Allele Symbol Stock Number Strain Name
Aw-J 002703On Hold
B6CBACa Aw-J /A -Hydinhy3 /J
Apoetm1Unc 007069Under Development for Production
AKR.129P2(B6)-Apoetm1Unc /J
Mice homozygous for this Apoe (apolipoprotein E) targeted mutation, Apoetm1Unc , may be useful for studying impaired immune response, lipid and leptin homeostasis, atherosclerosis, hematopoiesis, hearing loss, xanthoma, behavior and learning defects, neurodegeneration, Alzheimer's Disease and diet-induced obesity without diabetes.
Apoetm1Unc 007067Under Development for Production
D2.129P2(B6)-Apoetm1Unc /J
Mice homozygous for the Apoetm1Unc mutation on the DBA/2J background may be useful in studies of diet-induced obesity without diabetes, Alzheimer's Disease, neurodegeneration, atherosclerosis and hypercholesterolemia.
Atcayji 008140Under Development for Production
B6.C(Cg)-Atcayji /BurJ
Mice homozygous for the spontaneous mutation, jittery (ji ) in Atcay (ataxia, cerebellar, Cayman type homolog), exhibit severe, progressive ataxia and die at approximately 4 weeks of age. This mutant mouse strain represents a model that may be useful in studies of congenital ataxia.
Bchetm1Loc 008077Under Development for Production
129S1/Sv-Bchetm1Loc /J
These BChE (butyrylcholinesterase) mutant mice are a model for human butyrylcholinesterase deficiency and may be useful for studying metabolic effects of organophosphorus toxicants or nerve agents, neurotransmitter function, and anti-Alzheimer's drug therapies.
Car3tm1Gkim 005358Under Development for Cryo
129S6/SvEvTac-Car3tm1Gkim /J
Car4tm1Sly 008217Under Development for Production
B6.129S1-Car4tm1Sly /J
Mice that are homozygous for this targeted mutation exhibit decreased sensitivity to an inhibitor, benzolamide, of pH regulation in the extracellular space in the hippocampus when compared to wildtype controls. This mutant mouse strain may be useful in studies of pH shifts that accompany neuronal activity and neuronal physiology.
Cdh23ahl 000668On Hold
C57L/J
Cdh23ahl 007048On Hold
DBA/2J-Gpnmb+ /SjJ
This coisogenic strain has a functional allele of Gpnmb . Homozygous mice do not develop the elevated intraocular pressure or glaucoma found in DBA/2J mice (Stock 000671), although they exhibit a mild iris stromal atrophy (ISA). This strain provides a genetically matched control for DBA/2J.
Dldtm1Ptl 008333Under Development for Production
B6;129P2-Dldtm1Ptl /J
These Dld (dihydrolipoamide dehydrogenase or E3 component) mutant mice may be useful to study early murine embryonic metabolism, including glucose and mitochondrial metabolism during the early postimplantation period. As altered energy metabolism and reductions in alpha-ketoacid dehydrogenase complexes have also been associated with many neurodegenerative disorders, these mice may also be useful in studies related to Parkinson's disease, Huntington's disease, and/or Alzheimer's disease. Because the metabolic disturbances associated with E3 deficiency (Dld deficiency) cause a variant of Maple Syrup Urine Disease (MSUD) in which there is an accompanying lactic acidosis due to concomitant deficiency of pyruvate dehydrogenase complex, these mice may be useful in such studies or in conjunction with iMSUD mice (Stock No. 006999 ).
Drd4tm1Dkg 008084Under Development for Production
B6.129P2-Drd4tm1Dkg /J
These D4R-mutant mice harbor a dopamine receptor 4 (Drd4 ; also called dopamine D4 receptor (D4R)) targeted mutation where exon 2 is replaced with a neomycin resistance cassette, and may be useful in studying dopamine/neurotransmitter function, drug addiction, Parkinson's disease, and schizophrenia or other psychoses.
Efna2tm1Jgf 005992Under Development for Production
STOCK Efna2tm1Jgf Efna5tm1Ddmo /J
These ephrin A2/ephrin A5 double mutant mice may be useful in studies of retinocollicular mapping, axon topography, neuron projection, and modality-specific compartmentalization of visual, auditory, and somatosensory thalamic relay pathways.
Efna5tm1Ddmo 005992Under Development for Production
STOCK Efna2tm1Jgf Efna5tm1Ddmo /J
These ephrin A2/ephrin A5 double mutant mice may be useful in studies of retinocollicular mapping, axon topography, neuron projection, and modality-specific compartmentalization of visual, auditory, and somatosensory thalamic relay pathways.
Eif2ak4tm1.1Dron 008452Under Development for Production
B6;129-Eif2ak4tm1.1Dron /J
Mice homozygous for the GCN2.KO4conditional allele (also called GCN2.KO4c) have loxP sites flanking exon XII of the eukaryotic translation initiation factor 2 alpha kinase 4 (Eif2ak4 or GCN2) targeted gene, and may be useful in generating conditional mutations for studying eIF2 (eukaryotic initiation factor 2) phosphorylation in response to environmental stresses (amino acid starvation, proteasome inhibition and UV irradiation).
