JAX Mice Database - Internal/Organ Research

Strains Newly Available

Internal/Organ Research

Note: This list only includes strains that have become available within the last six months.

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Allele Symbol	Stock Number	Strain Name Description	Standard Supply
Bmp2^tm1Jfm	016230	B6;129S4-Bmp2^tm1Jfm/J	Under Development - Now Accepting Orders
		These Bmp2^floxneo mice have loxP sites flanking exon 3 of the (Bmp2) gene. Removal of the floxed sequence results in a null allele.
Bmp4^tm1Jfm	016878	B6;129S4-Bmp4^tm1Jfm/J	Under Development - Now Accepting Orders
		These Bmp4^floxneo mice have loxP sites flanking exon 4 of the bone morphogenetic protein 4 gene (Bmp4). Removal of the floxed sequence results in a null allele. They may have applications in studies related to bone morphogenetic protein signaling pathways, bone biology, cardiovascular biology and cancer.
CSF2	014595	C;129S4-Rag2^tm1.1Flv Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Il2rg^tm1.1Flv/J	Repository- Live
		This immunodeficient strain carrying humanized IL3 and CSF2 (GM-CSF) cytokines may be useful for studies of lung disease and infection.
Camp^tm1Rlg	017799	B6.129X1-Camp^tm1Rlg/J	Under Development - Now Accepting Orders
		In this strain exons 3 and 4 of the cathelicidin antimicrobial peptide gene are replaced by a PGK-neo cassette. Homozygous mice are more susceptible to bacterial infections and may be useful in studies of innate immune response, regulation of immune response, wound healing/angiogenesis and tumor development.
Csf2/Il3^{tm1.1(CSF2,IL3)Flv}	014595	C;129S4-Rag2^tm1.1Flv Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Il2rg^tm1.1Flv/J	Repository- Live
		This immunodeficient strain carrying humanized IL3 and CSF2 (GM-CSF) cytokines may be useful for studies of lung disease and infection.
FCGRT	016919	B6.Cg-Rag1^tm1Mom Fcgrt^tm1Dcr Tg(CAG-FCGRT)276Dcr/DcrJ	Repository- Live
		These Rag1-/- FcRn-/- hFcRn (276) Tg mice express a human FCGRT molecule in lieu of the endogenous mouse Fcgrt. The absence of Rag1 makes the mice immunodeficient and therefore permits the engraftment of tissues and cell lines, making these mice well-suited for applications associated with the study of the pharmacokinetics and efficacy of therapeutic monoclonal antibody and FC fusion protein treatment. Further, these mice are suitable for the evaluation of immunogenic compounds.
Fcgrt^tm1Dcr	017700	B6.129-Rag1^tm1Mom Fcgrt^tm1Dcr/DcrJ	Repository- Live
		Rag1-/- mFcRn-/- mice are immunodeficient. This strain serves as a control strain for 016919
Fcgrt^tm1Dcr	016919	B6.Cg-Rag1^tm1Mom Fcgrt^tm1Dcr Tg(CAG-FCGRT)276Dcr/DcrJ	Repository- Live
		These Rag1-/- FcRn-/- hFcRn (276) Tg mice express a human FCGRT molecule in lieu of the endogenous mouse Fcgrt. The absence of Rag1 makes the mice immunodeficient and therefore permits the engraftment of tissues and cell lines, making these mice well-suited for applications associated with the study of the pharmacokinetics and efficacy of therapeutic monoclonal antibody and FC fusion protein treatment. Further, these mice are suitable for the evaluation of immunogenic compounds.
GFP	017619	NOD.Cg-Prkdc^scid Tg(CAG-EGFP)1Osb/KupwJ	Under Development - Now Accepting Orders
		This compound mutant strain combines the immunodeficiency features of the Prkdc^scid mutation and widespread fluorescent cell labeling capabilities of CAG-EGFP on the NOD genetic background. These mice are effective recipients of allogeneic and xenogenic grafts, and are an excellent source of fluorescent-labeled cells for transfer experiments.
Gata4	016572	STOCK Tg(Myh6/tetO-Gata4)1Jmol/J	Repository- Live
		This Gata4 transgenic contains Gata4 sequence regulated by a tetracycline operator, driven by the cardiac specific α-MHC promoter. These mice may be useful as an inducible model of cardiac development and angiogenesis.
