Strains Newly Available

Cell Biology Research

Note: This list only includes strains that have become available within the last six months.


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Allele Symbol Stock Number Strain Name
 
Description		 Standard Supply
ABL1 015838 STOCK Tg(Camk2a-tTA)1Mmay Tg(tetO-ABL1*P242E*P249E)CPdav/J
Repository- Live
These AblPP/tTA double mutant mice allow the forebrain-specific expression of a constitutively active form of c-Abl (AblPP) to be regulated with tetracycline or its analog doxycycline (dox). AblPP/tTA mice need to be maintained on a doxycycline diet to prevent the neurological phenotype. When maintained without dox, AblPP/tTA mice develop early reactive gliosis and astrocyctosis that continues to a severe, progressive neurodegeneration in the CA1 region of the hippocampus, and early death. These AblPP/tTA mice may be useful for studying tau phosphorylation and the pathogenesis of neurodegeneration/neuroinflammation associated with Alzheimer's disease.
ABL1 014544 STOCK Tg(tetO-ABL1*P242E*P249E)CPdav/J
Repository- Live
This transgenic mouse has a Tet response element upstream of a human c-Abl 1b isoform modified to harbor two amino acid substitutions (P242E/P249E) in the conserved proline residues of the SH2-SH3 linker region that render the protein constitutively active (AblPP). Expression may be contoled via the Tet-Off/Tet-On system for use in studies related to tau phosphorylation.
Anapc2tm1Hez 017745 B6.129-Anapc2tm1Hez/J
Under Development - Now Accepting Orders
These mice possess loxP sites flanking exons 2 of the anaphase promoting complex subunit 2 (Anapc2) gene and may have applications in studies related to cell cycle regulation and early embryonic development.
Apbb1tm1Her 012865 B6;129S6-Apbb1tm1Her/J
Repository- Live
The FE65 knockout allele has a nuclear localized-lacZ replacing exon 2 of the Apbb1 gene. These FE65 mutant mice, along with FE65L1 mutant mice, may be useful in studying brain development (neuronal positioning and establishment of axonal projections) and abnormal brain morphology (Cobblestone Lissencephaly, marginal zone heterotopias, and pial basement membrane integrity); as well as the function of FE65 family proteins in amyloid precursor protein (APP) processing, Alzheimer's disease, and neuronal protein trafficking.
Apbb2tm1Her 012869 B6;129S6-Apbb2tm1Her/J
Repository- Live
These FE65L1 mutant mice, along with FE65 mutant mice, may be useful in studying brain development (neuronal positioning and establishment of axonal projections) and abnormal brain morphology (Cobblestone Lissencephaly, marginal zone heterotopias, and pial basement membrane integrity); as well as the function of FE65 family proteins in amyloid precursor protein (APP) processing, Alzheimer's disease, and neuronal protein trafficking.
Apoetm1Unc 013719 D2.Cg-Apoetm1Unc Ins2Akita/J
Cryopreserved - Ready for recovery
Double mutant, Apoe-null, Akita heterozygous, mice may be useful in studies of diabetes, metabolism, hyperglycemia, atherosclerosis, hypercholesterolemia, and diabetes-related macrovascular complications.
Arg1tm1Lky 015858 C.129S4(B6)-Arg1tm1Lky/J
Under Development - Now Accepting Orders
A targeting vector was designed to insert an internal ribosome entry site (IRES)-enhanced yellow fluorescent protein (eYFP) fusion protein, downstream of the endogenous stop codon of the arginase (Arg1) gene. These mice may be useful for visualization of arginase-containing cells and their response to infection.
Bmi1tm1Ilw 017351 BKa.Cg-Ptprcb Bmi1tm1Ilw Thy1a/J
Under Development - Now Accepting Orders
The Bmi-1GFP knock-in/knockout allele was designed to both abolish (Bmi1) gene function and express EGFP from the Bmi1 promoter/enhancer elements. Of note, these mice also harbor the CD45.2 (Ptprcb) and Thy1.1 leukocyte alloantigen (Thy1a) alleles to allow tracking of hematopoietic donor derived or transferred cells.
Bmp2tm1Jfm 016230 B6;129S4-Bmp2tm1Jfm/J
Under Development - Now Accepting Orders
These Bmp2floxneo mice have loxP sites flanking exon 3 of the (Bmp2) gene. Removal of the floxed sequence results in a null allele.
Bmp4tm1Jfm 016878 B6;129S4-Bmp4tm1Jfm/J
Under Development - Now Accepting Orders
These Bmp4floxneo mice have loxP sites flanking exon 4 of the bone morphogenetic protein 4 gene (Bmp4). Removal of the floxed sequence results in a null allele. They may have applications in studies related to bone morphogenetic protein signaling pathways, bone biology, cardiovascular biology and cancer.
CASP3 016882 B6.Cg-Tg(CMV-CASP3)14Edge/J
Repository- Live
Mos-iCsp3 transgenic mice have a CMV promoter directing expression of a floxed-lacZ-STOP cassette followed by two tandem FK506-binding sites (Fvs) and a downstream human Caspase 3 (Casp3) gene. These mice may be useful for cell ablation of specific cell types and as a model of degenerative diseases such as Parkinson's Disease, type 1 diabetes, alopecia, and deafness.
CASP3 016908 B6.Cg-Tg(CMV-CASP3)17Edge/J
Repository- Live
Mos-iCsp3 transgenic mice have a CMV promoter directing expression of a floxed-lacZ-STOP cassette followed by two tandem FK506-binding sites (Fvs) and a downstream human Caspase 3 (Casp3) gene. These mice may be useful for cell ablation of specific cell types and as a model of degenerative diseases such as Parkinson's Disease, type 1 diabetes, alopecia, and deafness.
