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Hematological Research

 
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Hematological Research

	Allele Symbol   Strain Description	Stock Number	Strain Name    (link to Data Sheet)
	Ccl11tm1Mer	017618 Awaiting Transfer from the Donor	C.129S6(Cg)-Ccl11tm1Mer/J
	These Ccl11 knockout mice exhibit a reduced total eosinophil count in peripheral blood and may be useful for studying eosinophilia and inflammatory disorders.
	Eif2c2tm3Ghan	014150 In Progress	B6;129S6-Eif2c2tm3Ghan/J
	This mutant strain lacks Eif2c2 catalytic activity and may be useful in studies of microRNA biogenesis and erythropoiesis.
	Hfe2tm1Nca	017788 In Progress	129S-Hfe2tm1Nca/J
	These Hfe2 knockout mice exhibit iron loading and have applications in studies of juvenile or Type2A hemochromatosis, iron homeostasis and iron-induced oxidative damage.
	Hfetm2Nca	017785 In Progress	129S-Hfetm2Nca/J
	These mice carry a targeted mutation of Hfe, hemochromatosis, exhibit iron loading, and have applications in studies of hereditary hemochromatosis, iron homeostasis and innate immune response
	Hfetm2Nca	017784 Under Development for Cryo	B6.129S6-Hfetm2Nca/J
	These mice carry a targeted mutation of Hfe, hemochromatosis, exhibit iron loading, and have applications in studies of hereditary hemochromatosis, iron homeostasis and innate immune response.
	Kitltm1.1Sjm	017860 Awaiting Transfer from the Donor	STOCK Kitltm1.1Sjm/J
	An EGFP reporter disrupts expression of the Kitl gene in this targeted mutation strain. EGFP is primarily expressed by perivascular endothelial and stromal cells throughout the bone marrow in heterozygotes.
	Lattm6(DTR)Mal	016937 In Progress	B6.129S2-Lattm6(DTR)Mal/J
	Latfl-dtr mutant mice contain a loxP site downstream from exon 1, and an internal ribosome entry site (IRES), a human diphtheria toxin receptor, and an enhanced green fluorescent protein (EGFP) followed by a second loxP site downstream of the internal stop codon of the linker for activation of T cells (Lat) gene. These mice may be useful for studying the TCR signaling cascade and T cell homeostasis.
	Mll1tm2(MLLT3)Thr	009079 On Hold	STOCK Mll1tm2(MLLT3)Thr/KsyJ
	Beginning around six months of age, these Mll-AF9 knock-in mice recapitulate the acute myeloid leukemia (AML) phenotype associated with the t(9;11)(p22;q23) translocation in humans and may be useful for studying hematopoietic development, cancer, and acute myeloid leukemia.
	Nanogtm1Hoch	016233 Awaiting Transfer from the Donor	129S;B6-Nanogtm1Hoch/J
	A GFP-IRES-puro-cassette replaces the coding region of the Nanog gene in these mice. Mouse embryonic fibroblasts containing this mutation may be useful for identifying induced pluripotent stem cells.
	Sept4tm1Hs	018160 Awaiting Transfer from the Donor	129-Sept4tm1Hs/J
	Septin 4 (Sept4) homozygous knockout males are sterile due to immotile and structurally defective sperm. Mice also exhibit increased incidence of hematopoietic malignancies having increased numbers of hematopoietic stem and progenitor cells (HSPCs).
	Sept4tm1Hs	018159 Awaiting Transfer from the Donor	B6.129P2-Sept4tm1Hs/J
	Septin 4 (Sept4) homozygous knockout males are sterile due to immotile and structurally defective sperm. Mice also exhibit increased incidence of hematopoietic malignancies having increased numbers of hematopoietic stem and progenitor cells (HSPCs).
	Sept4tm1Hs	018161 Awaiting Transfer from the Donor	FVB.129P2-Sept4tm1Hs/J
	Septin 4 (Sept4) homozygous knockout males are sterile due to immotile and structurally defective sperm. Mice also exhibit increased incidence of hematopoietic malignancies having increased numbers of hematopoietic stem and progenitor cells (HSPCs).
	Slc11a2tm2Nca	017789 In Progress	129S-Slc11a2tm2Nca/J
	These Dmt1fl mice possess loxP sites flanking exons 6-8 of the solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (Slc11a2) gene and have applications in studies related to anemia, iron homeostasis and micronutrient and drug absorption in the intestine.
	Slc40a1tm2Nca	017790 In Progress	129S-Slc40a1tm2Nca/J
	These ferroportinfl mice possess loxP sites flanking exons 6 and 7 of the solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1) gene and have applications in studies related to type 4 hemochromatosis, anemia, and iron homeostasis.
	Tg(CD4-Il17re)#Cdon	017943 In Progress	C57BL/6-Tg(CD4-Il17re)#Cdon/J
	These mice contain a transgene utilizing a human CD4 promoter driving expression of IL-17RE in Th17 cells. They exhibit a susceptibility to EAE.
	Tg(Cp-EGFP)25Gaia	005854 On Hold	STOCK Tg(Cp-EGFP)25Gaia/J
	Mice homozygous for the Notch reporter transgene are viable, fertile, normal in size, and do not display any behavioral abnormalities. Enhanced green fluorescent protein (EGFP) expression is present in a wide variety of hemizygous cell/tissue types during development and in the adult, including enriched hematopoietic stem cell (HSC) populations. The location of EGFP expression is consistent with Notch signaling pathway elements/genes and appears to faithfully reflect canonical (CBF1-mediated) Notch activity. With respect to hematopoiesis, low expression is shown in fully differentiated cells of the peripheral lymphoid organs (blood and spleen). Isolated HSC retain their ability to differentiate. Mice expressing this Notch reporter transgene may be useful in studying HSC populations and other cell types utilizing the Notch, CBF1, or Wnt signaling pathways. As immature (double negative [DN]) thymocytes have differential expression patterns as they progress from DN1-DN4, these mice may al ..... For more information please see the full phenotype on the strain data sheet
	Tg(H2-K-S100a9,GFP)1Gabr	018055 Awaiting Transfer from the Donor	B6.FVB-Tg(H2-K-S100a9,GFP)1Gabr/J
	These transgenic mice express S100a9 (S100 calcium binding protein A9 (calgranulin B)), a myeloid-related protein, and GFP under the control of the hematopoietic cell-specific H2-K promoter. Overexpression of S100a9 inhibits the differentiation of dendritic cells and macrophages while inducing an accumulation of myeloid-derived suppressor cells.
		018322 Awaiting Transfer from the Donor	STOCK Tg(Cp-EGFP)25Gaia/ReyaJ
	These Notch reporter mice are useful in studying hematopoietic stem cell populations utilizing the Notch or Wnt signaling pathways, as well as in thymocyte maturation studies.

(18 stocks)

 

Select another Research Area Application:

• Apoptosis Research
• Cancer Research
• Cardiovascular Research
• Cell Biology Research
• Dermatology Research
• Developmental Biology Research
• Diabetes and Obesity Research
• Endocrine Deficiency Research
• Hematological Research
• Immunology and Inflammation Research
• Internal/Organ Research
• Metabolism Research
• Mouse/Human Gene Homologs
• Neurobiology Research
• Reproductive Biology Research
• Research Tools
• Sensorineural Research
• Virology Research
• Under Review

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