Gata6	016571	FVB-Tg(Myh6/tetO-Gata6)2Jmol/J	Repository- Live
		These Gata6 transgenic mice contain the GATA binding protein 6 sequence regulated by a tetO sequence and the cardiac specific α-MHC promoter. These mice may be useful as an inducible model of cardiac hypertrophy.
Gsk3b^tm1Grc	017693	STOCK Gsk3b^tm1Grc/J	Under Development - Now Accepting Orders
		Mice homozygous for this Gsk3b conditional mutation express greatly reduced levels of a destabilized protein. When treated with rapamycin, functional protein expression is restored. This strain may be useful in studies of diabetes, inflammation, cardiovascular disease, cancer, neurodegenerative disease, and bipolar disorder.
H2-Ab1^tm1Gru	017637	NOD.Cg-Prkdc^scid Il2rg^tm1Wjl H2-Ab1^tm1Gru Tg(HLA-DRB1)31Dmz/SzJ	Under Development - Now Accepting Orders
		These NSG-Ab^o DR4 mice lack expression of the murine Prkdc gene, the X-linked Il2rg gene, and MHC class II, but express the human leukocyte antigen DR4 gene. These mice may be useful for targeting human CD4⁺ T cells in transplantation studies in the absence of xeno-GVHD.
Hfe^tm2Nca	017784	B6.129S6-Hfe^tm2Nca/J	Under Development for Cryo
		These mice carry a targeted mutation of Hfe, hemochromatosis, exhibit iron loading, and have applications in studies of hereditary hemochromatosis, iron homeostasis and innate immune response.
Hprt^b-m3	012480	NOD.Cg-Prkdc^scid Il2rg^tm1Wjl Hprt^b-m3/EshJ	Repository- Live
		These mutant mice combine the immunological characteristics of the NOD/ShiLtJ background, the severe combined immune deficiency mutation (scid), IL2 receptor gamma chain deficiency and a hypoxanthine phosphoribosyl transferase (Hprt^b-m3) null allele. This mutant mouse strain may be useful for xenotransplantation and drug screening.
IL3	014595	C;129S4-Rag2^tm1.1Flv Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Il2rg^tm1.1Flv/J	Repository- Live
		This immunodeficient strain carrying humanized IL3 and CSF2 (GM-CSF) cytokines may be useful for studies of lung disease and infection.
Il2rg^tm1.1Flv	014595	C;129S4-Rag2^tm1.1Flv Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Il2rg^tm1.1Flv/J	Repository- Live
		This immunodeficient strain carrying humanized IL3 and CSF2 (GM-CSF) cytokines may be useful for studies of lung disease and infection.
Il2rg^tm1Wjl	012480	NOD.Cg-Prkdc^scid Il2rg^tm1Wjl Hprt^b-m3/EshJ	Repository- Live
		These mutant mice combine the immunological characteristics of the NOD/ShiLtJ background, the severe combined immune deficiency mutation (scid), IL2 receptor gamma chain deficiency and a hypoxanthine phosphoribosyl transferase (Hprt^b-m3) null allele. This mutant mouse strain may be useful for xenotransplantation and drug screening.
Il2rg^tm1Wjl	014568	NOD.Cg-Rag1^tm1Mom Ins2^Akita Il2rg^tm1Wjl/SzJ	Repository- Live
		These NRG-Akita mutant mice are immunodeficient and spontaneously develop hyperglycemia. The strain may be useful as a diabetic host for human islet cells.
Il2rg^tm1Wjl	017637	NOD.Cg-Prkdc^scid Il2rg^tm1Wjl H2-Ab1^tm1Gru Tg(HLA-DRB1)31Dmz/SzJ	Under Development - Now Accepting Orders
		These NSG-Ab^o DR4 mice lack expression of the murine Prkdc gene, the X-linked Il2rg gene, and MHC class II, but express the human leukocyte antigen DR4 gene. These mice may be useful for targeting human CD4⁺ T cells in transplantation studies in the absence of xeno-GVHD.