Eif2ak4tm1.2Dron 008240Under Development for Production
B6.129S6-Eif2ak4tm1.2Dron /J
Mice homozygous for the GCN2.KO4 mutant locus (also called GCN2.KO4- , GCN2- , GCN2.KO4ex , or GCN2-KO) have a deletion of exon XII of the eukaryotic translation initiation factor 2 alpha kinase 4 (Eif2ak4 or GCN2) gene, and may be useful in studying eIF2 (eukaryotic initiation factor 2) phosphorylation in response to environmental stresses (amino acid starvation, proteasome inhibition and UV irradiation).
Epas1tm1Mcs 008407Under Development for Production
STOCK Epas1tm1Mcs /J
These mutant mice carrying a (floxed) Epas1 (endothelial PAS domain protein 1) allele, Epas12lox , may be useful in generating conditional mutations for studies related to erythropoiesis.
Fxntm1Mkn 008398Under Development for Production
B6.Cg-Fxntm1Mkn Tg(FXN)YG8Pook/J
Mice that are homozygous for the Fxntm1Mkn (frataxin) targeted allele and hemizygous for the Tg(FXN)YG8Pook (frataxin, human) transgene, display an age dependent, tissue specific expansion of the GAA repeat, with expansion accumulation in the CNS (particularly cerebellum), similar to the human pathology of Friedreich Ataxia. This strain is maintained heterozygous for the targeted mutation and hemizygous for the transgene.
Gabrb3tm2.1Geh 008310Under Development for Production
B6;129-Gabrb3tm2.1Geh /J
These Gabrb3 (gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3) conditional (floxed) mutant mice may be useful in generating conditional mutations for studying the role of neurodevelopmental diseases and sensitivity to anesthetics and ethanol.
Gli1tm3(cre/ESR1)Alj 007913Under Development for Production
STOCK Gli1tm3(cre/ESR1)Alj /J
When these Gli1-CreERT2 mice are bred with mice containing a loxP -flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Gli1 expressing cells; making them useful for studying axis patterning, proliferation, and cell fate specification of Hedgehog responding cells at different stages of embryogenesis.
Gpnmb+ 007048On Hold
DBA/2J-Gpnmb+ /SjJ
This coisogenic strain has a functional allele of Gpnmb . Homozygous mice do not develop the elevated intraocular pressure or glaucoma found in DBA/2J mice (Stock 000671), although they exhibit a mild iris stromal atrophy (ISA). This strain provides a genetically matched control for DBA/2J.
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo 007676Under Development for Production
B6.129(Cg)-Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo /J
These mT/mG mice are useful as a Cre reporter strain; expressing red fluorescence prior to, and green fluorescence following, Cre-mediated recombination in widespread cell and tissue types.
Gt(ROSA)26Sortm4(Ikbkb)Rsky 008242Under Development for Production
C57BL/6-Gt(ROSA)26Sortm1(Ikbkb)Rsky /J
These R26StopFL ikk2ca mice allow inducible expression of an activated form of Ikbkb (IKK2ca) and subsequent activation of the NF-kappaB transcription factor pathways.
Hc0 007048On Hold
DBA/2J-Gpnmb+ /SjJ
This coisogenic strain has a functional allele of Gpnmb . Homozygous mice do not develop the elevated intraocular pressure or glaucoma found in DBA/2J mice (Stock 000671), although they exhibit a mild iris stromal atrophy (ISA). This strain provides a genetically matched control for DBA/2J.
Hydinhy3 002703On Hold
B6CBACa Aw-J /A -Hydinhy3 /J
L1camtm1Sor 003518Under Development for Cryo
129/Sv-L1camtm1Sor /J
Leprtm1Mgmj 008518Under Development for Production
B6.129-Leprtm1Mgmj /J
Mice homozygous for the LeprS1138 mutant allele (or s/s mice) have a Tyr->Ser replacement at amino acid residue 1138 of the leptin receptor long form (LRb)-specific exon 18b that specifically disrupts LRb-STAT3 transcription factor signaling, and may be useful for studying LRb-STAT3 signaling in the physiological and metabolic function of leptin; specifically body energy homeostasis and neuroendocrine function, glucose homeostasis, melanocortin production, neuropeptide Y, obesity, diabetes, fertility and growth.
Leprtm2(cre)Rck 008320Under Development for Production
B6.129-Leprtm2(cre)Rck /J
Cre activity is demonstrable in the hypothalmus (arcuate, dorsomedial, lateral, and ventromedial nuclei), limbic and cortical brain regions (basolateral amygdaloid nucleus , piriform cortex, and lateral entorhinal cortex), and retrosplenial cortex. When bred with a mouse containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the flanked genome in tissues that normally express the targeted gene. This strain has been used in virus-assisted mapping of neural inputs and may be useful in studies of neural features of feeding behaviors.