CHRM3 014093 STOCK Tg(tetO-CHRM3*)1Blr/J
Under Development - Now Accepting Orders
These TRE-hM3Dq transgenic mice may be bred to generate Tet-Off/Tet-On mutant mice with conditional (inducible/reversible) expression of hM3Dq; a mutant G protein-coupled receptor (GPCR) that activates the canonical Gq pathway specifically following administration of the pharmacologically inert molecule clozapine-N-oxide (CNO). TRE-hM3Dq transgenic mice may be useful to study receptor-specific functions or general downstream cellular signaling emanating from the activated GPCR.
Cacna1ftm1.2Sdie 017762 B6(Cg)-Cacna1ftm1.2Sdie/J
Under Development for Cryo
These mice carry the I756T point mutation in exon 17, and loxP sites flanking exons 14 through 17, of the Cacna1f (calcium channel, voltage-dependent, alpha 1F subunit). This mutant mouse strain may be useful in studies of calcium channelopathies, an inherited retinal disorder, photoreceptor electrophysiology, and the role of the Cav1.4 channel in survival of naive T cells.
Cacna1ftm1Sdie 017760 B6(Cg)-Cacna1ftm1Sdie/J
Under Development for Cryo
These I756T+neo mice carry the I756T point mutation in exon 17 of the Cacna1f, calcium channel, voltage-dependent, alpha 1F subunit, (756 is the mouse equivalent to residue 745 in human CACNA1F) as well as a FRT flanked NEO selection cassette and loxP sites flanking exons 14 through 17. This mutant mouse strain may be useful in studies of calcium channelopathies, incomplete congenital stationary night blindness, photoreceptor electrophysiology, and the role of the Cav1.4 channel in survival of naive T cells.
Ccl25tm1Mal 016938 B6N.129S2(Cg)-Ccl25tm1Mal/J
Repository- Live
These knockout mice lack a portion of exon 2 and all of exons 3-4 of the chemokine (C-C motif) ligand 25 (Ccl25) gene. These mice may be useful for studying gut-specific lymphocyte trafficking and early T cell development.
Ccl7tm1Ifc 017638 B6.129S4-Ccl7tm1Ifc/J
Under Development - Now Accepting Orders
This knockout strain lacks the entire coding region of the Ccl7 gene. These mice may be useful for studying the role of MCP-3 during monocyte recruitment and homeostasis.
Ccne1tm2.1Pisc 017786 B6;129S4-Ccne1tm2.1Pisc/J
Under Development - Now Accepting Orders
The start codon of the Ccne1 gene is replaced by a Flag-HA epitope tag in this strain, allowing labeling and purification of cyclin E1 protein.
Cdc14btm1.2Pzg 016896 B6.129P2(Cg)-Cdc14btm1.2Pzg/J
Under Development - Now Accepting Orders
These Cdc14bdeltaE2 mutant mice are deficient in Cdc14b and exhibit premature aging and impaired DNA damage repair.
Cdkn1atm1Led 016565 B6.129S6(Cg)-Cdkn1atm1Led/J
Repository- Live
In this knockout strain, a neo cassette replaces exon 2 of the of the cyclin-dependent kinase inhibitor 1A (Cdkn1a or p21CIP1/WAF1) gene. These mice may be useful for studying cell cycle timing and arrest during cellular proliferation.
Col1a1tm1(tetO-mCherry)Eggn 014602 B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-mCherry)Eggn/J
Under Development - Now Accepting Orders
These double mutant Rosa26-rtTA::Col1a1-tetO-H2B-mCherry mice harbor the Rosa26-rtTA targeted mutation (an optimized form of reverse tetracycline controlled transactivator (rtTA-M2) downstream of the Gt(ROSA)26Sor promoter) and the Col1a1-tetO-H2B-mcherry targeted mutation (a tet-responsive element (tetO) and a histone H2B-mCherry fusion protein, targeted to the collagen, type I, alpha 1 (Col1a1) locus). These Rosa26-rtTA::Col1a1-tetO-H2B-mCherry mice may be useful for doxycycline-inducible studies which utilize the rtTA/tet-O (tet-on/TRE) system for visualizing pluripotent cells.
Csf3rtm1Link 017838 B6.129X1(Cg)-Csf3rtm1Link/J
Under Development - Now Accepting Orders
These Csf3r knockout mice are useful for studying granulopoiesis and hematopoietic stem cell regulation.
Cyp7b1tm1Rus 016108 B6;129S-Cyp7b1tm1Rus/J
Repository- Live
In this strain, a neomycin resistance cassette replaces part of exon 6 of the endogenous Cyp7b1 gene. These mice are useful for studying cholesterol and bile acid metabolism, oxysterol synthesis and breakdown, macrophage function, and B cell trafficking and activation in the immune system.
Dmdmdx 016622 STOCK Utrntm1Jrs Dmdmdx/J
Under Development - Now Accepting Orders
Mice homozygous for the Utrntm1Jrs and Dmdmdx exhibit an onset of skeletal muscle dystrophy as early as 4 weeks of age and are a model for Duchenne Type Muscular Dystrophy.
E4f1tm1Pisc 017583 B6;129S4-E4f1tm1Pisc/J
Under Development - Now Accepting Orders
These E4F transcription factor 1 knock out mutant mice exhibit embryonic lethality and abnormal apoptosis.
Eif2c2tm1.1Tara 016520 B6.129P2(129S4)-Eif2c2tm1.1Tara/J
Repository- Live
These mice carry a floxed allele that enables conditional inactivation of the Eif2c2 (eukaryotic translation initiation factor 2C, 2) gene. This strain may be useful in studies further characterizing the gene and its involvement with hematopoiesis and the microRNA (miRNA) pathway.
Eif2s1tm1Rjk 017601 B6.129-Eif2s1tm1Rjk/J
Under Development - Now Accepting Orders
Mutation of the EIF2α phosphorylation site results in a lack of translational and transcriptional regulation in the endoplasmic reticulum.
Fasl 014547 FVB/N-Tg(tetO-Fasl)BDepa/J
Repository- Live
These transgenic mice allow Tet-Off/Tet-On regulated expression of FasL. FasL overexpression leads to Fas/FasL receptor-mediated death-signaling pathway activation and results in cell apoptosis.
