All strains newly available
| Allele Symbol | Stock Number | Strain Name Description |
Standard Supply |
| + | 006790 | B6;129P2-Del(14)3Mom/MomJ | Repository- Live |
| 5830428H23RikGt(ROSA)76Sor | 007202 | B6;129S4-5830428H23RikGt(ROSA)76Sor/J | Repository- Live |
| These BC055757-mutant mice may be useful in studying cellular signaling in development and adult mice; specifically receptor tyrosine kinases (RTK; such as Ras, MAP kinase, PI3K and those in the platelet-derived growth factor (PDGF) family) and immediate early genes (IEG) induced shortly after RTK activation. Homozygous embryos exhibit hemorrhages and microaneurisms with vascular defects persisting into adulthood. Homozygotes also exhibit polychromasia, kidney defects and abnormalities in palate bone fusion and abnormal neural crest derived and thoracic skeleton development. | |||
| Agtpbp1pcd-8J | 008292 | BALB/cJ-Agtpbp1pcd-8J/J | Repository- Live |
| Akap6tm1Jsco | 007448 | B6.129-Akap6tm1Jsco/38J | Repository-Cryopreserved |
| These A kinase (PRKA) anchor protein 6 (Akap6)-mutant mice may be useful in studying developmental biology and craniofacial defects. | |||
| Akt2tm1.1Mbb | 006952 | B6.Cg-Akt2tm1.1Mbb Ldlrtm1Her/J | Repository- Live |
| These C57BL/6J Akt2+/- LDLR-/- mice harbor targeted mutations in both the Akt2 (thymoma viral proto-oncogene 2) and Ldlr (low density lipoprotein receptor) loci. Independently, homozygous Akt2 mutant mice develop insulin resistance and diabetes, while LDLR homozygotes are predisposed to atherosclerosis. When these C57BL/6J Akt2+/- LDLR-/- double mutant mice are heterozygous for the Akt2 mutation and homozygous for the LDLR mutation they are viable and fertile and may be useful to study diabetes, metabolism, hyperglycemia, and atherosclerosis. | |||
| Akt2tm1.1Mbb | 006966 | B6.Cg-Akt2tm1.1Mbb/J | Repository- Live |
| Mice homozygous for this Akt2 (thymoma viral proto-oncogene 2) mutant allele develop insulin resistance, hyperglycemia, impaired glucose tolerance, abnormal glucose uptake in muscle tissue, increased pancreatic beta-cell mass, and diabetes. | |||
| Apobtm1.1Zc | 007682 | B6.129X1-Apobtm1.1Zc/J | Repository- Live |
| These apoB38.9 mutant mice may be useful to study the genetic and molecular mechanism of apoB defects and lipid metabolism/liver fat accumulation, the relationship between hepatic steatosis and insulin resistance, the progression of advanced non-alcoholic fatty liver diseases (NAFLD), and atherosclerosis. In addition, all three congenic apoB38.9 strains (Stock No. 007679, Stock No. 007682, and Stock No. 007683) may be useful in conjunction with other apoB mutant mice, including Stock No. 002053 (apoB70), Stock No. 002876 (apoB48-only), and Stock No. 002877 (apoB100-only). | |||
| Apobtm1.1Zc | 007683 | CByJ.129X1(Cg)-Apobtm1.1Zc/J | Repository- Live |
| These apoB38.9 mutant mice may be useful to study the genetic and molecular mechanism of apoB defects and lipid metabolism/liver fat accumulation, the relationship between hepatic steatosis and insulin resistance, the progression of advanced non-alcoholic fatty liver diseases (NAFLD), and atherosclerosis. In addition, all three congenic apoB38.9 strains (Stock No. 007679, Stock No. 007682, and Stock No. 007683) may be useful in conjunction with other apoB mutant mice, including Stock No. 002053 (apoB70), Stock No. 002876 (apoB48-only), and Stock No. 002877 (apoB100-only). | |||
| Apobtm1.1Zc | 007679 | SWR.129X1(B6)-Apobtm1.1Zc/J | Repository- Live |
| These apoB38.9 mutant mice may be useful to study the genetic and molecular mechanism of apoB defects and lipid metabolism/liver fat accumulation, the relationship between hepatic steatosis and insulin resistance, the progression of advanced non-alcoholic fatty liver diseases (NAFLD), and atherosclerosis. In addition, all three congenic apoB38.9 strains (Stock No. 007679, Stock No. 007682, and Stock No. 007683) may be useful in conjunction with other apoB mutant mice, including Stock No. 002053 (apoB70), Stock No. 002876 (apoB48-only), and Stock No. 002877 (apoB100-only). | |||
| Apoetm1Unc | 007224 | B6.Cg-Apoetm1Unc(D12Mit182-D12Mit2)/Pgn | Repository-Cryopreserved |
| Arntltm1Weit | 007668 | B6.129S4(Cg)-Arntltm1Weit/J | Repository- Live |
| These Bmal1-floxed mutant mice may be useful in generating conditional mutations (whole-mouse or tissue-specific) to study the role of circadian clock/circadian rhythm in physiological and behavioral regulation. | |||
| Ath6C57BLKS/J | 007224 | B6.Cg-Apoetm1Unc(D12Mit182-D12Mit2)/Pgn | Repository-Cryopreserved |
| Atp8b3tm1Gar | 007659 | 129S-Atp8b3tm1Gar/J | Repository-Cryopreserved |
| -Sperm morphology and motility are unaffected, but tests show that phosphatidylserine (PS) already exists in the outer membrane leaflet before sperm capacitation. When the zona pellucida (ZP) is removed from eggs, fertilization rates are normal; although when the extracellular matrix is intact, fewer spermatozoa bind tightly or penetrate the ZP, and fewer undergo acrosome reactions. This strain may be useful in studies of male fertility. | |||
| B2mtm1Unc | 006611 | NOD.129P2(B6)-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs/DvsJ | Repository- Live |
| B2mtm1Unc | 004548 | NOD.Cg-B2mtm1Unc Tg(B2M)55Hpl Tg(HLA-A2.1)1Enge/DvsJ | Repository-Cryopreserved |
| Bdkrb2tm1Jfh | 006860 | B6.129-Ins2Akita Bdkrb2tm1Jfh/SmiJ | Repository- Live |
| Mice homozygous for this targeted mutation of the bradykinin receptor, beta 2 (Bdkrb2) gene and heterozygous for the Akita spontaneous mutation of the insulin 2 (Ins2) gene (Ins2Akita) are viable and fertile. They are extremely diabetic, underweight, hyperphagic, polyuric, and have severe kidney, skeletal, and testicular defects. essentially no subcutaneous fat, and a significantly reduced lifespan. This strain may be used to research the kallikrein-kinin system, specifically the role of bradykinin B2 receptor in diabetes, oxidative stress, mitochondrial DNA damage, apoptosis, kidney morphology and function, and other senescence-associated phenotypes. | |||
| Bicc1tm1Emdr | 007555 | B6SJL-Bicc1tm1Emdr/J | Repository-Cryopreserved |
| Bmpertm1Emdr | 007554 | B6SJL-Bmpertm1Emdr/J | Repository-Cryopreserved |
| Brunol4Ff | 008131 | C57BL/6J-Brunol4Ff/Frk | Repository-Cryopreserved |
| C5ar1tm1Cge | 006845 | C.129S4(B6)-C5ar1tm1Cge/J | Repository- Live |
| Cav1tm1Mls | 007083 | B6.Cg-Cav1tm1Mls/J | Repository- Live |
| Mice that are homozygous for this caveolin, caveolae protein 1 (Cav1) targeted mutation exhibit exercise intolerance when challenged, resistant to diet-induced obesity and are slightly hyperphagic. This mutant mouse strain may be useful in studies of vesicular and cholesterol trafficking, signal transduction and tumorigenesis. | |||
| Cd19tm1(cre)Cgn | 008100 | B6.129-Prdm1tm1Clme/J | Repository- Live |
| These Prdm1 floxed conditional mutant mice may be useful in generating conditional mutations to study humoral immune response, plasma memory B-cells, and B-lymphocyte development and differentiation. | |||
| Cd19tm1(cre)Cgn | 006922 | B6.Cg-Sfpi1tm2Dgt/J | Repository- Live |