Leprtm2Mgmj 008385Under Development for Production
B6.129-Leprtm2Mgmj /J
Mice homozygous for the LeprLeu985 mutant allele (or l/l mice) have a Tyr->Leu replacement at amino acid residue 985 of the leptin receptor long form (LRb)-specific exon 18b that specifically disrupts LRb-SHP2 and LRb-SOCS3 transcription factor signaling, and may be useful for studying the influence of LRb-SHP2 and LRb-SOCS3 signaling in the physiological and metabolic function of leptin; specifically body energy homeostasis and neuroendocrine function, glucose homeostasis, melanocortin production, neuropeptide Y, obesity, diabetes, fertility and growth.
Mecp2tm1Bird 007177Under Development for Production
B6.129P2-Mecp2tm1Bird /J
Mice with this X-linked floxed mutation of the methyl CpG binding protein 2 gene may be useful in neurological and developmental studies of Rett syndrome.
Mecp2tm1Bird 006847Under Development for Production
B6;129P2-Mecp2tm1Bird /J
Mice with this X-linked floxed mutation of the methyl CpG binding protein 2 gene may be useful in neurological and developmental studies of Rett syndrome.
Mlphln 000668On Hold
C57L/J
Nf1tm1Cbr 007923Under Development for Production
B6.129S1-Nf1tm1Cbr /J
Mice homozygous for this targeted allele (Nf123a-/-) lack the alternatively spliced exon 23a (which modifies the GTPase-activating protein (GAP) domain of Nf1). These mutant mice may be useful for neurological studies of Neurofibromatosis Type I, growth, differentiation, and learning and memory.
Nrgntm1Kph 008233Under Development for Production
B6.129-Nrgntm1Kph /J
These neurogranin mutant mice may be useful for neurological studies involving memory and learning, neuronal signaling pathways (including calmodulin, alpha-CaMKII, protein kinase A, protein kinase C, MAPK, and CREB), attention deficit-hyperactivity disorder (ADHD), and schizophrenia.
Nrxn1tm1Sud 006377Under Development for Cryo
B6;129-Nrxn3tm1Sud Nrxn1tm1Sud Nrxn2tm1Sud /J
Nrxn2tm1Sud 006377Under Development for Cryo
B6;129-Nrxn3tm1Sud Nrxn1tm1Sud Nrxn2tm1Sud /J
Nrxn2tm1Sud 006378Under Development for Production
B6;129-Nrxn2tm1Sud /J
Mice homozygous for this targeted mutation in neurexin II (Nrxn2 ) exhibit a high degree of perinatal lethality and their inhibitory postsynaptic currents (IPSC) are decreased in cortical slice cultures. These mice may be useful in the study of synaptic transmission.
Nrxn3tm1Sud 006377Under Development for Cryo
B6;129-Nrxn3tm1Sud Nrxn1tm1Sud Nrxn2tm1Sud /J
Obq3C57L/J 000668On Hold
C57L/J
Obq4C57L/J 000668On Hold
C57L/J
Pde10atm1Pfi 008210Under Development for Production
B6.D1-Pde10atm1Pfi /J
These PDE10AC57 mutant mice are deficient in phosphodiesterase 10A activity, and may be useful in neurobiological studies including metabolic inactivation of intracellular signal transduction pathways by cyclic phosphodiesterases (PDEs), regulation of information processing by basal ganglia circuitry, and striatal hypofunction or psychotic disease.
Per1tm1Brd 008530Under Development for Production
B6;129S7-Per1tm1Brd Per2tm1Brd /J
Mice that are double homozygous mutants for the Per1tm1Brd (period homolog 1 (Drosophila)) and Per2tm1Brd (period homolog 2 (Drosophila)) alleles do not exhibit circadian rhythm when kept in constant darkness. A light pulse does not reestablish circadian rhythm. This mutant mouse strain may be useful in studies of circadian rhythm.
Per1tm1Brd 008371Under Development for Production
B6;129S7-Per1tm1Brd /J
When housed in complete darkness mice that are homozygous for the Per1 (period homolog 1 (Drosophila)) targeted mutation display a significantly shorter average circadian period. Homozygotes also display a 6-fold increase in variability of circadian period length. This mutant mouse strain may be useful in studies of circadian rhythm.
Per2tm1Brd 008530Under Development for Production
B6;129S7-Per1tm1Brd Per2tm1Brd /J
Mice that are double homozygous mutants for the Per1tm1Brd (period homolog 1 (Drosophila)) and Per2tm1Brd (period homolog 2 (Drosophila)) alleles do not exhibit circadian rhythm when kept in constant darkness. A light pulse does not reestablish circadian rhythm. This mutant mouse strain may be useful in studies of circadian rhythm.
Pvalbtm1(cre)Arbr 008069Under Development for Production
B6;129P2-Pvalbtm1(cre)Arbr /J
This strain expresses Cre recombinase from the endogenous Pvalb , parvalbumin, locus. When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination results in tissue-specific deletion of the target.
This mutant mouse strain represents a model that may be useful in studies of neuronal differentiation.