Fbxl3Ovtm 016926 BTBR T+ tf-Fbxl3Ovtm/J
Repository- Live
Ovtm ENU-induced mutants contain an A to G transition at nucleotide in exon 5 of the F-box and leucine-rich repeat protein 3 (Fbxl3) gene that defines an amino acid change from isoleucine to threonine at residue 364. These mice may be useful for studying circadian rhythm modulation.
Fgfr3m1J 014182 CByJ.Cg-Fgfr3m1J/GrsrJ
Repository- Live
Mice homozygous for the recessive Fgfr3m1J allele have skeletal deformities that result in kyphosis, scoliosis, and a bent tail, which is often found to exit the pelvis at an abnormal angle. ABR threshold assessment shows hearing loss to the point of deafness at 3 to 4 weeks of age, the earliest age assessed. Male homozygotes display infertility, but females do breed and rear pups. Homozygotes have not been found to have a reduced lifespan, distinct from the reduced lifespan or prenatal lethality found in homozygotes for targeted deletions of this gene.
Flnctm1Lmk 014125 B6;129-Flnctm1Lmk/J
Repository- Live
The Flnc Δ41-48 mutant allele has the last eight exons (exons 41-48) of the filamin C (FLNc) locus deleted. The Flnc Δ41-48 mutant mice may be useful in studying muscle physiology, primary myogenesis, muscle differentiation, and maintenance of elongated muscle fiber structure in the sarcomere.
GFP 016836 B6;129S4-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm7(tetO-HIST1H2BJ/GFP)Jae/J
Repository- Live
These H2B-GFP (histone 2B, HIST1H2BJ) doxycycline-inducible compound mutant mice may be used for cell labeling studies.
GFP 016617 C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J
Repository- Live
Mice harboring the Nur77-GFPCre BAC transgene express an enhanced green fluorescent protein/codon-optimized "humanized" Cre recombinase fusion protein under control of the Nr4a1 promoter/enhancer regions within the BAC transgene. GFP expression level correlates to the strength of antigen receptor signaling.
GFP 017592 B6;129S-Sox2tm2Hoch/J
Under Development - Now Accepting Orders
The Sox2 open reading frame is replaced by EGFP in this knockin/knockout line. Strong EGFP expression is detected in blastocysts, neural progenitor cells and in many adult epithelial tissues.
GFP 017932 STOCK Tg(ACTB-EGFP*)10Luo/J
Under Development - Now Accepting Orders
The Miya10TG (M10TG) transgene has the CMV enhancer/chicken beta-actin core promoter upstream of a frt-flanked "MADM TG" cassette, all inserted into an intergenic region on chromosome 10 (~21 Mbp; between the Ahi1 and Myb loci). These mutant mice are designed for MADM-10 (mosaic analysis with double markers on chromosome 10), and provide a tool to generate genetic mosaics in which an individual organism contains somatic cells of different genotypes. This allows Cre recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation and mitosis.
GFP 017923 STOCK Tg(ACTB-EGFP*,-tdTomato)10Luo/J
Under Development - Now Accepting Orders
The Miya10GT (M10GT) transgene has the CMV enhancer/chicken beta-actin core promoter upstream of a frt-flanked "MADM GT" cassette, all inserted into an intergenic region on chromosome 10 (~21 Mbp; between the Ahi1 and Myb loci). These mutant mice are designed for MADM-10 (mosaic analysis with double markers on chromosome 10), and provide a tool to generate genetic mosaics in which an individual organism contains somatic cells of different genotypes. This allows Cre recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation and mitosis.
Git1Gt(FHCRC-GT-S10-12C1)Sor 016093 C.129S4(B6)-Git1Gt(FHCRC-GT-S10-12C1)Sor/WeisJ
Repository- Live
A targeting vector containing β-galactosidase, a polyadenylation signal, and a PGK Hygromycin selection cassette, was randomly inserted downstream of exon 1 of the endogenous G protein-coupled receptor kinase-interactor 1 (Git1) gene. These mice may be useful as a lacZ reporter for Git1 expression.
Git2Gt(XG510)Byg 016094 B6.129P2-Git2Gt(XG510)Byg/WeisJ
Repository- Live
A targeting vector containing β-galactosidase was randomly inserted downstream of exon 2 of the endogenous G protein-coupled receptor kinase-interactor 2 (Git2) gene. These mice may be useful as a lacZ reporter for Git2 expression.
Glra1tm1.1Geh 017521 STOCK Glra1tm1.1Geh/J
Repository- Live
These α1(Q266I) mice contain the amino acid mutation Q266I in exon 7 of the glycine receptor, alpha 1 subunit (Glra1) gene. These mice may be useful for studying glycine receptor sensitivity to alcohols and volatile anesthetics.
Glra1tm2.1Geh 017522 STOCK Glra1tm2.1Geh/J
Repository- Live
These α1(M287L) mice contain the amino acid mutation M287L in exon 8 of the glycine receptor, alpha 1 subunit (Glra1) gene. These mice may be useful for studying glycine receptor sensitivity to alcohols and volatile anesthetics.
Gmnntm1Tjm 016913 B6;129P2-Gmnntm1Tjm/J
Under Development - Now Accepting Orders
These mice possess loxP sites flanking exons 5-7 of the geminin (Gmnn) gene and have applications in studies related to hematopoietic stem cell growth and differentiation.
Gt(ROSA)26Sortm1(Foxo1/GFP)Jke 016262 B6;129-Gt(ROSA)26Sortm1(Foxo1/GFP)Jke/J
Repository- Live
The FOXO1/GFP allele contains a loxP-flanked transcriptional STOP cassette (PGK-Neo-polyA) upstream of a forkhead box O1 (Foxo1)-green fluorescent protein (GFP) fusion protein. These mice may be useful for generating conditional mutations for studying the role of PI3K-AKT signaling pathway on insulin resistance, glucose intolerance, diabetes, and aging.
