JAX Mice Database - Research Tools

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Research Tools

Note: This list only includes strains that have become available within the last six months.

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Allele Symbol	Stock Number	Strain Name Description	Standard Supply
ABL1	015838	STOCK Tg(Camk2a-tTA)1Mmay Tg(tetO-ABL1P242EP249E)CPdav/J	Repository- Live
		These AblPP/tTA double mutant mice allow the forebrain-specific expression of a constitutively active form of c-Abl (AblPP) to be regulated with tetracycline or its analog doxycycline (dox). AblPP/tTA mice need to be maintained on a doxycycline diet to prevent the neurological phenotype. When maintained without dox, AblPP/tTA mice develop early reactive gliosis and astrocyctosis that continues to a severe, progressive neurodegeneration in the CA1 region of the hippocampus, and early death. These AblPP/tTA mice may be useful for studying tau phosphorylation and the pathogenesis of neurodegeneration/neuroinflammation associated with Alzheimer's disease.
ABL1	014544	STOCK Tg(tetO-ABL1P242EP249E)CPdav/J	Repository- Live
		This transgenic mouse has a Tet response element upstream of a human c-Abl 1b isoform modified to harbor two amino acid substitutions (P242E/P249E) in the conserved proline residues of the SH2-SH3 linker region that render the protein constitutively active (AblPP). Expression may be contoled via the Tet-Off/Tet-On system for use in studies related to tau phosphorylation.
ALPP	016555	B6;SJL-Tg(Nqo1-ALPP)1Jaj/J	Repository- Live
		These ARE-hPAP transgenic reporter mice express the heat stable reporter, human ALPP, under the control of the antioxidant response element (ARE), rat Nqo1, NAD(P)H dehydrogenase, quinone 1, promoter. This mutant mouse strain may be useful in studies of oxidative stress in neurodegenerative diseases such as Parkinson's disease.
ALPP	014600	STOCK Tg(I12b-cre/ERT2,-ALPP)37Fsh/J	Repository- Live
		These transgenic mice express a tamoxifen-inducible Cre recombinase under the control of the mouse Dlx1/2 enhancer/ promoter and may be useful for generating temporal conditional mutations for studying gain or loss of function and/or fate mapping in Dlx1/2-expressing forebrain tissues, including interneurons of the olfactory bulb and neocortex.
ALPP	017524	B6;129-Tg(CMV-Bgeo,-WGA,-ALPP)1Mgmj/J	Under Development - Now Accepting Orders
		These iZ/WAP mice express a Cre recombinase-inducible wheat germ agglutinin in cre-expressing neurons, and have applications as a trans-synaptic tracer or marker.
ATP2B4	017542	FVB-Tg(Myh6/tetO-ATP2B4)1Jmol/J	Repository- Live
		These transgenic animals carry the human ATP2B4 cDNA driven by a conditional mouse Myh6-tetO cardiac-specific promoter. When crossed with a tTA/rtTA strain, these mice may be useful in studies of cardiac function and disease.
Adamts18^tm1Zdl	017982	B6.129S6-Adamts18^tm1Zdl/J	Under Development - Now Accepting Orders
		This conditional mutant of Adamts18 may be useful in studies related to tumor suppression.
Aim2^{Gt(CSG445)Byg}	013144	B6.129P2-Aim2^{Gt(CSG445)Byg}/J	Under Development - Now Accepting Orders
		These AIM2-/- mice may be useful as a lacZ reporter for AIM2 expression or as a knockout model for studying the innate immune systems response to bacterial and viral infection.
Aip^tm2Bra	013195	B6.129-Aip^tm2Bra/J	Cryopreserved - Ready for recovery
		These Aip^fx/fx conditional (floxed) mutant mice possess loxP sites flanking exons 3 through 6, and may be useful in generating conditional mutations for studying early embryonic development, vascular development, and toxicology.
Anapc2^tm1Hez	017745	B6.129-Anapc2^tm1Hez/J	Under Development - Now Accepting Orders
		These mice possess loxP sites flanking exons 2 of the anaphase promoting complex subunit 2 (Anapc2) gene and may have applications in studies related to cell cycle regulation and early embryonic development.
Apaf1^tm1Hez	017746	B6.129-Apaf1^tm1Hez/J	Under Development - Now Accepting Orders
		These mice possess loxP sites flanking exon 5 of the apoptotic protease activating factor 1 (Apaf1) gene and may have applications in studies related to regulation of apoptosis, carcinogenesis, cancer chemoresistance and apoptosis-based therapeutic treatments.
Apbb1^tm1Her	012865	B6;129S6-Apbb1^tm1Her/J	Repository- Live
		The FE65 knockout allele has a nuclear localized-lacZ replacing exon 2 of the Apbb1 gene. These FE65 mutant mice, along with FE65L1 mutant mice, may be useful in studying brain development (neuronal positioning and establishment of axonal projections) and abnormal brain morphology (Cobblestone Lissencephaly, marginal zone heterotopias, and pial basement membrane integrity); as well as the function of FE65 family proteins in amyloid precursor protein (APP) processing, Alzheimer's disease, and neuronal protein trafficking.
Apbb2^tm1Her	012869	B6;129S6-Apbb2^tm1Her/J	Repository- Live
		These FE65L1 mutant mice, along with FE65 mutant mice, may be useful in studying brain development (neuronal positioning and establishment of axonal projections) and abnormal brain morphology (Cobblestone Lissencephaly, marginal zone heterotopias, and pial basement membrane integrity); as well as the function of FE65 family proteins in amyloid precursor protein (APP) processing, Alzheimer's disease, and neuronal protein trafficking.
Apoe^tm4Mae	014556	129S6/SvEv-Apoe^tm4Mae/J	Repository- Live
		This Apoe^tm4Mae knockout on the 129S6 genetic background exhibits increased total plasma cholesterol and triglyceride levels with atherosclerotic lesions developing more rapidly at the aortic arch but more slowly at the aortic root, when compared to a similar allele on the C57BL/6 genetic background.
Arg1^tm1Lky	015858	C.129S4(B6)-Arg1^tm1Lky/J	Under Development - Now Accepting Orders
		A targeting vector was designed to insert an internal ribosome entry site (IRES)-enhanced yellow fluorescent protein (eYFP) fusion protein, downstream of the endogenous stop codon of the arginase (Arg1) gene. These mice may be useful for visualization of arginase-containing cells and their response to infection.
Aurka^tm1.1Tvd	017729	B6.129-Aurka^tm1.1Tvd/J	Under Development - Now Accepting Orders
		These AurA^f mice possess loxP sites flanking exon 2 of the aurora kinase A gene and have applications in studies related to regulation of mitosis and carcinogenesis.
Axin1	016998	B6.Cg-Tg(TetO-Axin1,EGFP)TA6Cos/J	Repository- Live
		These TRE2-Axin-GFP transgenic mice carry myc-tagged mouse Axin1 and EGFP regulated by a tetracycline operator (tetO). When mated to a mutant strain expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA), tissue Axin1 and EGFP expression may be regulated with the tetracycline analog doxycycline (dox) in the double mutant offspring.
