6N;SJL-Tg(Pdgfra-cre/ERT)467Dbe/J
These Pdgfra-creERTM transgenic mice are useful for studying cell replacement during central nervous system aging and repair.
Tg(Prox1-tdTomato)12Nrud
018128Awaiting Transfer from the Donor
C57BL/6J-Tg(Prox1-tdTomato)12Nrud/J
tdTomato expression is seen in the adult liver, lens, dentate gyrus, neuroendocrine cells of the adrenal medulla, megakaryocytes, and platelets of living ProxTom transgenic mice.
Tg(SOD1*G93A)1Gur
013199Awaiting Transfer from the Donor
FVB.Cg-Tg(SOD1*G93A)1Gur/J
These SOD1-G93A (also called G93A-SOD1) transgenic mice may be useful in studying neuromuscular disorders, including Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease).
Tg(Slc17a6-COP4*H134R/EYFP)2Oki
017978Awaiting Transfer from the Donor
C57BL/6N-Tg(Slc17a6-COP4*H134R/EYFP)2Oki/J
These transgenic mice express channel rhodopsin-2/EYFP fusion protein directed to locomotor regions of the spinal chord and hindbrain. This strain provides a useful tool for inducible photostimulation of glutamatergic neurons involved in rhythm generation and initiation of locomotion.
Tg(Slc17a8-EGFP)1Edw
018148Awaiting Transfer from the Donor
STOCK Tg(Slc17a8-EGFP)1Edw/J
Fluorescence is evident in the dorsal root ganglion of the spinal cord in these VGLUT3 eGFP mice.
Tg(Slc17a8-icre)1Edw
018147Awaiting Transfer from the Donor
STOCK Tg(Slc17a8-icre)1Edw/J
iCre recombinase expression is evident in interneurons of the brain and in amacrine cells of the inner retina.
Tg(Sox2-cre)1Amc
014094In Progress
B6N.Cg-Tg(Sox2-cre)1Amc/J
These Sox2Cre transgenic mice express Cre recombinase under the control of the mouse Sox2 promoter, and may be useful for generating epiblast-derived specific conditional mutations.
Tg(TcraCWM5,TcrbCWM5)1807Wuth
014550Under Development for Cryo
B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J
These Bd 1807 TCR transgenic mice feature a CD4+ T cell repertoire that are reactive to several types of dimorphic fungi that cause major systemic mycoses found in North America.
Tg(Th-FTH1)1Jkan
017862Awaiting Transfer from the Donor
B6;D2-Tg(Th-FTH1)1Jkan/J
These pTH-ferritin transgenic mice exhibit increased ferritin-bound iron levels in the brain, decreased ferrous iron levels in the substantia nigra, and reduced sensitivity to MPTP-induced Parkinson's disease-like symptoms. They have applications in studies related to iron deficiency and Parkinson's disease.
Tg(Thy1-DCTN1*G59S)M2Pcw
017590Awaiting Transfer from the Donor
B6SJL-Tg(Thy1-DCTN1*G59S)M2Pcw/J
Transgenic mice expressing FLAG-tagged full-length mutant (G59S) human dynactin 1 in the spinal cord are useful for studying autophagy defects in ALS.
Tg(Trp53R172H)8512Jmr
007962On Hold
B6.FVB-Tg(MMTV-neu/OT-I/OT-II)CBnel Tg(Trp53R172H)8512Jmr/J
Approximately 85% of the compound mutant females develop focal mammary tumors at 6-10 months of age. Both virgin and breeder mice develop tumors. Approximately 37% of tumor-bearing mice develop metastatic disease to the lung. High expression of neu is detected in tumor tissue while very low levels are found in lung and ovary. Female mice carrying only the neuOT-I/OT-II mutation develop focal mammary tumors at approximately 18 months of age.
