JAX Mice Database - Hematological Research

New strains under development - Research area: Hematological Research

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Hematological Research

Allele Symbol Strain Description	Stock Number	Strain Name (link to Data Sheet)
Eraf^tm1.1Mjwe	007858 Under Development for Production	B6.129S6(Cg)-Eraf^tm1.1Mjwe/J
The entire coding region of the erythroid associated factor gene has been disrupted in this mutant mouse line. This gene (also called a-hemoglobin stabilizing protein or AHSP) specifically binds the cytotoxic free a-Hb subunit of hemoglobin A. These AHSP-mutant mice may be useful in studying erythroid development/erythropoiesis, thalassemia, Heinz body hemolytic anemia, and other hemoglobinopathies.
Foxp3^sf	006775 On Hold	NOD.Cg-Foxp3^sf/DoiJ

Gpi1^b	005730 Under Development for Cryo	129S6.CB(B6)-Del(1)1Brk Gpi1^b/Gpi1^c/BrkMdfJ

Hlx^tm1Rph	008313 Under Development for Production	B6.129P2-Hlx^tm1Rph/J
Mice homozygous for this Hlx targeted mutation have an embryonic or perinatal lethal phenotype, failing to develop past ED15.5 or dying at birth. Homozygotes exhibit defective fetal hematopoiesis with abnormal liver and gut development. Naive CD4 T cells from heterozygotes on the FVB/NJ background exhibit increased responsiveness to IL-4, resulting in differentiation of more Th2 cells. This mutant mouse strain may be useful in studies of liver and gastrointestinal development and T helper 2 cell differentiation.
Hlx^tm1Rph	008315 Under Development for Production	FVB.129P2(Cg)-Hlx^tm1Rph/J
Mice homozygous for this Hlx targeted mutation have an embryonic or perinatal lethal phenotype, failing to develop past ED15.5 or dying at birth. Homozygotes exhibit defective fetal hematopoiesis with abnormal liver and gut development. Naive CD4 T cells from heterozygotes on the FVB/NJ background exhibit increased responsiveness to IL-4, resulting in differentiation of more Th2 cells. This mutant mouse strain may be useful in studies of liver and gastrointestinal development and T helper 2 cell differentiation.
Hmox1^tm1Poss	008311 Under Development for Production	FVB.129S2(B6)-Hmox1^tm1Poss/J
Mice that are homozygous for this Hmox1 (heme oxygenase (decycling) 1) targeted mutation develop anemia with diminished serum iron, increased serum ferritin, iron accumulation in kidney and liver and progressive chronic inflammatory disease. Homozygotes occur at a lower than expected frequency, or are not produced, from heterozygous crosses and have decreased postnatal survival. This mutant mouse strain may be useful in studies of hemochromatosis, inflammation and iron metabolism.
Il2rg^tm1Wjl	007799 Under Development for Production	NOD.Cg-Rag1^tm1Mom Il2rg^tm1Wjl/SzJ
These NOD-Rag1^null IL2rg^null double mutant mice may be useful for cell or tissue transplantation studies, particularly as a model for human lymphohematopoietic cell engraftment studies that require a radioresistant host.
Ltb4r1^tm1Adl	008102 Under Development for Production	B6.129S4-Ltb4r1^tm1Adl/J
As the G protein-coupled receptor BLTR/BLT1 is expressed on myeloid leukocytes (including neutrophils, macrophages, eosinophils, T cell lymphomas, and effector T cells (TH1 CD4⁺ cells, TH2 CD4⁺ cells, and effector memory CD8⁺ cells) during CD4⁺ migration/recruitment from the lymphoid compartment into peripheral tissues), these BLTR/BLT1 mutant mice may be useful for studying leukocyte function in inflammation, as well as the role of the LTB4-BLT1 pathway linking early immune system activation and multiple classes of acquired immune effector cells.
Mirn150^tm1Rsky	007750 Under Development for Production	B6;C-Mirn150^tm1Rsky/J
These miR150^-/- mice may be useful in mircoRNA biology, specifically to study the role of miR-150 and its target genes (including c-Myb) in lymphocyte development and function.
Mirn155^tm1.1Rsky	007745 Under Development for Production	B6.Cg-Mirn155^tm1.1Rsky/J
These bic/mir-155 mutant mice may be useful in mircoRNA biology, specifically to study the role of miR-155 and its target genes (including cytokines, chemokines, and transcription factors) in homeostasis and function of the immune system.
Ncf1^m1J	004742 On Hold	B6(Cg)-Ncf1^m1J/J