Il2rg^tm1Wjl	017830	NOD.Cg-Prkdc^scid Il2rg^tm1Wjl Tg(PGK1-KITLG*220)441Daw/SzJ	Under Development - Now Accepting Orders
		These NSG-Tg(hu-mSCF) mice provide a supportive microenvironment that is conducive to engraftment of human hematopoietic stem cells and would be useful in studies of human mast cell development and allergic responses.
Ins2^Akita	014568	NOD.Cg-Rag1^tm1Mom Ins2^Akita Il2rg^tm1Wjl/SzJ	Repository- Live
		These NRG-Akita mutant mice are immunodeficient and spontaneously develop hyperglycemia. The strain may be useful as a diabetic host for human islet cells.
Irf6^{Gt(OST398253)Lex}	016902	B6.129S5-Irf6^{Gt(OST398253)Lex}/J	Repository- Live
		In this strain a gene construct (VICTR48), containing a neomycin resistance (neo), integrated downstream of the splice donor site of the interferon regulatory factor 6 (Irf6) gene. These mice may be useful for studying craniofacial development and keratinocytes differentiation.
KITLG	017830	NOD.Cg-Prkdc^scid Il2rg^tm1Wjl Tg(PGK1-KITLG*220)441Daw/SzJ	Under Development - Now Accepting Orders
		These NSG-Tg(hu-mSCF) mice provide a supportive microenvironment that is conducive to engraftment of human hematopoietic stem cells and would be useful in studies of human mast cell development and allergic responses.
Lrrk2^tm2.1Shn	016209	B6;129-Lrrk2^tm2.1Shn/J	Repository- Live
		LRRK2 KO1 mice have the promoter and exon 1 of the Lrrk2 gene deleted. These mice may be useful in studying the cellular function of LRRK2 during aging in the maintenance of protein homeostasis.
Lrrk2^tm3.1Shn	016210	B6;129-Lrrk2^tm3.1Shn/J	Repository- Live
		LRRK2 KO2 mice have with exons 29-30 of the Lrrk2 gene deleted. These mice may be useful in studying the cellular function of LRRK2 during aging in the maintenance of protein homeostasis and, specifically, α-synuclein through the regulation of protein degradation pathways.
Mapk11^tm1Jda	012566	B6.Cg-Mapk11^tm1Jda Mapk14^tm1Jda/J	Repository- Live
		These p38αβ^Y323F mice harbor two polymorphic mutations, a p38β^Y323F mutation of the Mapk11 gene and a p38α^Y323F mutation of the Mapk14 gene. While the canonical MAPK cascade-induced p38 activation should not be affected, each polymorphism abolishes the T cell receptor (TCR)-mediated alternative activation pathway of p38.
Mapk14^tm1Jda	012566	B6.Cg-Mapk11^tm1Jda Mapk14^tm1Jda/J	Repository- Live
		These p38αβ^Y323F mice harbor two polymorphic mutations, a p38β^Y323F mutation of the Mapk11 gene and a p38α^Y323F mutation of the Mapk14 gene. While the canonical MAPK cascade-induced p38 activation should not be affected, each polymorphism abolishes the T cell receptor (TCR)-mediated alternative activation pathway of p38.
Megf8^b2b288Clo	013617	C57BL/6J-b2b288Clo/J	Cryopreserved - Ready for recovery
		This undefined mutation was identified in a screen of ENU-induced mutations and may be useful in studies of congenital heart disease and development.
Mir223^tm1Fcam	013198	B6.Cg-Ptprc^a Mir223^tm1Fcam/J	Repository- Live
		In this strain, the allele replaces the entire coding region of the microRNA-223 (Mir223) gene with a frt-flanked neomycin (neo) resistance cassette, abolishing gene function. These mice also harbor the CD45.1 (Ly5.1 or Ptprc^a) allele rather than the CD45.2 (Ly5.2 or Ptprc^b) allele normally present in C57BL/6 mice. These mice may be useful for studying granulocyte production and inflammatory response.
Mtpn	017319	FVB-Tg(Myh6-Mtpn)4Ssen/J	Repository- Live
		This Myo-Tg mutant mouse strain overexpresses myotrophin in the heart resulting in cardiac hypertrophy, which progresses to heart failure.
