Allele Symbol Stock Number Strain Name
Adam2tm1Dgm 008042Under Development for Production
B6;129P2-Adam2tm1Dgm /J
These fertilin b (Adam2 ) mutant mice may be useful in reproductive biology studies; specifically to determine the role of ADAM (A Disintegrin And Metalloprotease) family proteins in sperm-egg interactions, fertilization, and spermatogenesis. These mice may also be useful in conjunction with other ADAM family mutant mice, including the cyritestin (Adam3 )-deficient strain (see Stock No. 008043 ).
Adam3tm1Pmkf 008043Under Development for Production
B6;129P2-Adam3tm1Pmkf /J
These cyritestin (Adam3 ) mutant mice may be useful in reproductive biology studies; specifically to determine the role of ADAM (A Disintegrin And Metalloprotease) family proteins in sperm-egg interactions, fertilization, and spermatogenesis. These mice may also be useful in conjunction with other ADAM family mutant mice, including the fertilin b (Adam2 )-deficient strain (see Stock No. 008042 ).
Adipoqtm1Chan 008195Under Development for Production
B6.129-Adipoqtm1Chan /J
These adiponectin-deficient (Adipoq -/- or Adipo -/- ) mice may be useful in studying obesity, diabetes, insulin resistance, metabolism, inflammation, leukocyte-endothelium interactions, and colitis.
Alpltm1(cre)Nagy 008569Under Development for Production
129-Alpltm1(cre)Nagy /J
This strain expresses Cre recombinase from the targeted Alpl (alkaline phosphatase, liver/bone/kidney) locus. When crossed with a strain containing loxP site flanked sequence, Cre-mediated recombination results in tissue-specific deletion of the flanked sequence, primarily in embryonic primordial germ cells. This mutant mouse strain represents a model that may be useful in studies of reproductive and endocrine systems development.
Art2atm1Fkn 008252Under Development for Production
NOD.129S4(B6)-Art2atm1Fkn Art2btm1Fkn /LtJ
This Art2a and Art2b targeted mutant strain becomes diabetic at a similar onset and rate as NOD/Lt mice. The absence of ART2 expression on T cells from thymus and lymph nodes was confirmed by RT-PCR and FACS analysis. Cd4 + and CD8 + T cells from ART2 deficient NOD mice are completely resistant to NAD induced apoptosis at all concentrations in vitro. This ART2 deficient stock provides a tool to further dissect the interplay of ADP rybosylation and NAD-catabolizing enzymes and their effect on Tregs and iNKT involved in autoimmune diseases specifically, Type 1 Diabetes.
Art2btm1Fkn 008252Under Development for Production
NOD.129S4(B6)-Art2atm1Fkn Art2btm1Fkn /LtJ
This Art2a and Art2b targeted mutant strain becomes diabetic at a similar onset and rate as NOD/Lt mice. The absence of ART2 expression on T cells from thymus and lymph nodes was confirmed by RT-PCR and FACS analysis. Cd4 + and CD8 + T cells from ART2 deficient NOD mice are completely resistant to NAD induced apoptosis at all concentrations in vitro. This ART2 deficient stock provides a tool to further dissect the interplay of ADP rybosylation and NAD-catabolizing enzymes and their effect on Tregs and iNKT involved in autoimmune diseases specifically, Type 1 Diabetes.
Bchetm1Loc 008077Under Development for Production
129S1/Sv-Bchetm1Loc /J
These BChE (butyrylcholinesterase) mutant mice are a model for human butyrylcholinesterase deficiency and may be useful for studying metabolic effects of organophosphorus toxicants or nerve agents, neurotransmitter function, and anti-Alzheimer's drug therapies.
Car3tm1Gkim 005358Under Development for Cryo
129S6/SvEvTac-Car3tm1Gkim /J
Cd19tm1(cre)Cgn 007900Under Development for Production
C57BL/6-Gt(ROSA)26Sortm1(HBEGF)Awai /J
The Cre-inducible expression of DTR in these iDTR mutant mice render cells susceptible to ablation following Diphtheria toxin administration.
Cd19tm1(cre)Cgn 008242Under Development for Production
C57BL/6-Gt(ROSA)26Sortm1(Ikbkb)Rsky /J
These R26StopFL ikk2ca mice allow inducible expression of an activated form of Ikbkb (IKK2ca) and subsequent activation of the NF-kappaB transcription factor pathways.
Cd4tm1Mak 006483Under Development for Production
CBy.129S2(B6)-Cd4tm1Mak /J
Cell surface expression of CD4 protein is not detected on thymocytes and lymph node cells from mice homozygous for this Cd4 (CD4 antigen) targeted mutation. Homozygous mutant mice also show a Class II restricted deficit in helper T-cell activity and other T-cell responses. This mutant mouse strain may be useful in studies of T cell development, susceptibility to viral infection and inflammation.
Cdh23ahl 000668On Hold
C57L/J
Cdh2tm1Glr 007611Under Development for Production
B6.129S6(SJL)-Cdh2tm1Glr /J
These N-cadflox mutant mice may be useful in generating conditional mutations for studies of myocardium physiology.
D11Mit314 008059Under Development for Production
NOD.L-(D11Mit314-D11Mit339 )(D11Mit325-D11Mit42 )/McdfJ
Stock No.'s 008053 , 008054 , 008055, 008056 , 008057 , 008058 , 008059 and 008060 , are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
D11Mit314 008054Under Development for Production
NOD.L-(D11Mit314-D11Mit339 )/McdfJ
Stock No.'s 008053 , 008054, 008055, 008056 , 008057 , 008058 , 008059 and 008060 , are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
D11Mit314 008057Under Development for Production
NOD.L-(D11Mit314-D11Mit33 )/McdfJ
Stock No.'s 008053 , 008054 , 008055, 008056 , 008057, 008058 , 008059 and 008060 , are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
D11Mit325 008059Under Development for Production
NOD.L-(D11Mit314-D11Mit339 )(D11Mit325-D11Mit42 )/McdfJ
Stock No.'s 008053 , 008054 , 008055, 008056 , 008057 , 008058 , 008059 and 008060 , are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
D11Mit339 008059Under Development for Production
NOD.L-(D11Mit314-D11Mit339 )(D11Mit325-D11Mit42 )/McdfJ
Stock No.'s 008053 , 008054 , 008055, 008056 , 008057 , 008058 , 008059 and 008060 , are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
D11Mit339 008054Under Development for Production
NOD.L-(D11Mit314-D11Mit339 )/McdfJ
Stock No.'s 008053 , 008054, 008055, 008056 , 008057 , 008058 , 008059 and 008060 , are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
D11Mit33 008057Under Development for Production
NOD.L-(D11Mit314-D11Mit33 )/McdfJ
Stock No.'s 008053 , 008054 , 008055, 008056 , 008057, 008058 , 008059 and 008060 , are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
D11Mit42 008059Under Development for Production
NOD.L-(D11Mit314-D11Mit339 )(D11Mit325-D11Mit42 )/McdfJ
Stock No.'s 008053 , 008054 , 008055, 008056 , 008057 , 008058 , 008059 and 008060 , are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
D13Mit314 006061Under Development for Cryo
B6.D2-(D13Mit314 -D13Mit35 )/1LusJ
This strain is one of a set of overlapping congenic strains called genome-tagged mice (GTM). Each member of the panel carries an average of a 23 cM segment (range 8 to 58 cM) from DBA/2J introgressed on to a C57BL/6J background. GTM are a valuable resource for mapping and confirmation of loci contributing to complex traits.
