JAX Mice Database - Developmental Biology Research

New strains under development - Research area: Developmental Biology Research

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Developmental Biology Research

Allele Symbol Strain Description	Stock Number	Strain Name (link to Data Sheet)
A^w-J	002703 On Hold	B6CBACa A^w-J/A-Hydin^hy3/J

Akap6^tm1Jsco	007447 Under Development for Cryo	B6.129-Akap6^tm1Jsco/14J
These A kinase (PRKA) anchor protein 6 (Akap6)-mutant mice may be useful in studying developmental biology and craniofacial defects.
Atcay^ji	008140 Under Development for Production	B6.C(Cg)-Atcay^ji/BurJ
Mice homozygous for the spontaneous mutation, jittery (ji) in Atcay (ataxia, cerebellar, Cayman type homolog), exhibit severe, progressive ataxia and die at approximately 4 weeks of age. This mutant mouse strain represents a model that may be useful in studies of congenital ataxia.
Car4^tm1Sly	008217 Under Development for Production	B6.129S1-Car4^tm1Sly/J
Mice that are homozygous for this targeted mutation exhibit decreased sensitivity to an inhibitor, benzolamide, of pH regulation in the extracellular space in the hippocampus when compared to wildtype controls. This mutant mouse strain may be useful in studies of pH shifts that accompany neuronal activity and neuronal physiology.
Ddr2^slie	008172 Under Development for Production	BKS(HRS)-Ddr2^slie/JngJ
Mice homozygous for the spontaneous mutation smallie (slie) in the Ddr2 (discoidin domain receptor family, member 2) gene appear normal at birth but by weaning they exhibit dwarfism and minor craniofacial abnormalities. Homozygous females lack a corpora lutea by six weeks. By four months, homozygous males exhibit atrophy of spermatogonia, Sertoli and Leydig cells. This mutant mouse strain has characteristics similar to human Levi type dwarfism and may be useful in studies related to dwarfism and infertility.
Dld^tm1Ptl	008333 Under Development for Production	B6;129P2-Dld^tm1Ptl/J
These Dld (dihydrolipoamide dehydrogenase or E3 component) mutant mice may be useful to study early murine embryonic metabolism, including glucose and mitochondrial metabolism during the early postimplantation period. As altered energy metabolism and reductions in alpha-ketoacid dehydrogenase complexes have also been associated with many neurodegenerative disorders, these mice may also be useful in studies related to Parkinson's disease, Huntington's disease, and/or Alzheimer's disease. Because the metabolic disturbances associated with E3 deficiency (Dld deficiency) cause a variant of Maple Syrup Urine Disease (MSUD) in which there is an accompanying lactic acidosis due to concomitant deficiency of pyruvate dehydrogenase complex, these mice may be useful in such studies or in conjunction with iMSUD mice (Stock No. 006999).
Edar^dl-J	000255 On Hold	GL/Le Edar^dl-J +/+ Ostm1^gl/J

Efna2^tm1Jgf	005992 Under Development for Production	STOCK Efna2^tm1Jgf Efna5^tm1Ddmo/J
These ephrin A2/ephrin A5 double mutant mice may be useful in studies of retinocollicular mapping, axon topography, neuron projection, and modality-specific compartmentalization of visual, auditory, and somatosensory thalamic relay pathways.
Efna5^tm1Ddmo	005992 Under Development for Production	STOCK Efna2^tm1Jgf Efna5^tm1Ddmo/J
These ephrin A2/ephrin A5 double mutant mice may be useful in studies of retinocollicular mapping, axon topography, neuron projection, and modality-specific compartmentalization of visual, auditory, and somatosensory thalamic relay pathways.
Eraf^tm1.1Mjwe	007858 Under Development for Production	B6.129S6(Cg)-Eraf^tm1.1Mjwe/J
The entire coding region of the erythroid associated factor gene has been disrupted in this mutant mouse line. This gene (also called a-hemoglobin stabilizing protein or AHSP) specifically binds the cytotoxic free a-Hb subunit of hemoglobin A. These AHSP-mutant mice may be useful in studying erythroid development/erythropoiesis, thalassemia, Heinz body hemolytic anemia, and other hemoglobinopathies.
Foxp3^sf	006775 On Hold	NOD.Cg-Foxp3^sf/DoiJ

