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Metabolism Research

 
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Metabolism Research

Allele Symbol
 
Strain Description		 Stock Number Strain Name
   (link to Data Sheet)
Apoetm1Unc 007069
On Hold		 AKR.129P2(B6)-Apoetm1Unc/J
Mice homozygous for this Apoe (apolipoprotein E) targeted mutation, Apoetm1Unc, may be useful for studying impaired immune response, lipid and leptin homeostasis, atherosclerosis, hematopoiesis, hearing loss, xanthoma, behavior and learning defects, neurodegeneration, Alzheimer's Disease and diet-induced obesity without diabetes.
Arrdc3Gt(CSE151)Byg 017888
Awaiting Transfer from the Donor		 B6;129P2-Arrdc3Gt(CSE151)Byg/J
These Arrdc3 KO/KI mice express a LacZ/neo fusion protein from the Arrdc3 promoter. Surviving homozygotes display a range of metabolic traits.
Ccktm1Lcs 017710
In Progress		 B6.129-Ccktm1Lcs/J
The cholecystokinin gene is disrupted by the insertion of a β-geo fusion cassette in these knockin/knockout mice. LacZ is detected in the gut and brain, and homozygotes exhibit a range of metabolic and behavioral defects.
Cyp46a1tm1Rus 017759
In Progress		 B6;129S7-Cyp46a1tm1Rus/J
Expression of Cyp46a1 is disrupted in this tau-β-lacZ fusion protein knockin strain. These mice may be useful for studying cholesterol turnover in brain tissues.
Gnmttm1Cwa 018066
In Progress		 B6.129-Gnmttm1Cwa/J
In this strain a NEO cassette replaces exon1 and the promoter region of the Gnmt gene. This strain is a model for Glycine N-Methyltransferase Deficiency and has applications in studies of methionine metabolism, methylation and molecular markers for hepatocellular carcinoma.
Hfe2tm1Nca 017788
In Progress		 129S-Hfe2tm1Nca/J
These Hfe2 knockout mice exhibit iron loading and have applications in studies of juvenile or Type2A hemochromatosis, iron homeostasis and iron-induced oxidative damage.
Hfetm2Nca 017785
In Progress		 129S-Hfetm2Nca/J
These mice carry a targeted mutation of Hfe, hemochromatosis, exhibit iron loading, and have applications in studies of hereditary hemochromatosis, iron homeostasis and innate immune response
Hfetm2Nca 017784
Under Development for Cryo		 B6.129S6-Hfetm2Nca/J
These mice carry a targeted mutation of Hfe, hemochromatosis, exhibit iron loading, and have applications in studies of hereditary hemochromatosis, iron homeostasis and innate immune response.
Mc3rtm1Butl 017866
In Progress		 B6(Cg)-Mc3rtm1Butl/J
When these Mc3r-/- floxed-STOP mice are bred to mice that express Cre recombinase, resulting bi-allelic offspring will have a floxed-STOP sequence deleted in cre-expressing tissues, allowing Mc3r expression. These mice may be useful when studying metabolism and obesity.
Pasktm1Weng 017709
In Progress		 B6.129S6-Pasktm1Weng/J
The Pask gene is disrupted by the insertion of an IRES-β-geo fusion cassette in these knockin/knockout mice. LacZ is detected in testis and homozygotes exhibit a range of metabolic traits.
Pik3catm1Jjz 017704
Awaiting Transfer from the Donor		 B6N.129-Pik3catm1Jjz/J
These p110αflox mice possess loxP sites flanking exon 1 of the phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (Pik3ca) gene. This strain may be useful for studying insulin signaling, and hepatic glucose and lipid metabolism.
Pik3cbtm1Jjz 017705
Awaiting Transfer from the Donor		 B6N.129S(Cg)-Pik3cbtm1Jjz/J
These p110βflox mice possess loxP sites flanking exon 2 of the phosphatidylinositol 3-kinase, catalytic, beta polypeptide (Pik3cb) gene. These mice may be useful for studying insulin signaling and cell proliferation.
Sirt4tm1Fwa 012756
Awaiting Transfer from the Donor		 129-Sirt4tm1Fwa/J