D13Mit35 006061Under Development for Cryo
B6.D2-(D13Mit314 -D13Mit35 )/1LusJ
This strain is one of a set of overlapping congenic strains called genome-tagged mice (GTM). Each member of the panel carries an average of a 23 cM segment (range 8 to 58 cM) from DBA/2J introgressed on to a C57BL/6J background. GTM are a valuable resource for mapping and confirmation of loci contributing to complex traits.
D2Mit405 005154Under Development for Cryo
B6.D2-(D2Mit405 -D2Mit457 )/LusJ
This strain is one of a set of overlapping congenic strains called genome-tagged mice (GTM). Each member of the panel carries an average of a 23 cM segment (range 8 to 58 cM) from DBA/2J introgressed on to a C57BL/6J background. GTM are a valuable resource for mapping and confirmation of loci contributing to complex traits.
D2Mit457 005154Under Development for Cryo
B6.D2-(D2Mit405 -D2Mit457 )/LusJ
This strain is one of a set of overlapping congenic strains called genome-tagged mice (GTM). Each member of the panel carries an average of a 23 cM segment (range 8 to 58 cM) from DBA/2J introgressed on to a C57BL/6J background. GTM are a valuable resource for mapping and confirmation of loci contributing to complex traits.
D4Mit59 008065Under Development for Production
NOD.NZM2328-(D4Mit76-D4Mit59 )/McdfJ
This NOD congenic strain may be useful to identify candidate genes on Chromosome 4 associated with diabetes resistance and to identify genes with common roots in multiple autoimmune diseases.
D4Mit76 008065Under Development for Production
NOD.NZM2328-(D4Mit76-D4Mit59 )/McdfJ
This NOD congenic strain may be useful to identify candidate genes on Chromosome 4 associated with diabetes resistance and to identify genes with common roots in multiple autoimmune diseases.
D8Mit318 005174Under Development for Cryo
B6.D2-(D8Mit318 -D8Mit56 )/LusJ
This strain is one of a set of overlapping congenic strains called genome-tagged mice (GTM). Each member of the panel carries an average of a 23 cM segment (range 8 to 58 cM) from DBA/2J introgressed on to a C57BL/6J background. GTM are a valuable resource for mapping and confirmation of loci contributing to complex traits.
D8Mit56 005174Under Development for Cryo
B6.D2-(D8Mit318 -D8Mit56 )/LusJ
This strain is one of a set of overlapping congenic strains called genome-tagged mice (GTM). Each member of the panel carries an average of a 23 cM segment (range 8 to 58 cM) from DBA/2J introgressed on to a C57BL/6J background. GTM are a valuable resource for mapping and confirmation of loci contributing to complex traits.
D9Mit115 005175Under Development for Cryo
B6.D2-(D9Mit329 -D9Mit115 )/LusJ
This strain is one of a set of overlapping congenic strains called genome-tagged mice (GTM). Each member of the panel carries an average of a 23 cM segment (range 8 to 58 cM) from DBA/2J introgressed on to a C57BL/6J background. GTM are a valuable resource for mapping and confirmation of loci contributing to complex traits.
D9Mit329 005175Under Development for Cryo
B6.D2-(D9Mit329 -D9Mit115 )/LusJ
This strain is one of a set of overlapping congenic strains called genome-tagged mice (GTM). Each member of the panel carries an average of a 23 cM segment (range 8 to 58 cM) from DBA/2J introgressed on to a C57BL/6J background. GTM are a valuable resource for mapping and confirmation of loci contributing to complex traits.
Dicer1tm1Bdh 006366Under Development for Production
B6.Cg-Dicer1tm1Bdh /J
These mice contain loxP sites on either side of exon 23 of the Dicer1 (Dicer1, Dcr-1 homolog (Drosophila)) gene. Cre-mediated recombination (resulting in deletion of exon 23) in the germline leads to developmental arrest at embryonic day 7.5 (E7.5). Mutant mice can be used to generate cell/tissue-specific deletions of the endogenous gene for applications in embryonic development, translation, protein processing and miRNA/siRNA regulation of gene expression.
Dldtm1Ptl 008333Under Development for Production
B6;129P2-Dldtm1Ptl /J
These Dld (dihydrolipoamide dehydrogenase or E3 component) mutant mice may be useful to study early murine embryonic metabolism, including glucose and mitochondrial metabolism during the early postimplantation period. As altered energy metabolism and reductions in alpha-ketoacid dehydrogenase complexes have also been associated with many neurodegenerative disorders, these mice may also be useful in studies related to Parkinson's disease, Huntington's disease, and/or Alzheimer's disease. Because the metabolic disturbances associated with E3 deficiency (Dld deficiency) cause a variant of Maple Syrup Urine Disease (MSUD) in which there is an accompanying lactic acidosis due to concomitant deficiency of pyruvate dehydrogenase complex, these mice may be useful in such studies or in conjunction with iMSUD mice (Stock No. 006999 ).
Efna2tm1Jgf 005992Under Development for Production
STOCK Efna2tm1Jgf Efna5tm1Ddmo /J
These ephrin A2/ephrin A5 double mutant mice may be useful in studies of retinocollicular mapping, axon topography, neuron projection, and modality-specific compartmentalization of visual, auditory, and somatosensory thalamic relay pathways.
Efna5tm1Ddmo 005992Under Development for Production
STOCK Efna2tm1Jgf Efna5tm1Ddmo /J
These ephrin A2/ephrin A5 double mutant mice may be useful in studies of retinocollicular mapping, axon topography, neuron projection, and modality-specific compartmentalization of visual, auditory, and somatosensory thalamic relay pathways.
Eif2ak4tm1Munn 008240Under Development for Production
B6.129S6-Eif2ak4tm1Munn /J
Mice homozygous for the GCN2-KO allele have a deletion of exon XII of the eukaryotic translation initiation factor 2 alpha kinase 4 (Eif2ak4 or GCN2) gene, and may be useful in studying eIF2 (eukaryotic initiation factor 2) phosphorylation in response to environmental stresses (amino acid starvation, proteasome inhibition and UV irradiation).
Epas1tm1.1Mcs 008407Under Development for Production
STOCK Epas1tm1Mcs /J
These mutant mice carrying a (floxed) Epas1 (endothelial PAS domain protein 1) allele, Epas12lox , may be useful in generating conditional mutations for studies related to erythropoiesis.
Epas1tm1Mcs 008407Under Development for Production
STOCK Epas1tm1Mcs /J
These mutant mice carrying a (floxed) Epas1 (endothelial PAS domain protein 1) allele, Epas12lox , may be useful in generating conditional mutations for studies related to erythropoiesis.
Eraftm1.1Mjwe 007858Under Development for Production
B6.129S6(Cg)-Eraftm1.1Mjwe /J
The entire coding region of the erythroid associated factor gene has been disrupted in this mutant mouse line. This gene (also called a -hemoglobin stabilizing protein or AHSP) specifically binds the cytotoxic free a -Hb subunit of hemoglobin A. These AHSP-mutant mice may be useful in studying erythroid development/erythropoiesis, thalassemia, Heinz body hemolytic anemia, and other hemoglobinopathies.
Foxa2tm2.1(cre/Esr1)Moon 008464Under Development for Production
STOCK Foxa2tm2.1(cre/Esr1)Moon /J
This strain expresses the tamoxifen-inducible cre/Esr1 from the forkhead box A2 (Foxa2 ) locus. When crossed with a strain containing a loxP site flanked sequence of interest, the offspring are useful for generating tamoxifen-induced, Cre-mediated targeted deletions specifically in the developing endoderm, notochord, and floorplate.
