New strains under development - Research area: Diabetes and Obesity Research

 
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Diabetes and Obesity Research

	Allele Symbol   Strain Description	Stock Number	Strain Name    (link to Data Sheet)
	Adipoqtm1Chan	008195 Under Development for Production	B6.129-Adipoqtm1Chan/J
	These adiponectin-deficient (Adipoq-/- or Adipo-/-) mice may be useful in studying obesity, diabetes, insulin resistance, metabolism, inflammation, leukocyte-endothelium interactions, and colitis.
	Art2atm1Fkn	008252 Under Development for Production	NOD.129S4(B6)-Art2atm1Fkn Art2btm1Fkn/LtJ
	This Art2a and Art2b targeted mutant strain becomes diabetic at a similar onset and rate as NOD/Lt mice. The absence of ART2 expression on T cells from thymus and lymph nodes was confirmed by RT-PCR and FACS analysis. Cd4+ and CD8+ T cells from ART2 deficient NOD mice are completely resistant to NAD induced apoptosis at all concentrations in vitro. This ART2 deficient stock provides a tool to further dissect the interplay of ADP rybosylation and NAD-catabolizing enzymes and their effect on Tregs and iNKT involved in autoimmune diseases specifically, Type 1 Diabetes.
	Art2btm1Fkn	008252 Under Development for Production	NOD.129S4(B6)-Art2atm1Fkn Art2btm1Fkn/LtJ
	This Art2a and Art2b targeted mutant strain becomes diabetic at a similar onset and rate as NOD/Lt mice. The absence of ART2 expression on T cells from thymus and lymph nodes was confirmed by RT-PCR and FACS analysis. Cd4+ and CD8+ T cells from ART2 deficient NOD mice are completely resistant to NAD induced apoptosis at all concentrations in vitro. This ART2 deficient stock provides a tool to further dissect the interplay of ADP rybosylation and NAD-catabolizing enzymes and their effect on Tregs and iNKT involved in autoimmune diseases specifically, Type 1 Diabetes.
	D11Mit314	008059 Under Development for Production	NOD.L-(D11Mit314-D11Mit339)(D11Mit325-D11Mit42)/McdfJ
	Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
	D11Mit314	008054 Under Development for Production	NOD.L-(D11Mit314-D11Mit339)/McdfJ
	Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
	D11Mit314	008057 Under Development for Production	NOD.L-(D11Mit314-D11Mit33)/McdfJ
	Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
	D11Mit325	008059 Under Development for Production	NOD.L-(D11Mit314-D11Mit339)(D11Mit325-D11Mit42)/McdfJ
	Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
	D11Mit339	008059 Under Development for Production	NOD.L-(D11Mit314-D11Mit339)(D11Mit325-D11Mit42)/McdfJ
	Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
	D11Mit339	008054 Under Development for Production	NOD.L-(D11Mit314-D11Mit339)/McdfJ
	Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
	D11Mit33	008057 Under Development for Production	NOD.L-(D11Mit314-D11Mit33)/McdfJ
	Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
	D11Mit42	008059 Under Development for Production	NOD.L-(D11Mit314-D11Mit339)(D11Mit325-D11Mit42)/McdfJ
	Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
	D4Mit59	008065 Under Development for Production	NOD.NZM2328-(D4Mit76-D4Mit59)/McdfJ
	This NOD congenic strain may be useful to identify candidate genes on Chromosome 4 associated with diabetes resistance and to identify genes with common roots in multiple autoimmune diseases.
	D4Mit76	008065 Under Development for Production	NOD.NZM2328-(D4Mit76-D4Mit59)/McdfJ
	This NOD congenic strain may be useful to identify candidate genes on Chromosome 4 associated with diabetes resistance and to identify genes with common roots in multiple autoimmune diseases.
	Foxp3sf	006775 On Hold	NOD.Cg-Foxp3sf/DoiJ
	H2g7	001627 Under Development for Cryo	NON.NOD-H2g7/LtJ
	This histocompatibiity congenic strain carries the diabetogenic MHC from NOD/ShiLtJ mice. These mice exhibit some but not all of the immune dysfunctions of NOD/ShiLtJ mice. These mice are useful for dissecting the role of MHC versus non-MHC genes in producing aberrant immunophenotypes.