| Cd19tm1(cre)Cgn | 007895 | C57BL/6-Fastm1Cgn/J | Repository- Live |
| These Fasfl mice may be useful in generating conditional mutations for studying many aspects of immune function. For example, deletion of Fas in T cells can lead to pulmonary fibrosis (model of human idiopathic pulmonary fibrosis), whereas deletion of Fas in B cells can result in a lymphoproliferative disorder. | |||
| Cd22tm1Lam | 006940 | C57BL/6-Cd22tm1Lam /J | Repository- Live |
| CD22 deficient mutant mice exhibit a reduction in recirculating mature B cells in the bone marrow and fewer transitional B cells in the spleen. Splenic and peripheral B cells express lower levels of membrane bound IgM than wildtype. B cell activation is abnormal in mutant mice, with enhanced Ca2+ mobilization after stimulation. This mutant mouse strain may be useful in studies of glycosidic molecular interactions and function, B cell development and T cell independent immune response. | |||
| Cd33tm1Ajv | 006942 | B6.129-Cd33tm1Ajv/J | Repository- Live |
| CD33 deficient mice exhibit a slight decrease in the mean erythrocyte count and hematocrit and an increase in the mean concentration of serum aspartate aminotransaminase. Experimentally induced peritonitis and systemic inflammation results in reduced immunological response. This mutant mouse strain may be useful in studies of glycosidic molecular interactions and function, hematopoiesis and immune response. | |||
| Cd44tm1Ugu | 008008 | STOCK Cd44tm1Ugu/J | Repository- Live |
| Cdh23ahl | 007048 | DBA/2J-Gpnmb+/SjJ | Repository- Live |
| This coisogenic strain has a functional allele of Gpnmb. Homozygous mice do not develop the elevated intraocular pressure or glaucoma found in DBA/2J mice (Stock 000671), although they exhibit a mild iris stromal atrophy (ISA). This strain provides a genetically matched control for DBA/2J. | |||
| Cdh23v-11J | 008288 | B6(Cg)-Cdh23v-11J/J | Repository- Live |
| Cebpatm1Dgt | 006230 | B6.Cg-Cebpatm1Dgt Tg(Mx1-cre)1Cgn/J | Repository- Live |
| Chrdtm1Emdr | 007552 | B6SJL-Chrdtm1Emdr/J | Repository-Cryopreserved |
| Chst3tm1Tmu | 006945 | B6.129-Chst3tm1Tmu/J | Repository- Live |
| At 5 to 6 weeks of age, mice that are homozygous for this targeted mutation have a reduced number (approximately 68% of wildtype levels) of naive T cells in the spleen. This mutant mouse strain may be useful in studies of glycosidic molecular interactions and function. This strain was transferred from the collection of the Consortium for Functional Glycomics. | |||
| Clcn1adr-mto9J | 008253 | C57BL/6J-Clcn1adr-mto9J/J | Repository- Live |
| Clip2tm1.1Gal | 007566 | B6.129P2-Clip2tm1.1Gal/J | Repository- Live |
| Col1a1tm2(tetO-Pou5f1)Jae | 006911 | B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm2(tetO-Pou5f1)Jae/J | Repository- Live |
| These "Oct-4/rtTA" mutant mice may be useful for studies of tumorigenesis and pluripotent stem cells. | |||
| Col1a2tm1Mcbr | 007248 | B6.129(FVB)-Col1a2tm1Mcbr/J | Repository- Live |
| Csf2 | 008056 | NOD.L-(Csf2-D11Mit339)/McdfJ | Repository- Live |
| Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD/Bdc background. These strains are useful for identifying candidate genes within the Idd4 subloci. | |||
| Cx3cr1tm1Litt | 008451 | B6.129P(Cg)-Ptprca Cx3cr1tm1Litt/LittJ | Repository- Live |
| These CX3CR1-GFP mice express EGFP under control of the endogenous Cx3cr1 locus and also harbor the CD45.1 (Ly5.1 or Ptprca) allele, which is atypical for the C57BL/6 congenic background and may be useful in studies of leukocyte migration and trafficking, as well as for transplantation studies with C57BL/6 (CD45.2: Ptprcb) mice. | |||
| Cyp1a2/Cyp1a1tm2Dwn | 007580 | STOCK Cyp1a2/Cyp1a1tm2Dwn Tg(CYP1A1,CYP1A2)1Dwn/J | Repository- Live |
| These humanized hCYP1A1_1A2_Cyp1a2/Cyp1a1(-/-) mice may useful in drug or carcinogen metabolism research; specifically as a model for human risk assessment studies involving drug or environmental toxicants that may be substrates for cytochrome P450 family members. | |||
| Cyp1a2/Cyp1a1tm2Dwn | 007580 | STOCK Cyp1a2/Cyp1a1tm2Dwn Tg(CYP1A1,CYP1A2)1Dwn/J | Repository- Live |
| These humanized hCYP1A1_1A2_Cyp1a2/Cyp1a1(-/-) mice may useful in drug or carcinogen metabolism research; specifically as a model for human risk assessment studies involving drug or environmental toxicants that may be substrates for cytochrome P450 family members. | |||
| Cyp4a14tm1Jhc | 007175 | 129S-Cyp4a14tm1Jhc/J | Repository- Live |
| These "Cyp 4a14" mutant mice may be useful studying kidney function and metabolism, cardiovascular physiology, hypertension, and the relationships between blood pressure, sex hormones, and p450 w-hydroxylases. | |||
| D11Mit132 | 008060 | NOD.L-(D11Mit314-D11Mit339)(D11Mit132-D11Mit42)/McdfJ | Repository- Live |
| Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD/Bdc background. These strains are useful for identifying candidate genes within the Idd4 subloci. | |||
| D11Mit314 | 008060 | NOD.L-(D11Mit314-D11Mit339)(D11Mit132-D11Mit42)/McdfJ | Repository- Live |
| Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD/Bdc background. These strains are useful for identifying candidate genes within the Idd4 subloci. | |||
| D11Mit314 | 008053 | NOD.L-(D11Mit314-D11Mit42)/McdfJ | Repository- Live |
| Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD/Bdc background. These strains are useful for identifying candidate genes within the Idd4 subloci. | |||
| D11Mit339 | 008056 | NOD.L-(Csf2-D11Mit339)/McdfJ | Repository- Live |
| Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD/Bdc background. These strains are useful for identifying candidate genes within the Idd4 subloci. | |||
| D11Mit339 | 008060 | NOD.L-(D11Mit314-D11Mit339)(D11Mit132-D11Mit42)/McdfJ | Repository- Live |
| Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD/Bdc background. These strains are useful for identifying candidate genes within the Idd4 subloci. | |||
| D11Mit41 | 006809 | NOD.B6-(D11Nds1-D11Mit41)/J | Repository- Live |
| Chromosome 11 congenic mice are useful for identifying genes in the Idd4 region involved in diabetes resistance. | |||
| D11Mit42 | 008060 | NOD.L-(D11Mit314-D11Mit339)(D11Mit132-D11Mit42)/McdfJ | Repository- Live |
| Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD/Bdc background. These strains are useful for identifying candidate genes within the Idd4 subloci. | |||
| D11Mit42 | 008053 | NOD.L-(D11Mit314-D11Mit42)/McdfJ | Repository- Live |
| Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD/Bdc background. These strains are useful for identifying candidate genes within the Idd4 subloci. | |||
| D11Nds1 | 006809 | NOD.B6-(D11Nds1-D11Mit41)/J | Repository- Live |
| Chromosome 11 congenic mice are useful for identifying genes in the Idd4 region involved in diabetes resistance. | |||
| D12Mit182 | 007224 | B6.Cg-Apoetm1Unc(D12Mit182-D12Mit2)/Pgn | Repository-Cryopreserved |
| D12Mit2 | 007224 | B6.Cg-Apoetm1Unc(D12Mit182-D12Mit2)/Pgn | Repository-Cryopreserved |
| D7Mit242 | 008061 | NOD.L-(D7Mit253-D7Mit242)/McdfJ | Repository- Live |