Foxp3sf 006775On Hold
NOD.Cg-Foxp3sf /DoiJ
Fut1tm1Sdo 006939Under Development for Production
B6.129-Fut1tm1Sdo /J
FUT1-deficient mice do not have epididymal alpha(1,2)fucosylated glycans or the fucosylated glycolipid, fucosyl GA1, in pancreatic acinar glands. Homozygotes exhibit delayed maturation of nerve fibers in the glomerular layer of the olfactory bulb. This mutant mouse strain may be useful in studies of glycosidic molecular interactions and function, and olfactory nerve pathway development.
Gabrb3tm2.1Geh 008310Under Development for Production
B6;129-Gabrb3tm2.1Geh /J
These Gabrb3 (gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3) conditional (floxed) mutant mice may be useful in generating conditional mutations for studying the role of neurodevelopmental diseases and sensitivity to anesthetics and ethanol.
Gata4tm1.1Sad 008194Under Development for Production
STOCK Gata4tm1.1Sad /J
These GATA binding protein 4 conditional mice may be useful in generating conditional mutations for studying GATA4 function during organogenesis (such as cardiogenesis) or in adult mice.
Gata6tm2.1Sad 008196Under Development for Production
STOCK Gata6tm2.1Sad /J
These Gata6loxp mice may be useful in generating conditional GATA binding protein 6 mutations for studying GATA6 function in organogenesis or in adult mice.
Gata6tm2.2Sad 008196Under Development for Production
STOCK Gata6tm2.1Sad /J
These Gata6loxp mice may be useful in generating conditional GATA binding protein 6 mutations for studying GATA6 function in organogenesis or in adult mice.
Gli1tm3(cre/ESR1)Alj 007913Under Development for Production
STOCK Gli1tm3(cre/ESR1)Alj /J
When these Gli1-CreERT2 mice are bred with mice containing a loxP -flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Gli1 expressing cells; making them useful for studying axis patterning, proliferation, and cell fate specification of Hedgehog responding cells at different stages of embryogenesis.
Gt(ROSA)26Sortm1(HBEGF)Awai 007900Under Development for Production
C57BL/6-Gt(ROSA)26Sortm1(HBEGF)Awai /J
The Cre-inducible expression of DTR in these iDTR mutant mice render cells susceptible to ablation following Diphtheria toxin administration.
Gt(ROSA)26Sortm1(Notch1)Dam 008159Under Development for Production
STOCK Gt(ROSA)26Sortm1(Notch1)Dam /J
When used in conjunction with a Cre recombinase-expressing strain, these RosaN1-IC (or RosaNotch ) mutant mice may be useful in generating conditional mutations for studying the effects of Notch pathway activation.
Gt(ROSA)26Sortm1(rtTA*M2)Jae 006965Under Development for Production
B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae /J
Targeted mutant mice have widespread expression of an optimized form of reverse tetracycline-controlled transactivator (rtTA-M2) protein. This R26-M2rtTA strain may be useful for doxycycline-inducible studies which utilize rtTA/tet-O (tet-on/TRE) models.
Gt(ROSA)26Sortm4(Ikbkb)Rsky 008242Under Development for Production
C57BL/6-Gt(ROSA)26Sortm1(Ikbkb)Rsky /J
These R26StopFL ikk2ca mice allow inducible expression of an activated form of Ikbkb (IKK2ca) and subsequent activation of the NF-kappaB transcription factor pathways.
Idd4 008059Under Development for Production
NOD.L-(D11Mit314-D11Mit339 )(D11Mit325-D11Mit42 )/McdfJ
Stock No.'s 008053 , 008054 , 008055, 008056 , 008057 , 008058 , 008059 and 008060 , are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
Idd4 008054Under Development for Production
NOD.L-(D11Mit314-D11Mit339 )/McdfJ
Stock No.'s 008053 , 008054, 008055, 008056 , 008057 , 008058 , 008059 and 008060 , are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
Idd4 008057Under Development for Production
NOD.L-(D11Mit314-D11Mit33 )/McdfJ
Stock No.'s 008053 , 008054 , 008055, 008056 , 008057, 008058 , 008059 and 008060 , are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
Ightm1Janz 008332Under Development for Production
C.129S1-Ightm1Janz /J
These mutant mice carry a His6 -tagged myelocytomatosis oncogene (Myc ) gene (cDNA) sequence inserted in the endogenous immunoglobulin heavy chain complex (Igh ) locus, which mimics the human endemic Burkitt lymphoma t(8;14)(q24;q32) translocation and mouse plasmacytoma T(12;15) translocation. This mutant mouse strain may be useful in studies of Burkitt Lymphoma and plasma cell and B-cell neoplasia.
L1camtm1Sor 003518Under Development for Cryo
129/Sv-L1camtm1Sor /J
Ltb4r1tm1Adl 008102Under Development for Production
B6.129S4-Ltb4r1tm1Adl /J
As the G protein-coupled receptor BLTR/BLT1 is expressed on myeloid leukocytes (including neutrophils, macrophages, eosinophils, T cell lymphomas, and effector T cells (TH1 CD4+ cells, TH2 CD4+ cells, and effector memory CD8+ cells) during CD4+ migration/recruitment from the lymphoid compartment into peripheral tissues), these BLTR/BLT1 mutant mice may be useful for studying leukocyte function in inflammation, as well as the role of the LTB4-BLT1 pathway linking early immune system activation and multiple classes of acquired immune effector cells.
Lyz2tm1(cre)Ifo 008397Under Development for Production
B6.129-Pcyt1atm1Irt /J
These "CT alpha flox" mutant mice carry a loxP site-flanked allele of phosphate cytidylyltransferase 1, choline, alpha isoform (Pcyt1a ) and may be useful in generating conditional mutations for studying atherosclerosis.
Mecp2tm1Bird 006847Under Development for Production
B6;129P2-Mecp2tm1Bird /J
Mice with this X-linked floxed mutation of the methyl CpG binding protein 2 gene may be useful in neurological and developmental studies of Rett syndrome.
Mgat5tm1Jwd 006335Under Development for Production
B6.129-Mgat5tm1Jwd /J
Mgat5 (mannoside acetylglucosaminyltransferase 5) deficient mice exhibit increased responses to induced immune challenges and delayed tumor progression when bred with oncomice. This mutant mouse strain may be useful in studies of glycosidic molecular interactions and function, autoimmunity and antitumor immunity.
Mirn150tm1Rsky 007750Under Development for Production
B6;C-Mirn150tm1Rsky /J
These miR150-/- mice may be useful in mircoRNA biology, specifically to study the role of miR-150 and its target genes (including c-Myb) in lymphocyte development and function.
Mirn155tm1.1Rsky 007745Under Development for Production
B6.Cg-Mirn155tm1.1Rsky /J
These bic /mir-155 mutant mice may be useful in mircoRNA biology, specifically to study the role of miR-155 and its target genes (including cytokines, chemokines, and transcription factors) in homeostasis and function of the immune system.
Mlphln 000668On Hold
C57L/J
Myo5ad 006255Under Development for Production
BXD25/TyJRwwJ
The BXD# recombinant inbred (RI) strains originate from crosses between C57BL/6J and DBA/2J. They may be used to study the genetics of behavioral phenotypes (including alcohol and drug addiction, stress, and locomotor activity) and complex or potentially complex physiologic phenotypes (including differences in organ weight and bone mineral density).