Bgeo	017524	B6;129-Tg(CMV-Bgeo,-WGA,-ALPP)1Mgmj/J	Under Development - Now Accepting Orders
		These iZ/WAP mice express a Cre recombinase-inducible wheat germ agglutinin in cre-expressing neurons, and have applications as a trans-synaptic tracer or marker.
Bmi1^tm1Ilw	017351	BKa.Cg-Ptprc^b Bmi1^tm1Ilw Thy1^a/J	Under Development - Now Accepting Orders
		The Bmi-1^GFP knock-in/knockout allele was designed to both abolish (Bmi1) gene function and express EGFP from the Bmi1 promoter/enhancer elements. Of note, these mice also harbor the CD45.2 (Ptprc^b) and Thy1.1 leukocyte alloantigen (Thy1^a) alleles to allow tracking of hematopoietic donor derived or transferred cells.
Bmp2^tm1Jfm	016230	B6;129S4-Bmp2^tm1Jfm/J	Under Development - Now Accepting Orders
		These Bmp2^floxneo mice have loxP sites flanking exon 3 of the (Bmp2) gene. Removal of the floxed sequence results in a null allele.
Bmp4^tm1Jfm	016878	B6;129S4-Bmp4^tm1Jfm/J	Under Development - Now Accepting Orders
		These Bmp4^floxneo mice have loxP sites flanking exon 4 of the bone morphogenetic protein 4 gene (Bmp4). Removal of the floxed sequence results in a null allele. They may have applications in studies related to bone morphogenetic protein signaling pathways, bone biology, cardiovascular biology and cancer.
CASP3	016882	B6.Cg-Tg(CMV-CASP3)14Edge/J	Repository- Live
		Mos-iCsp3 transgenic mice have a CMV promoter directing expression of a floxed-lacZ-STOP cassette followed by two tandem FK506-binding sites (Fvs) and a downstream human Caspase 3 (Casp3) gene. These mice may be useful for cell ablation of specific cell types and as a model of degenerative diseases such as Parkinson's Disease, type 1 diabetes, alopecia, and deafness.
CASP3	016908	B6.Cg-Tg(CMV-CASP3)17Edge/J	Repository- Live
		Mos-iCsp3 transgenic mice have a CMV promoter directing expression of a floxed-lacZ-STOP cassette followed by two tandem FK506-binding sites (Fvs) and a downstream human Caspase 3 (Casp3) gene. These mice may be useful for cell ablation of specific cell types and as a model of degenerative diseases such as Parkinson's Disease, type 1 diabetes, alopecia, and deafness.
CFP	016922	STOCK Tg(Myh7-CFP)1Jrs/J	Repository- Live
		These MyI-CFP transgenic mice express Enhanced Cyan Fluorescent Protein specifically in Type I muscle fibers and may be useful for studies of muscle development, architecture, plasticity and innervation.
CHRM3	014093	STOCK Tg(tetO-CHRM3*)1Blr/J	Under Development - Now Accepting Orders
		These TRE-hM3Dq transgenic mice may be bred to generate Tet-Off/Tet-On mutant mice with conditional (inducible/reversible) expression of hM3Dq; a mutant G protein-coupled receptor (GPCR) that activates the canonical G_q pathway specifically following administration of the pharmacologically inert molecule clozapine-N-oxide (CNO). TRE-hM3Dq transgenic mice may be useful to study receptor-specific functions or general downstream cellular signaling emanating from the activated GPCR.
COP4	014546	B6.Cg-Tg(Chat-COP4*H134R/EYFP)6Gfng/J	Repository- Live
		ChAT-mhChR2-YFP BAC transgenic mice express an improved channelrhodopsin-2/EYFP fusion protein (mhChR2::YFP) directed to cholinergic neuronal populations by the mouse choline acetyltransferase (Chat or ChAT) promoter/enhancer regions on the BAC transgene. Illuminating mhChR2-expressing neurons with blue light (450-490 nm) leads to rapid and reversible photostimulation of action potential firing/neural activity in these cells. These transgenic mice can be used in optogenetic studies for in vivo control of motor behavior by addition or removal of blue light.
COP4	014548	B6.Cg-Tg(Slc32a1-COP4*H134R/EYFP)8Gfng/J	Repository- Live
		VGAT-mhChR2-YFP BAC transgenic mice express an improved channelrhodopsin-2/EYFP fusion protein (mhChR2::YFP) directed to GABAergic interneuronal populations by the mouse vesicular GABA transporter (VGAT or Slc32a1) promoter/enhancer regions on the BAC transgene. Illuminating mhChR2-expressing neurons with blue light (450-490 nm) leads to rapid and reversible photostimulation of action potential firing/neural activity in these cells. These transgenic mice can be used in optogenetic studies for in vivo control of motor behavior by addition or removal of blue light.
CR1	016911	B6.Cg-Tg(Gata1-CR1)1Rwf/J	Repository- Live
		These transgenic mice express human complement receptor 1, CR1, on erythrocytes. Erythrocytes from transgenic mice will adhere to beads coated with human or mouse serum complement, an attribute that may prove useful in studies of immune adherence and pathogen clearance.
CSF2	014595	C;129S4-Rag2^tm1.1Flv Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Il2rg^tm1.1Flv/J	Repository- Live
		This immunodeficient strain carrying humanized IL3 and CSF2 (GM-CSF) cytokines may be useful for studies of lung disease and infection.
Cacna1f^tm1.2Sdie	017762	B6(Cg)-Cacna1f^tm1.2Sdie/J	Under Development for Cryo
		These mice carry the I756T point mutation in exon 17, and loxP sites flanking exons 14 through 17, of the Cacna1f (calcium channel, voltage-dependent, alpha 1F subunit). This mutant mouse strain may be useful in studies of calcium channelopathies, an inherited retinal disorder, photoreceptor electrophysiology, and the role of the Cav1.4 channel in survival of naive T cells.
Cacna1f^tm1Sdie	017760	B6(Cg)-Cacna1f^tm1Sdie/J	Under Development for Cryo
		These I756T+neo mice carry the I756T point mutation in exon 17 of the Cacna1f, calcium channel, voltage-dependent, alpha 1F subunit, (756 is the mouse equivalent to residue 745 in human CACNA1F) as well as a FRT flanked NEO selection cassette and loxP sites flanking exons 14 through 17. This mutant mouse strain may be useful in studies of calcium channelopathies, incomplete congenital stationary night blindness, photoreceptor electrophysiology, and the role of the Cav1.4 channel in survival of naive T cells.
Cacnb2	013779	FVB-Tg(tetO-Cacnb2)2Jmol/J	Under Development - Now Accepting Orders
		Expression of Cacnb2 (calcium channel, voltage-dependent, beta 2 subunit) is regulated by a tetracycline operator (tetO). This strain may be useful in studies of cardiomyopathy.
Calm1	017755	STOCK Tg(tetO-GCAMP2)12iRyu/J	Under Development - Now Accepting Orders
		These inducible calcium sensing GCaMP2 transgenic mice allow transcranial imaging of neurons in live animals.
Camp^tm1Rlg	017799	B6.129X1-Camp^tm1Rlg/J	Under Development - Now Accepting Orders
		In this strain exons 3 and 4 of the cathelicidin antimicrobial peptide gene are replaced by a PGK-neo cassette. Homozygous mice are more susceptible to bacterial infections and may be useful in studies of innate immune response, regulation of immune response, wound healing/angiogenesis and tumor development.