Fut1^tm1Sdo	006939 Under Development for Production	B6.129-Fut1^tm1Sdo/J
FUT1-deficient mice do not have epididymal alpha(1,2)fucosylated glycans or the fucosylated glycolipid, fucosyl GA1, in pancreatic acinar glands. Homozygotes exhibit delayed maturation of nerve fibers in the glomerular layer of the olfactory bulb. This mutant mouse strain may be useful in studies of glycosidic molecular interactions and function, and olfactory nerve pathway development.
Gusb^tm3Sly	005644 Under Development for Production	B6.129X-Gusb^tm3Sly/J
Homozygous mice for this targeted mutation in beta glucuronidase (Gusb) exhibit growth retardation, shortened extremities, and facial dysmorphism. This model has increased urinary glycosaminoglycan and secondary elevation of other lysosomal storage enzymes. This strain represents a model of human GUS deficiency characterized by the most prevalent human mutation, L176F, and is associated with mild Mucopolysaccharidosis type VII (MPS VII or Sly Syndrome).
Hlx^tm1Rph	008313 Under Development for Production	B6.129P2-Hlx^tm1Rph/J
Mice homozygous for this Hlx targeted mutation have an embryonic or perinatal lethal phenotype, failing to develop past ED15.5 or dying at birth. Homozygotes exhibit defective fetal hematopoiesis with abnormal liver and gut development. Naive CD4 T cells from heterozygotes on the FVB/NJ background exhibit increased responsiveness to IL-4, resulting in differentiation of more Th2 cells. This mutant mouse strain may be useful in studies of liver and gastrointestinal development and T helper 2 cell differentiation.
Hlx^tm1Rph	008315 Under Development for Production	FVB.129P2(Cg)-Hlx^tm1Rph/J
Mice homozygous for this Hlx targeted mutation have an embryonic or perinatal lethal phenotype, failing to develop past ED15.5 or dying at birth. Homozygotes exhibit defective fetal hematopoiesis with abnormal liver and gut development. Naive CD4 T cells from heterozygotes on the FVB/NJ background exhibit increased responsiveness to IL-4, resulting in differentiation of more Th2 cells. This mutant mouse strain may be useful in studies of liver and gastrointestinal development and T helper 2 cell differentiation.
Hydin^hy3	002703 On Hold	B6CBACa A^w-J/A-Hydin^hy3/J

L1cam^tm1Sor	003518 Under Development for Cryo	129/Sv-L1cam^tm1Sor/J

Ltb4r1^tm1Adl	008102 Under Development for Production	B6.129S4-Ltb4r1^tm1Adl/J
As the G protein-coupled receptor BLTR/BLT1 is expressed on myeloid leukocytes (including neutrophils, macrophages, eosinophils, T cell lymphomas, and effector T cells (TH1 CD4⁺ cells, TH2 CD4⁺ cells, and effector memory CD8⁺ cells) during CD4⁺ migration/recruitment from the lymphoid compartment into peripheral tissues), these BLTR/BLT1 mutant mice may be useful for studying leukocyte function in inflammation, as well as the role of the LTB4-BLT1 pathway linking early immune system activation and multiple classes of acquired immune effector cells.
Mmp9^tm1Tvu	007084 Under Development for Production	B6.FVB(Cg)-Mmp9^tm1Tvu/J
This targeted mutation of the Mmp9 (matrix metalloproteinase 9) gene may be used to study injury response and repair, angiogenesis and inflammatory response.
Ostm1^gl	000255 On Hold	GL/Le Edar^dl-J +/+ Ostm1^gl/J