Ncf1m1J 004742On Hold
B6(Cg)-Ncf1m1J /J
Nrgntm1Kph 008233Under Development for Production
B6.129-Nrgntm1Kph /J
These neurogranin mutant mice may be useful for neurological studies involving memory and learning, neuronal signaling pathways (including calmodulin, alpha-CaMKII, protein kinase A, protein kinase C, MAPK, and CREB), attention deficit-hyperactivity disorder (ADHD), and schizophrenia.
Obq3C57L/J 000668On Hold
C57L/J
Obq4C57L/J 000668On Hold
C57L/J
Pcyt1atm1Irt 008397Under Development for Production
B6.129-Pcyt1atm1Irt /J
These "CT alpha flox" mutant mice carry a loxP site-flanked allele of phosphate cytidylyltransferase 1, choline, alpha isoform (Pcyt1a ) and may be useful in generating conditional mutations for studying atherosclerosis.
Pde10atm1Pfi 008210Under Development for Production
B6.D1-Pde10atm1Jasi /J
These PDE10AC57 mutant mice are deficient in phosphodiesterase 10A activity, and may be useful in neurobiological studies including metabolic inactivation of intracellular signal transduction pathways by cyclic phosphodiesterases (PDEs), regulation of information processing by basal ganglia circuitry, and striatal hypofunction or psychotic disease.
Pdgfratm8Sor 006492Under Development for Production
B6.Cg-Pdgfratm8Sor /EiJ
This strain carries a floxed allele of the platelet derived growth factor receptor alpha (Pdgfra ). When used in conjunction with a strain expressing Cre recombinase in the brain, this strain may be useful in studies of cardiovascular and craniofacial development.
Pepc 006259Under Development for Production
B6.Cg-Pepcb Ptprca Tg(UBC-scFv)2Nemz/J
These "kappa-macroself Ag#2" transgenic mice may be useful to study B cell receptor editing, B cell tolerance in polyclonal immune systems, and for the rapid screening of mutants of interest for potential defects in B cell tolerance.
Pou5f1tm1Jae 008204Under Development for Production
B6;129S4-Pou5f1tm1Jae /J
These Oct4-neo mutant mice may be useful for the selection of induced pluripotent stem (iPS) cells.
Pou5f1tm2Jae 008214Under Development for Production
B6;129S4-Pou5f1tm2Jae /J
These Oct4-EGFP mutant mice may be useful for the selection of induced pluripotent stem (iPS) cells, or more generally for fluorescent labeling of embryonic stem cells.
Ppargtm2Yba 008079Under Development for Production
129S-Ppargtm2Yba /J
These mice express tTA (tetracycline regulated transactivator) and a tetO-driven Flag-tagged Pparg from the endogenous Pparg locus. Although heterozygous mice exhibit lipodystrophy, hyperinsulinemia, pancreatic islet hyperplasia, and severe glucose intolerance, they do not develop steatosis or type II diabetes. Treatment with doxycycline prevents these phenotypes when administered starting at midgestation whereas a 6 week treatment administered to pubertal heterozygotes reverses most of these phenotypes. This strain may be useful in studies of lipodystrophy.
Ppargtm3Yba 008227Under Development for Production
B6.129S4-Ppargtm3Yba /J
These mice express tTA (tetracycline regulated transactivator) from the endogenous Pparg locus. Heterozygotes exhibit mild lipodystrophy with pale, unilocular brown adipocytes, hypertrophy of brown fat, reduced subcutaneous fat, reduced gonadal fat pads, mild hepatomegaly and develop insulin resistance and dyslipidemia. Treatment with doxycycline prevents this phenotype. This mutant mouse strain may be useful in studies of lipodystrophy.
Ptger3tm1Csml 008349Under Development for Production
129-Ptger3tm1Csml /J
These Ptger3 (prostaglandin E receptor 3 (subtype EP3) conditonal (floxed) mutant mice may be useful in generating conditional mutations for studying prostaglandin biology and fever response in inflammation.
Ptprc 006259Under Development for Production
B6.Cg-Pepcb Ptprca Tg(UBC-scFv)2Nemz/J
These "kappa-macroself Ag#2" transgenic mice may be useful to study B cell receptor editing, B cell tolerance in polyclonal immune systems, and for the rapid screening of mutants of interest for potential defects in B cell tolerance.
Pvalbtm1(cre)Arbr 008069Under Development for Production
B6;129P2-Pvalbtm1(cre)Arbr /J
This strain expresses Cre recombinase from the endogenous Pvalb , parvalbumin, locus. When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination results in tissue-specific deletion of the target.
This mutant mouse strain represents a model that may be useful in studies of neuronal differentiation.
Rag1tm1Mom 006770Under Development for Production
STOCK Rag1tm1Mom Tg(TIE2GFP)287Sato/J
To generate this double mutant strain, B6.Cg-Tg(TIE2GFP)287Sato/1J (Stock No. 004659 ) was crossed to C.129S7(B6)-Rag1tm1Mom /J (Stock No. 003145 ). This mutant mouse strain may be useful in studies examining angiogenesis in transplanted tissues.
Rag2tm1.1Cgn 008309Under Development for Production
C57BL/6-Rag2tm1Cgn /J
These RAG-2fl mice harbor loxP sites flanking the entire coding region of the Rag2 (recombination activating gene 2) locus. When bred to mice that express Cre recombinase, the resulting offspring will have exon 3 deleted in the cre -expressing tissue(s). These RAG-2fl mice may be useful in generating conditional mutations for studying the role of RAG-2 in B and T cell development (including cancer and toxicology research as a xenograft/transplant host), T and B cell receptor (V(D)J) recombination, hematopoiesis, hematology, immunology, and inflammation research.
Rag2tm1Cgn 008309Under Development for Production
C57BL/6-Rag2tm1Cgn /J
These RAG-2fl mice harbor loxP sites flanking the entire coding region of the Rag2 (recombination activating gene 2) locus. When bred to mice that express Cre recombinase, the resulting offspring will have exon 3 deleted in the cre -expressing tissue(s). These RAG-2fl mice may be useful in generating conditional mutations for studying the role of RAG-2 in B and T cell development (including cancer and toxicology research as a xenograft/transplant host), T and B cell receptor (V(D)J) recombination, hematopoiesis, hematology, immunology, and inflammation research.
Rai1tm1Jrl 005981On Hold
B6.129S7-Rai1tm1Jrl /J
Rmcfs 000668On Hold
C57L/J
Seletm1Dmil 008238Under Development for Production
129S-Seletm1Dmil /J
These E-selectin mutant mice may be useful in studying inflammation, leukocyte rolling, leukocyte-endothelial adhesion, angiogenesis, and cancer.
Seletm1Dmil 008236Under Development for Production
B6.129S4-Seletm1Dmil /J
These E-selectin mutant mice may be useful in studying inflammation, leukocyte rolling, leukocyte-endothelial adhesion, angiogenesis, and cancer.
Seletm1Dmil 008237Under Development for Production
C.129S4-Seletm1Dmil /J
These E-selectin mutant mice may be useful in studying inflammation, leukocyte rolling, leukocyte-endothelial adhesion, angiogenesis, and cancer.
Serpinb9tm1Arp 008158Under Development for Production
C57BL/6-Serpinb9tm1Arp /J
These Serpinb9-deficient (Spi6-/-) mutant mice have impaired cytotoxic T lymphocyte (CTL) immunity to viruses and may be useful in studies of viral immune response and inflammation, and the exocytosis pathway in CTL apoptosis.
Shhtm2(cre/ESR1)Cjt 008159Under Development for Production
STOCK Gt(ROSA)26Sortm1(Notch1)Dam /J
When used in conjunction with a Cre recombinase-expressing strain, these RosaN1-IC (or RosaNotch ) mutant mice may be useful in generating conditional mutations for studying the effects of Notch pathway activation.
