Allele Symbol Stock Number Strain Name
Bchetm1Loc 008077Under Development for Production
129S1/Sv-Bchetm1Loc /J
These BChE (butyrylcholinesterase) mutant mice are a model for human butyrylcholinesterase deficiency and may be useful for studying metabolic effects of organophosphorus toxicants or nerve agents, neurotransmitter function, and anti-Alzheimer's drug therapies.
Cd19tm1(cre)Cgn 008242Under Development for Production
C57BL/6-Gt(ROSA)26Sortm1(Ikbkb)Rsky /J
These R26StopFL ikk2ca mice allow inducible expression of an activated form of Ikbkb (IKK2ca) and subsequent activation of the NF-kappaB transcription factor pathways.
Cdh23ahl 000668On Hold
C57L/J
Eif2ak4tm1.2Dron 008240Under Development for Production
B6.129S6-Eif2ak4tm1Munn /J
Mice homozygous for the GCN2.KO4 mutant locus (also called GCN2.KO4- , GCN2- , GCN2.KO4ex , or GCN2-KO) have a deletion of exon XII of the eukaryotic translation initiation factor 2 alpha kinase 4 (Eif2ak4 or GCN2) gene, and may be useful in studying eIF2 (eukaryotic initiation factor 2) phosphorylation in response to environmental stresses (amino acid starvation, proteasome inhibition and UV irradiation).
Gt(ROSA)26Sortm4(Ikbkb)Rsky 008242Under Development for Production
C57BL/6-Gt(ROSA)26Sortm1(Ikbkb)Rsky /J
These R26StopFL ikk2ca mice allow inducible expression of an activated form of Ikbkb (IKK2ca) and subsequent activation of the NF-kappaB transcription factor pathways.
Ightm1Janz 008332Under Development for Production
C.129S1-Ightm1Janz /J
These mutant mice carry a His6 -tagged myelocytomatosis oncogene (Myc ) gene (cDNA) sequence inserted in the endogenous immunoglobulin heavy chain complex (Igh ) locus, which mimics the human endemic Burkitt lymphoma t(8;14)(q24;q32) translocation and mouse plasmacytoma T(12;15) translocation. This mutant mouse strain may be useful in studies of Burkitt Lymphoma and plasma cell and B-cell neoplasia.
Il2rgtm1Wjl 007799Under Development for Production
NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl /SzJ
These NOD-Rag1null IL2rg null double mutant mice may be useful for cell or tissue transplantation studies, particularly as a model for human lymphohematopoietic cell engraftment studies that require a radioresistant host.
Ltb4r1tm1Adl 008102Under Development for Production
B6.129S4-Ltb4r1tm1Adl /J
As the G protein-coupled receptor BLTR/BLT1 is expressed on myeloid leukocytes (including neutrophils, macrophages, eosinophils, T cell lymphomas, and effector T cells (TH1 CD4+ cells, TH2 CD4+ cells, and effector memory CD8+ cells) during CD4+ migration/recruitment from the lymphoid compartment into peripheral tissues), these BLTR/BLT1 mutant mice may be useful for studying leukocyte function in inflammation, as well as the role of the LTB4-BLT1 pathway linking early immune system activation and multiple classes of acquired immune effector cells.
Mirn155tm1.1Rsky 007745Under Development for Production
B6.Cg-Mirn155tm1.1Rsky /J
These bic /mir-155 mutant mice may be useful in mircoRNA biology, specifically to study the role of miR-155 and its target genes (including cytokines, chemokines, and transcription factors) in homeostasis and function of the immune system.
Mlphln 000668On Hold
C57L/J
Mmp9tm1Tvu 007084Under Development for Production
B6.FVB(Cg)-Mmp9tm1Tvu /J
This targeted mutation of the Mmp9 (matrix metalloproteinase 9) gene may be used to study injury response and repair, angiogenesis and inflammatory response.
Mtv2a 006131Under Development for Cryo
GR/J
The inbred strain, GR, carries the Mtv2a allele. This allele controls expression of endogenous MMTV and the early development of hormone-induced mammary tumors. Nearly all breeding females develop mammary tumors prior to one year of age. GR is used to study endocrine regulation of mammary gland development and tumorigenesis.
Obq3C57L/J 000668On Hold
C57L/J
Obq4C57L/J 000668On Hold
C57L/J
Rab3atm1Sud 006375Under Development for Production
B6;129-Rab3btm1Sud Rab3atm1Sud Rab3dtm1Rja Rab3ctm1Sud /J
These mice carry targeted mutations in the Rab3a (RAB3A, member RAS oncogene family, Rab3b (RAB3B, member RAS oncogene family), Rab3c (RAB3C, member RAS oncogene family), and Rab3d (RAB3D, member RAS oncogene family) genes. Mice homozygous for all four targeted mutations die shortly after birth due to respiratory problems. Mutant mice display no apparent changes in synapse structure or brain composition except for the loss of rabphilin. The size of the excitatory postsynaptic current (EPSC) induced by action potentials is ~30% smaller in mutant mice as compared to controls. This mutant mouse strain may be useful in studies of synaptic vesicle exocytosis mechanisms in neurons.