| This diabetes resistant strain commonly known as NOD.Lc7 or DR4 is viable and fertile. These NOD congenic mice are the result of crossing segments of C57L/J derived Chr 7 into the NOD/Bdc background distal to Idd7 or Idd27. Aged animals develop widespread islet associated infiltrates and invasive insulitis, while the beta cell mass and insulin content are well maintained. NOD.Lc11 mice are useful for studying and identifying candidate genes within this new and unique Idd region. | |||
| D7Mit253 | 008061 | NOD.L-(D7Mit253-D7Mit242)/McdfJ | Repository- Live |
| This diabetes resistant strain commonly known as NOD.Lc7 or DR4 is viable and fertile. These NOD congenic mice are the result of crossing segments of C57L/J derived Chr 7 into the NOD/Bdc background distal to Idd7 or Idd27. Aged animals develop widespread islet associated infiltrates and invasive insulitis, while the beta cell mass and insulin content are well maintained. NOD.Lc11 mice are useful for studying and identifying candidate genes within this new and unique Idd region. | |||
| D7Mit346 | 006436 | NOD.Cg-(Gpi1-D7Mit346)C57BL/6J Tg(TcraAI4)1Dvs/DvsJ | Repository-Cryopreserved |
| D7Mit346 | 006437 | NOD.Cg-(Gpi1-D7Mit346)C57BL/6J Tg(TcrbAI4)1Dvs/DvsJ | Repository-Cryopreserved |
| D8Mit113 | 007835 | B6.A-(D8Mit113)/Pgn | Repository-Cryopreserved |
| D8Mit113 | 007817 | B6.A-(D8Mit236-D8Mit113)/Pgn | Repository-Cryopreserved |
| D8Mit124 | 007816 | B6.A-(D8Mit124-D8Mit95)/Pgn | Repository-Cryopreserved |
| D8Mit132 | 007838 | B6.A-(D8Mit65-D8Mit132)/Pgn | Repository-Cryopreserved |
| D8Mit211 | 007839 | B6.A-(D8Mit261-D8Mit211)/Pgn | Repository-Cryopreserved |
| D8Mit236 | 007817 | B6.A-(D8Mit236-D8Mit113)/Pgn | Repository-Cryopreserved |
| D8Mit236 | 007836 | B6.A-(D8Mit261-D8Mit236)/Pgn | Repository-Cryopreserved |
| D8Mit261 | 007839 | B6.A-(D8Mit261-D8Mit211)/Pgn | Repository-Cryopreserved |
| D8Mit261 | 007836 | B6.A-(D8Mit261-D8Mit236)/Pgn | Repository-Cryopreserved |
| D8Mit271 | 007815 | B6.A-(D8Mit271-D8Mit49)/Pgn | Repository-Cryopreserved |
| D8Mit47 | 007814 | B6.A-(D8Mit65-D8Mit47)/Pgn | Repository-Cryopreserved |
| D8Mit49 | 007815 | B6.A-(D8Mit271-D8Mit49)/Pgn | Repository-Cryopreserved |
| D8Mit65 | 007838 | B6.A-(D8Mit65-D8Mit132)/Pgn | Repository-Cryopreserved |
| D8Mit65 | 007814 | B6.A-(D8Mit65-D8Mit47)/Pgn | Repository-Cryopreserved |
| D8Mit95 | 007816 | B6.A-(D8Mit124-D8Mit95)/Pgn | Repository-Cryopreserved |
| Dag1tm1Kcam | 006836 | B6.129-Dag1tm1Kcam/J | Repository- Live |
| Dbttm1Geh | 006999 | STOCK Dbttm1Geh Tg(tTALap)5Bjd Tg(tetO-DBT)A1Geh/J | Repository- Live |
| Dscamdel17 | 008000 | B6.CBy-Dscamdel17/RwbJ | Repository- Live |
| Mice homozygous for this spontaneous mutation become severely uncoordinated by postnatal day 3, developing spontaneous seizures and kyphosis. On the C57BL/6 background, homozygotes exhibit a severe phenotype and die shortly after birth. Retinal amacrine cells display defects in the arborization of processes and spacing of cell bodies. This mutant mouse strain may useful in studies of the retina and the mechanism of neuronal self-avoidance. | |||
| Dvl1tm1Awb | 007965 | 129S-Dvl1tm1Awb/J | Repository- Live |
| Homozygotes exhibit diminished social interaction behavior, do not barber or trim whiskers of cagemates, show subordinance in social dominance tests, do not sleep huddled together and do not build nests. This mutant mouse strain may be useful in studies of social behavior, sensorimotor gating, and possibly psychiatric disorders. | |||
| Dvl1tm1Awb | 007969 | B6.129S6-Dvl1tm1Awb/J | Repository- Live |
| Mice that are homozygous for this targeted mutation on the 129S genetic background exhibit diminished social interaction behavior, do not barber or trim whiskers of cagemates, show subordinance in social dominance tests, do not sleep huddled together and do not build nests. This mutant mouse strain may be useful in studies of social behavior, sensorimotor gating, and possibly psychiatric disorders. | |||
| Dvl2tm1Awb | 008001 | 129S-Dvl2tm1Awb/J | Repository- Live |
| Half of the mice that are homozygous for this targeted mutation exhibit a perinatal lethal phenotype. This mutant mouse strain may be useful in studies of bone and cardiac development, neural tube closure and spina bifida. | |||
| Dysftm1Kcam | 006830 | 129-Dysftm1Kcam/J | Repository- Live |
| These Dysf (dysferlin) targeted mutant mice develop a slowly progressive muscular dystrophy. By the age of 2 months, a few individual necrotic and centrally nucleated fibers can be detected throughout the muscle; the number increases with age. By 8 months, the muscle develops all of the pathological characteristics of muscular dystrophy (e.g. regenerating fibers, split fibers, muscle necrosis with macrophage infiltration and fat replacement). This mutant mouse strain represents a model that may be useful in studies of muscle disease and repair. | |||
| Efnb1tm1Sor | 007664 | 129S-Efnb1tm1Sor/J | Repository- Live |
| These mice possess loxP sites flanking exons 2 through 5 of the targeted gene. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exons 2 through 5 deleted in the cre-expressing tissue(s). These Efnb1 conditional mutant mice may be useful in studying cellular signaling in embryonic development and adult mice; specifically receptor tyrosine kinases. | |||
| Efnb2tm2Sor | 007843 | B6;129S4-Efnb2tm2Sor/J | Repository- Live |
| These mice express the histone 2B and Green fluorescent protein, H2BGFP, fusion gene under the control of the endogenous Efnb2 promoter. Homozygotes die at E10.5 due to cardiovascular defects. Homozygous embryos exhibit defects in cardiovascular and somite development, cranial and trunk neural crest cell populations. These mutant mice may be useful in studies of embryonic development. | |||
| EgfrVel | 006926 | C57BL/6J-EgfrVel/J | Repository- Live |
| Epb4.1l3tm1Jkis | 007681 | STOCK Epb4.1l3tm1Jkis/J | Repository- Live |
| Because 4.1B expression is frequently downregulated in human clinical prostate cancer (and a spectrum of other tumor types), these 4.1B mutant mice may be useful in studying the role of 4.1B as a negative regulator of cancer progression to metastatic disease. | |||
| Erap1tm1Luc | 006413 | B6.129S6-Erap1tm1Luc/J | Repository- Live |
| These mutant mice may be useful in immunological studies exploring the in vivo role of ERAP1 in optimizing peptides for presentation by MHC class I molecules. | |||
| Esrrbtm1.1Nat | 007674 | STOCK Esrrbtm1.1Nat/J | Repository- Live |
| These Nr3b2CKO mutant mice may be useful in generating conditional mutations to study disorders of hearing and balance, inner ear development (such as endolymph-producing epithelia within the auditory and vestibular divisions), and control of cell fate decisions by nuclear receptors. | |||
| Esrrbtm1.2Nat | 007674 | STOCK Esrrbtm1.1Nat/J | Repository- Live |
| These Nr3b2CKO mutant mice may be useful in generating conditional mutations to study disorders of hearing and balance, inner ear development (such as endolymph-producing epithelia within the auditory and vestibular divisions), and control of cell fate decisions by nuclear receptors. | |||
| Fastm1Cgn | 007895 | C57BL/6-Fastm1Cgn/J | Repository- Live |