Smn1tm1Msd 008203Under Development for Production
FVB.Cg-Smn1tm1Msd Tg(ACTA1-SMN)63Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn ; HSA63-SMN mice may be useful for neuromuscular studies including spinal muscular atrophy (SMA).
Smn1tm1Msd 008209Under Development for Production
FVB.Cg-Smn1tm1Msd Tg(ACTA1-SMN)69Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn ; HSA69-SMN mice may be useful for neuromuscular studies including spinal muscular atrophy (SMA).
Smn1tm1Msd 008206Under Development for Production
FVB.Cg-Smn1tm1Msd Tg(SMN2)566Ahmb/J
These mice may be useful in neuromuscular studies including spinal muscular atrophy (SMA).
Smn1tm1Msd 008212Under Development for Production
STOCK Smn1tm1Msd Tg(Prnp-SMN)92Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn ; PrP92-SMN mutant mice may be useful in neuromuscular studies including spinal muscular atrophy (SMA).
Tcfe2atm4Zhu 008303Under Development for Production
B6;129S4-Tcfe2atm4Zhu /J
This Tcfe2a , transcription factor E2a, targeted mutation strain may be useful in generating conditional mutations for studying B and T cell development and for other immunological applications.
Tcfe2atm5Zhu 008078Under Development for Production
B6;129S4-Tcfe2atm5Zhu /J
These mice contain an Enhanced Green Fluorescent Protein (EGFP) gene inserted into the endogenous Tcfe2a , transcription factor E2a, locus. This strain serves as a reporter strain, with functional Tcfe2a , transcription factor E2a, expression indicated by EGFP expression.
Traf1tm1Tsi 008074Under Development for Production
C.129S4-Traf1tm1Tsi /J
These TRAF1 mutant mice may be useful in studying negative regulation of tumor necrosis factor (TNF) signaling, NF-kB and AP-1 signaling, T cell receptor (TCR)-induced proliferation of T cells, Th2 responses, TRAF1/Bim function in CD8 memory T cell survival, allergic airway diseases and Rheumatoid arthritis, as well as the role of TRAF1 activation in the pathogenesis of lymphomas. Of note, TRAF1 mutant mice are available on either a BALB/c congenic (Stock No. 008074 ) or C57BL/6 congenic (Stock No. 008076 ) background.
Trp53tm2Xu 007218Under Development for Production
B6.129S6-Trp53tm2Xu /J
This targeted mutation of Trp53 (transformation related protein 53) contains two phosphorylation site disruptions: Ser18 to Ala (S18A), and Ser23 to Ala (S23A). Trp53-dependent apoptosis is essentially abolished in thymocytes from mice homozygous for this allele. This mutant mouse strain may be useful in studies of phosphorylation events, cancer development and apoptosis.
Usp18tm1Dzh 007225Under Development for Production
FVB.129(B6)-Usp18tm1Dzh /J
These Usp18 (or Ubp43)-mutant mice may be useful in studying interferons and their receptors, cellular function, signal transduction, and the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway.
Rb(16.17)7Bnr
001887Under Development for Cryo
(STOCK Rb(6.16)24Lub x STOCK Rb(16.17)7Bnr)F1/J
Rb(6.16)24Lub
001887Under Development for Cryo
(STOCK Rb(6.16)24Lub x STOCK Rb(16.17)7Bnr)F1/J
Rb(9.19)163H
000613On Hold
STOCK Rb(9.19)163H/J
Tg(ACTA1-SMN)63Ahmb
008203Under Development for Production
FVB.Cg-Smn1tm1Msd Tg(ACTA1-SMN)63Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn ; HSA63-SMN mice may be useful for neuromuscular studies including spinal muscular atrophy (SMA).
Tg(ACTA1-SMN)69Ahmb
008209Under Development for Production
FVB.Cg-Smn1tm1Msd Tg(ACTA1-SMN)69Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn ; HSA69-SMN mice may be useful for neuromuscular studies including spinal muscular atrophy (SMA).
Tg(APOE-DGAT2)24Far
007744Under Development for Production
C57BL/6-Tg(APOE-DGAT2)24Far/J
These Liv-DGAT2-low transgenic mice may be useful in studying hepatic steatosis, lipid, glucose, and insulin metabolism, as well as obesity and diabetes.
Tg(Alb1-Ren)1Unc
007853Under Development for Production
129S/SvEv-Tg(Alb1-Ren)1Unc/CofJ
These RenTgMK mice may be useful in studying the effects of genetically clamped renin (and angiotensin II) on hypertension, diabetic nephropathy, albuninurea, nephrosclerosis, and other aspects of the renin–angiotensin system (RAS).
Tg(CAG-Ngb,-EGFP)1Dgrn
007575Under Development for Production
B6.Cg-Tg(CAG-Ngb,-EGFP)1Dgrn/J
These transgenic mice overexpress neuroglobin (Ngb ) and GFP in multiple tissues, and are resistant to ischemia. When crossed to a mouse model of Alzheimer's disease, the disease phenotype is attenuated. They may be useful in studies of cerebral and myocardial ischemia, stroke, and neurodegenerative disease.
Tg(CAG-SAC/EGFP)35Rang
008080Under Development for Production
B6;C3-Tg(CAG-SAC/EGFP)35Rang/J
These SAC-GFP transgenic mice may be useful as a cancer-resistant model; evading oncogene-mediated tumorigenesis by expressing an archetypical anticancer therapeutic agent (SAC) that is well tolerated in vivo , does not compromise the normal tissue function or life span of the host, and is potent enough at physiologically innocuous levels to concomitantly suppress the NF-kappaB pro-cell survival pathway and induce tumor suppression via apoptosis.
Tg(CAG-Ub*G76V/GFP)1Dant
008111Under Development for Production
B6.Cg-Tg(CAG-Ub*G76V/GFP)1Dant/J
Both ubiquitin/proteasome system reporter (UPS reporter) founder lines, UbG76V -GFP/1 (Stock No. 008111) and UbG76V -GFP/2 (Stock No. 008112), may be useful for monitoring the role of ubiquitin/proteasome-dependent proteolysis in diverse disorders, and for efficacy trials testing the effect of compounds on the ubiquitin/proteasome system (including proteasome inhibitors effect as novel anticancer drugs).
Tg(CAG-Ub*G76V/GFP)2Dant
008112Under Development for Production
B6.Cg-Tg(CAG-Ub*G76V/GFP)2Dant/J
Both ubiquitin/proteasome system reporter (UPS reporter) founder lines, UbG76V -GFP/1 (Stock No. 008111) and UbG76V -GFP/2 (Stock No. 008112), may be useful for monitoring the role of ubiquitin/proteasome-dependent proteolysis in diverse disorders, and for efficacy trials testing the effect of compounds on the ubiquitin/proteasome system (including proteasome inhibitors effect as novel anticancer drugs).
Tg(CAG-lacZ-WGA)330Bbm
006477Under Development for Production
B6.Cg-Tg(CAG-lacZ-WGA)330Bbm/J
These ZW mice harbor a Cre-conditional pCZW transgene and have widespread expression of lacZ under the control of the CMV enhancer/chicken actin promoter. When bred to mice expressing Cre recombinase, the "floxed" lacZ sequence is removed in the resulting offspring, and lacZ expression is replaced by wheat germ agglutinin (plant lectin) expression in all cre -expressing cells. These ZW mice may be useful for global expression of lacZ or, when crossed to a cre -expressing strain, for tracing transneuronal or trans-synaptic connections and circuits in brain regions or in the spinal cord.
