New strains under development - Research area: Virology Research

 
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Virology Research

	Allele Symbol   Strain Description	Stock Number	Strain Name    (link to Data Sheet)
	Cd4tm1Mak	006483 Under Development for Production	CBy.129S2(B6)-Cd4tm1Mak/J
	Cell surface expression of CD4 protein is not detected on thymocytes and lymph node cells from mice homozygous for this Cd4 (CD4 antigen) targeted mutation. Homozygous mutant mice also show a Class II restricted deficit in helper T-cell activity and other T-cell responses. This mutant mouse strain may be useful in studies of T cell development, susceptibility to viral infection and inflammation.
	Mirn155tm1.1Rsky	007745 Under Development for Production	B6.Cg-Mirn155tm1.1Rsky/J
	These bic/mir-155 mutant mice may be useful in mircoRNA biology, specifically to study the role of miR-155 and its target genes (including cytokines, chemokines, and transcription factors) in homeostasis and function of the immune system.
	Rag2tm1Cgn	008309 Under Development for Production	C57BL/6-Rag2tm1Cgn/J
	These RAG-2fl mice harbor loxP sites flanking the entire coding region of the Rag2 (recombination activating gene 2) locus. When bred to mice that express Cre recombinase, the resulting offspring will have exon 3 deleted in the cre-expressing tissue(s). These RAG-2fl mice may be useful in generating conditional mutations for studying the role of RAG-2 in B and T cell development (including cancer and toxicology research as a xenograft/transplant host), T and B cell receptor (V(D)J) recombination, hematopoiesis, hematology, immunology, and inflammation research.
	Serpinb9tm1Arp	008158 Under Development for Production	C57BL/6-Serpinb9tm1Arp/J
	These Serpinb9-deficient (Spi6-/-) mutant mice have impaired cytotoxic T lymphocyte (CTL) immunity to viruses and may be useful in studies of viral immune response and inflammation, and the exocytosis pathway in CTL apoptosis.
	Usp18tm1Dzh	007225 Under Development for Production	FVB.129(B6)-Usp18tm1Dzh/J
	These Usp18 (or Ubp43)-mutant mice may be useful in studying interferons and their receptors, cellular function, signal transduction, and the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway.

(5 stocks)

 

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