| These Fasfl mice may be useful in generating conditional mutations for studying many aspects of immune function. For example, deletion of Fas in T cells can lead to pulmonary fibrosis (model of human idiopathic pulmonary fibrosis), whereas deletion of Fas in B cells can result in a lymphoproliferative disorder. | |||
| Faslgld | 008223 | NOD.C3(B6)-Faslgld /LwnJ | Repository- Live |
| Congenic NOD mice homozygous for the Faslgld mutation develop lymphadenopathy and systemic autoimmunity. It has been reported that this model displays an accelerated Lupus phenotype compared to the C57BL/6 congenic background. This model is useful for studying apoptosis of lymphocytes, particularly T cells, and Lupus. | |||
| Fcgrttm1Dcr | 003982 | B6.129X1-Fcgrttm1Dcr/DcrJ | Repository- Live |
| Fgfr1tm5Sor | 007671 | B6;129S4-Fgfr1tm5.1Sor/J | Repository- Live |
| When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exon 4 and the neomycin selection cassette deleted in the cre-expressing tissue(s). This mutant mouse strain may be useful in studies of fibroblast growth factor (Fgf) cellular signaling during embryonic development. | |||
| Foxp3tm2Tch | 006772 | B6.Cg-Foxp3tm2Tch/J | Repository- Live |
| Gabra4tm1.2Geh | 006874 | B6.129-Gabra4tm1.2Geh/J | Repository- Live |
| Gatad2atm1Rnu | 008105 | B6;129-Gatad2atm1Rnu/J | Repository-Cryopreserved |
| Gcnt3tm1Jxm | 006924 | B6.129-Gcnt3tm1Jxm/J | Repository- Live |
| The single coding exon of the glucosaminyl (N-acetyl) transferase 3, mucin type (Gcnt3) gene is flanked by loxP sites in these mice. When bred to cre transgenic strains, the exon is excised to produce a null allele. | |||
| Gja1tm1Dlg | 008039 | B6.129S7-Gja1tm1Dlg/J | Repository- Live |
| These Cx43flox mutant mice may be useful in generating conditional mutations for studying the role of connexin and gap junctions in various tissues and systems, including the cardiovascular system. | |||
| Gpi1 | 006436 | NOD.Cg-(Gpi1-D7Mit346)C57BL/6J Tg(TcraAI4)1Dvs/DvsJ | Repository-Cryopreserved |
| Gpi1 | 006437 | NOD.Cg-(Gpi1-D7Mit346)C57BL/6J Tg(TcrbAI4)1Dvs/DvsJ | Repository-Cryopreserved |
| Gpi1a-m1J | 006562 | B6.CBy(Cg)-Gusbmps Gpi1a-m1J/BrkJ | Repository- Live |
| Gpnmb+ | 007048 | DBA/2J-Gpnmb+/SjJ | Repository- Live |
| This coisogenic strain has a functional allele of Gpnmb. Homozygous mice do not develop the elevated intraocular pressure or glaucoma found in DBA/2J mice (Stock 000671), although they exhibit a mild iris stromal atrophy (ISA). This strain provides a genetically matched control for DBA/2J. | |||
| Grin3btm1Yaha | 007808 | B6.129P2-Grin3btm1Yaha/J | Repository- Live |
| These NR3B (Grin3b) mutant mice may be useful in neurobiological studies; specifically studies involving NMDA receptor and NR3B function in cranial and spinal somatic motor neurons. | |||
| Gsctm1Pgr | 007556 | B6SJL-Gsctm1Pgr/J | Repository-Cryopreserved |
| Gt(ROSA)26Sortm1(HD*103Q)Xwy | 007708 | B6.129-Gt(ROSA)26Sortm1(HD*103Q)Xwy/J | Repository- Live |
| These RosaHD mutant mice allow cre-conditional expression of the neuropathogenic mhtt-exon1 protein and may be useful in studying Huntington’s disease or other polyQ disorders. | |||
| Gt(ROSA)26Sortm1(rtTA*M2)Jae | 006911 | B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm2(tetO-Pou5f1)Jae/J | Repository- Live |
| These "Oct-4/rtTA" mutant mice may be useful for studies of tumorigenesis and pluripotent stem cells. | |||
| Gt(ROSA)26Sortm2Luo | 006080 | B6.129-Gt(ROSA)26Sortm2Luo/J | Repository- Live |
| Gt(ROSA)26Sortm3(phiC31*)Sor | 007670 | B6;129S4-Gt(ROSA)26Sortm3(phiC31*)Sor/J | Repository- Live |
| These mutant mice express a site-specific recombinase, PhiC31o, that has been targeted to the endogenous Gt(ROSA)26Sor locus and codon-optimized for expression in mouse tissues. PhiC31o mediates irreversible DNA recombination at specific nonidentical pairs of sequence sites, attB and attP. When crossed with a strain containing a sequence of interest flanked by attB and attP sites, PhiC31o-mediated recombination results in tissue-specific deletion of the targeted sequence. Recombination efficiency is similar to that of Cre recombinase. This strain represents an effective tool for generating tissue specific-targeted mutants. | |||
| Gt(ROSA)26Sortm3Luo | 006075 | B6.129-Gt(ROSA)26Sortm3Luo/J | Repository- Live |
| Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo | 007576 | STOCK Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J | Repository- Live |
| These mT/mG mice are useful as a Cre reporter strain; expressing red fluorescence prior to, and green fluorescence following, Cre-mediated recombination in widespread cell and tissue types. | |||
| Gucy2dtm2Mom | 006704 | B6;129P2-Gucy2dtm2Mom/MomJ | Repository- Live |
| Gusbmps | 006562 | B6.CBy(Cg)-Gusbmps Gpi1a-m1J/BrkJ | Repository- Live |
| Gusbmps | 006564 | B6(C)-KitW-41J Gusbmps/BrkJ | Repository-Cryopreserved |
| H2-M10.2tm1Mom | 006725 | B6;129P2-H2-M10.2tm1Mom/MomJ | Repository-Cryopreserved |
| H2-M10.2tm2Mom | 007878 | B6;129P2-H2-M10.2tm2Mom/MomJ | Repository-Cryopreserved |
| H2 | 007958 | B6.Cg-H2b3/FlaCmwJ | Repository- Live |
| This strain, commonly known as B6.K1, has a slow Ped or Qa2negative phenotype. These mice be used for research in embryonic and post-natal development. | |||
| H2 | 007959 | B6.Cg-H2b4/FlaCmwJ | Repository- Live |
| This strain, commonly known as B6.K2, has a fast Ped or Qa2positive phenotype was developed as a control for the slow Ped B6.K1 (Stock 007958). These mice be used for research in embryonic and post-natal development. | |||
| H2d | 005895 | B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J | Repository- Live |
| These Clone-1 TCR (also called Clone 1 Thy1.1 TCR or Cl.1 TCR) transgenic mice were designed to optimize conditions for tumor eradication by low avidity tumor-specific T cells and may also be useful in general studies of T cell avidity, tolerance, positive/negative selection, and activation. | |||
| Hap1tm1Xjl | 007749 | STOCK Hap1tm1Xjl/J | Repository- Live |
| These huntingtin-associated protein-1 (HAP1) mutant mice may be useful in studying hypothalamic neurodegeneration and the loss of body weight in Huntingon's disease (HD), neurotransmitters, microtubule-dependent transporters, intracellular trafficking, receptor tyrosine kinase and neurite function, and feeding. | |||
| Hc0 | 007048 | DBA/2J-Gpnmb+/SjJ | Repository- Live |
| This coisogenic strain has a functional allele of Gpnmb. Homozygous mice do not develop the elevated intraocular pressure or glaucoma found in DBA/2J mice (Stock 000671), although they exhibit a mild iris stromal atrophy (ISA). This strain provides a genetically matched control for DBA/2J. | |||
| Hdlq44A/J | 007817 | B6.A-(D8Mit236-D8Mit113)/Pgn | Repository-Cryopreserved |
| Hdlq44A/J | 007839 | B6.A-(D8Mit261-D8Mit211)/Pgn | Repository-Cryopreserved |
| Hdlq44A/J | 007836 | B6.A-(D8Mit261-D8Mit236)/Pgn | Repository-Cryopreserved |
| Hdlq44A/J | 007838 | B6.A-(D8Mit65-D8Mit132)/Pgn | Repository-Cryopreserved |
| Hdlq44A/J | 007814 | B6.A-(D8Mit65-D8Mit47)/Pgn | Repository-Cryopreserved |
| Hdlq50A/J | 007835 | B6.A-(D8Mit113)/Pgn | Repository-Cryopreserved |