Ccne1^tm2.1Pisc	017786	B6;129S4-Ccne1^tm2.1Pisc/J	Under Development - Now Accepting Orders
		The start codon of the Ccne1 gene is replaced by a Flag-HA epitope tag in this strain, allowing labeling and purification of cyclin E1 protein.
Cd1d1^tm1.1Aben	016929	C57BL/6-Cd1d1^tm1.1Aben/J	Repository- Live
		These mice carry a floxed allele of the Cd1d1 (CD1d1 antigen) gene. This strain may be useful in studies of natural killer T (NKT) cells.
Chat^tm1Jrs	016920	B6.129-Chat^tm1Jrs/J	Repository- Live
		These ChAT^flox mutant mice may be useful in generating conditional mutations for studying cholinergic neurotransmission and non-neuronal cholinergic systems.
Cntnap2^tm1Pele	017482	B6.129(Cg)-Cntnap2^tm1Pele/J	Under Development - Now Accepting Orders
		These Cntnap2 knockout mice mice exhibit hyperactivity, social and communication behavioral impairment, spontaneous seizures, abnormal cortical neuron migration, and abnormal neural synchrony. They may be useful in studies related to Cortical Dysplasia-Focal Epilepsy Syndrome and autism spectrum disorders.
Col1a1^{tm1(tetO-mCherry)Eggn}	014602	B6.Cg-Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}* Col1a1^{tm1(tetO-mCherry)Eggn}/J	Under Development - Now Accepting Orders
		These double mutant Rosa26-rtTA::Col1a1-tetO-H2B-mCherry mice harbor the Rosa26-rtTA targeted mutation (an optimized form of reverse tetracycline controlled transactivator (rtTA-M2) downstream of the Gt(ROSA)26Sor promoter) and the Col1a1-tetO-H2B-mcherry targeted mutation (a tet-responsive element (tetO) and a histone H2B-mCherry fusion protein, targeted to the collagen, type I, alpha 1 (Col1a1) locus). These Rosa26-rtTA::Col1a1-tetO-H2B-mCherry mice may be useful for doxycycline-inducible studies which utilize the rtTA/tet-O (tet-on/TRE) system for visualizing pluripotent cells.
Cops8^tm1Nwe	017444	B6.129S1(Cg)-Cops8^tm1Nwe/J	Under Development - Now Accepting Orders
		These mice possess loxP sites flanking exons 4-6 of the COP9 (constitutive photomorphogenic) homolog, subunit 8 (Arabidopsis thaliana)), Cops8, gene and have applications in studies of T cell activation and proliferation.
Crbn^tm1.1Jjh	017564	B6(Cg)-Crbn^tm1.1Jjh/J	Under Development - Now Accepting Orders
		These mice possess loxP sites flanking exons 3 and 4 of the cereblon (Crbn) gene and have applications in studies related to memory and learning.
Crim1^{tm1(GFP/cre/ERT2)Pzg}	017495	B6;129S7-Crim1^{tm1(GFP/cre/ERT2)Pzg}/J	Repository- Live
		These Crim1-GCE mutant knock in mice utilize a tamoxifen inducible Cre-mediated recombination system and may be useful in studies of genitourinary system development.
Crmp1^tm1Pako	016927	129-Crmp1^tm1Pako Dpysl4^tm1Ttq/J	Repository- Live
		In this strain an IRES-lacZ-neo cassette replaces part of exon 4 of the Crmp1 gene, and a second IRES-lacZ-neo cassette replaces exon 3 of the Dpysl4 gene. This strain may be useful for studying nervous system developmental disorders.
Csf2/Il3^{tm1.1(CSF2,IL3)Flv}	014595	C;129S4-Rag2^tm1.1Flv Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Il2rg^tm1.1Flv/J	Repository- Live
		This immunodeficient strain carrying humanized IL3 and CSF2 (GM-CSF) cytokines may be useful for studies of lung disease and infection.
Cxadr^tm1.1Ics	017359	B6;129S2-Cxadr^tm1.1Ics/J	Under Development - Now Accepting Orders
		These mice possess loxP sites flanking exon 2 of the Cxadr gene and have applications in studies of cardiac development.
Dgat1	017321	C57BL/6-Tg(Fabp4-Dgat1)2Far/J	Repository- Live
		This aP2-Dgat1 transgenic strain exhibit increased adiposity when fed a high fat diet, but not white adipose tissue inflammation and insulin resistance. This mutant strain may be useful in studies of diet induced obesity, inflammatory macrophage activation, lipid-induced inflammation and lipid metabolism.
Dgat1^tm2Far	017322	B6.129S4(Cg)-Dgat1^tm2Far/J	Repository- Live
		These Dgat1^flox mutant mice may be useful in generating conditional mutations for studying retinoid homeostasis, lipid metabolism and obesity.
Dicer1^tm1Smr	012284	B6;129S7-Dicer1^tm1Smr/J	Repository- Live
		These mice carry a floxed allele of Dicer1 (Dicer1, Dcr-1 homolog (Drosophila)) and may be useful in generating conditional mutants of Dicer1.
Dmd^mdx	016622	STOCK Utrn^tm1Jrs Dmd^mdx/J	Under Development - Now Accepting Orders
		Mice homozygous for the Utrn^tm1Jrs and Dmd^mdx exhibit an onset of skeletal muscle dystrophy as early as 4 weeks of age and are a model for Duchenne Type Muscular Dystrophy.
Dpysl4^tm1Ttq	016927	129-Crmp1^tm1Pako Dpysl4^tm1Ttq/J	Repository- Live
		In this strain an IRES-lacZ-neo cassette replaces part of exon 4 of the Crmp1 gene, and a second IRES-lacZ-neo cassette replaces exon 3 of the Dpysl4 gene. This strain may be useful for studying nervous system developmental disorders.
Dpysl5^tm1Gosh	016928	129;B6-Dpysl5^tm1Gosh/J	Repository- Live
		In this strain an IRES-lacZ-neo cassette replaces exons 2-6 of the Dpysl4 gene. These mice exhibit abnormally small Purkinje cells in the cerebellum during the period of dendritic branching and display long-term depression of excitatory synaptic transmissions.
E4f1^tm1.1Llca	017568	B6;129S4-E4f1^tm1.1Llca/J	Under Development - Now Accepting Orders
		These mice possess loxP sites flanking exons 4-14 of the E4F transcription factor 1 ( E4f1) gene and have applications in studies related to cell cycle regulation and cell proliferation and survival.
E4f1^tm1.1Llca	017569	STOCK Polr2a^{tm1(cre/ERT2)Bbd} E4f1^tm1.1Llca/J	Under Development - Now Accepting Orders
		These E4F1^-/flox;RERT double mutant mice may be useful in studies of epidermal stem cells and skin homeostasis.
ESR1	015855	B6;DBA-Tg(Upk3a-GFP/cre/ERT2)26Amc/J	Repository- Live
		This Upk3a-GCE transgenic strain expresses GFP and tamoxifen inducible Cre recombinase in developing bladder urothelium and ureters and may be useful in studies of genitourinary development.
