New strains under development - Research area: Endocrine Deficiency Research

 
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Endocrine Deficiency Research

Allele Symbol
 
Strain Description		 Stock Number Strain Name
   (link to Data Sheet)
B4galt1tm1Shur 006941
Under Development for Production		 B6.129S7-B4galt1tm1Shur/J
These mutant mice do not express the long or short isoforms of Beta 1,4-galactosyltransferase enzyme. 90% of homozygotes die soon after birth or within 2-3 weeks of birth. This mutant mouse strain may be useful in studies of glycosidic molecular interactions and function, and polyglandular endocrine insufficiency.
B4galt1tm2Shur 006943
Under Development for Production		 B6.129S7-B4galt1tm2Shur/J
These mutant mice do not express the long isoform of the beta 1,4-galactosyltransferase enzyme. Homozygotes exhibit abnormal acrosomal exocytosis and mammary gland morphogenesis. This mutant mouse strain may be useful in studies of glycosidic molecular interactions and function, and cell-to-extracellular matrix (ECM) interactions.
Ddr2slie 008172
Under Development for Production		 BKS(HRS)-Ddr2slie/JngJ
Mice homozygous for the spontaneous mutation smallie (slie) in the Ddr2 (discoidin domain receptor family, member 2) gene appear normal at birth but by weaning they exhibit dwarfism and minor craniofacial abnormalities. Homozygous females lack a corpora lutea by six weeks. By four months, homozygous males exhibit atrophy of spermatogonia, Sertoli and Leydig cells. This mutant mouse strain has characteristics similar to human Levi type dwarfism and may be useful in studies related to dwarfism and infertility.
Edardl-J 000255
On Hold		 GL/Le Edardl-J +/+ Ostm1gl/J
Foxp3sf 006775
On Hold		 NOD.Cg-Foxp3sf/DoiJ
Mmp9tm1Tvu 007084
Under Development for Production		 B6.FVB(Cg)-Mmp9tm1Tvu/J
This targeted mutation of the Mmp9 (matrix metalloproteinase 9) gene may be used to study injury response and repair, angiogenesis and inflammatory response.
Ostm1gl 000255
On Hold		 GL/Le Edardl-J +/+ Ostm1gl/J
Per1tm1Brd 008530
Under Development for Production		 B6;129S7-Per1tm1Brd Per2tm1Brd/J
Mice that are double homozygous mutants for the Per1tm1Brd (period homolog 1 (Drosophila)) and Per2tm1Brd (period homolog 2 (Drosophila)) alleles do not exhibit circadian rhythm when kept in constant darkness. A light pulse does not reestablish circadian rhythm. This mutant mouse strain may be useful in studies of circadian rhythm.
Per2tm1Brd 008530
Under Development for Production		 B6;129S7-Per1tm1Brd Per2tm1Brd/J
Mice that are double homozygous mutants for the Per1tm1Brd (period homolog 1 (Drosophila)) and Per2tm1Brd (period homolog 2 (Drosophila)) alleles do not exhibit circadian rhythm when kept in constant darkness. A light pulse does not reestablish circadian rhythm. This mutant mouse strain may be useful in studies of circadian rhythm.
Ptgs2tm2.1(Ptgs1)Fun 008104
Under Development for Production		 B6.129(FVB)-Ptgs2tm2.1(Ptgs1)Fun/J
These mutant mice develop chronic peritonitis and progressive kidney deterioration. COX1 protein (Ptgs1 gene product) is increased 5 fold in LPS-stimulated macrophages from homozygotes. This mutant mouse strain may be useful in studies of prostaglandin synthesis and inflammation.
Ssttm1Ute 008117
Under Development for Production		 B6.129S4(129S6)-Ssttm1Ute/J
Somatostatin deficient mice exhibit increased baseline plasma growth hormone, corticosterone and total ghrelin levels and impaired motor performance. Hippocampal amyloid beta 42 peptides levels are elevated. This mutant mouse strain may be useful in studies of gastric homeostasis, learning and memory and endocrinology.
Tff3tm1Dkpy 008243
Under Development for Production		 129-Tff3tm1Dkpy/J
These intestinal trefoil factor (ITF or Tff3) mutant mice may be useful in studying gastrointestinal tract injury (including inflammatory bowel diseases), maintenance of the mucosal barrier, migration and turnover of the intestinal epithelium, and therapies for colon cancer.
Tnftm1Gkl 007082
Under Development for Production		 CByJ.129S(B6)-Tnftm1Gkl/J
Mice homozygous for the Tnftm1Gkl targeted mutation may be useful in studies of susceptibility to parasitic amd bacterial infection, endotoxin sensitivity and immune response.
Tg(Alb1-Ren)1Unc 007853
Under Development for Production		 129S/SvEv-Tg(Alb1-Ren)1Unc/CofJ
These RenTgMK mice may be useful in studying the effects of genetically clamped renin (and angiotensin II) on hypertension, diabetic nephropathy, albuninurea, nephrosclerosis, and other aspects of the renin–angiotensin system (RAS).
Tg(Ela1-TAg*)289Mjt 008247
Under Development for Production		 B6.Cg-Tg(Ela1-TAg*)289Mjt/J
These T1-147 transgenic mice (harboring the E1-T147 transgene) develop metastatic pancreatic acinar cell cancer as a result of expression of the 1-147 amino acid fragment of simian virus 40 large T antigen (TAg) directed to pancreatic acinar cells by the rat elastase 1 (Ela1 or E1) upstream control region.
007748
Under Development for Production		 B6129-Cebpbtm1Vpo/J
These C/EBP-beta mutant mice may be useful in studying metabolism, obesity, mammary gland development, or lymphoproliferative disorders.

(16 stocks)

 

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