JAX Mice Database - Mouse/Human Gene Homologs

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Mouse/Human Gene Homologs

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Mouse/Human Gene Homologs

Allele Symbol Strain Description	Stock Number	Strain Name (link to Data Sheet)
Apoe^tm1Unc	007069 On Hold	AKR.129P2(B6)-Apoe^tm1Unc/J
Mice homozygous for this Apoe (apolipoprotein E) targeted mutation, Apoe^tm1Unc, may be useful for studying impaired immune response, lipid and leptin homeostasis, atherosclerosis, hematopoiesis, hearing loss, xanthoma, behavior and learning defects, neurodegeneration, Alzheimer's Disease and diet-induced obesity without diabetes.
Cacna1f^tm1Sdie	017760 Under Development for Cryo	B6(Cg)-Cacna1f^tm1Sdie/J
These I756T+neo mice carry the I756T point mutation in exon 17 of the Cacna1f, calcium channel, voltage-dependent, alpha 1F subunit, (756 is the mouse equivalent to residue 745 in human CACNA1F) as well as a FRT flanked NEO selection cassette and loxP sites flanking exons 14 through 17. This mutant mouse strain may be useful in studies of calcium channelopathies, incomplete congenital stationary night blindness, photoreceptor electrophysiology, and the role of the Cav1.4 channel in survival of naive T cells.
Cmah^tm1Avrk	017929 Awaiting Transfer from the Donor	B10.Cg-Cmah^tm1Avrk Dmd^mdx/PtmJ
These Cmah-mdx mice are useful for studying how human-like CMAH-deficiency accelerates the onset and severity of the Duchenne muscular dystrophy (DMD) seen in Dmd^mdx mice. These mice are useful for studying the metabolic accumulation of dietary N-glycolylneuraminic acid (Neu5Gc; a foreign sialyl-containing glycan in humans and Cmah-deficient mice), the subsequent generation of Neu5Gc-specific antibodies and the deposition of activated (C5b-9) complement on muscle fibers. These Cmah-mdx mice represent a new small animal model for DMD that better approximates the human glycome and its contributions to muscular dystrophy.
Dmd^mdx	017929 Awaiting Transfer from the Donor	B10.Cg-Cmah^tm1Avrk Dmd^mdx/PtmJ
These Cmah-mdx mice are useful for studying how human-like CMAH-deficiency accelerates the onset and severity of the Duchenne muscular dystrophy (DMD) seen in Dmd^mdx mice. These mice are useful for studying the metabolic accumulation of dietary N-glycolylneuraminic acid (Neu5Gc; a foreign sialyl-containing glycan in humans and Cmah-deficient mice), the subsequent generation of Neu5Gc-specific antibodies and the deposition of activated (C5b-9) complement on muscle fibers. These Cmah-mdx mice represent a new small animal model for DMD that better approximates the human glycome and its contributions to muscular dystrophy.
Dmd^mdx	018018 Awaiting Transfer from the Donor	B10ScSn.Cg-Prkdc^scid Dmd^mdx/J
MDX/SCID mice exhibit necrosis, centrally located nuclei and and the muscle degeneration characteristic of DMD and may be used a dystrophic model for the transplantation of human donor cells to evaluate skeletal muscle regeneration.
Dmd^mdx	013141 Awaiting Transfer from the Donor	D2.B10-Dmd^mdx/J
These Dmd^mdx mutant mice may be useful for studying Duchenne muscular dystrophy (DMD).
Hfe2^tm1Nca	017788 In Progress	129S-Hfe2^tm1Nca/J
These Hfe2 knockout mice exhibit iron loading and have applications in studies of juvenile or Type2A hemochromatosis, iron homeostasis and iron-induced oxidative damage.
Hfe^tm2Nca	017785 In Progress	129S-Hfe^tm2Nca/J
These mice carry a targeted mutation of Hfe, hemochromatosis, exhibit iron loading, and have applications in studies of hereditary hemochromatosis, iron homeostasis and innate immune response
Hfe^tm2Nca	017784 Under Development for Cryo	B6.129S6-Hfe^tm2Nca/J
These mice carry a targeted mutation of Hfe, hemochromatosis, exhibit iron loading, and have applications in studies of hereditary hemochromatosis, iron homeostasis and innate immune response.