Gt(ROSA)26Sortm10(ACTB-tdTomato)Luo 017922 STOCK Gt(ROSA)26Sortm10(ACTB-tdTomato)Luo/J
Under Development - Now Accepting Orders
The R26TT allele has a CMV enhancer/chicken beta-actin core promoter-driven "MADM TT" cassette inserted into the Gt(ROSA)26Sor locus on chromosome 6. These R26TT mice exhibit widespread expression of tdTomato-3Myc (tdT3Myc) and represent the tdTomato-expressing control strain for "new MADM-6" (new mosaic analysis with double markers on chromosome 6) experiments.
Gt(ROSA)26Sortm38(CAG-GCaMP3)Hze 014538 B6;129S-Gt(ROSA)26Sortm38(CAG-GCaMP3)Hze/J
Repository- Live
The fluorescent calcium indicator protein GCaMP3 is a circularly permutated EGFP sequence and a rat calmodulin (Calm) sequence modified to increase the fluorescence change for small calcium transients. These Ai38 mice conditionally express GCaMP3 from the endogenous Gt(ROSA)26Sor locus. Expression is enhanced by the presence of a CAG promoter. Following Cre-mediated removal of the STOP cassette, GCaMP3 expression (EGFP fluorescence) is detected in the cre-expressing tissues. Following subsequent calcium binding (such as neuronal activation), bright EGFP fluorescence is observed.
Gt(ROSA)26Sortm6(ACTB-EGFP*,-tdTomato)Luo 017912 STOCK Gt(ROSA)26Sortm6(ACTB-EGFP*,-tdTomato)Luo/J
Under Development - Now Accepting Orders
The R26GT allele has a CMV enhancer/chicken beta-actin core promoter-driven "MADM GT" cassette (GFPN-terminus-intron-tdT3MycATG-less) inserted into the Gt(ROSA)26Sor locus on chromosome 6. Like the original MADM system, this "new MADM-6" system provides a tool to generate genetic mosaics in which an individual organism contains somatic cells of different genotypes. This allows Cre or FLP recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation and mitosis.
Gt(ROSA)26Sortm7(ACTB-EGFP*)Luo 017921 STOCK Gt(ROSA)26Sortm7(ACTB-EGFP*)Luo/J
Under Development - Now Accepting Orders
The R26TG allele has a CMV enhancer/chicken beta-actin core promoter-driven "MADM TG" cassette (ATG-intron-GFPC-terminus) inserted into the Gt(ROSA)26Sor locus on chromosome 6. The new TG cassette in R26TG mice is compatible with any "GX cassette" (GFPN-terminus-intron-XATG-less) where XATG-less is any gene without the start codon. Like the original MADM system, the "new MADM-6" system provides a tool to generate genetic mosaics in which an individual organism contains somatic cells of different genotypes. This allows Cre or FLP recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation and mitosis, as well as for the MADM-Tet system.
Gt(ROSA)26Sortm8(ACTB-EGFP*,-tTA2)Luo 017909 STOCK Gt(ROSA)26Sortm8(ACTB-EGFP*,-tTA2)Luo/J
Under Development - Now Accepting Orders
The R26G-tTA2 allele has a CMV enhancer/chicken beta-actin core promoter-driven "MADM G-tTA2" (GFPN-terminus-intron-tTA2ATG-less) inserted into the Gt(ROSA)26Sor locus on chromosome 6. These mutant mice are designed to combine the "new MADM-6" system with a Tet-Off binary expression system to create MADM-Tet (mosaic analysis with double markers combined with Tet-Off). This is a tool to generate genetic mosaics in which an individual organism contains somatic cells of different genotypes. This allows Cre or FLP recombinase-induced fluorescent labeling/tTA2-expression in daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice are also a Tet-Off tool enabling a TRE transgene to be conditionally expressed in a subset of MADM-labeled cells.
HIST1H2BJ 016836 B6;129S4-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm7(tetO-HIST1H2BJ/GFP)Jae/J
Repository- Live
These H2B-GFP (histone 2B, HIST1H2BJ) doxycycline-inducible compound mutant mice may be used for cell labeling studies.
Hcn1tm2Kndl 016566 B6.129S-Hcn1tm2Kndl/J
Repository- Live
HCN1 knockout mice lack the p region and S6 transmembrane (pore-S6) domain of the hyperpolarization-activated, cyclic nucleotide-gated K+ 1 (Hcn1) gene. This mutant mouse strain may be useful in studies of learning, memory, neurophysiology, and Parkinson's Disease.
Hmgn1tm1Mbus 017296 B6.129X1-Hmgn1tm1Mbus/J
Under Development - Now Accepting Orders
Embryonic fibroblasts from these Hmgn1, high mobility group nucleosomal binding domain 1, knock out mice exhibit defective DNA repair.
IGF1R 016618 FVB-Tg(Ckm-IGF1R*K1003R)1Dlr/J
Repository- Live
MKR transgenic mice have the murine Ckm promoter directing expression of the human IGF-1R gene containing the K1003R mutation. These mice may be useful for studying insulin signaling and Type 2 Diabetes.
Ifih1tm1.1Cln 015812 B6.Cg-Ifih1tm1.1Cln/J
Repository- Live
These Ifih1 knockout mice may be useful for studying immune responses to viruses and other pathogens.
Il2rgtm1Wjl 014568 NOD.Cg-Rag1tm1Mom Ins2Akita Il2rgtm1Wjl/SzJ
Repository- Live
These NRG-Akita mutant mice are immunodeficient and spontaneously develop hyperglycemia. The strain may be useful as a diabetic host for human islet cells.
Ins2Akita 014568 NOD.Cg-Rag1tm1Mom Ins2Akita Il2rgtm1Wjl/SzJ
Repository- Live
These NRG-Akita mutant mice are immunodeficient and spontaneously develop hyperglycemia. The strain may be useful as a diabetic host for human islet cells.