The targeted mutation replace exon 1-3 of the mouse sirtuin (silent information regulator 2 (Sir2)) homolog 4, Sirt4, gene with a β-galactosidase (lacZ) cassette, abolishing gene function. These mice may be useful in studying life span and the effects of sirtuin and calorie restriction on amino acid-stimulated insulin secretion and mitochondrial regulation.
Sirt5tm1Fwa 012757
Awaiting Transfer from the Donor		 129-Sirt5tm1Fwa/J
The targeted mutation replace exon 2-5 of the mouse sirtuin (silent information regulator 2 (Sir2)) homolog 5, Sirt5, gene with a β-galactosidase (lacZ) cassette, abolishing gene function. These mice may be useful in studying life span and the effects of sirtuin and food restriction on ammonia detoxification and disposal though CPS1 activation.
Slc11a2tm2Nca 017789
In Progress		 129S-Slc11a2tm2Nca/J
These Dmt1fl mice possess loxP sites flanking exons 6-8 of the solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (Slc11a2) gene and have applications in studies related to anemia, iron homeostasis and micronutrient and drug absorption in the intestine.
Slc19a3tm1Said 017343
In Progress		 STOCK Slc19a3tm1Said/J
This THTR-2- knockout mouse line has a deletion of exons 1-2 of the Slc19a3 gene. These mice may be useful in studying the role of thiamin transporters in regulating thiamin homeostasis in different cells; including liver and kidney cells.
Slc29a1tm1Msg 017739
Awaiting Transfer from the Donor		 B6.129X1-Slc29a1tm1Msg/J
These ENT-/- mice are deficient for Slc29a1 and exhibit decreased sensitivity to the effects of ethanol intoxication, decreased anxiety-like behavior and increased alcohol consumption. They have applications in studies related to alcohol dependence.
Slc29a1tm2Msg 017792
Awaiting Transfer from the Donor		 129X1/SvJ-Slc29a1tm2Msg/J
These ENT1 flox mice have loxP sites flanking exons 2 through 4 of the Slc29a1 gene and have applications in studies related to anxiety and alcohol dependence.
Slc40a1tm2Nca 017790
In Progress		 129S-Slc40a1tm2Nca/J
These ferroportinfl mice possess loxP sites flanking exons 6 and 7 of the solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1) gene and have applications in studies related to type 4 hemochromatosis, anemia, and iron homeostasis.
Tg(CAG-CYP27A1)23Etl 009109
On Hold		 B6.CBA-Tg(CAG-CYP27A1)23Etl/J
These CYP27 overexpressor transgenic mice (or CYP27overexp mice) have widespread expression of human cytochrome P450, family 27, subfamily A, polypeptide 1 directed by the CAG promoter. These mice may be useful in studying the conversion of cholesterol to bile acids (bile acid synthesis) by both the classical and alternate pathways, as well as lipid and cholesterol homeostasis research.
Tg(SOD1*G93A)1Gur 013199
Awaiting Transfer from the Donor		 FVB.Cg-Tg(SOD1*G93A)1Gur/J
These SOD1-G93A (also called G93A-SOD1) transgenic mice may be useful in studying neuromuscular disorders, including Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease).
Tg(Th-FTH1)1Jkan 017862
Awaiting Transfer from the Donor		 B6;D2-Tg(Th-FTH1)1Jkan/J
These pTH-ferritin transgenic mice exhibit increased ferritin-bound iron levels in the brain, decreased ferrous iron levels in the substantia nigra, and reduced sensitivity to MPTP-induced Parkinson's disease-like symptoms. They have applications in studies related to iron deficiency and Parkinson's disease.
Tg(tetO-Hamp)2181Nca 017791
Under Development for Cryo		 B6.Cg-Tg(tetO-Hamp)2181Nca/J
This TRE.Hepc1 transgenic strain can be used to generate bitransgenic mice with spatio-temporal specific inducible overexpression of mouse Hamp, which may be useful in studies of anemia of inflammation and iron homeostasis.

(23 stocks)

 

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