Rag1^tm1Mom	007799 Under Development for Production	NOD.Cg-Rag1^tm1Mom Il2rg^tm1Wjl/SzJ
These NOD-Rag1^null IL2rg^null double mutant mice may be useful for cell or tissue transplantation studies, particularly as a model for human lymphohematopoietic cell engraftment studies that require a radioresistant host.
Rag2^tm1.1Cgn	008309 Under Development for Production	C57BL/6-Rag2^tm1Cgn/J
These RAG-2^fl mice harbor loxP sites flanking the entire coding region of the Rag2 (recombination activating gene 2) locus. When bred to mice that express Cre recombinase, the resulting offspring will have exon 3 deleted in the cre-expressing tissue(s). These RAG-2^fl mice may be useful in generating conditional mutations for studying the role of RAG-2 in B and T cell development (including cancer and toxicology research as a xenograft/transplant host), T and B cell receptor (V(D)J) recombination, hematopoiesis, hematology, immunology, and inflammation research.
Rag2^tm1Cgn	008309 Under Development for Production	C57BL/6-Rag2^tm1Cgn/J
These RAG-2^fl mice harbor loxP sites flanking the entire coding region of the Rag2 (recombination activating gene 2) locus. When bred to mice that express Cre recombinase, the resulting offspring will have exon 3 deleted in the cre-expressing tissue(s). These RAG-2^fl mice may be useful in generating conditional mutations for studying the role of RAG-2 in B and T cell development (including cancer and toxicology research as a xenograft/transplant host), T and B cell receptor (V(D)J) recombination, hematopoiesis, hematology, immunology, and inflammation research.
Rpsa	008369 Under Development for Production	B6.129S6-Rpsa^tm1Ells/J
Mice that are heterozygous for the Rpsa^tm1Ells, ribosomal protein SA, targeted mutation exhibit a signficantly lower mean corpuscular hemoglobin concentration (MCHC) when treated with a myelosuppressor. This mutant mouse strain may be useful in studies of Diamond Blackfan anemia.
Tyro3^tm1Grl	007937 Under Development for Production	B6.129-Tyro3^tm1Grl/J
Mice that are homozygous for this mutation may be useful in studies of thrombosis and platelet aggregation. Mutants exhibit reduced pathological thrombosis and impaired platelet aggregation.
Usp18^tm1Dzh	007225 Under Development for Production	FVB.129(B6)-Usp18^tm1Dzh/J
These Usp18 (or Ubp43)-mutant mice may be useful in studying interferons and their receptors, cellular function, signal transduction, and the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway.
Del(1)1Brk	005730 Under Development for Cryo	129S6.CB(B6)-Del(1)1Brk Gpi1^b/Gpi1^c/BrkMdfJ

Tg(MMTV-neu/OT-I/OT-II)CBnel	007962 Under Development for Production	B6.FVB-Tg(MMTV-neu/OT-I/OT-II)CBnel Tg(Trp53R172H)8512Jmr/J
Approximately 85% of the compound mutant females develop focal mammary tumors at 6-10 months of age. Both virgin and breeder mice develop tumors. Approximately 37% of tumor-bearing mice develop metastatic disease to the lung. High expression of neu is detected in tumor tissue while very low levels are found in lung and ovary. Female mice carrying only the neu^OT-I/OT-II mutation develop focal mammary tumors at approximately 18 months of age.
Tg(Mx1-cre)1Cgn	008309 Under Development for Production	C57BL/6-Rag2^tm1Cgn/J
These RAG-2^fl mice harbor loxP sites flanking the entire coding region of the Rag2 (recombination activating gene 2) locus. When bred to mice that express Cre recombinase, the resulting offspring will have exon 3 deleted in the cre-expressing tissue(s). These RAG-2^fl mice may be useful in generating conditional mutations for studying the role of RAG-2 in B and T cell development (including cancer and toxicology research as a xenograft/transplant host), T and B cell receptor (V(D)J) recombination, hematopoiesis, hematology, immunology, and inflammation research.
Tg(Trp53R172H)8512Jmr	007962 Under Development for Production	B6.FVB-Tg(MMTV-neu/OT-I/OT-II)CBnel Tg(Trp53R172H)8512Jmr/J
Approximately 85% of the compound mutant females develop focal mammary tumors at 6-10 months of age. Both virgin and breeder mice develop tumors. Approximately 37% of tumor-bearing mice develop metastatic disease to the lung. High expression of neu is detected in tumor tissue while very low levels are found in lung and ovary. Female mice carrying only the neu^OT-I/OT-II mutation develop focal mammary tumors at approximately 18 months of age.

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