| Hdlq50A/J | 007817 | B6.A-(D8Mit236-D8Mit113)/Pgn | Repository-Cryopreserved |
| Hdlq50A/J | 007839 | B6.A-(D8Mit261-D8Mit211)/Pgn | Repository-Cryopreserved |
| Hdlq50A/J | 007814 | B6.A-(D8Mit65-D8Mit47)/Pgn | Repository-Cryopreserved |
| He | 007947 | B6;129P2-He/J | Repository-Cryopreserved |
| Hlb426 | 008411 | C57BL/6J-Hlb426/J | Repository-Cryopreserved |
| Hlb476 | 008263 | C57BL/6J-Hlb476/J | Repository-Cryopreserved |
| Hlb594 | 008262 | C57BL/6J-Hlb594/J | Repository-Cryopreserved |
| Hps6ru-7J | 005559 | B6(129S4)-Hps6ru-7J/J | Repository- Live |
| Idd3A/J | 007931 | NOD.A-Idd3A/J/MrkJ | Repository- Live |
| The 5 strains that comprise this NOD congenic set (Stock No.'s 007930, 007931, 007932, 007933, 007934) contain the Idd 3 region from non-NOD strains. All of these strains are viable and fertile. Stocks containing the Idd 3 region from SWR/J, A/J, or CAST/EiJ are diabetes susceptible, while the congenic stocks containing the Idd 3 region derived from C57BL/6 or CZECHI/EiJ are diabetes resistant and produce more IL2 mRNA than the diabetes susceptible strains. These strains have been used to positionally clone Idd3 on Chr. 3 and continue to be valued to study the biological effects of variation of genes within the Idd3 region and for studying long-range chromosome remodeling. | |||
| Idd3CAST/EiJ | 007932 | NOD.CAST-Idd3CAST/EiJ/MrkJ | Repository- Live |
| The 5 strains that comprise this NOD congenic set (Stock No.'s 007930, 007931, 007932, 007933, 007934) contain the Idd 3 region from non-NOD strains. All of these strains are viable and fertile. Stocks containing the Idd 3 region from SWR/J, A/J, or CAST/EiJ are diabetes susceptible, while the congenic stocks containing the Idd 3 region derived from C57BL/6 or CZECHI/EiJ are diabetes resistant and produce more IL2 mRNA than the diabetes susceptible strains. These strains have been used to positionally clone Idd3 on Chr. 3 and continue to be valued to study the biological effects of variation of genes within the Idd3 region and for studying long-range chromosome remodeling. | |||
| Idd3CZECHI/EiJ | 007933 | NOD.CZI-Idd3CZECHI/EiJ/MrkTacJ | Repository- Live |
| The 5 strains that comprise this NOD congenic set (Stock No.'s 007930, 007931, 007932, 007933, 007934) contain the Idd 3 region from non-NOD strains. All of these strains are viable and fertile. Stocks containing the Idd 3 region from SWR/J, A/J, or CAST/EiJ are diabetes susceptible, while the congenic stocks containing the Idd 3 region derived from C57BL/6 or CZECHI/EiJ are diabetes resistant and produce more IL2 mRNA than the diabetes susceptible strains. These strains have been used to positionally clone Idd3 on Chr. 3 and continue to be valued to study the biological effects of variation of genes within the Idd3 region and for studying long-range chromosome remodeling. | |||
| Idd3SWR/J | 007930 | NOD.SWR-Idd3SWR/J/MrkJ | Repository- Live |
| The 5 strains that comprise this NOD congenic set (Stock No.'s 007930, 007931, 007932, 007933, 007934) contain the Idd 3 region from non-NOD strains. All of these strains are viable and fertile. Stocks containing the Idd 3 region from SWR/J, A/J, or CAST/EiJ are diabetes susceptible, while the congenic stocks containing the Idd 3 region derived from C57BL/6 or CZECHI/EiJ are diabetes resistant and produce more IL2 mRNA than the diabetes susceptible strains. These strains have been used to positionally clone Idd3 on Chr. 3 and continue to be valued to study the biological effects of variation of genes within the Idd3 region and for studying long-range chromosome remodeling. | |||
| Idd4 | 006809 | NOD.B6-(D11Nds1-D11Mit41)/J | Repository- Live |
| Chromosome 11 congenic mice are useful for identifying genes in the Idd4 region involved in diabetes resistance. | |||
| Idd4 | 008056 | NOD.L-(Csf2-D11Mit339)/McdfJ | Repository- Live |
| Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD/Bdc background. These strains are useful for identifying candidate genes within the Idd4 subloci. | |||
| Idd4 | 008060 | NOD.L-(D11Mit314-D11Mit339)(D11Mit132-D11Mit42)/McdfJ | Repository- Live |
| Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD/Bdc background. These strains are useful for identifying candidate genes within the Idd4 subloci. | |||
| Idd4 | 008053 | NOD.L-(D11Mit314-D11Mit42)/McdfJ | Repository- Live |
| Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD/Bdc background. These strains are useful for identifying candidate genes within the Idd4 subloci. | |||
| Ightm1Mnz | 007775 | CBy.129P2(B6)-Ightm1Mnz/J | Repository-Cryopreserved |
| In combination with immunoglobulin lambda light chain, this heavy chain variable (V) region produces antibody that binds hapten NP (4-hydroxy-3-nitrophenylacetyl). A Trp to Leu point mutation at codon 33 results in a 40-fold increase in antigen binding affinity (B1-8hi). Despite the significantly enhanced affinity for NP, there is only a 2-3 fold difference in the T-independent proliferative response of B cells that carry high or low affinity receptors. In T cell-dependent responses there is no difference in the ability of B1-8 high vs. B1-8 low affinity cells to enter germinal center reactions. However, high affinity B cells were recruited preferentially in response to both T cell-dependent and T cell-independent antigens. | |||
| Ighmbp2nmd-2J | 006514 | B6.Cg-Ighmbp2nmd-2J Tg(Ttn-Ighmbp2)108Cx/Cx | Research Strain |
| Ighmbp2nmd-2J | 006513 | B6.Cg-Ighmbp2nmd-2J Tg(Ttn-Ighmbp2)45Cx/Cx | Research Strain |
| Ighmbp2nmd-2J | 003834 | B6.Cg-Tg(Eno2-Ighmbp2)90Cx Ighmbp2nmd-2J/Cx | Research Strain |
| Igk-Ctm1(IGKC)Mnz | 007595 | B6;129-Igk-Ctm1(IGKC)Mnz/J | Repository-Cryopreserved |
| Il12btm1Lky | 006412 | B6.129-Il12btm1Lky/J | Repository- Live |
| Il2tm1Hor | 002573 | NOD.129P2(B6)-Il2tm1Hor/DvsJ | Repository-Cryopreserved |
| Il8rbtm1Mwm | 006848 | B6.129S2(C)-Il8rbtm1Mwm/J | Repository- Live |
| Ins2Akita | 006860 | B6.129-Ins2Akita Bdkrb2tm1Jfh/SmiJ | Repository- Live |
| Mice homozygous for this targeted mutation of the bradykinin receptor, beta 2 (Bdkrb2) gene and heterozygous for the Akita spontaneous mutation of the insulin 2 (Ins2) gene (Ins2Akita) are viable and fertile. They are extremely diabetic, underweight, hyperphagic, polyuric, and have severe kidney, skeletal, and testicular defects. essentially no subcutaneous fat, and a significantly reduced lifespan. This strain may be used to research the kallikrein-kinin system, specifically the role of bradykinin B2 receptor in diabetes, oxidative stress, mitochondrial DNA damage, apoptosis, kidney morphology and function, and other senescence-associated phenotypes. | |||
| Ins2Akita | 006580 | B6.Cg-Ins2Akita Ldlrtm1Her/J | Repository- Live |
| Ins2Akita | 007562 | D2.B6-Ins2Akita/MatbJ | Repository- Live |