Ins2Akita 013719 D2.Cg-Apoetm1Unc Ins2Akita/J
Cryopreserved - Ready for recovery
Double mutant, Apoe-null, Akita heterozygous, mice may be useful in studies of diabetes, metabolism, hyperglycemia, atherosclerosis, hypercholesterolemia, and diabetes-related macrovascular complications.
Ip6k2tm1Dlin 016221 B6;129-Ip6k2tm1Dlin/J
Repository- Live
In this knockout strain the first 202 nucleotides of exon 2 of the inositol hexaphosphate kinase 2 (Ip6k2) gene is disrupted. These mice may be useful for studying the mechanisms of IP6K2-dependent tumorigenesis.
Itga3tm1Rdav 008818 B6.129S7-Itga3tm1Rdav/J
Repository- Live
These f(α3) mutant mice harbor loxP sites flanking exons 11-18 of the Itga3 (integrin alpha 3 (or alpha3-integrin (α3-integrin)) gene and may be useful in generating conditional mutations for studying the role of Itga3 transmembrane cell adhesion receptors in neuronal functions in the developing and adult central nervous system, including synaptic plasticity and memory formation.
Itga8tm1.1Rdav 015840 B6.129S6-Itga8tm1.1Rdav/J
Repository- Live
These f(α8) conditional mutant mice have loxP sites flanking the exons encoding the transmembrane and the cytoplasmic domains of the Itga8 gene (also called integrin alpha 8, alpha8-integrin, or α8-integrin). These f(α8) mutant mice may be useful in generating conditional mutations for studying the role of Itga8 transmembrane cell adhesion receptors in neuronal function in the developing and adult central nervous system, including intracellular signaling, behavior, synaptic plasticity, and memory formation.
Itgaltm1Bll 016898 NOD.129S7(B6)-Itgaltm1Bll/CgkJ
Repository- Live
This diabetes resistant congenic NOD.Itgal deficient mutant may be useful to further study the role of leukocyte intergrins in inflammatory disease models, specifically Type 1 Diabetes.
Itgb2tm2Bay 016897 NOD.129S7(B6)-Itgb2tm2Bay/CgkJ
Cryopreserved - Ready for recovery
This diabetes resistant congenic NOD.Itgb2 deficient mutant may be useful for in vivo analysis of leukocyte integrin-dependent adhesion in inflammatory disease models, specifically Type 1 Diabetes.
Juptm1.1Glr 017575 STOCK Juptm1.1Glr/J
Repository- Live
These PGflox mutant mice possess loxP sites flanking exon 1 of the junction plakoglobin (Jup) gene. This strain may be useful for studying plakoglobin in the assembly of adherens junctions and desmosomes, and in the regulation of Wnt/β-catenin signalling.
Klf4 011001 B6;129S4-Col1a1tm1(tetO-Pou5f1,-Klf4,-Sox2,-Myc)Hoch/J
Repository- Live
Col1a1-tetO-OKSM mice have expression of the OKSM cassette (four mouse reprogramming genes Oct4 [Pou5f1], Klf4, Sox2, and c-Myc [Myc]) under the control of the bi-directional tet-responsive element (tetO; also called tetracycline operator, tet-operator, or tetracycline-responsive element [TRE]) with CMV minimal enhancer-less promoter. When bred with another mouse expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA), expression of the OKSM cassette can be regulated with the tetracycline analog doxycycline (dox) in the resulting double mutant offspring. Somatic expression of the OKSM reprogramming factors allows multiple somatic cell types to be directly reprogrammed to generate induced pluripotent stem cells (iPSCs).
Lamc1tm1Strl 016917 B6.129P2-Lamc1tm1Strl/J
Repository- Live
These mutant mice possess a frt-flanked neomycin resistance cassette upstream of exon 2, and loxP sites flanking exon 2 of the Lamc1 gene. This strain may be useful for studying neuronal regeneration, embryonic development, organogenesis, and basement membrane assembly.
Mapk11tm1Jda 012566 B6.Cg-Mapk11tm1Jda Mapk14tm1Jda/J
Repository- Live
These p38αβY323F mice harbor two polymorphic mutations, a p38βY323F mutation of the Mapk11 gene and a p38αY323F mutation of the Mapk14 gene. While the canonical MAPK cascade-induced p38 activation should not be affected, each polymorphism abolishes the T cell receptor (TCR)-mediated alternative activation pathway of p38.
Mapk14 012736 B6.Cg-Mapk14tm1.1Dvb/J
Repository- Live
These p38AF mice harbor dominant-negative mutations of the activating phosphorylation sites of the p38MAPK gene that result in specifically attenuated p38MAPK signaling. These p38AF mice may be useful in studying cell cycle inhibitors, cellular senescence, ageing, and cell proliferation/regeneration in response to stress.
Mapk14tm1Jda 012566 B6.Cg-Mapk11tm1Jda Mapk14tm1Jda/J
Repository- Live
These p38αβY323F mice harbor two polymorphic mutations, a p38βY323F mutation of the Mapk11 gene and a p38αY323F mutation of the Mapk14 gene. While the canonical MAPK cascade-induced p38 activation should not be affected, each polymorphism abolishes the T cell receptor (TCR)-mediated alternative activation pathway of p38.
Mapk8ip1tm3.1Rjd 013536 B6.129-Mapk8ip1tm3.1Rjd/J
Repository- Live
In this strain, codon 103 in exon 3 of the endogenous mitogen-activated protein kinase 8 interacting protein 1 (Mapk8ip1 or Jip1) gene is mutated from a Threonine (ACT) to an Alanine (GCC). These mice may be useful for studying MAP kinase signaling pathways and activation of JNK in response to metabolic stress.
