New strains under development - Research area: Metabolism Research

 
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Strains Newly Available for all Metabolism Research models.
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Metabolism Research

	Allele Symbol   Strain Description	Stock Number	Strain Name    (link to Data Sheet)
	Adipoqtm1Chan	008195 Under Development for Production	B6.129-Adipoqtm1Chan/J
	These adiponectin-deficient (Adipoq-/- or Adipo-/-) mice may be useful in studying obesity, diabetes, insulin resistance, metabolism, inflammation, leukocyte-endothelium interactions, and colitis.
	Bchetm1Loc	008077 Under Development for Production	129S1/Sv-Bchetm1Loc/J
	These BChE (butyrylcholinesterase) mutant mice are a model for human butyrylcholinesterase deficiency and may be useful for studying metabolic effects of organophosphorus toxicants or nerve agents, neurotransmitter function, and anti-Alzheimer's drug therapies.
	Car3tm1Gkim	005358 Under Development for Cryo	129S6/SvEvTac-Car3tm1Gkim/J
	Dldtm1Ptl	008333 Under Development for Production	B6;129P2-Dldtm1Ptl/J
	These Dld (dihydrolipoamide dehydrogenase or E3 component) mutant mice may be useful to study early murine embryonic metabolism, including glucose and mitochondrial metabolism during the early postimplantation period. As altered energy metabolism and reductions in alpha-ketoacid dehydrogenase complexes have also been associated with many neurodegenerative disorders, these mice may also be useful in studies related to Parkinson's disease, Huntington's disease, and/or Alzheimer's disease. Because the metabolic disturbances associated with E3 deficiency (Dld deficiency) cause a variant of Maple Syrup Urine Disease (MSUD) in which there is an accompanying lactic acidosis due to concomitant deficiency of pyruvate dehydrogenase complex, these mice may be useful in such studies or in conjunction with iMSUD mice (Stock No. 006999).
	Gusbtm3Sly	005644 Under Development for Production	B6.129X-Gusbtm3Sly/J
	Homozygous mice for this targeted mutation in beta glucuronidase (Gusb) exhibit growth retardation, shortened extremities, and facial dysmorphism. This model has increased urinary glycosaminoglycan and secondary elevation of other lysosomal storage enzymes. This strain represents a model of human GUS deficiency characterized by the most prevalent human mutation, L176F, and is associated with mild Mucopolysaccharidosis type VII (MPS VII or Sly Syndrome).
	Hmox1tm1Poss	008311 Under Development for Production	FVB.129S2(B6)-Hmox1tm1Poss/J
	Mice that are homozygous for this Hmox1 (heme oxygenase (decycling) 1) targeted mutation develop anemia with diminished serum iron, increased serum ferritin, iron accumulation in kidney and liver and progressive chronic inflammatory disease. Homozygotes occur at a lower than expected frequency, or are not produced, from heterozygous crosses and have decreased postnatal survival. This mutant mouse strain may be useful in studies of hemochromatosis, inflammation and iron metabolism.
	Ppargtm2Yba	008079 Under Development for Production	129S-Ppargtm2Yba/J
	These mice express tTA (tetracycline regulated transactivator) and a tetO-driven Flag-tagged Pparg from the endogenous Pparg locus. Although heterozygous mice exhibit lipodystrophy, hyperinsulinemia, pancreatic islet hyperplasia, and severe glucose intolerance, they do not develop steatosis or type II diabetes. Treatment with doxycycline prevents these phenotypes when administered starting at midgestation whereas a 6 week treatment administered to pubertal heterozygotes reverses most of these phenotypes. This strain may be useful in studies of lipodystrophy.
	Ppargtm3Yba	008227 Under Development for Production	B6.129S4-Ppargtm3Yba/J
	These mice express tTA (tetracycline regulated transactivator) from the endogenous Pparg locus. Heterozygotes exhibit mild lipodystrophy with pale, unilocular brown adipocytes, hypertrophy of brown fat, reduced subcutaneous fat, reduced gonadal fat pads, mild hepatomegaly and develop insulin resistance and dyslipidemia. Treatment with doxycycline prevents this phenotype. This mutant mouse strain may be useful in studies of lipodystrophy.
	Tg(APOE-DGAT2)24Far	007744 Under Development for Production	C57BL/6-Tg(APOE-DGAT2)24Far/J
	These Liv-DGAT2-low transgenic mice may be useful in studying hepatic steatosis, lipid, glucose, and insulin metabolism, as well as obesity and diabetes.
	Tg(APOE-NPC1L1)20Lqyu	008408 Under Development for Production	B6;D2-Tg(APOE-NPC1L1)20Lqyu/J
	These transgenic mice express the human NPC1 (Niemann-Pick disease, type C1, gene)-like 1 (NPC1L1) gene under the control of the human apolipoprotein E (APOE) promoter and hepatic control region. This mutant mouse strain exhibits decreased biliary cholesterol levels, which is associated with increased plasma cholesterol levels, and may be useful in studies related to lipid metabolism and cholesterol transport.
	Tg(Alb1-Ren)1Unc	007853 Under Development for Production	129S/SvEv-Tg(Alb1-Ren)1Unc/CofJ
	These RenTgMK mice may be useful in studying the effects of genetically clamped renin (and angiotensin II) on hypertension, diabetic nephropathy, albuninurea, nephrosclerosis, and other aspects of the renin–angiotensin system (RAS).
	Tg(IGFBP1)2Miel	008221 Under Development for Production	B6.Cg-Tg(IGFBP1)2Miel/J
	These hIGFBP-1 (insulin-like growth factor binding protein 1, human) transgenic mice may be useful in studying metabolic and vascular homeostasis, diabetes, and the role of insulin-like growth factor binding protein in placentation and preeclampsia.
	Tg(IGFBP2)1Miel	008222 Under Development for Production	B6.FVB-Tg(IGFBP2)1Miel/J
	These IGFBP-2 overexpressing transgenic mice may be useful in studying metabolic homeostasis, adipocyte biology, and the role of insulin-like growth factor binding protein in protecting against obesity- and age-associated complications (such as hypertension and diabetes).

(13 stocks)

 

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