JAX Mice Database - Reproductive Biology Research

New strains under development - Research area: Reproductive Biology Research

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Reproductive Biology Research

Allele Symbol Strain Description	Stock Number	Strain Name (link to Data Sheet)
Adam2^tm1Dgm	008042 Under Development for Production	B6;129P2-Adam2^tm1Dgm/J
These fertilin b (Adam2) mutant mice may be useful in reproductive biology studies; specifically to determine the role of ADAM (A Disintegrin And Metalloprotease) family proteins in sperm-egg interactions, fertilization, and spermatogenesis. These mice may also be useful in conjunction with other ADAM family mutant mice, including the cyritestin (Adam3)-deficient strain (see Stock No. 008043).
Adam3^tm1Pmkf	008043 Under Development for Production	B6;129P2-Adam3^tm1Pmkf/J
These cyritestin (Adam3) mutant mice may be useful in reproductive biology studies; specifically to determine the role of ADAM (A Disintegrin And Metalloprotease) family proteins in sperm-egg interactions, fertilization, and spermatogenesis. These mice may also be useful in conjunction with other ADAM family mutant mice, including the fertilin b (Adam2)-deficient strain (see Stock No. 008042).
B4galt1^tm1Shur	006941 Under Development for Production	B6.129S7-B4galt1^tm1Shur/J
These mutant mice do not express the long or short isoforms of Beta 1,4-galactosyltransferase enzyme. 90% of homozygotes die soon after birth or within 2-3 weeks of birth. This mutant mouse strain may be useful in studies of glycosidic molecular interactions and function, and polyglandular endocrine insufficiency.
B4galt1^tm2Shur	006943 Under Development for Production	B6.129S7-B4galt1^tm2Shur/J
These mutant mice do not express the long isoform of the beta 1,4-galactosyltransferase enzyme. Homozygotes exhibit abnormal acrosomal exocytosis and mammary gland morphogenesis. This mutant mouse strain may be useful in studies of glycosidic molecular interactions and function, and cell-to-extracellular matrix (ECM) interactions.
Ddr2^slie	008172 Under Development for Production	BKS(HRS)-Ddr2^slie/JngJ
Mice homozygous for the spontaneous mutation smallie (slie) in the Ddr2 (discoidin domain receptor family, member 2) gene appear normal at birth but by weaning they exhibit dwarfism and minor craniofacial abnormalities. Homozygous females lack a corpora lutea by six weeks. By four months, homozygous males exhibit atrophy of spermatogonia, Sertoli and Leydig cells. This mutant mouse strain has characteristics similar to human Levi type dwarfism and may be useful in studies related to dwarfism and infertility.
Foxp3^sf	006775 On Hold	NOD.Cg-Foxp3^sf/DoiJ

Gpi1^b	005730 Under Development for Cryo	129S6.CB(B6)-Del(1)1Brk Gpi1^b/Gpi1^c/BrkMdfJ

Pctp^R120H	002105 On Hold	NZO/HlLtJ

Ptgs2^tm1.1Fun	008101 Under Development for Production	B6.129S6(FVB)-Ptgs2^tm1.1Fun/J
These mutant mice have an amino acid substitution that inactivates the cyclooxygenase activity but not the peroxidase activity of the gene product. Mutant mice exhibit abnormal kidney development and function as well as elevated systolic blood pressure, which may make them useful in studies of thrombogenesis and hypertension.
Ptgs2^{tm2.1(Ptgs1)Fun}	008104 Under Development for Production	B6.129(FVB)-Ptgs2^{tm2.1(Ptgs1)Fun}/J
These mutant mice develop chronic peritonitis and progressive kidney deterioration. COX1 protein (Ptgs1 gene product) is increased 5 fold in LPS-stimulated macrophages from homozygotes. This mutant mouse strain may be useful in studies of prostaglandin synthesis and inflammation.
Tyrp1^B-lt	006252 Under Development for Cryo	LT/SvEiJ

a	006252 Under Development for Cryo	LT/SvEiJ

Del(1)1Brk	005730 Under Development for Cryo	129S6.CB(B6)-Del(1)1Brk Gpi1^b/Gpi1^c/BrkMdfJ

Tg(Scg2-tTA)1Jt	008278 Under Development for Production	B6.Cg-Tg(tetO-Clock)1Jt/J
These animals express the mouse Clock gene under the control of a tetracycline-responsive promoter element (TRE; tetO). When hemizygotes are bred with another transgenic mouse expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA) under the regulation of tissue-specific promoters, transgene expression can be conditionally regulated in the appropriate tissue of the bitransgenic offspring with the tetracycline analog, doxycycline. When bred to a strain expressing tTA in brain (see Stock No. 008284 for example), this mutant mouse strain may be useful in studies of circadian behavior.
Tg(Scg2-tTA)1Jt	008277 Under Development for Production	B6.Cg-Tg(tetO-Clock^m1Jt)CL57Jt/J
These animals express the Clock-delta19 mutation under the control of a tetracycline-responsive promoter element (TRE; tetO). When hemizygotes are bred with another transgenic mouse expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA) under the regulation of tissue-specific promoters, transgene expression can be conditionally regulated in the appropriate tissue of the bitransgenic offspring with the tetracycline analog, doxycycline. This dominant negative mutant transgene lengthens the period of circadian locomotor rhythms in mice. This effect can be reversibly inhibited by low doses of doxycyline in the drinking water. These mice may be useful in studies of the brain and behavior in the mouse.
Tg(tetO-Clock)1Jt	008278 Under Development for Production	B6.Cg-Tg(tetO-Clock)1Jt/J
These animals express the mouse Clock gene under the control of a tetracycline-responsive promoter element (TRE; tetO). When hemizygotes are bred with another transgenic mouse expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA) under the regulation of tissue-specific promoters, transgene expression can be conditionally regulated in the appropriate tissue of the bitransgenic offspring with the tetracycline analog, doxycycline. When bred to a strain expressing tTA in brain (see Stock No. 008284 for example), this mutant mouse strain may be useful in studies of circadian behavior.
Tg(tetO-Clock^m1Jt)CL57Jt	008277 Under Development for Production	B6.Cg-Tg(tetO-Clock^m1Jt)CL57Jt/J
These animals express the Clock-delta19 mutation under the control of a tetracycline-responsive promoter element (TRE; tetO). When hemizygotes are bred with another transgenic mouse expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA) under the regulation of tissue-specific promoters, transgene expression can be conditionally regulated in the appropriate tissue of the bitransgenic offspring with the tetracycline analog, doxycycline. This dominant negative mutant transgene lengthens the period of circadian locomotor rhythms in mice. This effect can be reversibly inhibited by low doses of doxycyline in the drinking water. These mice may be useful in studies of the brain and behavior in the mouse.

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