Rab3atm1Sud 006375Under Development for Production
B6;129-Rab3btm1Sud Rab3atm1Sud Rab3dtm1Rja Rab3ctm1Sud /J
These mice carry targeted mutations in the Rab3a (RAB3A, member RAS oncogene family, Rab3b (RAB3B, member RAS oncogene family), Rab3c (RAB3C, member RAS oncogene family), and Rab3d (RAB3D, member RAS oncogene family) genes. Mice homozygous for all four targeted mutations die shortly after birth due to respiratory problems. Mutant mice display no apparent changes in synapse structure or brain composition except for the loss of rabphilin. The size of the excitatory postsynaptic current (EPSC) induced by action potentials is ~30% smaller in mutant mice as compared to controls. This mutant mouse strain may be useful in studies of synaptic vesicle exocytosis mechanisms in neurons.
Rab3btm1Sud 006375Under Development for Production
B6;129-Rab3btm1Sud Rab3atm1Sud Rab3dtm1Rja Rab3ctm1Sud /J
These mice carry targeted mutations in the Rab3a (RAB3A, member RAS oncogene family, Rab3b (RAB3B, member RAS oncogene family), Rab3c (RAB3C, member RAS oncogene family), and Rab3d (RAB3D, member RAS oncogene family) genes. Mice homozygous for all four targeted mutations die shortly after birth due to respiratory problems. Mutant mice display no apparent changes in synapse structure or brain composition except for the loss of rabphilin. The size of the excitatory postsynaptic current (EPSC) induced by action potentials is ~30% smaller in mutant mice as compared to controls. This mutant mouse strain may be useful in studies of synaptic vesicle exocytosis mechanisms in neurons.
Rab3ctm1Sud 006375Under Development for Production
B6;129-Rab3btm1Sud Rab3atm1Sud Rab3dtm1Rja Rab3ctm1Sud /J
These mice carry targeted mutations in the Rab3a (RAB3A, member RAS oncogene family, Rab3b (RAB3B, member RAS oncogene family), Rab3c (RAB3C, member RAS oncogene family), and Rab3d (RAB3D, member RAS oncogene family) genes. Mice homozygous for all four targeted mutations die shortly after birth due to respiratory problems. Mutant mice display no apparent changes in synapse structure or brain composition except for the loss of rabphilin. The size of the excitatory postsynaptic current (EPSC) induced by action potentials is ~30% smaller in mutant mice as compared to controls. This mutant mouse strain may be useful in studies of synaptic vesicle exocytosis mechanisms in neurons.
Rab3dtm1Rja 006375Under Development for Production
B6;129-Rab3btm1Sud Rab3atm1Sud Rab3dtm1Rja Rab3ctm1Sud /J
These mice carry targeted mutations in the Rab3a (RAB3A, member RAS oncogene family, Rab3b (RAB3B, member RAS oncogene family), Rab3c (RAB3C, member RAS oncogene family), and Rab3d (RAB3D, member RAS oncogene family) genes. Mice homozygous for all four targeted mutations die shortly after birth due to respiratory problems. Mutant mice display no apparent changes in synapse structure or brain composition except for the loss of rabphilin. The size of the excitatory postsynaptic current (EPSC) induced by action potentials is ~30% smaller in mutant mice as compared to controls. This mutant mouse strain may be useful in studies of synaptic vesicle exocytosis mechanisms in neurons.
Rmcfs 000668On Hold
C57L/J
Sgcbtm1Kcam 006831On Hold
129-Sgcbtm1Kcam /J
Slc6a3tm1.1(cre)Bkmn 006660Under Development for Production
B6.SJL-Slc6a3tm1.1(cre)Bkmn /J
These dopamine transporter IRES-cre (DATIREScre ) mutant mice exhibit co-localization of Cre recombinase and endogenous Slc6a3 (solute carrier family 6 (neurotransmitter transporter, dopamine), member 3) gene expression and may be useful in neurobiological studies to facilitate the analysis of gene function in dopaminergic neurons, such as drug addiction or Parkinson's disease.
Smn1tm1Msd 008203Under Development for Production
FVB.Cg-Smn1tm1Msd Tg(ACTA1-SMN)63Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn ; HSA63-SMN mice may be useful for neuromuscular studies including spinal muscular atrophy (SMA).
Smn1tm1Msd 008209Under Development for Production
FVB.Cg-Smn1tm1Msd Tg(ACTA1-SMN)69Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn ; HSA69-SMN mice may be useful for neuromuscular studies including spinal muscular atrophy (SMA).
Smn1tm1Msd 008206Under Development for Production
FVB.Cg-Smn1tm1Msd Tg(SMN2)566Ahmb/J
These mice may be useful in neuromuscular studies including spinal muscular atrophy (SMA).
Smn1tm1Msd 008212Under Development for Production
STOCK Smn1tm1Msd Tg(Prnp-SMN)92Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn ; PrP92-SMN mutant mice may be useful in neuromuscular studies including spinal muscular atrophy (SMA).