Tg(Camk2a-cre)T29-1Stl
008310Under Development for Production
B6;129-Gabrb3tm2.1Geh /J
These Gabrb3 (gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3) conditional (floxed) mutant mice may be useful in generating conditional mutations for studying the role of neurodevelopmental diseases and sensitivity to anesthetics and ethanol.
Tg(Cspg4-DsRed.T1)1Akik
008241Under Development for Production
STOCK Tg(Cspg4-DsRed.T1)1Akik/J
These NG2DsRedBAC transgenic mice express an optimized red fluorescent protein variant (DsRed.T1) under the control of the mouse NG2 (Cspg4 ) promoter/enhancer and may be useful for fluorescent labeling of NG2 cells (oligodendrocyte progenitor cells) in the central nervous system and NG2-expressing cells in other organs, as well as for isolating NG2 cell populations via FACS.
Tg(DR4)1Jae
003208On Hold
STOCK Tg(DR4)1Jae/J
Tg(EIIa-cre)C5379Lmgd
008196Under Development for Production
STOCK Gata6tm2.1Sad /J
These Gata6loxp mice may be useful in generating conditional GATA binding protein 6 mutations for studying GATA6 function in organogenesis or in adult mice.
Tg(Ela1-TAg*)289Mjt
008247Under Development for Production
B6.Cg-Tg(Ela1-TAg*)289Mjt/J
These T1-147 transgenic mice (harboring the E1-T147 transgene) develop metastatic pancreatic acinar cell cancer as a result of expression of the 1-147 amino acid fragment of simian virus 40 large T antigen (TAg) directed to pancreatic acinar cells by the rat elastase 1 (Ela1 or E1) upstream control region.
Tg(Eno2-YFP/Cox8a)ZRwb
007860Under Development for Production
C57BL/6J-Tg(Eno2-YFP/Cox8a)ZRwb/J
These transgenic mice express Yellow Fluorescent Protein (YFP ) under the control of the neuron-specific rat, enolase 2, gamma, Eno2 , promoter. YFP is specifically localized to the mitochondria by a mouse cytochrome c oxidase, subunit VIIIa, gene targeting signal fused to the N-terminus. This mutant mouse strain may be useful in studies of mitochondrial transport.
Tg(HDexon1)61Gpb
007578Under Development for Production
CBy.Cg-Tg(HDexon1)61Gpb/J
These HDexon1 mice may be useful in Huntington's Disease research.
Tg(IGFBP1)2Miel
008221Under Development for Production
B6.Cg-Tg(IGFBP1)2Miel/J
These hIGFBP-1 (insulin-like growth factor binding protein 1, human) transgenic mice may be useful in studying metabolic and vascular homeostasis, diabetes, and the role of insulin-like growth factor binding protein in placentation and preeclampsia.
Tg(IGFBP2)1Miel
008222Under Development for Production
B6.FVB-Tg(IGFBP2)1Miel/J
These IGFBP-2 overexpressing transgenic mice may be useful in studying metabolic homeostasis, adipocyte biology, and the role of insulin-like growth factor binding protein in protecting against obesity- and age-associated complications (such as hypertension and diabetes).
Tg(IGH@,IGL@)1Skmr
008103Under Development for Production
B6.Cg-Tg(IGH@,IGL@)1Skmr/J
These transgenic mice express and secrete a complete functional human IgG, immunoglobulin and are naturally tolerant to human IgG. This mutant mouse strain may be useful in testing human antibody based therapies, or as a source of mouse B cells with human IgG as a cell surface marker.
Tg(Ins1-EGFP)1Hara
008173Under Development for Production
NOD.Cg-Tg(Ins1-EGFP)1Hara/QtngJ
Congenic NOD mice hemizygous for Enhanced Green Florescent Protein, EGFP , under the control of the Mouse Insulin I promoter, InsI , (MIP-GFP) express green florescence in tissues where insulin I is normally detected, specifically in pancreatic beta-cells. Transgenic mice are reported to develop diabetes at a similar or higher rate and kenetics as wildtype controls. Transgenic mice may be useful in studies of diabetes and pancreatic beta islet cell biology.
Tg(Ins2-IAPP)RHFSoel
008232Under Development for Production
FVB/N-Tg(Ins2-IAPP)RHFSoel/J
These RIPHAT transgenic mice express human islet amyloid polypeptide (h-IAPP) under the regulatory control of the rat insulin II promoter and may be useful in studying the beta-cell destruction and islet amyloid deposition associated with non-insulin-dependent diabetes mellitus (NIDDM) or Type II diabetes, as well as beta-cell apoptosis and characteristics of the endoplasmic reticulum (ER) stress pathway.
Tg(Ins2-cre/Esr1)1Dam
008122Under Development for Production
STOCK Tg(Ins2-cre/Esr1)1Dam/J
When these RIP-CreER mice are bred with mice containing a loxP -flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in pancreatic beta cells. This mutant mouse strain may be useful in studying pancreatic development, diabetes and obesity.
Tg(Ins2-rtTA)2Efr
008250Under Development for Production
STOCK Tg(Ins2-rtTA)2Efr/J
Ins-rtTA or RIP7-rtTA transgenic mice express the reverse tetracycline-controlled transactivator (rtTA) protein under the control of the rat insulin 2 promoter. When mated to a second transgenic strain carrying a gene under the regulatory control of a tetracycline-responsive promoter element (TRE or tetO), expression of the gene in pancreatic beta cells is induced with administration of the tetracycline analog, doxycycline (dox). This strain provides a Tet-On tool that allows the inducible expression of genes in pancreatic beta cells.
Tg(Itgax-DTR/EGFP)57Lan
008549Under Development for Production
NOD.FVB-Tg(Itgax-DTR/EGFP)57Lan/JdkJ
Congenic NOD mice hemizygous for a simian diphtheria toxin receptor - green fluorescent protein fusion protein under the control of mouse integrin alpha X, Itgax , promoter (CD11c ). These transgenic mice provide a diphtheria toxin inducible system that transiently depletes dendritic cell populations. This congenic NOD, transgenic strain is useful for studying the specific role of dendritic cells in the immune response, specifically type 1 diabetes.
Tg(Itgax-cre,-EGFP)4097Ach
007567Under Development for Production
C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
These CD11c-Cre-GFP transgenic mice may be useful in immunological studies utilizing Cre-lox technology or fluorescent protein expression in dendritic cells.
Tg(MMTV-neu/OT-I/OT-II)CBnel
007962Under Development for Production
B6.FVB-Tg(MMTV-neu/OT-I/OT-II)CBnel Tg(Trp53R172H)8512Jmr/J
Approximately 85% of the compound mutant females develop focal mammary tumors at 6-10 months of age. Both virgin and breeder mice develop tumors. Approximately 37% of tumor-bearing mice develop metastatic disease to the lung. High expression of neu is detected in tumor tissue while very low levels are found in lung and ovary.
Female mice carrying only the neuOT-I/OT-II mutation develop focal mammary tumors at approximately 18 months of age.
Tg(Mx1-cre)1Cgn
008309Under Development for Production
C57BL/6-Rag2tm1Cgn /J
These RAG-2fl mice harbor loxP sites flanking the entire coding region of the Rag2 (recombination activating gene 2) locus. When bred to mice that express Cre recombinase, the resulting offspring will have exon 3 deleted in the cre -expressing tissue(s). These RAG-2fl mice may be useful in generating conditional mutations for studying the role of RAG-2 in B and T cell development (including cancer and toxicology research as a xenograft/transplant host), T and B cell receptor (V(D)J) recombination, hematopoiesis, hematology, immunology, and inflammation research.