Pparg^tm2Yba	008079 Under Development for Production	129S-Pparg^tm2Yba/J
These mice express tTA (tetracycline regulated transactivator) and a tetO-driven Flag-tagged Pparg from the endogenous Pparg locus. Although heterozygous mice exhibit lipodystrophy, hyperinsulinemia, pancreatic islet hyperplasia, and severe glucose intolerance, they do not develop steatosis or type II diabetes. Treatment with doxycycline prevents these phenotypes when administered starting at midgestation whereas a 6 week treatment administered to pubertal heterozygotes reverses most of these phenotypes. This strain may be useful in studies of lipodystrophy.
Pparg^tm3Yba	008227 Under Development for Production	B6.129S4-Pparg^tm3Yba/J
These mice express tTA (tetracycline regulated transactivator) from the endogenous Pparg locus. Heterozygotes exhibit mild lipodystrophy with pale, unilocular brown adipocytes, hypertrophy of brown fat, reduced subcutaneous fat, reduced gonadal fat pads, mild hepatomegaly and develop insulin resistance and dyslipidemia. Treatment with doxycycline prevents this phenotype. This mutant mouse strain may be useful in studies of lipodystrophy.
Ptgs2^tm1.1Fun	008101 Under Development for Production	B6.129S6(FVB)-Ptgs2^tm1.1Fun/J
These mutant mice have an amino acid substitution that inactivates the cyclooxygenase activity but not the peroxidase activity of the gene product. Mutant mice exhibit abnormal kidney development and function as well as elevated systolic blood pressure, which may make them useful in studies of thrombogenesis and hypertension.
Rag2^tm1.1Cgn	008309 Under Development for Production	C57BL/6-Rag2^tm1Cgn/J
These RAG-2^fl mice harbor loxP sites flanking the entire coding region of the Rag2 (recombination activating gene 2) locus. When bred to mice that express Cre recombinase, the resulting offspring will have exon 3 deleted in the cre-expressing tissue(s). These RAG-2^fl mice may be useful in generating conditional mutations for studying the role of RAG-2 in B and T cell development (including cancer and toxicology research as a xenograft/transplant host), T and B cell receptor (V(D)J) recombination, hematopoiesis, hematology, immunology, and inflammation research.
Rag2^tm1Cgn	008309 Under Development for Production	C57BL/6-Rag2^tm1Cgn/J
These RAG-2^fl mice harbor loxP sites flanking the entire coding region of the Rag2 (recombination activating gene 2) locus. When bred to mice that express Cre recombinase, the resulting offspring will have exon 3 deleted in the cre-expressing tissue(s). These RAG-2^fl mice may be useful in generating conditional mutations for studying the role of RAG-2 in B and T cell development (including cancer and toxicology research as a xenograft/transplant host), T and B cell receptor (V(D)J) recombination, hematopoiesis, hematology, immunology, and inflammation research.
Rai1^tm1Jrl	005981 On Hold	B6.129S7-Rai1^tm1Jrl/J

Rpsa	008369 Under Development for Production	B6.129S6-Rpsa^tm1Ells/J
Mice that are heterozygous for the Rpsa^tm1Ells, ribosomal protein SA, targeted mutation exhibit a signficantly lower mean corpuscular hemoglobin concentration (MCHC) when treated with a myelosuppressor. This mutant mouse strain may be useful in studies of Diamond Blackfan anemia.
Sele^tm1Dmil	008238 Under Development for Production	129S-Sele^tm1Dmil/J
These E-selectin mutant mice may be useful in studying inflammation, leukocyte rolling, leukocyte-endothelial adhesion, angiogenesis, and cancer.
Sele^tm1Dmil	008236 Under Development for Production	B6.129S4-Sele^tm1Dmil/J
These E-selectin mutant mice may be useful in studying inflammation, leukocyte rolling, leukocyte-endothelial adhesion, angiogenesis, and cancer.
Sele^tm1Dmil	008237 Under Development for Production	C.129S4-Sele^tm1Dmil/J
These E-selectin mutant mice may be useful in studying inflammation, leukocyte rolling, leukocyte-endothelial adhesion, angiogenesis, and cancer.
Smn1^tm1Msd	008203 Under Development for Production	FVB.Cg-Smn1^tm1Msd Tg(ACTA1-SMN)63Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn; HSA63-SMN mice may be useful for neuromuscular studies including spinal muscular atrophy (SMA).
Smn1^tm1Msd	008209 Under Development for Production	FVB.Cg-Smn1^tm1Msd Tg(ACTA1-SMN)69Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn; HSA69-SMN mice may be useful for neuromuscular studies including spinal muscular atrophy (SMA).
Smn1^tm1Msd	008206 Under Development for Production	FVB.Cg-Smn1^tm1Msd Tg(SMN2)566Ahmb/J
These mice may be useful in neuromuscular studies including spinal muscular atrophy (SMA).
Smn1^tm1Msd	008212 Under Development for Production	STOCK Smn1^tm1Msd Tg(Prnp-SMN)92Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn; PrP92-SMN mutant mice may be useful in neuromuscular studies including spinal muscular atrophy (SMA).
Smn1^tm2Mrph	007246 Under Development for Production	B6;129-Smn1^tm2Mrph/J
This strain functions as a reporter strain for Smn1 (survival motor neuron 1) in the heterozygous state. Exons 1 through 8 of the mouse Smn1 gene (12.8 kb) were replaced with lacZ and an FRT site remaining from the deletion of a selection marker. This mutant mouse strain may be useful in studies of Spinal Muscular Atrophy.
Smn1^{tm3(SMN2/Smn1)Mrph}	007249 Under Development for Production	B6;129-Smn1^{tm3(SMN2/Smn1)Mrph}/J
This allele is a functional null of survival motor neuron 1 (Smn1) in the non-recombined state and is engineered to revert to a fully functional Smn1 allele upon Cre-mediated recombination. This mutant mouse strain may be useful in studies of Spinal Muscular Atrophy.
Sox10^Dom	000290 On Hold	B6C3Fe a/a-Sox10^Dom/J