ESR1	017310	B6N.Cg-Tg(Hsd17b1-icre/ERT2)3Casa/J	Repository- Live
		Mice hemizygous for the BAC Hsd17b1-icreER^T2 transgene are viable, fertile, and normal in size with iCre-ER^T2 expression directed by the hydroxysteroid (17-beta) dehydrogenase 1 (Hsd17b1) promoter/enhancer regions within the BAC transgene. These mice may be useful for studying gene function in ovarian granulose cells.
ESR1	016582	C57BL/6N-Tg(Slc32a1-icre/ERT2)3Gloss/J	Repository- Live
		These VGAT-iCreER transgenic mice express a tamoxifen-inducible Cre recombinase under the control of the mouse Slc32a1 promoter region and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping throughout the brain in neurons that structurally resemble interneurons.
ESR1	016583	C57BL/6N-Tg(Slc6a3-icre/ERT2)2Gloss/J	Repository- Live
		These DAT-iCreER transgenic mice express a tamoxifen-inducible Cre recombinase under the control of the mouse Slc6a3 promoter region and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping of dopaminergic cells in the substantia nigra and locus coeruleus.
ESR1	014600	STOCK Tg(I12b-cre/ERT2,-ALPP)37Fsh/J	Repository- Live
		These transgenic mice express a tamoxifen-inducible Cre recombinase under the control of the mouse Dlx1/2 enhancer/ promoter and may be useful for generating temporal conditional mutations for studying gain or loss of function and/or fate mapping in Dlx1/2-expressing forebrain tissues, including interneurons of the olfactory bulb and neocortex.
Eif2c2^tm1.1Tara	016520	B6.129P2(129S4)-Eif2c2^tm1.1Tara/J	Repository- Live
		These mice carry a floxed allele that enables conditional inactivation of the Eif2c2 (eukaryotic translation initiation factor 2C, 2) gene. This strain may be useful in studies further characterizing the gene and its involvement with hematopoiesis and the microRNA (miRNA) pathway.
Erc2^tm1.2Sud	015831	STOCK Erc2^tm1.2Sud/J	Repository- Live
		When crossed with a Cre recombinase-expressing strain, this floxed mutant strain is useful in eliminating tissue-specific expression of the Erc2 (ELKS/RAB6-interacting/CAST family member 2) gene.
FCGRT	016919	B6.Cg-Rag1^tm1Mom Fcgrt^tm1Dcr Tg(CAG-FCGRT)276Dcr/DcrJ	Repository- Live
		These Rag1-/- FcRn-/- hFcRn (276) Tg mice express a human FCGRT molecule in lieu of the endogenous mouse Fcgrt. The absence of Rag1 makes the mice immunodeficient and therefore permits the engraftment of tissues and cell lines, making these mice well-suited for applications associated with the study of the pharmacokinetics and efficacy of therapeutic monoclonal antibody and FC fusion protein treatment. Further, these mice are suitable for the evaluation of immunogenic compounds.
FLP1	012930	B6.129S4-Gt(ROSA)26Sor^tm2(FLP)Sor*/J	Repository- Live
		This FLPo deleter strain may be useful for generating frt-FLP conditional mutations and serves as a source of FLPo-expressing primary cell lines.
Fasl	014547	FVB/N-Tg(tetO-Fasl)BDepa/J	Repository- Live
		These transgenic mice allow Tet-Off/Tet-On regulated expression of FasL. FasL overexpression leads to Fas/FasL receptor-mediated death-signaling pathway activation and results in cell apoptosis.
Fastk^tm1.1Andp	017295	B6.129S6(FVB)-Fastk^tm1.1Andp/J	Repository- Live
		These FAST^-/- knock out mice are less sensitive to induced pulmonary inflammation and may be useful in studies of mRNA stability, stress granules, immune response and FAS-mediated apoptosis.
Fbxl3^Ovtm	016926	BTBR T⁺ tf-Fbxl3^Ovtm/J	Repository- Live
		Ovtm ENU-induced mutants contain an A to G transition at nucleotide in exon 5 of the F-box and leucine-rich repeat protein 3 (Fbxl3) gene that defines an amino acid change from isoleucine to threonine at residue 364. These mice may be useful for studying circadian rhythm modulation.
Fcgrt^tm1Dcr	017700	B6.129-Rag1^tm1Mom Fcgrt^tm1Dcr/DcrJ	Repository- Live
		Rag1-/- mFcRn-/- mice are immunodeficient. This strain serves as a control strain for 016919
Fcgrt^tm1Dcr	016919	B6.Cg-Rag1^tm1Mom Fcgrt^tm1Dcr Tg(CAG-FCGRT)276Dcr/DcrJ	Repository- Live
		These Rag1-/- FcRn-/- hFcRn (276) Tg mice express a human FCGRT molecule in lieu of the endogenous mouse Fcgrt. The absence of Rag1 makes the mice immunodeficient and therefore permits the engraftment of tissues and cell lines, making these mice well-suited for applications associated with the study of the pharmacokinetics and efficacy of therapeutic monoclonal antibody and FC fusion protein treatment. Further, these mice are suitable for the evaluation of immunogenic compounds.
Flnc^tm1Lmk	014125	B6;129-Flnc^tm1Lmk/J	Repository- Live
		The Flnc Δ41-48 mutant allele has the last eight exons (exons 41-48) of the filamin C (FLNc) locus deleted. The Flnc Δ41-48 mutant mice may be useful in studying muscle physiology, primary myogenesis, muscle differentiation, and maintenance of elongated muscle fiber structure in the sarcomere.
GFP	017458	B6(C)-Tg(UAS-EGFP,-SOD1*G37R)135Gsn/J	Repository- Live
		EGFP and the human SOD1 G37R mutation are driven by an inducible upstream activation sequence (UAS) promoter in this transgenic strain. These mice may be crossed with a GAL4 strain to activate gene expression in studies of familial amyotrophic lateral sclerosis (ALS) and motor neuron disease.
GFP	017460	B6(C)-Tg(UAS-EGFP,-SOD1*G37R)677Gsn/J	Repository- Live
		EGFP and the human SOD1 G37R mutation are driven by an inducible upstream activation sequence (UAS) promoter in this transgenic strain. These mice may be crossed with a GAL4 strain to activate gene expression in studies of familial amyotrophic lateral sclerosis (ALS) and motor neuron disease.
GFP	016998	B6.Cg-Tg(TetO-Axin1,EGFP)TA6Cos/J	Repository- Live
		These TRE2-Axin-GFP transgenic mice carry myc-tagged mouse Axin1 and EGFP regulated by a tetracycline operator (tetO). When mated to a mutant strain expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA), tissue Axin1 and EGFP expression may be regulated with the tetracycline analog doxycycline (dox) in the double mutant offspring.
GFP	015854	B6;129P2-Foxl2^{tm1(GFP/cre/ERT2)Pzg}/J	Repository- Live
		These Fox L2-GCE mutant knock in mice utilize a tamoxifen inducible Cre-mediated recombination system and may be useful in studies of genitourinary system development.
GFP	016836	B6;129S4-Gt(ROSA)26Sor^{tm1(rtTAM2)Jae} Col1a1^{tm7(tetO-HIST1H2BJ/GFP)Jae}*/J	Repository- Live
		These H2B-GFP (histone 2B, HIST1H2BJ) doxycycline-inducible compound mutant mice may be used for cell labeling studies.