| Whereas congenic DBA/2J mice homozygous for the Akita spontaneous mutation of the insulin 2 gene (Ins2Akita) rarely survive beyond 12 weeks of age, heterozygotes are viable and fertile, developing hyperglycemia, hypoinsulinemia, polydipsia, and polyuria, which is more severe in the male mutants than female mutants. Obesity and insulitis do not accompany diabetes. This strain responds to exogenously administered insulin, and is an excellent substitute for mice made insulin-dependent diabetic with alloxan or streptozotocin. It is also ideally suited to allogeneic or xenogeneic islet transplantation. These mice are useful for studying diabetic complecations specifically nephropathy. | |||
| Ins2Akita | 006867 | FVB.B6-Ins2Akita/MlnJ | Repository- Live |
| Whereas untreated FVB/NJ mice homozygous for the Akita spontaneous mutation of the insulin 2 gene (Ins2Akita) rarely survive beyond 12 weeks of age, heterozygotes are viable and fertile. Hyperglycemia, hypoinsulinemia, polydipsia, and polyuria, are more severe than in C57BL/6-Ins2Akita/J (Stock No.003548) mutants. Obesity and insulitis do not accompany diabetes. Hyperglycemia in females becomes more severe during pregnancy and leading to embryo malformations and reabsorption, even with insulin therapy. This strain responds to exogenously administered insulin, and is an excellent substitute for mice made insulin-dependent diabetic with alloxan or streptozotocin. It is also ideally suited to allogeneic or xenogeneic islet transplantation. | |||
| Isl2tm1Arbr | 007603 | STOCK Isl2tm1Arbr/J | Repository- Live |
| These Isl2DTA mutant mice have the diphtheria toxin (DTA) gene inserted into the Isl2 (insulin related protein 2 (islet 2)) locus. Expression of DTA in Isl2-expressing cells is blocked by an upstream loxP-flanked STOP sequence. When bred to Cre recombinase-expressing mice, the STOP sequence is deleted in tissues where Cre is present, permitting DTA expression and subsequent cell ablation. | |||
| Itgb7tm1Mshi | 007707 | C57BL/6-Itgb7tm1Mshi/J | Repository- Live |
| As the mouse integrin b7 chain is found as a cell surface heterodimer in association with either of two alpha chains (a4 and aE), these b7 (D146A) mutant mice may be useful in studying intestinal leukocyte migration and trafficking, integrin/ligand interactions (VCAM-1, fibronectin, MadCAM-1, E-cadherin), intraepithelial lymphocytes, and inflammatory bowel diseases. | |||
| KitW-19H | 002283 | B6.Cg-KitW-19H/EiJ | Repository-Cryopreserved |
| KitW-41J | 006564 | B6(C)-KitW-41J Gusbmps/BrkJ | Repository-Cryopreserved |
| KitlSl-18H | 002993 | B6.Cg-KitlSl-18H/EiJ | Repository-Cryopreserved |
| Ldlrtm1Her | 006952 | B6.Cg-Akt2tm1.1Mbb Ldlrtm1Her/J | Repository- Live |
| These C57BL/6J Akt2+/- LDLR-/- mice harbor targeted mutations in both the Akt2 (thymoma viral proto-oncogene 2) and Ldlr (low density lipoprotein receptor) loci. Independently, homozygous Akt2 mutant mice develop insulin resistance and diabetes, while LDLR homozygotes are predisposed to atherosclerosis. When these C57BL/6J Akt2+/- LDLR-/- double mutant mice are heterozygous for the Akt2 mutation and homozygous for the LDLR mutation they are viable and fertile and may be useful to study diabetes, metabolism, hyperglycemia, and atherosclerosis. | |||
| Ldlrtm1Her | 006580 | B6.Cg-Ins2Akita Ldlrtm1Her/J | Repository- Live |
| Ldlrtm1Her | 006877 | B6.Cg-Ldlrtm1Her Tg(H2-K-AKR1B1)1Tj/J | Repository- Live |
| Ldlrtm1Her | 006906 | B6.Cg-Lepob Ldlrtm1Her/J | Repository- Live |
| The mice may be useful in studies of diabetes, metabolism, hyperglycemia, atherosclerosis, and hypercholesterolemia. | |||
| Lepob | 006906 | B6.Cg-Lepob Ldlrtm1Her/J | Repository- Live |
| The mice may be useful in studies of diabetes, metabolism, hyperglycemia, atherosclerosis, and hypercholesterolemia. | |||
| Leprdb-9J | 006846 | STOCK Leprdb-9J/Jgn | Repository-Cryopreserved |
| Lgals1tm1Rob | 006337 | B6.Cg-Lgals1tm1Rob/J | Repository- Live |
| Lgals3tm1Poi | 006338 | B6.Cg-Lgals3tm1Poi/J | Repository- Live |
| Homozygotes carrying the lectin, galactose binding, soluble 3 (Lgals3) targeted mutation have an impaired acute inflammation response, chondrocyte differentiation during long bone development and myofibroblast activation. This mutant mouse strain may be useful in studies of bone development, endochondral ossification, inflammatory response, and liver fibrosis. | |||
| Ly9tm1Mckn | 006011 | B6;129-Ly9tm1Mckn/J | Repository-Cryopreserved |
| Man1a2tm1.1Ahe | 007672 | B6;129S4-Man1a2tm1.1Ahe/J | Repository- Live |
| Mice that are homozygous for this targeted mutation have a perinatal lethal phenotype and die within hours of birth. At embryonic day 18.5 homozygous embryos exhibit reduced alveolar air space, thickened alveolar walls, small atelectactic areas and delayed lung development. This mutant mouse strain may be useful in studies of lung development and pulmonary physiology. | |||
| Mapttm1Hnd | 007251 | B6.129-Mapttm1Hnd/J | Repository- Live |
| Hippocampal neurons (primary culture) from embryos that are homozygous for the microtubule-associated protein tau (Mapt) targeted mutation, TAU-/-, have delayed axonal extension and shorter total dendritic length and abnormal mitochondrial placement and movement. This mutant mouse strain may be useful in studies of neuronal development, axonogenesis, and organelle movement. | |||
| Mc3rtm1Cone | 007809 | B6.129S4-Mc3rtm1Cone/J | Repository- Live |
| Mice homozygous for this targeted mutation exhibit an increase in adiposity without obesity, reduced energy expenditure and can develop salt sensitive hypertension. This mutant mouse strain may be useful in studies of energy homeostasis, regulation of satiety, salt-sensitive hypertension and metabolism. | |||
| Mcm4chaos3 | 006863 | C3Fe.B6-Mcm4chaos3/J | Repository- Live |
| Mecp2tm2Bird | 006849 | B6;129P2-Mecp2tm2Bird/J | Repository- Live |
| Mice with this X-linked lox-STOP mutation of the methyl CpG binding protein 2 gene may be useful in neurological and developmental studies of Rett syndrome and its amelioration upon excision of the lox-STOP cassette. | |||
| Meox2tm1(cre)Sor | 007664 | 129S-Efnb1tm1Sor/J | Repository- Live |
| These mice possess loxP sites flanking exons 2 through 5 of the targeted gene. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exons 2 through 5 deleted in the cre-expressing tissue(s). These Efnb1 conditional mutant mice may be useful in studying cellular signaling in embryonic development and adult mice; specifically receptor tyrosine kinases. | |||
| Mgat4atm1Jxm | 006894 | B6;129-Mgat4atm1Jxm/J | Repository- Live |
| Mnx1tm4(cre)Tmj | 006600 | B6.129S1-Mnx1tm4(cre)Tmj/J | Repository- Live |
| When these HB9cre mice are bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination in the resulting offspring leads to deletion of the flanked sequences in Mnx1/HB9 expressing cells; making them useful in neurodevelopmental studies of homeobox genes, motor neuron function and differentiation, and the central nervous system. | |||
| Mnx1tm4(cre)Tmj | 007603 | STOCK Isl2tm1Arbr/J | Repository- Live |
| These Isl2DTA mutant mice have the diphtheria toxin (DTA) gene inserted into the Isl2 (insulin related protein 2 (islet 2)) locus. Expression of DTA in Isl2-expressing cells is blocked by an upstream loxP-flanked STOP sequence. When bred to Cre recombinase-expressing mice, the STOP sequence is deleted in tissues where Cre is present, permitting DTA expression and subsequent cell ablation. | |||