Itga7^tm1Burk	016857 In Progress	B6;129-Itga7^tm1Burk/J
The α7^- (or α7βgal^-) mutant allele is designed to both abolish endogenous gene expression and place β-galactosidase under transcriptional control of the α7 integrin promoter/enhancer region.
Mecp2^tm1.1Joez	017741 Awaiting Transfer from the Donor	B6N.129(Cg)-Mecp2^tm1.1Joez/J
The amino acid mutation T158A was introduced into exon 4 of the mouse methyl-CpG binding protein 2 (Mecp2) gene, resulting in a phenotypic pattern similar to that observed in patients with Rett Syndrome.
Prkdc^scid	018018 Awaiting Transfer from the Donor	B10ScSn.Cg-Prkdc^scid Dmd^mdx/J
MDX/SCID mice exhibit necrosis, centrally located nuclei and and the muscle degeneration characteristic of DMD and may be used a dystrophic model for the transplantation of human donor cells to evaluate skeletal muscle regeneration.
Prnp^tm1Cwe	018122 Awaiting Transfer from the Donor	FVB.129S7(B6)-Prnp^tm1Cwe/J
These prion protein-deficient mice are resistant to prion disease and serve as a PrP-deficient background for mouse models of spongiform encephalopathies and neurologic prion disorders.
Slc26a4^tm1Egr	018424 Awaiting Transfer from the Donor	129S-Slc26a4^tm1Egr/AjgJ
Pds^-/- mice are useful for studying deafness and vestibular dysfunction associtated with Pendred syndrome.
Thy1^a	014550 Under Development for Cryo	B6.Cg-Thy1^a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J
These Bd 1807 TCR transgenic mice feature a CD4+ T cell repertoire that are reactive to several types of dimorphic fungi that cause major systemic mycoses found in North America.
Tg(CAG-Tfb1m)AGsha	018021 Awaiting Transfer from the Donor	B6.Cg-Tg(CAG-Tfb1m)AGsha/J
In these trangenic mice, widespread overexpression of the mitochondrial ribosomal RNA methyltransferase, mtTFB1, results in maternally inherited deafness.
Tg(Prnp-tTA)F959Sbp	018124 Awaiting Transfer from the Donor	STOCK Tg(Prnp-tTA)F959Sbp/J
These mice may be useful for regulating gene expression in tissues that typically express the prion protein Prnp gene via a tetracycline regulated transactivator.
Tg(SOD1*G93A)1Gur	013199 Awaiting Transfer from the Donor	FVB.Cg-Tg(SOD1*G93A)1Gur/J
These SOD1-G93A (also called G93A-SOD1) transgenic mice may be useful in studying neuromuscular disorders, including Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease).
Tg(TcraCWM5,TcrbCWM5)1807Wuth	014550 Under Development for Cryo	B6.Cg-Thy1^a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J
These Bd 1807 TCR transgenic mice feature a CD4+ T cell repertoire that are reactive to several types of dimorphic fungi that cause major systemic mycoses found in North America.
Tg(Thy1-DCTN1*G59S)M2Pcw	017590 Awaiting Transfer from the Donor	B6SJL-Tg(Thy1-DCTN1*G59S)M2Pcw/J
Transgenic mice expressing FLAG-tagged full-length mutant (G59S) human dynactin 1 in the spinal cord are useful for studying autophagy defects in ALS.
Tg(Thy1-TARDBP*G298S)S97Pcw	017589 Awaiting Transfer from the Donor	B6SJL-Tg(Thy1-TARDBP*G298S)S97Pcw/J
Transgenic mice expressing full-length mutant(G298S) human TARDBP exhibit a late onset motor neuron disease.
	017761 Under Development for Cryo	C57BL/6-Cacna1f^tm1.1Sdie/J
These mice carry a targeted mutation with exons 14 through 17 of the Cacna1f (calcium channel, voltage-dependent, alpha 1F subunit) gene deleted. This mutant mouse strain may be useful in studies of calcium channelopathies, incomplete congenital stationary night blindness, photoreceptor electrophysiology, and the role of the Cav1.4 channel in survival of naive T cells.

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Mouse/Human Gene Homologs

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Mouse/Human Gene Homologs