Mir21tm1Yoli 016856 B6;129S6-Mir21tm1Yoli/J
Under Development - Now Accepting Orders
These miR-21 knockout mice are characterized by an increase in apoptotic cells found in the epidermal layer. Keratinocytes in particular exhibit increased apoptosis, elevated expression of several miR-21 target proteins (including Spry1, Pten, and Pdcd4), and attenuated Ras signaling/inhibition of Ras effector pathways.
Msh2tm2.1Rak 016231 B6.Cg-Msh2tm2.1Rak/J
Repository- Live
Mice harboring the Msh2LoxP allele have loxP sites flanking exon 12 of the mutS homolog 2 (E. coli) [Msh2] gene. When bred to mice that express Cre recombinase, the resulting offspring will have the sequences encoding a portion of the essential ATPase domain of MSH2 protein deleted in the cre-expressing tissues.
Myc 011001 B6;129S4-Col1a1tm1(tetO-Pou5f1,-Klf4,-Sox2,-Myc)Hoch/J
Repository- Live
Col1a1-tetO-OKSM mice have expression of the OKSM cassette (four mouse reprogramming genes Oct4 [Pou5f1], Klf4, Sox2, and c-Myc [Myc]) under the control of the bi-directional tet-responsive element (tetO; also called tetracycline operator, tet-operator, or tetracycline-responsive element [TRE]) with CMV minimal enhancer-less promoter. When bred with another mouse expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA), expression of the OKSM cassette can be regulated with the tetracycline analog doxycycline (dox) in the resulting double mutant offspring. Somatic expression of the OKSM reprogramming factors allows multiple somatic cell types to be directly reprogrammed to generate induced pluripotent stem cells (iPSCs).
Myd88 016133 C57BL/6-Tg(Defa2-Myd88)1Lvh/J
Repository- Live
The mouse Defa2 (defensin, alpha, 2; also known as cryptdin 2 or CR2) promoter directs expression of FLAG-tagged Myd88 (myeloid differentiation primary response gene 88) to intestinal Paneth cells. This strain may be useful in studies of microbial/immune system interactions and antimicrobial transcriptional responses at the intestinal epithelial barrier.
Myd88tm1Defr 012622 NOD.Cg-Myd88tm1Defr/J
Repository- Live
These Myd88fl mice have loxP sites flanking exon 3 of the myeloid differentiation primary response gene 88 (Myd88). These mutant mice may be useful for Cre-lox studying signal transduction, Toll-like receptor signaling and natural killer cells.
Ncor1tm1Anh 017632 STOCK Ncor1tm1Anh/J
Under Development - Now Accepting Orders
These NCoRlox mutant mice possess loxP sites flanking exons 37-40 of the nuclear receptor co-repressor 1 (Ncor1) gene. This strain may be useful for studying the role of NCOR1 on regulation of nuclear receptor signaling.
Pawrtm1Rang 015823 C57BL/6N-Pawrtm1Rang/J
Repository- Live
These mice contain loxP sites flanking exon 2 of the targeted PRKC, apoptosis, WT1, regulator (Pawr or Par-4) gene. These mutant mice may be useful in generating conditional mutations for studying tumor development and treatment.
Pkd2tm1.1Tjwt 017292 B6.129X1(Cg)-Pkd2tm1.1Tjwt/J
Repository- Live
These Pkd2cond mutant mice possess loxP sites flanking exons 11-13 of the polycystic kidney disease 2 (Pkd2) gene. This strain may be useful for studying renal development in autosomal dominant polycystic kidney disease.
Pou5f1 011001 B6;129S4-Col1a1tm1(tetO-Pou5f1,-Klf4,-Sox2,-Myc)Hoch/J
Repository- Live
Col1a1-tetO-OKSM mice have expression of the OKSM cassette (four mouse reprogramming genes Oct4 [Pou5f1], Klf4, Sox2, and c-Myc [Myc]) under the control of the bi-directional tet-responsive element (tetO; also called tetracycline operator, tet-operator, or tetracycline-responsive element [TRE]) with CMV minimal enhancer-less promoter. When bred with another mouse expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA), expression of the OKSM cassette can be regulated with the tetracycline analog doxycycline (dox) in the resulting double mutant offspring. Somatic expression of the OKSM reprogramming factors allows multiple somatic cell types to be directly reprogrammed to generate induced pluripotent stem cells (iPSCs).
Ppp3r1tm2Grc 017692 B6;129S-Ppp3r1tm2Grc/J
Under Development - Now Accepting Orders
This strain carries a floxed allele of the Ppp3r1 gene. Cre excision disrupts calcineurin enzymatic activity in non-germline cell types. These mice have been useful in studies of T cell development/selection.
Prkaa1tm1.1Sjm 014141 STOCK Prkaa1tm1.1Sjm/J
Repository- Live
These Prkaa1 mutant mice possess loxP sites flanking exon 3 of the protein kinase, AMP-activated, alpha 1 catalytic subunit (Prkaa1) gene. This strain may be useful for studying cell growth and energy expenditure.
Prkaa2tm1.1Sjm 014142 B6(Cg)-Prkaa2tm1.1Sjm/J
Repository- Live
These Prkaa2 mutant mice possess loxP sites flanking exon 2 of the protein kinase, AMP-activated, alpha 2 catalytic subunit (Prkaa2) gene. This strain may be useful for studying cell growth and energy expenditure.
Ptpn5tm1Pjlo 016556 B6N.129-Ptpn5tm1Pjlo/J
Repository- Live
In this STEP KO strain, a neo cassette replaces the catalytic site of the protein tyrosine phosphatase, non-receptor type 5 (Ptpn5) gene, abolishing gene expression. These mice may be useful for studying the role of STEP in regulating synaptic plasticity in Alzheimer's Disease.
Ptprcb 017351 BKa.Cg-Ptprcb Bmi1tm1Ilw Thy1a/J
Under Development - Now Accepting Orders
The Bmi-1GFP knock-in/knockout allele was designed to both abolish (Bmi1) gene function and express EGFP from the Bmi1 promoter/enhancer elements. Of note, these mice also harbor the CD45.2 (Ptprcb) and Thy1.1 leukocyte alloantigen (Thy1a) alleles to allow tracking of hematopoietic donor derived or transferred cells.