Tg(Myh11-cre,-EGFP)2Mik
007742Under Development for Production
B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
These smMHC/Cre/eGFP transgenic mice may be useful in studies utilizing “Cre-lox” technology or fluorescent protein expression in smooth muscle, especially separation of vascular myocytes from the surrounding cellular environment to isolate muscle specific adaptations or disease responses.
Tg(Myh6-tTA)6Smbf
008168Under Development for Production
STOCK Tg(tetO-DTA)1Gfi/J
These tet-DTA mice express diphtheria toxin A (DTA) under the control of a tetracycline operator (tetO ; also called tetracycline-responsive element (TRE) or tet-operator) and a cytomegalovirus minimal promoter, and may be useful in generating bi-transgenic mutant mice for the reversible, inducible deletion of specific groups of cells.
Tg(NPHS2-rtTA2*M2)1Jbk
008202Under Development for Production
FVB/N-Tg(NPHS2-rtTA2*M2)1Jbk/J
These podocin-rtTA mice provide a Tet-On tool that allows dox-inducible expression of genes in podocytes, and may be useful in studying the role of podocyte nephrobiology in renal disorders.
Tg(Nes-cre)1Kln
008349Under Development for Production
129-Ptger3tm1Csml /J
These Ptger3 (prostaglandin E receptor 3 (subtype EP3) conditonal (floxed) mutant mice may be useful in generating conditional mutations for studying prostaglandin biology and fever response in inflammation.
Tg(Nes-cre)1Kln
006847Under Development for Production
B6;129P2-Mecp2tm1Bird /J
Mice with this X-linked floxed mutation of the methyl CpG binding protein 2 gene may be useful in neurological and developmental studies of Rett syndrome.
Tg(Neurog3-cre/Esr1)1Dam
008119Under Development for Production
STOCK Tg(Neurog3-cre/Esr1)1Dam/J
When these Ngn3/CreERTM mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Neurog3 expressing cells such as pancreatic islet cells and undifferentiated spermatogonia. This mutant mouse strain may be useful for studying pancreatic development and lineage mapping of Neurog3 expressing cells.
Tg(Prnp-SMN)92Ahmb
008212Under Development for Production
STOCK Smn1tm1Msd Tg(Prnp-SMN)92Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn ; PrP92-SMN mutant mice may be useful in neuromuscular studies including spinal muscular atrophy (SMA).
Tg(Prrx1-cre)1Cjt
006366Under Development for Production
B6.Cg-Dicer1tm1Bdh /J
These mice contain loxP sites on either side of exon 23 of the Dicer1 (Dicer1, Dcr-1 homolog (Drosophila)) gene. Cre-mediated recombination (resulting in deletion of exon 23) in the germline leads to developmental arrest at embryonic day 7.5 (E7.5). Mutant mice can be used to generate cell/tissue-specific deletions of the endogenous gene for applications in embryonic development, translation, protein processing and miRNA/siRNA regulation of gene expression.
Tg(RARE-Hspa1b/lacZ)12Jrt
008477Under Development for Production
STOCK Tg(RARE-Hspa1b/lacZ)12Jrt/J
These transgenic mice express beta-galactosidase (lacZ ) gene under the control of the retinoic acid responsive element (RARE). Retinoic acid signaling is indicated by beta-galactosidase activity. This mutant mouse strain may be useful in tracking retinoic acid signaling pattern.
Tg(SMN2)566Ahmb
008206Under Development for Production
FVB.Cg-Smn1tm1Msd Tg(SMN2)566Ahmb/J
These mice may be useful in neuromuscular studies including spinal muscular atrophy (SMA).
Tg(SMN2)89Ahmb
008203Under Development for Production
FVB.Cg-Smn1tm1Msd Tg(ACTA1-SMN)63Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn ; HSA63-SMN mice may be useful for neuromuscular studies including spinal muscular atrophy (SMA).
Tg(SMN2)89Ahmb
008209Under Development for Production
FVB.Cg-Smn1tm1Msd Tg(ACTA1-SMN)69Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn ; HSA69-SMN mice may be useful for neuromuscular studies including spinal muscular atrophy (SMA).
Tg(SMN2)89Ahmb
008212Under Development for Production
STOCK Smn1tm1Msd Tg(Prnp-SMN)92Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn ; PrP92-SMN mutant mice may be useful in neuromuscular studies including spinal muscular atrophy (SMA).
Tg(Sox2-cre)1Amc
008454Under Development for Production
B6.Cg-Tg(Sox2-cre)1Amc/J
These transgenic mice express Cre recombinase under the control of the mouse SRY-box containing gene 2 promoter. This strain represents an effective tool for generating epiblast-derived specific targeted mutants that would be useful to study genes critical to embryogenesis.
Tg(TIE2GFP)287Sato
006770Under Development for Production
STOCK Rag1tm1Mom Tg(TIE2GFP)287Sato/J
To generate this double mutant strain, B6.Cg-Tg(TIE2GFP)287Sato/1J (Stock No. 004659 ) was crossed to C.129S7(B6)-Rag1tm1Mom /J (Stock No. 003145 ). This mutant mouse strain may be useful in studies examining angiogenesis in transplanted tissues.
Tg(Tagln-tTA)1Mrab
008082Under Development for Production
B6;SJL-Tg(Tagln-tTA)1Mrab Tg(tetO-Mcpt1)1Mrab/J
These SM22a-tTA/TRE-RVCH-HA bi-transgenic mice allow targeted overexpression or Tet-Off conditional expression of vascular chymase in smooth muscle cells, and may be useful in studying the role of elevated chymase activity in systemic hypertension and cardiovascular disease.
Tg(Tek-rtTA,TRE-lacZ)1425Tpr
005493On Hold
STOCK Tg(Tek-rtTA,TRE-lacZ)1425Tpr/J
Tg(Thy1-COP4/EYFP)9Gfng
007615Under Development for Production
B6.Cg-Tg(Thy1-COP4/EYFP)9Gfng/J
These transgenic mice, founder line 9, express the light activated ion channel, Channelrhodopsin-2 (from the green alga Chlamydomonas reinhardtii ), and Yellow Fluorescent Protein fusion gene (ChR2-YFP) under the control of the mouse thymus cell antigen 1 promoter. This mutant mouse strain may be useful for ex vivo and in vivo studies of neural circuitry by light stimulation, such as evoked mapping of neural connectivity.
Tg(Thy1-Stx1a/EYFP)1Sud
007880Under Development for Cryo
B6SJL-Tg(Thy1-Stx1a/EYFP)1Sud/J
The mice express a syntaxin 1A (brain)-enhanced yellow fluorescent protein fusion protein under the control of a Thy1 promoter. Fluorescence patterns have not been characterized.
Tg(Trp53R172H)8512Jmr
007962Under Development for Production
B6.FVB-Tg(MMTV-neu/OT-I/OT-II)CBnel Tg(Trp53R172H)8512Jmr/J
Approximately 85% of the compound mutant females develop focal mammary tumors at 6-10 months of age. Both virgin and breeder mice develop tumors. Approximately 37% of tumor-bearing mice develop metastatic disease to the lung. High expression of neu is detected in tumor tissue while very low levels are found in lung and ovary.
Female mice carrying only the neuOT-I/OT-II mutation develop focal mammary tumors at approximately 18 months of age.
Tg(UBC-cre/ESR1)1Ejb
008407Under Development for Production
STOCK Epas1tm1Mcs /J
These mutant mice carrying a (floxed) Epas1 (endothelial PAS domain protein 1) allele, Epas12lox , may be useful in generating conditional mutations for studies related to erythropoiesis.