GFP	015814	B6;CBA-Tg(Thy1-spH)64Vnmu/FrkJ	Repository- Live
		These spH64 transgenic mice express the fluorescent indicator synaptopHluorin in many regions of the brain and may be useful in studies of synaptic vesicle recycling.
GFP	017494	B6;D-Tg(Tshz3-GFP/cre)43Amc/J	Repository- Live
		These Tshz3-GC transgenic mice utilize a tamoxifen inducible Cre-mediated recombination system and may be useful in studies of genitourinary system development.
GFP	015855	B6;DBA-Tg(Upk3a-GFP/cre/ERT2)26Amc/J	Repository- Live
		This Upk3a-GCE transgenic strain expresses GFP and tamoxifen inducible Cre recombinase in developing bladder urothelium and ureters and may be useful in studies of genitourinary development.
GFP	010545	C.FVB-Tg(CAG-luc,-GFP)L2G85Chco/FathJ	Repository- Live
		These L2G85.BALB/c mice harbor the CAG-luc-eGFP L2G85 transgene, exhibit widespread expression of firefly luciferase directed by the CAG promoter, and may be useful in studies of transplantation, noninvasive lineage mapping, in vivo bioluminescence imaging and technology development.
GFP	016617	C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J	Repository- Live
		Mice harboring the Nur77-GFPCre BAC transgene express an enhanced green fluorescent protein/codon-optimized "humanized" Cre recombinase fusion protein under control of the Nr4a1 promoter/enhancer regions within the BAC transgene. GFP expression level correlates to the strength of antigen receptor signaling.
GFP	013116	NOD.B6-Tg(Ins2-luc/EGFP/TK)300Kauf/J	Repository- Live
		These NOD.MIP-TF mice harbor the tri-fusion transgene of three imaging reporters, luciferase/EGFP/thymidine kinase, under the control of mouse insulin promoter. Longitudinal noninvasive imaging of beta cells in the same transgenic animal by CCD and microPET, and the identification of beta cells at the cellular level by fluorescent microscopy is possible. This transgenic model provides a new tool for monitoring beta cells from the single cell level to non-invasive longitudinal assessments of beta cells in animal models of type 1 diabetes.
GFP	012452	STOCK Tg(Rr5-GFP/cre)1Sapc/J	Repository- Live
		Hoxb4-ENE-GFPCre transgenic mice have expression of a GFP/Cre fusion protein directed primarily to developing spinal cord and hindbrain by the mouse homeobox B4 early neuronal enhancer (ENE) region and heat shock protein 1B minimal promoter. These Hoxb4-ENE-GFPCre transgenic mice may be useful as a Cre-lox or fluorescent tool for the fate-mapping/lineage-tracing of Hoxb4-expressing neurons in the developing neural tube.
GFP	016981	STOCK Tg(Uchl1-HIST2H2BE/mCherry/EGFP*)FSout/J	Repository- Live
		This Uchl1-mCherry/GFPgpi transgenic strain expresses a dual fluorescent protein reporter in the developing enteric nervous system and urogenital tract.
GFP	017592	B6;129S-Sox2^tm2Hoch/J	Under Development - Now Accepting Orders
		The Sox2 open reading frame is replaced by EGFP in this knockin/knockout line. Strong EGFP expression is detected in blastocysts, neural progenitor cells and in many adult epithelial tissues.
GFP	017484	FVB-Tg(JPH3-GFP,-JPH3*)GXwy/J	Under Development - Now Accepting Orders
		These BAC-HDL-STOP transgenic mice express only a JPH3 antisense expanded CAG repeat, while silencing sense strand transcription. By 12 months of age, these transgenic mice exhibit polyQ pathogenesis including nuclear inclusions and motor deficits, but not neurodegeneration.
GFP	017619	NOD.Cg-Prkdc^scid Tg(CAG-EGFP)1Osb/KupwJ	Under Development - Now Accepting Orders
		This compound mutant strain combines the immunodeficiency features of the Prkdc^scid mutation and widespread fluorescent cell labeling capabilities of CAG-EGFP on the NOD genetic background. These mice are effective recipients of allogeneic and xenogenic grafts, and are an excellent source of fluorescent-labeled cells for transfer experiments.
GFP	017932	STOCK Tg(ACTB-EGFP*)10Luo/J	Under Development - Now Accepting Orders
		The Miya10^TG (M10^TG) transgene has the CMV enhancer/chicken beta-actin core promoter upstream of a frt-flanked "MADM TG" cassette, all inserted into an intergenic region on chromosome 10 (~21 Mbp; between the Ahi1 and Myb loci). These mutant mice are designed for MADM-10 (mosaic analysis with double markers on chromosome 10), and provide a tool to generate genetic mosaics in which an individual organism contains somatic cells of different genotypes. This allows Cre recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation and mitosis.
GFP	017923	STOCK Tg(ACTB-EGFP*,-tdTomato)10Luo/J	Under Development - Now Accepting Orders
		The Miya10^GT (M10^GT) transgene has the CMV enhancer/chicken beta-actin core promoter upstream of a frt-flanked "MADM GT" cassette, all inserted into an intergenic region on chromosome 10 (~21 Mbp; between the Ahi1 and Myb loci). These mutant mice are designed for MADM-10 (mosaic analysis with double markers on chromosome 10), and provide a tool to generate genetic mosaics in which an individual organism contains somatic cells of different genotypes. This allows Cre recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation and mitosis.
GFP	017530	STOCK Tg(ACTB-tdTomato,-EGFP)11Luo Trp53^tm1Tyj Nf1^tm1Par/J	Under Development - Now Accepting Orders
		The MADM-TG,p53KO,NF1-flox strain may be used as a genetic mosaicism model for different types of cancers when bred to the companion MADAM strain (Stock No. 013749), and to a Cre recombinase expressing strain.
GFP	017755	STOCK Tg(tetO-GCAMP2)12iRyu/J	Under Development - Now Accepting Orders
		These inducible calcium sensing GCaMP2 transgenic mice allow transcranial imaging of neurons in live animals.
Gabrg2^tm2Lusc	016830	129X1.Cg-Gabrg2^tm2Lusc/J	Repository- Live
		These floxed gamma2 mutant mice may be useful in generating conditional mutations for studying the role of gamma2 subunit of the GABA-A receptor in neurophysiology and major depression.
Gata4	016572	STOCK Tg(Myh6/tetO-Gata4)1Jmol/J	Repository- Live
		This Gata4 transgenic contains Gata4 sequence regulated by a tetracycline operator, driven by the cardiac specific α-MHC promoter. These mice may be useful as an inducible model of cardiac development and angiogenesis.
Gata6	016571	FVB-Tg(Myh6/tetO-Gata6)2Jmol/J	Repository- Live
		These Gata6 transgenic mice contain the GATA binding protein 6 sequence regulated by a tetO sequence and the cardiac specific α-MHC promoter. These mice may be useful as an inducible model of cardiac hypertrophy.
Gfi1b	016163	B6.129-Gfi1^{tm3(Gfib1)Tmo}/J	Repository- Live
		These Gfi1:Gfi1b knock-in mice express mouse Gfi1b (growth factor independent 1B) from the endogenous Gfi1 (growth factor independent 1) locus and may be useful in studies of deafness, hematopoiesis, and lymphopoiesis.