Tg(Wnt1-GAL4)11Rth
007807On Hold
STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/MileJ
Wnt-1/GAL4/cre-11 transgenic mice were created by co-injection of both the pWEXP2-GAL4 transgene (Wnt1-GAL4) and the pWEXP3C-cre transgene (Wnt1-Cre). These Wnt-1/GAL4/cre-11 transgenic mice have expression of both Cre recombinase and the GAL4 transcriptional activator directed to midbrain and developing neural tube by the wingless-related MMTV integration site 1 (Wnt1 ) promoter/regulatory sequences. When Wnt-1/GAL4/cre-11 transgenic mice are bred to mice containing loxP site-flanked sequences, cre -mediated recombination results in deletion of the floxed sequences in the midbrain and developing neural tube of the resulting offspring.
Tg(Wnt1-cre)11Rth
007807On Hold
STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/MileJ
Wnt-1/GAL4/cre-11 transgenic mice were created by co-injection of both the pWEXP2-GAL4 transgene (Wnt1-GAL4) and the pWEXP3C-cre transgene (Wnt1-Cre). These Wnt-1/GAL4/cre-11 transgenic mice have expression of both Cre recombinase and the GAL4 transcriptional activator directed to midbrain and developing neural tube by the wingless-related MMTV integration site 1 (Wnt1 ) promoter/regulatory sequences. When Wnt-1/GAL4/cre-11 transgenic mice are bred to mice containing loxP site-flanked sequences, cre -mediated recombination results in deletion of the floxed sequences in the midbrain and developing neural tube of the resulting offspring.
Tg(tetO-Cacna1g)1Jmol
013777In Progress
FVB-Tg(tetO-Cacna1g)1Jmol/J
Expression of Cacna1g is regulated by a tetracycline operator (tetO) in this transgenic strain which may be useful in studies of cardiomyopathy.
Tg(tetO-Cdkn1b)1Scpr
017613Awaiting Transfer from the Donor
C57BL/6-Tg(tetO-Cdkn1b)1Scpr/J
These mice express a cyclin-dependent kinase inhibitor 1B (Cdkn1b ) cDNA under the direction of the tetracycline operator. These mice may be useful for studying cellular replication and aging.
Tg(tetO-Gnai2*,-lacZ)382Kndl
017333In Progress
FVB-Tg(tetO-Gnai2*,-lacZ)382Kndl/J
A constitutively active R179C mutant form of Gnai2 (also called G-alpha-i2) was cointegrated with lacZ under the control of the tetO promoter in this transgenic strain. This strain may be useful in a variety of studies involving G-protein coupled signaling.
Tg(tetO-Hamp)2181Nca
017791Under Development for Cryo
B6.Cg-Tg(tetO-Hamp)2181Nca/J
This TRE.Hepc1 transgenic strain can be used to generate bitransgenic mice with spatio-temporal specific inducible overexpression of mouse Hamp , which may be useful in studies of anemia of inflammation and iron homeostasis.
Tg(tetO-LRRK2)C7874Cai
013583In Progress
B6.Cg-Tg(tetO-LRRK2)C7874Cai/J
These hemizygous transgenic mice carry a human leucine-rich repeat kinase 2 gene, LRRK2 , regulated by a tetracycline operator (tetO ). When mated to a mutant strain expressing tetracycline-controlled transactivator protein (tTA), expression of LRRK2 protein may be regulated with the tetracycline analog doxycycline (dox) in the double mutant offspring. These mice may be useful for studying the Parkinson's disease pathogenesis and neurodegeneration.
Tg(tetO-Ppp3ca*)11255Kndl
017331In Progress
B6.Cg-Tg(tetO-Ppp3ca*)11255Kndl/J
TetO drives expression of calcineurin (Ppp3ca , protein phosphatase 3, catalytic subunit, alpha isoform) lacking the autoinhibitory domain in these transgenic mice. When crossed with a tTA strain, transgene expression can be temporally regulated by doxycycline administration.
Tg(tetO-Ppp3ca*)13967Kndl
017332In Progress
B6.Cg-Tg(tetO-Ppp3ca*)13967Kndl/J
TetO drives expression of the calcineurin (Ppp3ca , protein phosphatase 3, catalytic subunit, alpha isoform) autoinhibitory domain in these transgenic mice. When crossed with a tTA strain, transgene expression can be temporally regulated by doxycycline administration.