RFP 017923 STOCK Tg(ACTB-EGFP*,-tdTomato)10Luo/J
Under Development - Now Accepting Orders
The Miya10GT (M10GT) transgene has the CMV enhancer/chicken beta-actin core promoter upstream of a frt-flanked "MADM GT" cassette, all inserted into an intergenic region on chromosome 10 (~21 Mbp; between the Ahi1 and Myb loci). These mutant mice are designed for MADM-10 (mosaic analysis with double markers on chromosome 10), and provide a tool to generate genetic mosaics in which an individual organism contains somatic cells of different genotypes. This allows Cre recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation and mitosis.
Rag1tm1Mom 014568 NOD.Cg-Rag1tm1Mom Ins2Akita Il2rgtm1Wjl/SzJ
Repository- Live
These NRG-Akita mutant mice are immunodeficient and spontaneously develop hyperglycemia. The strain may be useful as a diabetic host for human islet cells.
Rr13tm3Mom 016609 C57BL/6-Rr13tm3Mom/MomJ
Cryopreserved - Ready for recovery
Rr13 (regulatory region 13), shown to alter the selection for expression of specific olfactory receptor genes, has been deleted in these targeted mutant mice.
Sec61a1m1Gek 016131 C57BL/6J-Sec61a1m1Gek/J
Repository- Live
The Sec61a1Y344H mutation is an ENU-induced missense histidine to tyrosine substitution at amino acid 344 of the Sec61 alpha 1 subunit (S. cerevisiae) gene that renders mice diabetic. These Sec61a1Y344H mutant mice may be useful in studying diabetes, ER protein trafficking/processing/secretion, ER stress, obesity, fat metabolism, and other high-fat diet-associated disorders.
Slc17a9tm1.1Rpa 014604 B6.129-Slc17a9tm1.1Rpa/J
Repository- Live
Mice homozygous for this Slc17a9flox allele are viable and fertile, with loxP sites flanking exons 2-3 of the solute carrier family 17, member 9 (Slc17a9) gene. These mutant mice may be useful in generating conditional mutations for studying the role of Slc17a9 in vesicular storage and ATP exocytosis.
Smc1atm1Mbk 013122 B6;129S1-Smc1atm1Mbk/J
Repository- Live
This strain contains mutations in exon 19 of the endogenous structural maintenance of chromosomes 1A Smc1a gene. These mice may be useful for studying cell survival and chromosomal stability after DNA damage.
Sox2 011001 B6;129S4-Col1a1tm1(tetO-Pou5f1,-Klf4,-Sox2,-Myc)Hoch/J
Repository- Live
Col1a1-tetO-OKSM mice have expression of the OKSM cassette (four mouse reprogramming genes Oct4 [Pou5f1], Klf4, Sox2, and c-Myc [Myc]) under the control of the bi-directional tet-responsive element (tetO; also called tetracycline operator, tet-operator, or tetracycline-responsive element [TRE]) with CMV minimal enhancer-less promoter. When bred with another mouse expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA), expression of the OKSM cassette can be regulated with the tetracycline analog doxycycline (dox) in the resulting double mutant offspring. Somatic expression of the OKSM reprogramming factors allows multiple somatic cell types to be directly reprogrammed to generate induced pluripotent stem cells (iPSCs).
Stk11tm1.1Sjm 014143 STOCK Stk11tm1.1Sjm/J
Repository- Live
These Stk11 mutant mice possess loxP sites flanking exons 3-6 of the serine/threonine kinase 11 (Stk11) gene. This strain may be useful for studying cell growth and tumor suppression.
T+ 016926 BTBR T+ tf-Fbxl3Ovtm/J
Repository- Live
Ovtm ENU-induced mutants contain an A to G transition at nucleotide in exon 5 of the F-box and leucine-rich repeat protein 3 (Fbxl3) gene that defines an amino acid change from isoleucine to threonine at residue 364. These mice may be useful for studying circadian rhythm modulation.
TRPC3 016570 FVB-Tg(Myh6-TRPC3*)6.6Jmol/J
Repository- Live
The dnTRPC3 transgene contains a cardiac specific dominant negative human TRPC3 gene. These mice may be useful for studying the role plyed by TRPC in calcineurin signaling and myocardial growth.
Terf1tm2.1Tdl 012336 B6;129P2-Terf1tm2.1Tdl/J
Repository- Live
Mice homozygous for this TRF1F allele are viable and fertile, with loxP sites flanking exon 1 of the targeted gene. When bred to mice that express Cre recombinase, the resulting offspring will have the sequences encoding the endogenous translation start site deleted in the cre-expressing tissues.
Terf2iptm1.1Tdl 012346 B6;129-Terf2iptm1.1Tdl/J
Repository- Live
These Rap1F mice harbor loxP sites flanking exon 2 (encoding the TRF2 binding domain) of the mouse Rap1 locus (also called mRap1, TRF2-interacting factor, Terf2ip, or telomeric repeat binding factor 2 interacting protein). Telomeres serve a dual role in protecting the chromosome ends from degradation/repair activities and in intracellular signaling for regulating cell proliferation. Mammalian telomeres are formed by tandem TTAGGG sequence repeats bound by a specialized complex of six telomere-associated proteins called the shelterin complex. As Rap1 is one of the components of shelterin, these Rap1F mutant mice may be useful in generating conditional mutations for studying the shelterin complex of telomeres, telomere maintenance, chromosomal stability, cancer, and aging.
Thy1a 017351 BKa.Cg-Ptprcb Bmi1tm1Ilw Thy1a/J
Under Development - Now Accepting Orders
The Bmi-1GFP knock-in/knockout allele was designed to both abolish (Bmi1) gene function and express EGFP from the Bmi1 promoter/enhancer elements. Of note, these mice also harbor the CD45.2 (Ptprcb) and Thy1.1 leukocyte alloantigen (Thy1a) alleles to allow tracking of hematopoietic donor derived or transferred cells.