Ncor1^tm1Anh	017632	STOCK Ncor1^tm1Anh/J	Under Development - Now Accepting Orders
		These NCoR^lox mutant mice possess loxP sites flanking exons 37-40 of the nuclear receptor co-repressor 1 (Ncor1) gene. This strain may be useful for studying the role of NCOR1 on regulation of nuclear receptor signaling.
Pdha1^tm1Ptl	017443	B6.129P2-Pdha1^tm1Ptl/J	Repository- Live
		These Pdha1^flox8 mutant mice possess loxP sites flanking exon 8 of the pyruvate dehydrogenase E1 alpha 1 (Pdha1) gene. This strain may be useful for studying lipid metabolism, glucose metabolism, and insulin sensitivity.
Pkd2^tm1.1Tjwt	017292	B6.129X1(Cg)-Pkd2^tm1.1Tjwt/J	Repository- Live
		These Pkd2^cond mutant mice possess loxP sites flanking exons 11-13 of the polycystic kidney disease 2 (Pkd2) gene. This strain may be useful for studying renal development in autosomal dominant polycystic kidney disease.
Prkdc^scid	012480	NOD.Cg-Prkdc^scid Il2rg^tm1Wjl Hprt^b-m3/EshJ	Repository- Live
		These mutant mice combine the immunological characteristics of the NOD/ShiLtJ background, the severe combined immune deficiency mutation (scid), IL2 receptor gamma chain deficiency and a hypoxanthine phosphoribosyl transferase (Hprt^b-m3) null allele. This mutant mouse strain may be useful for xenotransplantation and drug screening.
Prkdc^scid	017637	NOD.Cg-Prkdc^scid Il2rg^tm1Wjl H2-Ab1^tm1Gru Tg(HLA-DRB1)31Dmz/SzJ	Under Development - Now Accepting Orders
		These NSG-Ab^o DR4 mice lack expression of the murine Prkdc gene, the X-linked Il2rg gene, and MHC class II, but express the human leukocyte antigen DR4 gene. These mice may be useful for targeting human CD4⁺ T cells in transplantation studies in the absence of xeno-GVHD.
Prkdc^scid	017830	NOD.Cg-Prkdc^scid Il2rg^tm1Wjl Tg(PGK1-KITLG*220)441Daw/SzJ	Under Development - Now Accepting Orders
		These NSG-Tg(hu-mSCF) mice provide a supportive microenvironment that is conducive to engraftment of human hematopoietic stem cells and would be useful in studies of human mast cell development and allergic responses.
Prkdc^scid	017619	NOD.Cg-Prkdc^scid Tg(CAG-EGFP)1Osb/KupwJ	Under Development - Now Accepting Orders
		This compound mutant strain combines the immunodeficiency features of the Prkdc^scid mutation and widespread fluorescent cell labeling capabilities of CAG-EGFP on the NOD genetic background. These mice are effective recipients of allogeneic and xenogenic grafts, and are an excellent source of fluorescent-labeled cells for transfer experiments.
Ptprc^a	013198	B6.Cg-Ptprc^a Mir223^tm1Fcam/J	Repository- Live
		In this strain, the allele replaces the entire coding region of the microRNA-223 (Mir223) gene with a frt-flanked neomycin (neo) resistance cassette, abolishing gene function. These mice also harbor the CD45.1 (Ly5.1 or Ptprc^a) allele rather than the CD45.2 (Ly5.2 or Ptprc^b) allele normally present in C57BL/6 mice. These mice may be useful for studying granulocyte production and inflammatory response.
RBM45	017637	NOD.Cg-Prkdc^scid Il2rg^tm1Wjl H2-Ab1^tm1Gru Tg(HLA-DRB1)31Dmz/SzJ	Under Development - Now Accepting Orders
		These NSG-Ab^o DR4 mice lack expression of the murine Prkdc gene, the X-linked Il2rg gene, and MHC class II, but express the human leukocyte antigen DR4 gene. These mice may be useful for targeting human CD4⁺ T cells in transplantation studies in the absence of xeno-GVHD.