Smn1tm2Mrph 007246Under Development for Production
B6;129-Smn1tm2Mrph /J
This strain functions as a reporter strain for Smn1 (survival motor neuron 1) in the heterozygous state. Exons 1 through 8 of the mouse Smn1 gene (12.8 kb) were replaced with lacZ and an FRT site remaining from the deletion of a selection marker. This mutant mouse strain may be useful in studies of Spinal Muscular Atrophy.
Smn1tm3(SMN2/Smn1)Mrph 007249Under Development for Production
B6;129-Smn1tm3(SMN2/Smn1)Mrph /J
This allele is a functional null of survival motor neuron 1 (Smn1 ) in the non-recombined state and is engineered to revert to a fully functional Smn1 allele upon Cre-mediated recombination. This mutant mouse strain may be useful in studies of Spinal Muscular Atrophy.
Smn1tm3(SMN2/Smn1)Mrph 007951Under Development for Production
STOCK Smn1tm3(SMN2/Smn1)Mrph Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb/J
This triple mutant mouse harbors two transgenic alleles and a single targeted mutation. The Tg(SMN2*delta7)4299Ahmb allele consists of a human SMN2 (survival of motor neuron 2, centromeric) cDNA lacking exon 7 whereas the Tg(SMN2)89Ahmb allele consists of the entire human SMN2 gene. The targeted mutant Smn1tm3(SMN2/Smn1/SMN2)Mrph allele is engineered to revert to a fully functional Smn1 allele upon Cre-mediated recombination. This mutant mouse strain may be useful in studies of Spinal Muscular Atrophy.
Smn1tm4(SMN2)Mrph 008383Under Development for Production
B6;129-Smn1tm4(SMN2)Mrph /J
In this hybrid allele, exon 7 of Smn1 (survival motor neuron 1) is replaced with the equivalent exon from human SMN2 (survival of motor neuron 2, centromeric), and is skipped in approximately 90% of the processed mRNA. Further characterization is currently in progress. This mutant mouse strain may be useful in studies of Spinal Muscular Atrophy.
Smn1tm5(Smn1/SMN2)Mrph 008384Under Development for Production
B6;129-Smn1tm5(Smn1/SMN2)Mrph /J
In this hybrid allele, Smn allele C, contains two tandem Smn1/SMN2 genes. Further characterization is currently in progress. This mutant mouse strain may be useful in studies of Spinal Muscular Atrophy.
Ssttm1Ute 008117Under Development for Production
B6.129S4(129S6)-Ssttm1Ute /J
Somatostatin deficient mice exhibit increased baseline plasma growth hormone, corticosterone and total ghrelin levels and impaired motor performance. Hippocampal amyloid beta 42 peptides levels are elevated. This mutant mouse strain may be useful in studies of gastric homeostasis, learning and memory and endocrinology.
Timp2tm1Pds 008120Under Development for Production
B6.129S4-Timp2tm1Pds /J
These mice are deficient in TIMP-2, tissue inhibitor of metalloproteinase 2, and exhibit locomotor impairment, abnormal fear conditioning behavior, and defective neuronal differentiation. This mutant mouse strain may be useful in studies of extracellular matrix homeostasis, synaptic plasticity in behavior, learning and memory, neuronal differentiation and development of neuromuscular junctions.
Tnftm1Gkl 007082Under Development for Production
CByJ.129S(B6)-Tnftm1Gkl /J
Mice homozygous for the Tnftm1Gkl targeted mutation may be useful in studies of susceptibility to parasitic amd bacterial infection, endotoxin sensitivity and immune response.
Usp18tm1Dzh 007225Under Development for Production
FVB.129(B6)-Usp18tm1Dzh /J
These Usp18 (or Ubp43)-mutant mice may be useful in studying interferons and their receptors, cellular function, signal transduction, and the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway.
Rb(16.17)7Bnr
001887Under Development for Cryo
(STOCK Rb(6.16)24Lub x STOCK Rb(16.17)7Bnr)F1/J
Rb(6.16)24Lub
001887Under Development for Cryo
(STOCK Rb(6.16)24Lub x STOCK Rb(16.17)7Bnr)F1/J
Tg(ACTA1-SMN)63Ahmb
008203Under Development for Production
FVB.Cg-Smn1tm1Msd Tg(ACTA1-SMN)63Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn ; HSA63-SMN mice may be useful for neuromuscular studies including spinal muscular atrophy (SMA).
Tg(ACTA1-SMN)69Ahmb
008209Under Development for Production
FVB.Cg-Smn1tm1Msd Tg(ACTA1-SMN)69Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn ; HSA69-SMN mice may be useful for neuromuscular studies including spinal muscular atrophy (SMA).
Tg(APPSw)40Btla
008609Under Development for Production
129S1.129(Cg)-Tg(APPSw)40Btla/2J
These R1.40 transgenic mice express all mRNA and protein isoforms of the human amyloid beta (A4) precursor protein APP containing the Familial Alzheimer's Disease (FAD) Swedish mutation K670N/M671L, and may be useful in studying the pathogenesis of Familial Alzheimer's Disease and possible therapeutic treatments.
