Strains Newly Available

Apoptosis Research

Note: This list only includes strains that have become available within the last six months.


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Allele Symbol Stock Number Strain Name
 
Description		 Standard Supply
Apaf1tm1Hez 017746 B6.129-Apaf1tm1Hez/J
Under Development - Now Accepting Orders
These mice possess loxP sites flanking exon 5 of the apoptotic protease activating factor 1 (Apaf1) gene and may have applications in studies related to regulation of apoptosis, carcinogenesis, cancer chemoresistance and apoptosis-based therapeutic treatments.
Aurkatm1.1Tvd 017729 B6.129-Aurkatm1.1Tvd/J
Under Development - Now Accepting Orders
These AurAf mice possess loxP sites flanking exon 2 of the aurora kinase A gene and have applications in studies related to regulation of mitosis and carcinogenesis.
CASP3 016882 B6.Cg-Tg(CMV-CASP3)14Edge/J
Repository- Live
Mos-iCsp3 transgenic mice have a CMV promoter directing expression of a floxed-lacZ-STOP cassette followed by two tandem FK506-binding sites (Fvs) and a downstream human Caspase 3 (Casp3) gene. These mice may be useful for cell ablation of specific cell types and as a model of degenerative diseases such as Parkinson's Disease, type 1 diabetes, alopecia, and deafness.
CASP3 016908 B6.Cg-Tg(CMV-CASP3)17Edge/J
Repository- Live
Mos-iCsp3 transgenic mice have a CMV promoter directing expression of a floxed-lacZ-STOP cassette followed by two tandem FK506-binding sites (Fvs) and a downstream human Caspase 3 (Casp3) gene. These mice may be useful for cell ablation of specific cell types and as a model of degenerative diseases such as Parkinson's Disease, type 1 diabetes, alopecia, and deafness.
Casp1tm1Flv 016621 B6N.129S2-Casp1tm1Flv/J
Under Development - Now Accepting Orders
This strain, relevant to studies of inflammation and cell death, carries a knockout allele of the Casp1 gene as well as an incidental Casp4 deficiency.
Csf3rtm1Link 017838 B6.129X1(Cg)-Csf3rtm1Link/J
Under Development - Now Accepting Orders
These Csf3r knockout mice are useful for studying granulopoiesis and hematopoietic stem cell regulation.
Eif2s1tm1Rjk 017601 B6.129-Eif2s1tm1Rjk/J
Under Development - Now Accepting Orders
Mutation of the EIF2α phosphorylation site results in a lack of translational and transcriptional regulation in the endoplasmic reticulum.
Fasl 014547 FVB/N-Tg(tetO-Fasl)BDepa/J
Repository- Live
These transgenic mice allow Tet-Off/Tet-On regulated expression of FasL. FasL overexpression leads to Fas/FasL receptor-mediated death-signaling pathway activation and results in cell apoptosis.
GFP 017530 STOCK Tg(ACTB-tdTomato,-EGFP)11Luo Trp53tm1Tyj Nf1tm1Par/J
Under Development - Now Accepting Orders
The MADM-TG,p53KO,NF1-flox strain may be used as a genetic mosaicism model for different types of cancers when bred to the companion MADAM strain (Stock No. 013749), and to a Cre recombinase expressing strain.
Ip6k2tm1Dlin 016221 B6;129-Ip6k2tm1Dlin/J
Repository- Live
In this knockout strain the first 202 nucleotides of exon 2 of the inositol hexaphosphate kinase 2 (Ip6k2) gene is disrupted. These mice may be useful for studying the mechanisms of IP6K2-dependent tumorigenesis.
Juptm1.1Glr 017575 STOCK Juptm1.1Glr/J
Repository- Live
These PGflox mutant mice possess loxP sites flanking exon 1 of the junction plakoglobin (Jup) gene. This strain may be useful for studying plakoglobin in the assembly of adherens junctions and desmosomes, and in the regulation of Wnt/β-catenin signalling.
Mapk8ip1tm3.1Rjd 013536 B6.129-Mapk8ip1tm3.1Rjd/J
Repository- Live
In this strain, codon 103 in exon 3 of the endogenous mitogen-activated protein kinase 8 interacting protein 1 (Mapk8ip1 or Jip1) gene is mutated from a Threonine (ACT) to an Alanine (GCC). These mice may be useful for studying MAP kinase signaling pathways and activation of JNK in response to metabolic stress.
Mir21tm1Yoli 016856 B6;129S6-Mir21tm1Yoli/J
Under Development - Now Accepting Orders
These miR-21 knockout mice are characterized by an increase in apoptotic cells found in the epidermal layer. Keratinocytes in particular exhibit increased apoptosis, elevated expression of several miR-21 target proteins (including Spry1, Pten, and Pdcd4), and attenuated Ras signaling/inhibition of Ras effector pathways.
Nf1tm1Par 017530 STOCK Tg(ACTB-tdTomato,-EGFP)11Luo Trp53tm1Tyj Nf1tm1Par/J
Under Development - Now Accepting Orders
The MADM-TG,p53KO,NF1-flox strain may be used as a genetic mosaicism model for different types of cancers when bred to the companion MADAM strain (Stock No. 013749), and to a Cre recombinase expressing strain.
Pawrtm1Rang 015823 C57BL/6N-Pawrtm1Rang/J
Repository- Live
These mice contain loxP sites flanking exon 2 of the targeted PRKC, apoptosis, WT1, regulator (Pawr or Par-4) gene. These mutant mice may be useful in generating conditional mutations for studying tumor development and treatment.
RFP 017530 STOCK Tg(ACTB-tdTomato,-EGFP)11Luo Trp53tm1Tyj Nf1tm1Par/J
Under Development - Now Accepting Orders
The MADM-TG,p53KO,NF1-flox strain may be used as a genetic mosaicism model for different types of cancers when bred to the companion MADAM strain (Stock No. 013749), and to a Cre recombinase expressing strain.
Trp53tm1Tyj 017530 STOCK Tg(ACTB-tdTomato,-EGFP)11Luo Trp53tm1Tyj Nf1tm1Par/J
Under Development - Now Accepting Orders
The MADM-TG,p53KO,NF1-flox strain may be used as a genetic mosaicism model for different types of cancers when bred to the companion MADAM strain (Stock No. 013749), and to a Cre recombinase expressing strain.

(17 stocks)

 

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