	Idd4	008059 Under Development for Production	NOD.L-(D11Mit314-D11Mit339)(D11Mit325-D11Mit42)/McdfJ
	Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
	Idd4	008054 Under Development for Production	NOD.L-(D11Mit314-D11Mit339)/McdfJ
	Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
	Idd4	008057 Under Development for Production	NOD.L-(D11Mit314-D11Mit33)/McdfJ
	Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD background. There appear to be multiple diabetes resistant regions (Idd4 ) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
	PctpR120H	002105 On Hold	NZO/HlLtJ
	Pomctm2Ute	008115 Under Development for Production	B6.129X1-Pomctm2Ute/J
	These mutant mice lack pro-opiomelanocortin-alpha (POMC) and all POMC-derived peptides. Homozygotes are twice the weight of wildtype controls and have no detectable serum adrenocorticotropic hormone (ACTH), corticosterone, or aldosterone. This mutant mouse strain may be useful in studies of obesity, energy homeostasis and endocrinology.
	Rai1tm1Jrl	005981 On Hold	B6.129S7-Rai1tm1Jrl/J
	Tg(IGFBP1)2Miel	008221 Under Development for Production	B6.Cg-Tg(IGFBP1)2Miel/J
	These hIGFBP-1 (insulin-like growth factor binding protein 1, human) transgenic mice may be useful in studying metabolic and vascular homeostasis, diabetes, and the role of insulin-like growth factor binding protein in placentation and preeclampsia.
	Tg(IGFBP2)1Miel	008222 Under Development for Production	B6.FVB-Tg(IGFBP2)1Miel/J
	These IGFBP-2 overexpressing transgenic mice may be useful in studying metabolic homeostasis, adipocyte biology, and the role of insulin-like growth factor binding protein in protecting against obesity- and age-associated complications (such as hypertension and diabetes).
	Tg(Ins1-EGFP)1Hara	008173 Under Development for Production	NOD.Cg-Tg(Ins1-EGFP)1Hara/QtngJ
	Congenic NOD mice hemizygous for Enhanced Green Florescent Protein, EGFP, under the control of the Mouse Insulin I promoter, InsI, (MIP-GFP) express green florescence in tissues where insulin I is normally detected, specifically in pancreatic beta-cells. Transgenic mice are reported to develop diabetes at a similar or higher rate and kenetics as wildtype controls. Transgenic mice may be useful in studies of diabetes and pancreatic beta islet cell biology.
	Tg(Ins2-IAPP)RHFSoel	008232 Under Development for Production	FVB/N-Tg(Ins2-IAPP)RHFSoel/J
	These RIPHAT transgenic mice express human islet amyloid polypeptide (h-IAPP) under the regulatory control of the rat insulin II promoter and may be useful in studying the beta-cell destruction and islet amyloid deposition associated with non-insulin-dependent diabetes mellitus (NIDDM) or Type II diabetes, as well as beta-cell apoptosis and characteristics of the endoplasmic reticulum (ER) stress pathway.
	Tg(Itgax-DTR/EGFP)57Lan	008549 Under Development for Production	NOD.FVB-Tg(Itgax-DTR/EGFP)57Lan/JdkJ
	Congenic NOD mice hemizygous for a simian diphtheria toxin receptor - green fluorescent protein fusion protein under the control of mouse integrin alpha X, Itgax, promoter (CD11c). These transgenic mice provide a diphtheria toxin inducible system that transiently depletes dendritic cell populations. This congenic NOD, transgenic strain is useful for studying the specific role of dendritic cells in the immune response, specifically type 1 diabetes.

(26 stocks)

 

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• Apoptosis Research
• Cancer Research
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• Cell Biology Research
• Dermatology Research
• Developmental Biology Research
• Diabetes and Obesity Research
• Endocrine Deficiency Research
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• Immunology and Inflammation Research
• Internal/Organ Research
• Metabolism Research
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