Rab3btm1Sud 006375Under Development for Production
B6;129-Rab3btm1Sud Rab3atm1Sud Rab3dtm1Rja Rab3ctm1Sud /J
These mice carry targeted mutations in the Rab3a (RAB3A, member RAS oncogene family, Rab3b (RAB3B, member RAS oncogene family), Rab3c (RAB3C, member RAS oncogene family), and Rab3d (RAB3D, member RAS oncogene family) genes. Mice homozygous for all four targeted mutations die shortly after birth due to respiratory problems. Mutant mice display no apparent changes in synapse structure or brain composition except for the loss of rabphilin. The size of the excitatory postsynaptic current (EPSC) induced by action potentials is ~30% smaller in mutant mice as compared to controls. This mutant mouse strain may be useful in studies of synaptic vesicle exocytosis mechanisms in neurons.
Rab3ctm1Sud 006375Under Development for Production
B6;129-Rab3btm1Sud Rab3atm1Sud Rab3dtm1Rja Rab3ctm1Sud /J
These mice carry targeted mutations in the Rab3a (RAB3A, member RAS oncogene family, Rab3b (RAB3B, member RAS oncogene family), Rab3c (RAB3C, member RAS oncogene family), and Rab3d (RAB3D, member RAS oncogene family) genes. Mice homozygous for all four targeted mutations die shortly after birth due to respiratory problems. Mutant mice display no apparent changes in synapse structure or brain composition except for the loss of rabphilin. The size of the excitatory postsynaptic current (EPSC) induced by action potentials is ~30% smaller in mutant mice as compared to controls. This mutant mouse strain may be useful in studies of synaptic vesicle exocytosis mechanisms in neurons.
Rab3dtm1Rja 006375Under Development for Production
B6;129-Rab3btm1Sud Rab3atm1Sud Rab3dtm1Rja Rab3ctm1Sud /J
These mice carry targeted mutations in the Rab3a (RAB3A, member RAS oncogene family, Rab3b (RAB3B, member RAS oncogene family), Rab3c (RAB3C, member RAS oncogene family), and Rab3d (RAB3D, member RAS oncogene family) genes. Mice homozygous for all four targeted mutations die shortly after birth due to respiratory problems. Mutant mice display no apparent changes in synapse structure or brain composition except for the loss of rabphilin. The size of the excitatory postsynaptic current (EPSC) induced by action potentials is ~30% smaller in mutant mice as compared to controls. This mutant mouse strain may be useful in studies of synaptic vesicle exocytosis mechanisms in neurons.
Rag1tm1Mom 007799Under Development for Production
NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl /SzJ
These NOD-Rag1null IL2rg null double mutant mice may be useful for cell or tissue transplantation studies, particularly as a model for human lymphohematopoietic cell engraftment studies that require a radioresistant host.
Rmcfs 000668On Hold
C57L/J
Seletm1Dmil 008238Under Development for Production
129S-Seletm1Dmil /J
These E-selectin mutant mice may be useful in studying inflammation, leukocyte rolling, leukocyte-endothelial adhesion, angiogenesis, and cancer.
Seletm1Dmil 008236Under Development for Production
B6.129S4-Seletm1Dmil /J
These E-selectin mutant mice may be useful in studying inflammation, leukocyte rolling, leukocyte-endothelial adhesion, angiogenesis, and cancer.
Seletm1Dmil 008237Under Development for Production
C.129S4-Seletm1Dmil /J
These E-selectin mutant mice may be useful in studying inflammation, leukocyte rolling, leukocyte-endothelial adhesion, angiogenesis, and cancer.
Ssttm1Ute 008117Under Development for Production
B6.129S4(129S6)-Ssttm1Ute /J
Somatostatin deficient mice exhibit increased baseline plasma growth hormone, corticosterone and total ghrelin levels and impaired motor performance. Hippocampal amyloid beta 42 peptides levels are elevated. This mutant mouse strain may be useful in studies of gastric homeostasis, learning and memory and endocrinology.
Traf1tm1Tsi 008074Under Development for Production
C.129S4-Traf1tm1Tsi /J
These TRAF1 mutant mice may be useful in studying negative regulation of tumor necrosis factor (TNF) signaling, NF-kB and AP-1 signaling, T cell receptor (TCR)-induced proliferation of T cells, Th2 responses, TRAF1/Bim function in CD8 memory T cell survival, allergic airway diseases and Rheumatoid arthritis, as well as the role of TRAF1 activation in the pathogenesis of lymphomas. Of note, TRAF1 mutant mice are available on either a BALB/c congenic (Stock No. 008074 ) or C57BL/6 congenic (Stock No. 008076 ) background.