Tg(CAG-EGFP,-ALPP)2.6Ggc
008200Under Development for Production
FVB/N-Tg(CAG-EGFP,-ALPP)2.6Ggc/J
These piGAP transgenic reporter mice have expression of the eGFP-F-IRES-hPLAP dicistronic gene blocked by an upstream loxP -flanked STOP-polyA sequence. When bred to mice that express Cre recombinase, the resulting offspring will have the STOP-polyA sequence deleted in the cre -expressing tissue(s), permitting dicistronic expression of human Placental Alkaline Phosphatase (PLAP or ALPP ) and farnesylated Enhanced Green Fluorescent Protein (eGFP-F; optimized to target expression to the cytoplasmic side of the plasma membrane). These piGAP transgenic reporter mice allow Cre-inducible, eGFP-F and hPLAP expression in multiple cell and tissue types.
Tg(CAG-EGFP/CETN2)3-4Jgg
008234Under Development for Production
CB6-Tg(CAG-EGFP/CETN2)3-4Jgg/J
Transgenic GFP-CETN2 mice express an enhanced green fluorescent protein-labeled human Centrin-2 (EGFP-CETN2) under the control of the chicken beta-actin promoter (with cytomegalovirus immediate early enhancer). These GFP-CETN2 mice allow fluorescent staining of the centrioles of the centrosome, and may be useful for studying mitosis, microtubule organization, cell-cycle regulation, signal transduction, transcription activation, cell migration, DNA damage repair, and cancer.
Tg(CAG-Ub*G76V/GFP)1Dant
008111Under Development for Production
B6.Cg-Tg(CAG-Ub*G76V/GFP)1Dant/J
Both ubiquitin/proteasome system reporter (UPS reporter) founder lines, UbG76V -GFP/1 (Stock No. 008111) and UbG76V -GFP/2 (Stock No. 008112), may be useful for monitoring the role of ubiquitin/proteasome-dependent proteolysis in diverse disorders, and for efficacy trials testing the effect of compounds on the ubiquitin/proteasome system (including the effect of proteasome inhibitors as novel anticancer drugs).
Tg(Cspg4-DsRed.T1)1Akik
008241Under Development for Production
STOCK Tg(Cspg4-DsRed.T1)1Akik/J
These NG2DsRedBAC transgenic mice express an optimized red fluorescent protein variant (DsRed.T1) under the control of the mouse NG2 (Cspg4 ) promoter/enhancer and may be useful for fluorescent labeling of NG2 cells (oligodendrocyte progenitor cells) in the central nervous system and NG2-expressing cells in other organs, as well as for isolating NG2 cell populations via FACS.
Tg(DRD1-ctxA)7Burt
008367Under Development for Production
C.Cg-Tg(DRD1-ctxA)7Burt/J
These transgenic mice express the cholera toxin intracellular enzymatic subunit A1 under the direction of the human dopamine receptor D1, DRD1, promoter. Expression of the cholera toxin in the D1 dopamine receptor subtype neurons results in chronic potentiate neural activity in this specific neuron subset. This mutant mouse strain may be useful in studies of obsessive-compulsive disorder (OCD), Gilles De La Tourette Syndrome and Trichotillomania.
Tg(FXN)YG8Pook
008398Under Development for Production
B6.Cg-Fxntm1Mkn Tg(FXN)YG8Pook/J
Mice that are homozygous for the Fxntm1Mkn (frataxin) targeted allele and hemizygous for the Tg(FXN)YG8Pook (frataxin, human) transgene, display an age dependent, tissue specific expansion of the GAA repeat, with expansion accumulation in the CNS (particularly cerebellum), similar to the human pathology of Friedreich Ataxia. This strain is maintained heterozygous for the targeted mutation and hemizygous for the transgene.
Tg(HDexon1)62Gpb
004601On Hold
B6CBA-Tg(HDexon1)62Gpb/2J
Tg(HTT*97Q)IXwy
008197Under Development for Production
FVB/N-Tg(HTT*97Q)IXwy/J
These BACHD transgenic mice express a neuropathogenic, full-length human mutant Huntingtin (fl-mhtt) gene modified to harbor a loxP -flanked human mutant htt exon 1 sequence (containing 97 mixed CAA-CAG repeats encoding a continuous polyglutamine (polyQ) stretch). These mice may be useful in the testing of candidate therapeutics and in studies examining the contribution of mhtt expression in individual neuronal and non-neuronal cell types in the pathogenesis of HD-like phenotypes in vivo .
Tg(Mc4r-MAPT/GFP*)21Rck
008323Under Development for Production
B6.Cg-Tg(Mc4r-MAPT/GFP*)21Rck/J
These mice express a tau (MAPT)-sapphire green fluorescent protein (GFP) under the transcriptional control of the mouse melanocortin 4 receptor (Mc4r) promoter. This strain may be useful in studying the role of melanocortin signaling in the regulation of feeding behavior and autonomic homeostasis.