Timp2^tm1Pds	008120 Under Development for Production	B6.129S4-Timp2^tm1Pds/J
These mice are deficient in TIMP-2, tissue inhibitor of metalloproteinase 2, and exhibit locomotor impairment, abnormal fear conditioning behavior, and defective neuronal differentiation. This mutant mouse strain may be useful in studies of extracellular matrix homeostasis, synaptic plasticity in behavior, learning and memory, neuronal differentiation and development of neuromuscular junctions.
Usp18^tm1Dzh	007225 Under Development for Production	FVB.129(B6)-Usp18^tm1Dzh/J
These Usp18 (or Ubp43)-mutant mice may be useful in studying interferons and their receptors, cellular function, signal transduction, and the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway.
a	000290 On Hold	B6C3Fe a/a-Sox10^Dom/J

Rb(16.17)7Bnr	001887 Under Development for Cryo	(STOCK Rb(6.16)24Lub x STOCK Rb(16.17)7Bnr)F1/J

Rb(6.16)24Lub	001887 Under Development for Cryo	(STOCK Rb(6.16)24Lub x STOCK Rb(16.17)7Bnr)F1/J

Tg(ACTA1-SMN)63Ahmb	008203 Under Development for Production	FVB.Cg-Smn1^tm1Msd Tg(ACTA1-SMN)63Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn; HSA63-SMN mice may be useful for neuromuscular studies including spinal muscular atrophy (SMA).
Tg(ACTA1-SMN)69Ahmb	008209 Under Development for Production	FVB.Cg-Smn1^tm1Msd Tg(ACTA1-SMN)69Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn; HSA69-SMN mice may be useful for neuromuscular studies including spinal muscular atrophy (SMA).
Tg(HDexon1)61Gpb	007578 Under Development for Production	CBy.Cg-Tg(HDexon1)61Gpb/J
These HDexon1 mice may be useful in Huntington's Disease research.
Tg(HDexon1)62Gpb	004601 On Hold	B6CBA-Tg(HDexon1)62Gpb/2J

Tg(Mx1-cre)1Cgn	008309 Under Development for Production	C57BL/6-Rag2^tm1Cgn/J
These RAG-2^fl mice harbor loxP sites flanking the entire coding region of the Rag2 (recombination activating gene 2) locus. When bred to mice that express Cre recombinase, the resulting offspring will have exon 3 deleted in the cre-expressing tissue(s). These RAG-2^fl mice may be useful in generating conditional mutations for studying the role of RAG-2 in B and T cell development (including cancer and toxicology research as a xenograft/transplant host), T and B cell receptor (V(D)J) recombination, hematopoiesis, hematology, immunology, and inflammation research.
Tg(Myh11-cre,-EGFP)2Mik	007742 Under Development for Production	B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
These smMHC/Cre/eGFP transgenic mice may be useful in studies utilizing “Cre-lox” technology or fluorescent protein expression in smooth muscle, especially separation of vascular myocytes from the surrounding cellular environment to isolate muscle specific adaptations or disease responses.
Tg(Prnp-SMN)92Ahmb	008212 Under Development for Production	STOCK Smn1^tm1Msd Tg(Prnp-SMN)92Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn; PrP92-SMN mutant mice may be useful in neuromuscular studies including spinal muscular atrophy (SMA).
Tg(SMN2)566Ahmb	008206 Under Development for Production	FVB.Cg-Smn1^tm1Msd Tg(SMN2)566Ahmb/J
These mice may be useful in neuromuscular studies including spinal muscular atrophy (SMA).
Tg(SMN2)89Ahmb	008203 Under Development for Production	FVB.Cg-Smn1^tm1Msd Tg(ACTA1-SMN)63Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn; HSA63-SMN mice may be useful for neuromuscular studies including spinal muscular atrophy (SMA).
Tg(SMN2)89Ahmb	008209 Under Development for Production	FVB.Cg-Smn1^tm1Msd Tg(ACTA1-SMN)69Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn; HSA69-SMN mice may be useful for neuromuscular studies including spinal muscular atrophy (SMA).
Tg(SMN2)89Ahmb	008212 Under Development for Production	STOCK Smn1^tm1Msd Tg(Prnp-SMN)92Ahmb Tg(SMN2)89Ahmb/J
These SMN2; Smn; PrP92-SMN mutant mice may be useful in neuromuscular studies including spinal muscular atrophy (SMA).

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