Trp53tm2Xu 007218Under Development for Production
B6.129S6-Trp53tm2Xu /J
This targeted mutation of Trp53 (transformation related protein 53) contains two phosphorylation site disruptions: Ser18 to Ala (S18A), and Ser23 to Ala (S23A). Trp53-dependent apoptosis is essentially abolished in thymocytes from mice homozygous for this allele. This mutant mouse strain may be useful in studies of phosphorylation events, cancer development and apoptosis.
Tyrp1B-lt 006252Under Development for Cryo
LT/SvEiJ
Usp18tm1Dzh 007225Under Development for Production
FVB.129(B6)-Usp18tm1Dzh /J
These Usp18 (or Ubp43)-mutant mice may be useful in studying interferons and their receptors, cellular function, signal transduction, and the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway.
a 006252Under Development for Cryo
LT/SvEiJ
Tg(CAG-SAC/EGFP)35Rang
008080Under Development for Production
B6;C3-Tg(CAG-SAC/EGFP)35Rang/J
These SAC-GFP transgenic mice may be useful as a cancer-resistant model; evading oncogene-mediated tumorigenesis by expressing an archetypical anticancer therapeutic agent (SAC) that is well tolerated in vivo , does not compromise the normal tissue function or life span of the host, and is potent enough at physiologically innocuous levels to concomitantly suppress the NF-kappaB pro-cell survival pathway and induce tumor suppression via apoptosis.
Tg(CAG-Ub*G76V/GFP)1Dant
008111Under Development for Production
B6.Cg-Tg(CAG-Ub*G76V/GFP)1Dant/J
Both ubiquitin/proteasome system reporter (UPS reporter) founder lines, UbG76V -GFP/1 (Stock No. 008111) and UbG76V -GFP/2 (Stock No. 008112), may be useful for monitoring the role of ubiquitin/proteasome-dependent proteolysis in diverse disorders, and for efficacy trials testing the effect of compounds on the ubiquitin/proteasome system (including proteasome inhibitors effect as novel anticancer drugs).
Tg(CAG-Ub*G76V/GFP)2Dant
008112Under Development for Production
B6.Cg-Tg(CAG-Ub*G76V/GFP)2Dant/J
Both ubiquitin/proteasome system reporter (UPS reporter) founder lines, UbG76V -GFP/1 (Stock No. 008111) and UbG76V -GFP/2 (Stock No. 008112), may be useful for monitoring the role of ubiquitin/proteasome-dependent proteolysis in diverse disorders, and for efficacy trials testing the effect of compounds on the ubiquitin/proteasome system (including proteasome inhibitors effect as novel anticancer drugs).
Tg(Ela1-TAg*)289Mjt
008247Under Development for Production
B6.Cg-Tg(Ela1-TAg*)289Mjt/J
These T1-147 transgenic mice (harboring the E1-T147 transgene) develop metastatic pancreatic acinar cell cancer as a result of expression of the 1-147 amino acid fragment of simian virus 40 large T antigen (TAg) directed to pancreatic acinar cells by the rat elastase 1 (Ela1 or E1) upstream control region.
Tg(MMTV-neu/OT-I/OT-II)CBnel
007962Under Development for Production
B6.FVB-Tg(MMTV-neu/OT-I/OT-II)CBnel Tg(Trp53R172H)8512Jmr/J
Approximately 85% of the compound mutant females develop focal mammary tumors at 6-10 months of age. Both virgin and breeder mice develop tumors. Approximately 37% of tumor-bearing mice develop metastatic disease to the lung. High expression of neu is detected in tumor tissue while very low levels are found in lung and ovary.
Female mice carrying only the neuOT-I/OT-II mutation develop focal mammary tumors at approximately 18 months of age.
Tg(Trp53R172H)8512Jmr
007962Under Development for Production
B6.FVB-Tg(MMTV-neu/OT-I/OT-II)CBnel Tg(Trp53R172H)8512Jmr/J
Approximately 85% of the compound mutant females develop focal mammary tumors at 6-10 months of age. Both virgin and breeder mice develop tumors. Approximately 37% of tumor-bearing mice develop metastatic disease to the lung. High expression of neu is detected in tumor tissue while very low levels are found in lung and ovary.
Female mice carrying only the neuOT-I/OT-II mutation develop focal mammary tumors at approximately 18 months of age.
008452Under Development for Production
STOCK Eif2ak4tm1Dron /J
Mice homozygous for the GCN2.KO4conditional allele (also called GCN2.KO4c) have loxP sites flanking exon XII of the eukaryotic translation initiation factor 2 alpha kinase 4 (Eif2ak4 or GCN2) targeted gene, and may be useful in generating conditional mutations for studying eIF2 (eukaryotic initiation factor 2) phosphorylation in response to environmental stresses (amino acid starvation, proteasome inhibition and UV irradiation).
Strains Newly Available for all Cancer Research models.