| Mrc1tm1Mnz | 007620 | B6.129P2-Mrc1tm1Mnz/J | Repository-Cryopreserved |
| -Mice are defective in clearing proteins that bear accessible mannose and N-acetylglucosamine residues and have elevated levels of eight different lysosomal hydrolases. Clearance of a subset of mannose-bearing serum glycoproteins that are normally elevated during inflammation is impaired. This strain may be useful in studies of serum glycoprotein homeostasis. | |||
| Mycntm1Psk | 007003 | B6.129-Mycntm1Psk/J | Repository- Live |
| Myf5tm3(cre)Sor | 007845 | B6;129S4-Myf5tm3(cre)Sor/J | Repository- Live |
| This strain expresses Cre recombinase from the endogenous Myf5 locus. When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination results in tissue-specific deletion of the target. This mutant mouse strain represents a model that may be useful in studies of skeletal development. | |||
| Myo1eGt(ROSA)74Sor | 007205 | 129S-Myo1eGt(ROSA)74Sor/J | Repository- Live |
| These Myo1e-mutant mice may be useful in studying cellular signaling in development and adult mice; specifically receptor tyrosine kinases (RTK; such as Ras, MAP kinase, PI3K and those in the platelet-derived growth factor (PDGF) family) and immediate early genes (IEG) induced shortly after RTK activation. Homozygotes occur at lower than Mendelian ratio (15%) and exhibit abnormalities in vascular development, anemia and polychromasia. | |||
| Myo6sv-4J | 008456 | 129S1/SvImJ-Myo6sv-4J/J | Repository- Live |
| Nkd1tm1Kwha | 006958 | B6;129S-Nkd1tm1Kwha/J | Repository- Live |
| Because the naked cuticle (NKD) genes are considered targets for Wnt/b-catenin signaling, these nkd1lacZ mutant mice (as well as the similar nkd2lacZ mutant strain; Stock No. 006960) may be useful as a reporter for Wnt/b-catenin-dependent transcriptional activity during embryonic development or in adult mice. | |||
| Nkd2tm1Kwha | 006960 | B6;129S-Nkd2tm1Kwha/J | Repository- Live |
| Because the naked cuticle (NKD) genes are considered targets for Wnt/b-catenin signaling, these nkd2lacZ mutant mice (as well as the similar nkd1lacZ mutant strain; Stock No. 006958) may be useful as a reporter for Wnt/b-catenin-dependent transcriptional activity during embryonic development or in adult mice. | |||
| Notch1tm2Rko | 007181 | B6.129X1-Notch1tm2Rko/GridJ | Repository- Live |
| Npr3lgj-4J | 008254 | NOD/ShiLtJ-Npr3lgj-4J/J | Repository- Live |
| Nr0b1tm1.1Lja | 007007 | D2.129(B6)-Nr0b1tm1.1Lja/EiJ | Repository-Cryopreserved |
| Nr0b1tm1Lja | 007006 | B6Ei.129-Nr0b1tm1Lja/EiJ | Repository-Cryopreserved |
| Nr1h4tm1Gonz | 007214 | B6.129X1(FVB)-Nr1h4tm1Gonz/J | Repository- Live |
| Mice homozygous for this targeted mutant allele display a proatherogenic serum lipoprotein profile characterized by elevated levels of serum and hepatic cholesterol and triglycerides. This mutant mouse strain represents a model that may be useful in studies related to bile acid and lipid homeostasis. | |||
| Olfr151tm28Mom | 006677 | STOCK Olfr151tm28Mom/MomJ | Repository- Live |
| Olfr17tm1Mom | 006595 | B6;129P2-Olfr17tm1Mom/MomJ | Repository- Live |
| Oprd1tm1Kff | 007557 | B6.129S2-Oprd1tm1Kff/J | Repository- Live |
| Oprk1tm1Kff | 007558 | B6.129S2-Oprk1tm1Kff/J | Repository- Live |
| Oprm1tm1Kff | 007559 | B6.129S2-Oprm1tm1Kff/J | Repository- Live |
| Pafah1b1tm2Awb | 008002 | 129S-Pafah1b1tm2Awb/J | Repository- Live |
| These mice possess loxP sites flanking exons 3 through 6 of the targeted gene. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exons 3 through 6 deleted in the cre-expressing tissue(s). This mutant mouse strain may be useful in studies of neurological development. | |||
| Park2tm1Rpa | 007587 | 129S-Park2tm1Rpa/J | Repository- Live |
| Mice carrying this mutation are viable, fertile, and display no apparent defects or abnormalities. Mutations in the human homolog of this gene are associated with autosomal juvenile parkinsonism, a heritable form of Parkinson's disease. | |||
| Park7tm1Shn | 006577 | B6.Cg-Park7tm1Shn/J | Repository- Live |
| Pdgfratm11(EGFP)Sor | 007669 | B6.129S4-Pdgfratm11(EGFP)Sor/J | Repository- Live |
| These mice express the H2B-eGFP fusion gene from the endogenous Pdgfra locus. Fluorescence patterns mimick the expression pattern of the endogenous gene. Homozygotes exhibit abnormal placenta development and placenta vasculature. This mutant mouse strain may be useful in studies of cellular signaling during development and in adult mice; specifically receptor tyrosine kinases (RTK; such as Ras, MAP kinase, PI3K and those in the platelet-derived growth factor (PDGF) family). | |||
| Pdgfrbtm1Sor | 007846 | 129S-Pdgfrbtm1Sor/J | Repository- Live |
| Homozygous embryos exhibit purpura, edema, anemia, polychromasia, anisocytosis and abnormal kidney development. Some homozygous embryos do not survive past E18.5. This mutant mouse strain may be useful in studies of hematopoiesis, kidney development and and cellular signaling during development. | |||
| Ped | 007958 | B6.Cg-H2b3/FlaCmwJ | Repository- Live |
| This strain, commonly known as B6.K1, has a slow Ped or Qa2negative phenotype. These mice be used for research in embryonic and post-natal development. | |||
| Ped | 007959 | B6.Cg-H2b4/FlaCmwJ | Repository- Live |
| This strain, commonly known as B6.K2, has a fast Ped or Qa2positive phenotype was developed as a control for the slow Ped B6.K1 (Stock 007958). These mice be used for research in embryonic and post-natal development. | |||
| Plekha1Gt(ROSA)82Sor | 007201 | B6;129S4-Plekha1Gt(ROSA)82Sor/J | Repository- Live |
| These Plekha1-mutant mice may be useful in studying cellular signaling in development and adult mice; specifically receptor tyrosine kinases (RTK; such as Ras, MAP kinase, PI3K and those in the platelet-derived growth factor (PDGF) family) and immediate early genes (IEG) induced shortly after RTK activation. Homozygous males are infertile and, after 3 weeks of age, exhibit higher than normal (wildtype) weight gain. | |||
| Pparatm1Gonz | 008154 | B6.129S4-Pparatm1Gonz/J | Repository- Live |
| Ppara deficient mutant mice exhibit increased gonadal adipose tissue stores, abnormal epidermal development and delayed wound healing. This mutant mouse strain may be useful in studies of lipid metabolism, cell proliferation, diabetes, obesity, and wound healing. | |||
| Ppp3r1tm1Stl | 006581 | C57BL/6-Ppp3r1tm1Stl/J | Repository- Live |
| Prdm1tm1Clme | 008100 | B6.129-Prdm1tm1Clme/J | Repository- Live |
| These Prdm1 floxed conditional mutant mice may be useful in generating conditional mutations to study humoral immune response, plasma memory B-cells, and B-lymphocyte development and differentiation. | |||
| Prkdcscid | 007840 | NOD.Cg-Prkdcscid Tg(Ins2-CD86)12B70Flv/FswJ | Repository- Live |
| Psen1tm1Vln | 007605 | B6.129P-Psen1tm1Vln/J | Repository- Live |
| These PS1-floxed mice may be useful in generating conditional knockouts of Presenilin 1 for studying Alzheimer’s Disease. | |||
| Ptprc | 008451 | B6.129P(Cg)-Ptprca Cx3cr1tm1Litt/LittJ | Repository- Live |