Gmnn^tm1Tjm	016913	B6;129P2-Gmnn^tm1Tjm/J	Under Development - Now Accepting Orders
		These mice possess loxP sites flanking exons 5-7 of the geminin (Gmnn) gene and have applications in studies related to hematopoietic stem cell growth and differentiation.
Gsk3b^tm1Grc	017693	STOCK Gsk3b^tm1Grc/J	Under Development - Now Accepting Orders
		Mice homozygous for this Gsk3b conditional mutation express greatly reduced levels of a destabilized protein. When treated with rapamycin, functional protein expression is restored. This strain may be useful in studies of diabetes, inflammation, cardiovascular disease, cancer, neurodegenerative disease, and bipolar disorder.
Gt(ROSA)26Sor^{tm1(CAG-GFP/Eif2c2)Zjh}	017626	B6(Cg)-Gt(ROSA)26Sor^{tm1(CAG-GFP/Eif2c2)Zjh}/J	Under Development - Now Accepting Orders
		These R26-LSL-tAGO2 mice are used in the miRAP (miRNA tagging and Affinity Purification) method in conjunction with Cre recombinase expressing mice, for genetically targeted microRNA tagging and generating tissue specific miRNA expression profiles.
Gt(ROSA)26Sor^{tm1(Foxo1/GFP)Jke}	016262	B6;129-Gt(ROSA)26Sor^{tm1(Foxo1/GFP)Jke}/J	Repository- Live
		The FOXO1/GFP allele contains a loxP-flanked transcriptional STOP cassette (PGK-Neo-polyA) upstream of a forkhead box O1 (Foxo1)-green fluorescent protein (GFP) fusion protein. These mice may be useful for generating conditional mutations for studying the role of PI3K-AKT signaling pathway on insulin resistance, glucose intolerance, diabetes, and aging.
Gt(ROSA)26Sor^{tm1(xstpx-rtTA2SM2)Whsu}*	016999	B6;129S6-Gt(ROSA)26Sor^{tm1(xstpx-rtTA2SM2)Whsu}*/J	Repository- Live
		This R26STOPrtTA mutant mouse strain combines two popular conditionally-regulated expression methodologies (Tet Expression and Cre Recombinase) providing a tool for doxycycline-inducible spatiotemporal and lineage specific expression of genes.
Gt(ROSA)26Sor^{tm10(ACTB-tdTomato)Luo}	017922	STOCK Gt(ROSA)26Sor^{tm10(ACTB-tdTomato)Luo}/J	Under Development - Now Accepting Orders
		The R26^TT allele has a CMV enhancer/chicken beta-actin core promoter-driven "MADM TT" cassette inserted into the Gt(ROSA)26Sor locus on chromosome 6. These R26^TT mice exhibit widespread expression of tdTomato-3Myc (tdT3Myc) and represent the tdTomato-expressing control strain for "new MADM-6" (new mosaic analysis with double markers on chromosome 6) experiments.
Gt(ROSA)26Sor^{tm38(CAG-GCaMP3)Hze}	014538	B6;129S-Gt(ROSA)26Sor^{tm38(CAG-GCaMP3)Hze}/J	Repository- Live
		The fluorescent calcium indicator protein GCaMP3 is a circularly permutated EGFP sequence and a rat calmodulin (Calm) sequence modified to increase the fluorescence change for small calcium transients. These Ai38 mice conditionally express GCaMP3 from the endogenous Gt(ROSA)26Sor locus. Expression is enhanced by the presence of a CAG promoter. Following Cre-mediated removal of the STOP cassette, GCaMP3 expression (EGFP fluorescence) is detected in the cre-expressing tissues. Following subsequent calcium binding (such as neuronal activation), bright EGFP fluorescence is observed.
Gt(ROSA)26Sor^{tm6(ACTB-EGFP,-tdTomato)Luo}*	017912	STOCK Gt(ROSA)26Sor^{tm6(ACTB-EGFP,-tdTomato)Luo}*/J	Under Development - Now Accepting Orders
		The R26^GT allele has a CMV enhancer/chicken beta-actin core promoter-driven "MADM GT" cassette (GFP^N-terminus-intron-tdT3Myc^ATG-less) inserted into the Gt(ROSA)26Sor locus on chromosome 6. Like the original MADM system, this "new MADM-6" system provides a tool to generate genetic mosaics in which an individual organism contains somatic cells of different genotypes. This allows Cre or FLP recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation and mitosis.
Gt(ROSA)26Sor^{tm7(ACTB-EGFP)Luo}*	017921	STOCK Gt(ROSA)26Sor^{tm7(ACTB-EGFP)Luo}*/J	Under Development - Now Accepting Orders
		The R26^TG allele has a CMV enhancer/chicken beta-actin core promoter-driven "MADM TG" cassette (ATG-intron-GFP^C-terminus) inserted into the Gt(ROSA)26Sor locus on chromosome 6. The new TG cassette in R26^TG mice is compatible with any "GX cassette" (GFP^N-terminus-intron-X^ATG-less) where X^ATG-less is any gene without the start codon. Like the original MADM system, the "new MADM-6" system provides a tool to generate genetic mosaics in which an individual organism contains somatic cells of different genotypes. This allows Cre or FLP recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation and mitosis, as well as for the MADM-Tet system.
Gt(ROSA)26Sor^{tm8(ACTB-EGFP,-tTA2)Luo}*	017909	STOCK Gt(ROSA)26Sor^{tm8(ACTB-EGFP,-tTA2)Luo}*/J	Under Development - Now Accepting Orders
		The R26^G-tTA2 allele has a CMV enhancer/chicken beta-actin core promoter-driven "MADM G-tTA2" (GFP^N-terminus-intron-tTA2^ATG-less) inserted into the Gt(ROSA)26Sor locus on chromosome 6. These mutant mice are designed to combine the "new MADM-6" system with a Tet-Off binary expression system to create MADM-Tet (mosaic analysis with double markers combined with Tet-Off). This is a tool to generate genetic mosaics in which an individual organism contains somatic cells of different genotypes. This allows Cre or FLP recombinase-induced fluorescent labeling/tTA2-expression in daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice are also a Tet-Off tool enabling a TRE transgene to be conditionally expressed in a subset of MADM-labeled cells.
H2-Ab1^tm1Gru	017637	NOD.Cg-Prkdc^scid Il2rg^tm1Wjl H2-Ab1^tm1Gru Tg(HLA-DRB1)31Dmz/SzJ	Under Development - Now Accepting Orders
		These NSG-Ab^o DR4 mice lack expression of the murine Prkdc gene, the X-linked Il2rg gene, and MHC class II, but express the human leukocyte antigen DR4 gene. These mice may be useful for targeting human CD4⁺ T cells in transplantation studies in the absence of xeno-GVHD.
HBEGF	016603	NOD.B6-Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/DvsJ	Cryopreserved - Ready for recovery
		The Cre-inducible expression of DTR in these iDTR mutant mice render cells susceptible to ablation following Diphtheria toxin administration.