Rag1^tm1Mom	017700	B6.129-Rag1^tm1Mom Fcgrt^tm1Dcr/DcrJ	Repository- Live
		Rag1-/- mFcRn-/- mice are immunodeficient. This strain serves as a control strain for 016919
Rag1^tm1Mom	016919	B6.Cg-Rag1^tm1Mom Fcgrt^tm1Dcr Tg(CAG-FCGRT)276Dcr/DcrJ	Repository- Live
		These Rag1-/- FcRn-/- hFcRn (276) Tg mice express a human FCGRT molecule in lieu of the endogenous mouse Fcgrt. The absence of Rag1 makes the mice immunodeficient and therefore permits the engraftment of tissues and cell lines, making these mice well-suited for applications associated with the study of the pharmacokinetics and efficacy of therapeutic monoclonal antibody and FC fusion protein treatment. Further, these mice are suitable for the evaluation of immunogenic compounds.
Rag1^tm1Mom	014568	NOD.Cg-Rag1^tm1Mom Ins2^Akita Il2rg^tm1Wjl/SzJ	Repository- Live
		These NRG-Akita mutant mice are immunodeficient and spontaneously develop hyperglycemia. The strain may be useful as a diabetic host for human islet cells.
Rag2^tm1.1Flv	014595	C;129S4-Rag2^tm1.1Flv Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Il2rg^tm1.1Flv/J	Repository- Live
		This immunodeficient strain carrying humanized IL3 and CSF2 (GM-CSF) cytokines may be useful for studies of lung disease and infection.
SNCA	010710	FVB;129S6-Snca^tm1Nbm Tg(SNCA)1Nbm/J	Repository- Live
		These PAC-Tg(SNCA^WT);Snca^-/- mice harbor a Snca knockout allele and a transgene encoding the human α-synuclein. PAC-Tg(SNCA^WT);Snca^-/- mice are the experimental control for strains that model the very early gastrointestinal dysfunction in the absence of major central nervous system pathology seen in human Parkinson's disease (Stock No. 010788 and Stock No. 010799).
Sdccag8^{Tn(sb-Tyr)2161B.CA1C2Ove}	017598	FVB/N-Sdccag8^{Tn(sb-Tyr)2161B.CA1C2Ove}/J	Under Development - Now Accepting Orders
		These OVE2161B-CA1C-2 mice harbor a loss-of-function mutation created by random insertion of the pT2-BART3 transposon transgene into the serologically defined colon cancer antigen 8 gene (Sdccag8) on chromosome 1. These mice may be useful for studying cleft palate, preaxial polydactyly, and polycystic kidney disease.
Sec61a1^m1Gek	016131	C57BL/6J-Sec61a1^m1Gek/J	Repository- Live
		The Sec61a1^Y344H mutation is an ENU-induced missense histidine to tyrosine substitution at amino acid 344 of the Sec61 alpha 1 subunit (S. cerevisiae) gene that renders mice diabetic. These Sec61a1^Y344H mutant mice may be useful in studying diabetes, ER protein trafficking/processing/secretion, ER stress, obesity, fat metabolism, and other high-fat diet-associated disorders.
Snca^tm1Nbm	010710	FVB;129S6-Snca^tm1Nbm Tg(SNCA)1Nbm/J	Repository- Live
		These PAC-Tg(SNCA^WT);Snca^-/- mice harbor a Snca knockout allele and a transgene encoding the human α-synuclein. PAC-Tg(SNCA^WT);Snca^-/- mice are the experimental control for strains that model the very early gastrointestinal dysfunction in the absence of major central nervous system pathology seen in human Parkinson's disease (Stock No. 010788 and Stock No. 010799).
UGT1A1	014170	B6N.Cg-Tg(UGT1A1*28)1Rhtu/J	Repository- Live
		Transgenic UGT1A128* mice carry the entire human uridine diphosphate (UDP) glucuronosyltransferase 1 (UGT1) locus, and includes a mutant form of the human UGT1 polypeptide A1 (UGT1A1) promoter. These mice may be useful for studying the regulatory and functional properties of glucuronidation, and may also serve as a model for pharmacological studies associated with Gilbert's syndrome.
UPF1	010939	B6.Cg-Tg(ACTB-UPF1*R844C)581Hcd/J	Under Development for Cryo
		Human beta actin drives expression of the dominant negative R844C form of the human (UPF1)cDNA in these transgenic mice resulting in T cell-related defects.