| These CX3CR1-GFP mice express EGFP under control of the endogenous Cx3cr1 locus and also harbor the CD45.1 (Ly5.1 or Ptprca) allele, which is atypical for the C57BL/6 congenic background and may be useful in studies of leukocyte migration and trafficking, as well as for transplantation studies with C57BL/6 (CD45.2: Ptprcb) mice. | |||
| Relnrl-4J | 005250 | B6;129S2-Relnrl-4J/J | Repository- Live |
| Rnl27 | 008412 | C57BL/6J-Rnl27/J | Repository-Cryopreserved |
| Rom1tm1Mci | 004510 | STOCK Rom1tm1Mci/J | Repository- Live |
| Rorctm2Litt | 007572 | B6.129P2(Cg)-Rorctm2Litt/J | Repository- Live |
| These RorcgtGFP mutant mice may be useful in studying immune system homeostasis, T cell repertoire selection, CD4/CD8 double positive (CD4+/CD8+) thymocyte survival, lymphoid organogenesis, proinflammatory T-helper cell (Th17) development, mucosal immunology, and the role of inflammatory disease in autoimmunity and cancer progression. | |||
| Schip1Gt(ROSA)77Sor | 007209 | 129S-Schip1Gt(ROSA)77Sor/J | Repository- Live |
| These Schip1-mutant mice may be useful in studying cellular signaling in development and adult mice; specifically receptor tyrosine kinases (RTK; such as Ras, MAP kinase, PI3K and those in the platelet-derived growth factor (PDGF) family) and immediate early genes (IEG) induced shortly after RTK activation. Homozygotes occur at lower than Mendelian ratio (19%) and exhibit abnormalities in neural crest-derived and thoracic skeleton development, and palate bone fusion. | |||
| ScribCrc | 006130 | CBACa.Cg-ScribCrc/RachJ | Repository- Live |
| Mice homozygous for this spontaneous mutation develop severe neural tube defects and die at birth. In it's most severe form, the neural tube fails to initiate Closure 1 (craniorachischichisis). Heterozygotes, predominantly males, often exhibit a looping or kinked tail. This strain may used to research neural tube defects. | |||
| Selplgtm1Rpmc | 006336 | B6.129-Selplgtm1Rpmc/J | Repository- Live |
| Sfpi1tm2Dgt | 006922 | B6.Cg-Sfpi1tm2Dgt/J | Repository- Live |
| Sgpl1Gt(ROSA)78Sor | 007199 | 129S-Sgpl1Gt(ROSA)78Sor/J | Repository- Live |
| These Sgpl1-mutant mice may be useful in studying cellular signaling in development and adult mice; specifically receptor tyrosine kinases (RTK; such as Ras, MAP kinase, PI3K and those in the platelet-derived growth factor (PDGF) family) and immediate early genes (IEG) induced shortly after RTK activation. Homozygotes exhibit vascular defects, polychromasia, kidney defects and palate bone fusion abnormalities. | |||
| Sharpincpdm | 007599 | C57BL/KaLawRij-Sharpincpdm/RijSunJ | Repository- Live |
| Mice homozygous for this spontaneous mutation develop a severe, chronic, inflammatory skin disease beginning at 3-5 weeks of age. This mutant mouse strain may be useful in studies related to eosinophilic dermatitis, inflammation and secondary lymphoid organ development. | |||
| Sim1tm1.2Az | 007570 | STOCK Sim1tm1.2Az/J | Repository- Live |
| These "Sim1-floxed exon 1" (2-loxP) mice may be useful in generating conditional mutations for studying basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) transcription factors, central nervous system development, early-onset/hyperphagic obesity, and regulation of appetite and energy balance. | |||
| Sirt1tm1Ygu | 008041 | B6;129-Sirt1tm1Ygu/J | Repository- Live |
| These SirT1co/co mice may be useful in generating conditional mutations for studying the role of estrogen, insulin growth factor-1 (IGF-1), and transcription factors (including NF-kappaB) in mammary gland development, breast cancer, apoptosis, and metabolic diseases. | |||
| Slc6a3tm1.1(cre)Bkmn | 006302 | B6;SJL-Slc6a3tm1.1(cre)Bkmn/J | Repository- Live |
| Sle1NZM2410/Aeg | 007228 | BcN/LmoJ | Repository- Live |
| Mice homozygous for the NZM2410 lupus susceptibility QTL (Sle1, Sle2, Sle3) on the C57BL/6J background develop a systemic autoimmunity with fatal glomerulonephritis. In comparison to NZM2410 (see Stock No. 002676), disease onset in this strain is slightly delayed however, breeding and survival are improved. This strain may used in autoimmunity and lupus research. | |||
| Sle2NZM2410/Aeg | 007228 | BcN/LmoJ | Repository- Live |
| Mice homozygous for the NZM2410 lupus susceptibility QTL (Sle1, Sle2, Sle3) on the C57BL/6J background develop a systemic autoimmunity with fatal glomerulonephritis. In comparison to NZM2410 (see Stock No. 002676), disease onset in this strain is slightly delayed however, breeding and survival are improved. This strain may used in autoimmunity and lupus research. | |||
| Sle3NZM2410/Aeg | 007228 | BcN/LmoJ | Repository- Live |
| Mice homozygous for the NZM2410 lupus susceptibility QTL (Sle1, Sle2, Sle3) on the C57BL/6J background develop a systemic autoimmunity with fatal glomerulonephritis. In comparison to NZM2410 (see Stock No. 002676), disease onset in this strain is slightly delayed however, breeding and survival are improved. This strain may used in autoimmunity and lupus research. | |||
| Smad1tm1Sor | 007608 | B6;129-Smad1tm1Sor/J | Repository- Live |
| Homozygotes for the Smad1tm1Sor (also called Smad1C) allele have an embryonic lethal phenotype and do not survive past ED9.5. This mutant mouse strain may be useful in studies of homeostasis and BMP and MAPK signaling pathways during development and in the adult. | |||
| Smad1tm2Sor | 007613 | B6;129-Smad1tm2Sor/J | Repository- Live |
| Homozygotes for the Smad1tm2Sor (also called Smad1L) allele have abnormal gastic mucosal cell homeostasis and fewer primordial germ cells than wildtype controls. This mutant mouse strain may be useful in studies of stomach development, gastic mucosal homeostasis and BMP and MAPK signaling pathways during development and in the adult. | |||
| Sncatm1Sud | 006390 | B6;129-Sncatm1Sud Sncbtm1.1Sud/J | Repository- Live |
| Sncbtm1.1Sud | 006390 | B6;129-Sncatm1Sud Sncbtm1.1Sud/J | Repository- Live |
| Sncbtm1Sud | 008133 | B6.129-Sncbtm1Sud/J | Repository-Cryopreserved |
| These mice possess loxP sites on either side of exon 2 of the targeted gene. Mice that are homozygous for this allele are viable, normal in size and do not display any gross physical or behavioral abnormalities, but breed very poorly. Protein levels are normal. When bred to a strain expressing Cre recombinase, this mutant mouse strain may be useful in studies of presynaptic proteins and synaptic vesicles. | |||
| Snord116tm1.1Uta | 008149 | B6(Cg)-Snord116tm1.1Uta/J | Repository- Live |
| These Snord116del mice may be useful in studying growth and feeding regulation, mechanisms of obesity, and pathophysiology of Prader-Willi syndrome. Of note, mice harboring a loxP-flanked Snord116 cluster are also available (see Stock No. 008118). | |||
| Snord116tm1Uta | 008118 | B6(Cg)-Snord116tm1Uta/J | Repository- Live |
| As deletions of the Snord116 cluster are associated with Prader-Willi syndrome (PWS), mice carrying the 2-loxP (floxed) allele may be useful in generating conditional mutations for studying the role of Snord116 in growth and feeding regulation, mechanisms of obesity, and pathophysiology of Prader-Willi syndrome. Of note, mice harboring a deletion of the Snord116 cluster are also available (see Stock No. 0 | |||