Tg(Npy-MAPT/GFP*)1Rck
008321Under Development for Production
B6.Cg-Tg(Npy-MAPT/GFP*)1Rck/J
These mice express a tau (MAPT)-sapphire green fluorescent protein (GFP) under the transcriptional control of the mouse neuropeptide Y (Npy) promoter. Fluorescence is observed in distinct neuronal populations of the hypothalamic arcuate nucleus. This strain has been useful in studying the role of neuropeptide Y and leptin in food intake. Hemizygotes are viable and fertile and do not display any gross physical or behavioral abnormalities.
Tg(Pomc-MAPT/GFP*)1Rck
008322Under Development for Production
B6.Cg-Tg(Pomc-MAPT/GFP*)1Rck/J
These mice express a tau (MAPT)-sapphire green fluorescent protein (GFP) under the transcriptional control of the mouse pro-opiomelanocortin-alpha (Pomc ) promoter. Immunohistochemistry for POMC in colchicine-treated animals demonstrated greater than 99% colocalization of POMC with the GFP-expressing neurons in the hypothalamic arcuate nucleus. This strain has been useful in studying the role of Pomc and leptin in food intake and may be useful in further understanding the function of the associated neurons.
Tg(Prnp-Abca1)EHol
008596Under Development for Production
B6.Cg-Tg(Prnp-Abca1)EHol/J
These transgenic mice express the mouse Abca1 (ATP-binding cassette, sub-family A (ABC1), member 1) gene under the control of the mouse Prnp (prion protein) promoter. These founder line E mice have a 6-fold increase in expression of ABCA1 in the cortex over wild-type levels. Transgenic mice exhibit reduced apoE levels in the hippocampus and cerebrospinal fluid (CSF). These mice may be useful in studies of the underlying mechanism of amyloid deposition in the brain and Alzheimers disease.
Tg(Prnp-ITM2B/APP695*42)A12Emcg
007182Under Development for Production
B6.Cg-Tg(Prnp-ITM2B/APP695*42)A12Emcg/J
These BRI-Abeta42 transgenic mice harbor a mouse prion promoter-driven BRI-Abeta42 fusion construct (containing a human type 2 transmembrane protein (BRI or ITM2B ) fused in-frame with a "wildtype APP695" cDNA sequence encoding amyloid-beta42 (Abeta42) at the furin-like cleavage site (the C-terminal 23 amino acid ABri peptide of BRI was replaced with the Abeta42 sequence)). As Abeta1-42 is fused to the C terminus of the BRI protein at the furin-like cleavage site, cleavage releases Abeta into the lumen or extracellular space, resulting in efficient secretion of Abeta1-42. Therefore, these BRI-Abeta42 transgenic mice specifically express the Abeta1-42 isoform in the absence of human amyloid beta protein precursor (APP) overexpression and may be useful in neurological studies of Alzheimer's disease, neurodegeneration, and amyloid plaque formation.
Tg(Prnp-SMN)92Ahmb
008212Under Development for Production
STOCK Smn1tm1Msd Tg(Prnp-SMN)92Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn ; PrP92-SMN mutant mice may be useful in neuromuscular studies including spinal muscular atrophy (SMA).
Tg(SMN2)566Ahmb
008206Under Development for Production
FVB.Cg-Smn1tm1Msd Tg(SMN2)566Ahmb/J
These mice may be useful in neuromuscular studies including spinal muscular atrophy (SMA).
Tg(SMN2)89Ahmb
008203Under Development for Production
FVB.Cg-Smn1tm1Msd Tg(ACTA1-SMN)63Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn ; HSA63-SMN mice may be useful for neuromuscular studies including spinal muscular atrophy (SMA).
Tg(SMN2)89Ahmb
008209Under Development for Production
FVB.Cg-Smn1tm1Msd Tg(ACTA1-SMN)69Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn ; HSA69-SMN mice may be useful for neuromuscular studies including spinal muscular atrophy (SMA).
Tg(SMN2)89Ahmb
008212Under Development for Production
STOCK Smn1tm1Msd Tg(Prnp-SMN)92Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn ; PrP92-SMN mutant mice may be useful in neuromuscular studies including spinal muscular atrophy (SMA).
Tg(SMN2)89Ahmb
007951Under Development for Production
STOCK Smn1tm3(SMN2/Smn1)Mrph Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb/J
This triple mutant mouse harbors two transgenic alleles and a single targeted mutation. The Tg(SMN2*delta7)4299Ahmb allele consists of a human SMN2 (survival of motor neuron 2, centromeric) cDNA lacking exon 7 whereas the Tg(SMN2)89Ahmb allele consists of the entire human SMN2 gene. The targeted mutant Smn1tm3(SMN2/Smn1/SMN2)Mrph allele is engineered to revert to a fully functional Smn1 allele upon Cre-mediated recombination. This mutant mouse strain may be useful in studies of Spinal Muscular Atrophy.