Tmem173gt 017537 C57BL/6J-Tmem173gt/J
Under Development - Now Accepting Orders
goldenticket, Tmem173gt, mice do not produce IFN-β in response to cyclic dinucleotides or Listeria monocytogenes infection, and may be useful in studies of cytosolic detection of pathogen DNA and innate immune response.
Trp53tm1.1Dgk 017767 B6;129-Trp53tm1.1Dgk/J
Under Development - Now Accepting Orders
Exons 2-6 of the pro-apoptotic transformation related protein 53 (Trp53) gene are flanked by Frt-sites, allowing for disruption of gene expression.
Ulk1tm1Thsn 017976 B6.129-Ulk1tm1Thsn/J
Under Development - Now Accepting Orders
These floxed Ulk1FL mice may be useful for studying the mechanisms of autophagy.
Utrntm1Jrs 016622 STOCK Utrntm1Jrs Dmdmdx/J
Under Development - Now Accepting Orders
Mice homozygous for the Utrntm1Jrs and Dmdmdx exhibit an onset of skeletal muscle dystrophy as early as 4 weeks of age and are a model for Duchenne Type Muscular Dystrophy.
Zap70 016096 B6.Cg-Tg(Zap70*M413A)2Weis/J
Repository- Live
These mutant mice harbor a BAC Zap70*M413A transgene that expresses a mutant form of mouse Zap70. These mice may be useful for studying selective, reversible Zap70 inhibition and its effect on T cell receptor signaling.
cre 016617 C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J
Repository- Live
Mice harboring the Nur77-GFPCre BAC transgene express an enhanced green fluorescent protein/codon-optimized "humanized" Cre recombinase fusion protein under control of the Nr4a1 promoter/enhancer regions within the BAC transgene. GFP expression level correlates to the strength of antigen receptor signaling.
cre 017593 B6;129S-Sox2tm1(cre/ERT2)Hoch/J
Under Development - Now Accepting Orders
These Sox2-CreER knockin mice have the Sox2 open reading frame replaced with a CreERT2 fusion gene. These mice may be useful for inducible Cre recombinase expression/floxed gene deletion in blastocysts, neural progenitor cells and in many adult epithelial tissues.
rtTA 016836 B6;129S4-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm7(tetO-HIST1H2BJ/GFP)Jae/J
Repository- Live
These H2B-GFP (histone 2B, HIST1H2BJ) doxycycline-inducible compound mutant mice may be used for cell labeling studies.
rtTA 016116 STOCK Waptm2(rtTA)Kuw/J
Repository- Live
These mice contain a reverse tetracycline-controlled transactivator (rtTA) protein in the 5' untranslated region of the whey acidic protein gene. Theses Wap-rtTA mice are useful in regulating the expression of proteins (including oncoproteins) in mammary epithelium.
rtTA 014602 B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-mCherry)Eggn/J
Under Development - Now Accepting Orders
These double mutant Rosa26-rtTA::Col1a1-tetO-H2B-mCherry mice harbor the Rosa26-rtTA targeted mutation (an optimized form of reverse tetracycline controlled transactivator (rtTA-M2) downstream of the Gt(ROSA)26Sor promoter) and the Col1a1-tetO-H2B-mcherry targeted mutation (a tet-responsive element (tetO) and a histone H2B-mCherry fusion protein, targeted to the collagen, type I, alpha 1 (Col1a1) locus). These Rosa26-rtTA::Col1a1-tetO-H2B-mCherry mice may be useful for doxycycline-inducible studies which utilize the rtTA/tet-O (tet-on/TRE) system for visualizing pluripotent cells.
tTA 015838 STOCK Tg(Camk2a-tTA)1Mmay Tg(tetO-ABL1*P242E*P249E)CPdav/J
Repository- Live
These AblPP/tTA double mutant mice allow the forebrain-specific expression of a constitutively active form of c-Abl (AblPP) to be regulated with tetracycline or its analog doxycycline (dox). AblPP/tTA mice need to be maintained on a doxycycline diet to prevent the neurological phenotype. When maintained without dox, AblPP/tTA mice develop early reactive gliosis and astrocyctosis that continues to a severe, progressive neurodegeneration in the CA1 region of the hippocampus, and early death. These AblPP/tTA mice may be useful for studying tau phosphorylation and the pathogenesis of neurodegeneration/neuroinflammation associated with Alzheimer's disease.
tf 016926 BTBR T+ tf-Fbxl3Ovtm/J
Repository- Live
Ovtm ENU-induced mutants contain an A to G transition at nucleotide in exon 5 of the F-box and leucine-rich repeat protein 3 (Fbxl3) gene that defines an amino acid change from isoleucine to threonine at residue 364. These mice may be useful for studying circadian rhythm modulation.
tetO 011001 B6;129S4-Col1a1tm1(tetO-Pou5f1,-Klf4,-Sox2,-Myc)Hoch/J
Repository- Live
Col1a1-tetO-OKSM mice have expression of the OKSM cassette (four mouse reprogramming genes Oct4 [Pou5f1], Klf4, Sox2, and c-Myc [Myc]) under the control of the bi-directional tet-responsive element (tetO; also called tetracycline operator, tet-operator, or tetracycline-responsive element [TRE]) with CMV minimal enhancer-less promoter. When bred with another mouse expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA), expression of the OKSM cassette can be regulated with the tetracycline analog doxycycline (dox) in the resulting double mutant offspring. Somatic expression of the OKSM reprogramming factors allows multiple somatic cell types to be directly reprogrammed to generate induced pluripotent stem cells (iPSCs).
tetO 016836 B6;129S4-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm7(tetO-HIST1H2BJ/GFP)Jae/J
Repository- Live
These H2B-GFP (histone 2B, HIST1H2BJ) doxycycline-inducible compound mutant mice may be used for cell labeling studies.

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