New strains under development - Research area: Cardiovascular Research

 
View a Full List of New Strains Under Development Sorted by Gene Symbol.
Go Back To REGISTER INTEREST: New Strains Under Development.
Select another Research Area.

 

Strains Newly Available for all Cardiovascular Research models.
View all Research Models for Cardiovascular Research
Search JAX® Mice Database

How to Register Interest

 
Please indicate your interest in purchasing any of the strains listed below when they become available for distribution by checking the box next to the strain(s) of interest and then selecting the "Continue" button which leads to an Interest Form.  

Cardiovascular Research

Allele Symbol
 
Strain Description		 Stock Number Strain Name
   (link to Data Sheet)
Adipoqtm1Chan 008195
Under Development for Production		 B6.129-Adipoqtm1Chan/J
These adiponectin-deficient (Adipoq-/- or Adipo-/-) mice may be useful in studying obesity, diabetes, insulin resistance, metabolism, inflammation, leukocyte-endothelium interactions, and colitis.
Cdh23ahl 000668
On Hold		 C57L/J
Mlphln 000668
On Hold		 C57L/J
Mmp9tm1Tvu 007084
Under Development for Production		 B6.FVB(Cg)-Mmp9tm1Tvu/J
This targeted mutation of the Mmp9 (matrix metalloproteinase 9) gene may be used to study injury response and repair, angiogenesis and inflammatory response.
Obq3C57L/J 000668
On Hold		 C57L/J
Obq4C57L/J 000668
On Hold		 C57L/J
Ptgs2tm1.1Fun 008101
Under Development for Production		 B6.129S6(FVB)-Ptgs2tm1.1Fun/J
These mutant mice have an amino acid substitution that inactivates the cyclooxygenase activity but not the peroxidase activity of the gene product. Mutant mice exhibit abnormal kidney development and function as well as elevated systolic blood pressure, which may make them useful in studies of thrombogenesis and hypertension.
Rmcfs 000668
On Hold		 C57L/J
Seletm1Dmil 008238
Under Development for Production		 129S-Seletm1Dmil/J
These E-selectin mutant mice may be useful in studying inflammation, leukocyte rolling, leukocyte-endothelial adhesion, angiogenesis, and cancer.
Seletm1Dmil 008236
Under Development for Production		 B6.129S4-Seletm1Dmil/J
These E-selectin mutant mice may be useful in studying inflammation, leukocyte rolling, leukocyte-endothelial adhesion, angiogenesis, and cancer.
Seletm1Dmil 008237
Under Development for Production		 C.129S4-Seletm1Dmil/J
These E-selectin mutant mice may be useful in studying inflammation, leukocyte rolling, leukocyte-endothelial adhesion, angiogenesis, and cancer.
Sgcbtm1Kcam 006832
On Hold		 129-Sgcbtm1Kcam/J
Tyro3tm1Grl 007937
Under Development for Production		 B6.129-Tyro3tm1Grl/J
Mice that are homozygous for this mutation may be useful in studies of thrombosis and platelet aggregation. Mutants exhibit reduced pathological thrombosis and impaired platelet aggregation.
Tg(APOE-DGAT2)24Far 007744
Under Development for Production		 C57BL/6-Tg(APOE-DGAT2)24Far/J
These Liv-DGAT2-low transgenic mice may be useful in studying hepatic steatosis, lipid, glucose, and insulin metabolism, as well as obesity and diabetes.
Tg(Alb1-Ren)1Unc 007853
Under Development for Production		 129S/SvEv-Tg(Alb1-Ren)1Unc/CofJ
These RenTgMK mice may be useful in studying the effects of genetically clamped renin (and angiotensin II) on hypertension, diabetic nephropathy, albuninurea, nephrosclerosis, and other aspects of the renin–angiotensin system (RAS).
Tg(CAG-Ngb,-EGFP)1Dgrn 007575
Under Development for Production		 B6.Cg-Tg(CAG-Ngb,-EGFP)1Dgrn/J
These transgenic mice overexpress neuroglobin (Ngb) and GFP in multiple tissues, and are resistant to ischemia. When crossed to a mouse model of Alzheimer's disease, the disease phenotype is attenuated. They may be useful in studies of cerebral and myocardial ischemia, stroke, and neurodegenerative disease.
Tg(IGFBP1)2Miel 008221
Under Development for Production		 B6.Cg-Tg(IGFBP1)2Miel/J
These hIGFBP-1 (insulin-like growth factor binding protein 1, human) transgenic mice may be useful in studying metabolic and vascular homeostasis, diabetes, and the role of insulin-like growth factor binding protein in placentation and preeclampsia.
Tg(IGFBP2)1Miel 008222
Under Development for Production		 B6.FVB-Tg(IGFBP2)1Miel/J
These IGFBP-2 overexpressing transgenic mice may be useful in studying metabolic homeostasis, adipocyte biology, and the role of insulin-like growth factor binding protein in protecting against obesity- and age-associated complications (such as hypertension and diabetes).
Tg(Myh11-cre,-EGFP)2Mik 007742
Under Development for Production		 B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
These smMHC/Cre/eGFP transgenic mice may be useful in studies utilizing “Cre-lox” technology or fluorescent protein expression in smooth muscle, especially separation of vascular myocytes from the surrounding cellular environment to isolate muscle specific adaptations or disease responses.
Tg(Tagln-tTA)1Mrab 008082
Under Development for Production		 B6;SJL-Tg(Tagln-tTA)1Mrab Tg(tetO-Mcpt1)1Mrab/J
These SM22a-tTA/TRE-RVCH-HA bi-transgenic mice allow targeted overexpression or Tet-Off conditional expression of vascular chymase in smooth muscle cells, and may be useful in studying the role of elevated chymase activity in systemic hypertension and cardiovascular disease.
Tg(tetO-Mcpt1)1Mrab 008082
Under Development for Production		 B6;SJL-Tg(Tagln-tTA)1Mrab Tg(tetO-Mcpt1)1Mrab/J
These SM22a-tTA/TRE-RVCH-HA bi-transgenic mice allow targeted overexpression or Tet-Off conditional expression of vascular chymase in smooth muscle cells, and may be useful in studying the role of elevated chymase activity in systemic hypertension and cardiovascular disease.

(21 stocks)

 

Select another Research Area Application:


Send questions to our Technical Support team using the Express Technical Support Form.
(2.15)