Ucp1^tm1Kz	003124	B6.129-Ucp1^tm1Kz/J	Repository- Live
		These Ucp knockout mice are sensitive to cold temperatures, exhibit altered metabolism and are resistant to diet induced obesity when maintained at 20°C. This mutant mouse strain may be useful in studies of obesity, metabolic homeostasis, and adaptive thermogenesis.
b2b019Clo	013632	C57BL/6-b2b019Clo/J	Cryopreserved - Ready for recovery
		This undefined b2b019Clo mutation was identified in a screen of ENU-induced mutations and may be useful in studies of congenital heart disease and craniofacial development.
b2b386Clo	013618	C57BL/6J-b2b386Clo/J	Cryopreserved - Ready for recovery
		This undefined mutation was identified in a screen of ENU-induced mutations and may be useful in studies of congenital heart disease and craniofacial development.
cre	016223	B6(Cg)-Tg(Phox2b-cre)3Jke/J	Repository- Live
		Phox2b-Cre BAC transgenic mice from founder line 3 have Cre recombinase expression directed primarily to the hindbrain (dorsal motor nucleus of the vagus (DMV) in parasympathetic visceral and branchial motor neurons, nodose sensory ganglia, and nucleus of the solitary tract (NTS) cells) by the Phox2b promoter/enhancer regions within the BAC transgene. These Phox2b-Cre BAC transgenic mice may be used to generate conditional mutations for studying neuronal cell types expressing/depending on the Phox2b transcription factor for energy balance, glucose homeostasis, and autonomic breathing/respiration. Specifically, these mice may be useful for studying human respiratory disease, central chemoreceptive neurons in the retrotrapezoid nucleus, respiratory rhythmogenesis, and autonomic nervous system dysregulation (such as congenital central hypoventilation syndrome (CCHS) or Ondine-Hirschsprung disease).
cre	016241	B6.Cg-Tg(Col1a1-cre/ERT2)1Crm/J	Repository- Live
		This Col1a1-CreERT2 mutant mouse strain carries a transgene with tamoxifen inducible Cre recombinase and may be useful for generating osteoblast and odontoblast specific targeted mutants for studies of bone physiology and homeostasis.
rtTA	016567	129S.Cg-Tg(Hoxb7-rtTA*M2)2Cos/J	Repository- Live
		RS-HTA2 transgenic mice have the homeobox B7 promoter/enhancer sequences driving expression of an optimized form of the reverse tetracycline-controlled transactivator (rtTA*M2) protein. These mice may be useful for the inducible expression of genes throughout the Wolffian duct, ureteric bud (UB) epithelium, and developing kidney.
rtTA	016146	STOCK Tg(SFTPC-rtTA)2Jaw/J	Under Development - Now Accepting Orders
		These transgenic mice express the rtTA protein under the control of the human SFTPC promoter. This strain provides an improved Tet-On tool that allows the inducible expression of genes in the developing and adult lung and respiratory epithelium.
rtTA	016145	STOCK Tg(Scgb1a1-rtTA)2Jaw/J	Under Development - Now Accepting Orders
		These CCSP-rtTA transgenic mice express the rtTA protein under the control of the rat Scgb1a1 gene promoter and provides an improved "Tet-On" tool that allows the inducible expression of genes in the developing and adult lung and respiratory epithelium.
tTA	017722	B6.Cg-Tg(Tal1-tTA)19Dgt/J	Under Development - Now Accepting Orders
		Hemizygotes are viable, fertile, normal in size, and do not display any behavioral abnormalities. Hemizygotes express tetracycline-controlled transactivator protein (tTA) in bone marrow hematopoietic stem cells (HSC) and in common myeloid progenitors (CMP)). tTA activity also is detected in lung. Little to no tTA activity is detected in thymus, lymph node, intestine or spleen. When bred to other transgenic mice carrying a gene of interest coupled to a tetracycline-responsive promoter element (TRE; tetO), expression of the target gene in the bitransgenic offspring can be induced by withdrawal of tetracycline or doxycycline. This strain represents an effective tool for generating bitrangenic animals to study inducible gene expression in blood stem and progenitor cells. In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

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