HIST1H2BJ	016836	B6;129S4-Gt(ROSA)26Sor^{tm1(rtTAM2)Jae} Col1a1^{tm7(tetO-HIST1H2BJ/GFP)Jae}*/J	Repository- Live
		These H2B-GFP (histone 2B, HIST1H2BJ) doxycycline-inducible compound mutant mice may be used for cell labeling studies.
HIST2H2BE	016981	STOCK Tg(Uchl1-HIST2H2BE/mCherry/EGFP*)FSout/J	Repository- Live
		This Uchl1-mCherry/GFPgpi transgenic strain expresses a dual fluorescent protein reporter in the developing enteric nervous system and urogenital tract.
HSV-TK	013116	NOD.B6-Tg(Ins2-luc/EGFP/TK)300Kauf/J	Repository- Live
		These NOD.MIP-TF mice harbor the tri-fusion transgene of three imaging reporters, luciferase/EGFP/thymidine kinase, under the control of mouse insulin promoter. Longitudinal noninvasive imaging of beta cells in the same transgenic animal by CCD and microPET, and the identification of beta cells at the cellular level by fluorescent microscopy is possible. This transgenic model provides a new tool for monitoring beta cells from the single cell level to non-invasive longitudinal assessments of beta cells in animal models of type 1 diabetes.
Hamp	017791	B6.Cg-Tg(tetO-Hamp)2181Nca/J	Under Development for Cryo
		This TRE.Hepc1 transgenic strain can be used to generate bitransgenic mice with spatio-temporal specific inducible overexpression of mouse Hamp, which may be useful in studies of anemia of inflammation and iron homeostasis.
Hey2^tm1Eno	014178	STOCK Hey2^tm1Eno/J	Repository- Live
		These Hrt2^loxP floxed mutant mice may be useful in generating conditional mutations for studying cardiac development.
Hfe^tm2Nca	017784	B6.129S6-Hfe^tm2Nca/J	Under Development for Cryo
		These mice carry a targeted mutation of Hfe, hemochromatosis, exhibit iron loading, and have applications in studies of hereditary hemochromatosis, iron homeostasis and innate immune response.
Hilpda^tm1.1Nat	017360	STOCK Hilpda^tm1.1Nat/J	Repository- Live
		This strain carries a conditional targeted mutation of the 2310016C08Rik gene (commonly called Hig2, hypoxia inducible gene 2). This strain may be helpful in further characterization of the locus.
Hprt^b-m3	012480	NOD.Cg-Prkdc^scid Il2rg^tm1Wjl Hprt^b-m3/EshJ	Repository- Live
		These mutant mice combine the immunological characteristics of the NOD/ShiLtJ background, the severe combined immune deficiency mutation (scid), IL2 receptor gamma chain deficiency and a hypoxanthine phosphoribosyl transferase (Hprt^b-m3) null allele. This mutant mouse strain may be useful for xenotransplantation and drug screening.
Hspa2^tm1Dix	013584	B6.129P2-Hspa2^tm1Dix/J	Repository- Live
		Male mice homozygous for this heat shock protein 2 knock out are infertile. This Hsp70-2 mutant strain may be useful in studies of infertility and meiosis.
Htr2c^tm1Jke	015821	B6.129-Htr2c^tm1Jke/J	Repository- Live
		These mutant mice contain a loxP-flanked transcriptional blocker cassette inserted between exon 3 and 4 of the Htr2c gene. The floxed-transcriptional blocker cassette abolishes gene function. These mice may be useful for studying serotonin induced appetite suppression in obesity and diabetes.
Htt^tm2Detl	016523	B6.129P2-Htt^tm2Detl/200J	Repository- Live
		These HdhQ200 mice carry a mutant knock in allele with a 200 CAG/polyQ repeat mutation, and exhibit a more aggressive and earlier onset of the behavioral and neurological phenotype as compared to the HdhQ150 strain (STOCK no. 4595) with progressive motor deficits starting at 50 weeks of age. This mutant strain may be useful in studies related to Huntington's disease.
Htt^tm2Detl	016524	B6.129P2-Htt^tm2Detl/250J	Repository- Live
		These HdhQ250 mice carry a mutant knock in allele with a 250 CAG/polyQ repeat mutation, and exhibit an earlier onset of phenotype as compared to the HdhQ150 strain (STOCK no. 4595). This mutant strain may be useful in studies related to Huntington's disease.
Htt^tm2Detl	016525	B6.129P2-Htt^tm2Detl/315J	Repository- Live
		These HdhQ315 mice carry a mutant knock in allele with a 315 CAG/polyQ repeat mutation, and exhibit an earlier onset of phenotype as compared to the HdhQ150 strain (STOCK no. 4595). This mutant strain may be useful in studies related to Huntington's disease.
IL3	014595	C;129S4-Rag2^tm1.1Flv Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Il2rg^tm1.1Flv/J	Repository- Live
		This immunodeficient strain carrying humanized IL3 and CSF2 (GM-CSF) cytokines may be useful for studies of lung disease and infection.
Igf1^tm1Dlr	016831	B6.129(FVB)-Igf1^tm1Dlr/J	Repository- Live
		These mutant mice possess loxP sites flanking exon 4 of the Igf1 gene and a neomycin resistance (neo) cassette. This strain may be useful for studying postnatal growth and development.
Il27ra^tm1Mak	018078	B6N.129P2-Il27ra^tm1Makv/J	Under Development - Now Accepting Orders
		These WSX-1 KO mice are useful for studying Th1 cell induced cytokine production during infection and inflammation.
Il2rg^tm1.1Flv	014595	C;129S4-Rag2^tm1.1Flv Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Il2rg^tm1.1Flv/J	Repository- Live
		This immunodeficient strain carrying humanized IL3 and CSF2 (GM-CSF) cytokines may be useful for studies of lung disease and infection.
Il2rg^tm1.1Flv	014593	C;129S4-Rag2^tm1.1Flv Il2rg^tm1.1Flv/J	Repository- Live
		These Rag2/Il2rg compound mutant mice (also called Rag2^-/- γc^-/- mice) exhibit T cell, B cell and NK cell immunodeficiencies that make them effective transplant hosts for human immune cells.
Il2rg^tm1.1Flv	014594	C;129S4-Rag2^tm1.1Flv Thpo^{tm1.1(TPO)Flv} Il2rg^tm1.1Flv/J	Repository- Live
		This immunodeficient strain carrying humanized Thpo (thrombopoietin) may be useful for transplantation studies, particularly those involving hematopoiesis.
Il2rg^tm1.1Flv	017707	C;129S4-Rag2^tm1.1Flv Il2rg^tm1.1Flv Tg(SIRPA)1Flv/J	Under Development - Now Accepting Orders
		This humanized SIRPA (signal-regulatory protein alpha), Rag2, Il2rg, compound mutant strain is a useful immunodeficient model for improved human hematopoietic cell engraftment with potential utility in human vaccine development.
Il2rg^tm1Wjl	012480	NOD.Cg-Prkdc^scid Il2rg^tm1Wjl Hprt^b-m3/EshJ	Repository- Live
		These mutant mice combine the immunological characteristics of the NOD/ShiLtJ background, the severe combined immune deficiency mutation (scid), IL2 receptor gamma chain deficiency and a hypoxanthine phosphoribosyl transferase (Hprt^b-m3) null allele. This mutant mouse strain may be useful for xenotransplantation and drug screening.