Tg(UBC-scFv)2Nemz
006259Under Development for Production
B6.Cg-Pepcb Ptprca Tg(UBC-scFv)2Nemz/J
These "kappa-macroself Ag#2" transgenic mice may be useful to study B cell receptor editing, B cell tolerance in polyclonal immune systems, and for the rapid screening of mutants of interest for potential defects in B cell tolerance.
Tg(Vil-cre)997Gum
008196Under Development for Production
STOCK Gata6tm2.1Sad /J
These Gata6loxp mice may be useful in generating conditional GATA binding protein 6 mutations for studying GATA6 function in organogenesis or in adult mice.
Tg(tetO-DTA)1Gfi
008168Under Development for Production
STOCK Tg(tetO-DTA)1Gfi/J
These tet-DTA mice express diphtheria toxin A (DTA) under the control of a tetracycline operator (tetO ; also called tetracycline-responsive element (TRE) or tet-operator) and a cytomegalovirus minimal promoter, and may be useful in generating bi-transgenic mutant mice for the reversible, inducible deletion of specific groups of cells.
Tg(tetO-Mcpt1)1Mrab
008082Under Development for Production
B6;SJL-Tg(Tagln-tTA)1Mrab Tg(tetO-Mcpt1)1Mrab/J
These SM22a-tTA/TRE-RVCH-HA bi-transgenic mice allow targeted overexpression or Tet-Off conditional expression of vascular chymase in smooth muscle cells, and may be useful in studying the role of elevated chymase activity in systemic hypertension and cardiovascular disease.
Tg(tetO-cre)1Jaw
006234Under Development for Production
B6.Cg-Tg(tetO-cre)1Jaw/J
These transgenic mice express Cre recombinase under the control of a tetracycline-responsive promoter element (TRE or tetO) and are an effective tool for generating inducible, tissue-specific, targeted mutants to study cell lineage during development. When bred with another transgenic mouse expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA), Cre mediated recombination in the resulting bitransgenic offspring can be regulated with the tetracycline analog, doxycycline.
Tg(tetO-cre)1Jaw
008244Under Development for Production
FVB.Cg-Tg(tetO-cre)1Jaw/J
This strain represents an effective tool for generating inducible, tissue-specific-targeted mutants to study cell lineage during development.
006226On Hold
C57BL/6J-Chr 4PWD/Ph /ForeJ
000735On Hold
CASA/RkJ
005156Under Development for Cryo
B6.D2-(rs3653796 -rs3022971 )/LusJ
This strain is one of a set of overlapping congenic strains called genome-tagged mice (GTM). Each member of the panel carries an average of a 23 cM segment (range 8 to 58 cM) from DBA/2J introgressed on to a C57BL/6J background. GTM are a valuable resource for mapping and confirmation of loci contributing to complex traits.
005205Under Development for Cryo
B6.D2-(rs3696933 -rs3672215 )/LusJ
This strain is one of a set of overlapping congenic strains called genome-tagged mice (GTM). Each member of the panel carries an average of a 23 cM segment (range 8 to 58 cM) from DBA/2J introgressed on to a C57BL/6J background. GTM are a valuable resource for mapping and confirmation of loci contributing to complex traits.
007676Under Development for Production
B6.129(CD1)-Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo /J
These mT/mG mice are useful as a Cre reporter strain; expressing red fluorescence prior to, and green fluorescence following, Cre-mediated recombination in widespread cell and tissue types.
006059Under Development for Production
B6.CAST-(rs134763180-rs13476395 )/LusJ
This strain is one of a set of overlapping congenic strains called genome-tagged mice (GTM). Each member of the panel carries an average of a 23 cM segment (range 8 to 58 cM) from CAST/Ei introgressed on to a C57BL/6J background. GTM are a valuable resource for mapping and confirmation of loci contributing to complex traits.
007093Under Development for Production
BXD43/RwwJ
The BXD#/Rww recombinant inbred (RI) strains originate from crosses between C57BL/6J (000664) females and DBA/2J (000671) males and were generated using a strategy of advanced intercrosses (AI). They may be used to study the genetics of behavioral phenotypes (including alcohol and drug addiction, stress, and locomotor activity) and complex or potentially complex physiologic phenotypes (including differences in organ weight and bone mineral density).
007105Under Development for Production
BXD60/RwwJ
The BXD#/Rww recombinant inbred (RI) strains originate from crosses between C57BL/6J (000664) females and DBA/2J (000671) males and were generated using a strategy of advanced intercrosses (AI). They may be used to study the genetics of behavioral phenotypes (including alcohol and drug addiction, stress, and locomotor activity) and complex or potentially complex physiologic phenotypes (including differences in organ weight and bone mineral density).
007115Under Development for Production
BXD70/RwwJ
The BXD#/Rww recombinant inbred (RI) strains originate from crosses between C57BL/6J (000664) females and DBA/2J (000671) males and were generated using a strategy of advanced intercrosses (AI). They may be used to study the genetics of behavioral phenotypes (including alcohol and drug addiction, stress, and locomotor activity) and complex or potentially complex physiologic phenotypes (including differences in organ weight and bone mineral density).
007121Under Development for Production
BXD77/RwwJ
The BXD#/Rww recombinant inbred (RI) strains originate from crosses between C57BL/6J (000664) females and DBA/2J (000671) males and were generated using a strategy of advanced intercrosses (AI). They may be used to study the genetics of behavioral phenotypes (including alcohol and drug addiction, stress, and locomotor activity) and complex or potentially complex physiologic phenotypes (including differences in organ weight and bone mineral density).
007124Under Development for Production
BXD80/RwwJ
The BXD#/Rww recombinant inbred (RI) strains originate from crosses between C57BL/6J (000664) females and DBA/2J (000671) males and were generated using a strategy of advanced intercrosses (AI). They may be used to study the genetics of behavioral phenotypes (including alcohol and drug addiction, stress, and locomotor activity) and complex or potentially complex physiologic phenotypes (including differences in organ weight and bone mineral density).
007135Under Development for Production
BXD92/RwwJ
The BXD#/Rww recombinant inbred (RI) strains originate from crosses between C57BL/6J (000664) females and DBA/2J (000671) males and were generated using a strategy of advanced intercrosses (AI). They may be used to study the genetics of behavioral phenotypes (including alcohol and drug addiction, stress, and locomotor activity) and complex or potentially complex physiologic phenotypes (including differences in organ weight and bone mineral density).
005519Under Development for Production
C57BL/6J-Chr 13PWD/Ph /ForeJ
This strain represents one of a panel of inter-species chromosome substitution (or consomic) strains (IC-ISS). Each strain carries a chromosome from the Mus musculus musculus wild-derived strain PWD/Ph introgressed into a Mus musculus domesticus C57BL/6J background. The IC-ISS strains represent a tool for dissection of quantitative trait loci.
005996Under Development for Production
C57BL/6J-Chr 7PWD/Ph /ForeJ
008452Under Development for Production
STOCK Eif2ak4tm1Dron /J
Mice homozygous for the GCN2.KO4conditional allele have loxP sites flanking exon XII of the eukaryotic translation initiation factor 2 alpha kinase 4 (Eif2ak4 or GCN2) targeted gene, and may be useful in generating conditional mutations for studying eIF2 (eukaryotic initiation factor 2) phosphorylation in response to environmental stresses (amino acid starvation, proteasome inhibition and UV irradiation).
Strains Newly Available for all Research Tools models.