Tg(tetO-SNCA*A53T)33Vle
016976Awaiting Transfer from the Donor
B6C3-Tg(tetO-SNCA*A53T)33Vle/J
These transgenic mice carry a humanized synuclein mutant (SNCA*A53T ) gene regulated by a tetracycline operator. When mated to a mutant strain expressing tTA, expression of SNCA*A53T protein may be regulated with the tetracycline analog doxycycline in the double mutant offspring.
Tg(tetO-TAg)1Efr
017719Awaiting Transfer from the Donor
C3HeB/FeJ-Tg(tetO-TAg)1Efr/J
These tet-Tag transgenic mice express the SV40 large T antigen under the direction of the tetracycline operator. These mice may be useful for studying tumorigenesis and cancer progression.
018422Awaiting Transfer from the Donor
B6;FVB-Tg(Aicda-cre)1Rcas/J
These AID-Cre mice may be useful for fate mapping of B cells originating in the follicular germinal centers of the spleen and lymph nodes.
017606Awaiting Transfer from the Donor
STOCK Hopxtm2.1(cre/ERT2)Joe /J
These knockin mice harbor a tamoxifen-inducible CreERT2 fusion gene in the 3' UTR of the Hopx gene. Cre activity is observed in intestinal epithelial stem cells.
018322Awaiting Transfer from the Donor
STOCK Tg(Cp-EGFP)25Gaia/ReyaJ
These Notch reporter mice are useful in studying hematopoietic stem cell populations utilizing the Notch or Wnt signaling pathways, as well as in thymocyte maturation studies.
000330On Hold
BXD20/TyJ
The BXD RI strains are used to study the genetics of behavioral phenotypes including alcohol and drug addiction, stress, and locomotor activity.The BXD set of RI strains also are used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in organ weight and bone mineral density. The strain distribution pattern (SDP) for BXD RI strains is available through the Mouse Genome Informatics Recombinant Inbred Strain Distribution Patterns Query Form .
017962In Progress
B6;129-Gt(ROSA)26Sortm1(RAC1*)Jkis /J
These Rosa26-LSL-Rac1b mice allow for the conditional expression of a Rac1 isoform b cDNA. They may be useful in applications associated with the initiation and progression of tumorigenesis.
010530In Progress
B6;129-Pax7tm2(cre)Mrc /J
In this targeted mutation strain, the mouse paired box gene 7 (Pax7 ) promoter drives expression of cre in progenitor cells of skeletal muscle lineage and satelllite cells. Crossing this mouse with another carrying a loxP-flanked genomic segment of interest enables tissue-specific excision of the floxed segment in the offspring.
007108In Progress
BXD63/RwwJ
The BXD#/Rww recombinant inbred (RI) strains originate from crosses between C57BL/6J (000664 ) females and DBA/2J (000671 ) males and were generated using a strategy of advanced intercrosses (AI). They may be used to study the genetics of behavioral phenotypes (including alcohol and drug addiction, stress, and locomotor activity) and complex or potentially complex physiologic phenotypes (including differences in organ weight and bone mineral density).
017750In Progress
BXD88/2RwwJ
The BXD#/Rww recombinant inbred strains originate from crosses between C57BL/6J females and DBA/2J males. They may be used to study the genetics of behavioral phenotypes and complex or potentially complex physiologic phenotypes.
018067In Progress
FVB-Tg(Snap25-mcherry,Mobp-YFP/HA,Aldh1l1-Cerulean/Myc)1849Htz/J
This tri-allelic Prism JD1849 mouse model allows distinct fluorescent visualization of neurons, astrocytes, and oligodendrocytes and may be useful for noninvasive and/or in vivo studies of the central nervous system and neural circuits, as well as a source for cell culture experiments.
View Strains Newly Available for all Research Tools models.