Tg(SMN2*delta7)4299Ahmb
007951Under Development for Production
STOCK Smn1tm3(SMN2/Smn1)Mrph Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb/J
This triple mutant mouse harbors two transgenic alleles and a single targeted mutation. The Tg(SMN2*delta7)4299Ahmb allele consists of a human SMN2 (survival of motor neuron 2, centromeric) cDNA lacking exon 7 whereas the Tg(SMN2)89Ahmb allele consists of the entire human SMN2 gene. The targeted mutant Smn1tm3(SMN2/Smn1/SMN2)Mrph allele is engineered to revert to a fully functional Smn1 allele upon Cre-mediated recombination. This mutant mouse strain may be useful in studies of Spinal Muscular Atrophy.
Tg(SOD1*G37R)42Dpr
008342Under Development for Production
B6.Cg-Tg(SOD1*G37R)42Dpr/J
These high-expressing G37R(42) (or G37R-SOD1 line 42) transgenic mice may be useful in studying neuromuscular disorders, including Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease).
Tg(SOD1*G85R)148Dwc
008248Under Development for Production
B6.Cg-Tg(SOD1*G85R)148Dwc/J
These G85R-SOD1 transgenic mice may be useful in studying neuromuscular disorders, including Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease).
Tg(THY1-SNCA*A30P)TS2Sud
008134Under Development for Production
B6.Cg-Tg(THY1-SNCA*A30P)TS2Sud/J
The A30P mutation in this transgenic strain is associated with the development of familial Parkinson's disease. The onset of hind limb mobility problems occurs around 12 months of age (sometimes earlier), induced by a loss of motor neurons and associated with the formation of insoluble alpha synuclein aggregates. This strain may be useful in studies of Parkinson's disease.
Tg(Thy1-APPSwDutIowa)BWevn
007027Under Development for Production
C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/J
These transgenic mice express the human amyloid beta-precursor protein, APP gene, 770 isoform, with the Swedish K670N/M671L, Dutch E693Q and Iowa D694N mutations, under the control of the mouse thymus cell antigen 1, theta, Thy1 , promoter. Plaque-like deposits of amyloid beta that are similar to the plaques observed in human patients with the Dutch and Iowa familial disorders, are initially detected at approximately 3 months of age in the subiculum, hippocampus and cortex. Amyloid beta deposits are detected throughout the forebrain by 12 months of age. This mutant mouse strain may be useful in studies of Alzheimer's disease.
Tg(Thy1-SOD1*G93A)T3Hgrd
008230Under Development for Production
FVB(Cg)-Tg(Thy1-SOD1*G93A)T3Hgrd/J
Thy1.2-G93A (or T3) transgenic mice express human G93A mutant SOD1 (G93A-SOD1)in neurons throughout the brain and spinal cord (including spinal motor neurons), and may be useful in studying neuromuscular disorders, such as Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease).
Tg(Thy1-Stx1a/EYFP)1Sud
007880Under Development for Cryo
B6SJL-Tg(Thy1-Stx1a/EYFP)1Sud/J
The mice express a syntaxin 1A (brain)-enhanced yellow fluorescent protein fusion protein under the control of a Thy1 promoter. Fluorescence patterns have not been characterized.
Tg(tetO-Clock)1Jt
008278Under Development for Production
B6.Cg-Tg(tetO-Clock)1Jt/J
These animals express the mouse Clock gene under the control of a tetracycline-responsive promoter element (TRE; tetO). When hemizygotes are bred with another transgenic mouse expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA) under the regulation of tissue-specific promoters, transgene expression can be conditionally regulated in the appropriate tissue of the bitransgenic offspring with the tetracycline analog, doxycycline. When bred to a strain expressing tTA in brain (see Stock No. 008284 for example), this mutant mouse strain may be useful in studies of circadian behavior.
Tg(tetO-DTA)1Gfi
008168Under Development for Production
STOCK Tg(tetO-DTA)1Gfi/J
These tet-DTA mice express diphtheria toxin A (DTA) under the control of a tetracycline operator (tetO ; also called tetracycline-responsive element (TRE) or tet-operator) and a cytomegalovirus minimal promoter, and may be useful in generating bi-transgenic mutant mice for the reversible, inducible deletion of specific groups of cells.
Tg(tetO-cre)1Jaw
008244Under Development for Production
FVB.Cg-Tg(tetO-cre)1Jaw/J
This strain represents an effective tool for generating inducible, tissue-specific-targeted mutants to study cell lineage during development.
008473Under Development for Production
B6.Cg-Tg(THY1-SNCA*A30P)M30Sud/J
This strain carries an A30P mutant form of the human SNCA (synuclein, alpha) gene associated with the development of familial Parkinson's disease. The onset of hind limb mobility problems and a resting tremor phenotype occur around 10 months of age due to a loss of motor neurons. No Lewy body-like pathology has been observed. Extensive cell death in the spinal cord and brain are seen. This strain may be useful in studies of Parkinson's disease. Hemizygous mice are viable and fertile, and survive to approximately 14 months of age.
Strains Newly Available for all Neurobiology Research models.