Il2rg^tm1Wjl	014568	NOD.Cg-Rag1^tm1Mom Ins2^Akita Il2rg^tm1Wjl/SzJ	Repository- Live
		These NRG-Akita mutant mice are immunodeficient and spontaneously develop hyperglycemia. The strain may be useful as a diabetic host for human islet cells.
Il2rg^tm1Wjl	017637	NOD.Cg-Prkdc^scid Il2rg^tm1Wjl H2-Ab1^tm1Gru Tg(HLA-DRB1)31Dmz/SzJ	Under Development - Now Accepting Orders
		These NSG-Ab^o DR4 mice lack expression of the murine Prkdc gene, the X-linked Il2rg gene, and MHC class II, but express the human leukocyte antigen DR4 gene. These mice may be useful for targeting human CD4⁺ T cells in transplantation studies in the absence of xeno-GVHD.
Il2rg^tm1Wjl	017830	NOD.Cg-Prkdc^scid Il2rg^tm1Wjl Tg(PGK1-KITLG*220)441Daw/SzJ	Under Development - Now Accepting Orders
		These NSG-Tg(hu-mSCF) mice provide a supportive microenvironment that is conducive to engraftment of human hematopoietic stem cells and would be useful in studies of human mast cell development and allergic responses.
Ins2^Akita	014568	NOD.Cg-Rag1^tm1Mom Ins2^Akita Il2rg^tm1Wjl/SzJ	Repository- Live
		These NRG-Akita mutant mice are immunodeficient and spontaneously develop hyperglycemia. The strain may be useful as a diabetic host for human islet cells.
Irf8^tm1.1Hm	014175	B6(Cg)-Irf8^tm1.1Hm/J	Repository- Live
		This Irf8^f/f floxed targeted mutation strain may be useful in generating conditional mutants for studying B cell differentiation, immune response and hematopoiesis.
Itga3^tm1Rdav	008818	B6.129S7-Itga3^tm1Rdav/J	Repository- Live
		These f(α3) mutant mice harbor loxP sites flanking exons 11-18 of the Itga3 (integrin alpha 3 (or alpha3-integrin (α3-integrin)) gene and may be useful in generating conditional mutations for studying the role of Itga3 transmembrane cell adhesion receptors in neuronal functions in the developing and adult central nervous system, including synaptic plasticity and memory formation.
Itga8^tm1.1Rdav	015840	B6.129S6-Itga8^tm1.1Rdav/J	Repository- Live
		These f(α8) conditional mutant mice have loxP sites flanking the exons encoding the transmembrane and the cytoplasmic domains of the Itga8 gene (also called integrin alpha 8, alpha8-integrin, or α8-integrin). These f(α8) mutant mice may be useful in generating conditional mutations for studying the role of Itga8 transmembrane cell adhesion receptors in neuronal function in the developing and adult central nervous system, including intracellular signaling, behavior, synaptic plasticity, and memory formation.
Itpr1	014155	FVB-Tg(Myh6/tetO-Itpr1)22.3Jmol/J	Repository- Live
		This conditional transgenic strain may be useful for chelating inositol 1,4,5-triphosphate (IP3) in vivo and has applications in studies related to cardiac hypertrophy and heart disease.
JPH3	017484	FVB-Tg(JPH3-GFP,-JPH3*)GXwy/J	Under Development - Now Accepting Orders
		These BAC-HDL-STOP transgenic mice express only a JPH3 antisense expanded CAG repeat, while silencing sense strand transcription. By 12 months of age, these transgenic mice exhibit polyQ pathogenesis including nuclear inclusions and motor deficits, but not neurodegeneration.
Jup^tm1.1Glr	017575	STOCK Jup^tm1.1Glr/J	Repository- Live
		These PG^flox mutant mice possess loxP sites flanking exon 1 of the junction plakoglobin (Jup) gene. This strain may be useful for studying plakoglobin in the assembly of adherens junctions and desmosomes, and in the regulation of Wnt/β-catenin signalling.
KITLG	017830	NOD.Cg-Prkdc^scid Il2rg^tm1Wjl Tg(PGK1-KITLG*220)441Daw/SzJ	Under Development - Now Accepting Orders
		These NSG-Tg(hu-mSCF) mice provide a supportive microenvironment that is conducive to engraftment of human hematopoietic stem cells and would be useful in studies of human mast cell development and allergic responses.
Kdr^tm2.1Jrt	017006	STOCK Kdr^tm2.1Jrt/J	Repository- Live
		In this Flk1-GFP strain an EGFP cassette replaces exon 1 of the Kdr gene. These mice exhibit a fluorescence pattern that mimics that of the endogenous gene.
Klf4	011001	B6;129S4-Col1a1^{tm1(tetO-Pou5f1,-Klf4,-Sox2,-Myc)Hoch}/J	Repository- Live
		Col1a1-tetO-OKSM mice have expression of the OKSM cassette (four mouse reprogramming genes Oct4 [Pou5f1], Klf4, Sox2, and c-Myc [Myc]) under the control of the bi-directional tet-responsive element (tetO; also called tetracycline operator, tet-operator, or tetracycline-responsive element [TRE]) with CMV minimal enhancer-less promoter. When bred with another mouse expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA), expression of the OKSM cassette can be regulated with the tetracycline analog doxycycline (dox) in the resulting double mutant offspring. Somatic expression of the OKSM reprogramming factors allows multiple somatic cell types to be directly reprogrammed to generate induced pluripotent stem cells (iPSCs).
Lair1^tm1Jco	017905	B6(Cg)-Lair1^tm1Jco/J	Under Development - Now Accepting Orders
		These mutant mice possess loxP sites flanking exons 4 to 8 of the leukocyte-associated Ig-like receptor 1 (Lair1) gene, an inhibitory receptor protein, and may be useful for studying immune cell regulation.
Lamc1^tm1Strl	016917	B6.129P2-Lamc1^tm1Strl/J	Repository- Live
		These mutant mice possess a frt-flanked neomycin resistance cassette upstream of exon 2, and loxP sites flanking exon 2 of the Lamc1 gene. This strain may be useful for studying neuronal regeneration, embryonic development, organogenesis, and basement membrane assembly.
Lepr^tm5.1Mgmj	017527	B6.129(FVB)-Lepr^tm5Mgmj/J	Under Development - Now Accepting Orders
		These mice harbor a point mutation in the endogenous Lepr gene resulting in an inability of the targeted gene to activate STAT5. Reported phenotypic traits include increased weight gain and impaired estrous cycling.
Lrrk2^tm1Mjfa	012444	C57BL/6-Lrrk2^tm1Mjfa/J	Repository- Live
		This LRRK2 KO targeted mutation strain exhibits enhanced neuritic outgrowth and may be useful in studies of dendritic neuronal arborization and Parkinson's disease.
Mapk11^tm1Jda	012566	B6.Cg-Mapk11^tm1Jda Mapk14^tm1Jda/J	Repository- Live
		These p38αβ^Y323F mice harbor two polymorphic mutations, a p38β^Y323F mutation of the Mapk11 gene and a p38α^Y323F mutation of the Mapk14 gene. While the canonical MAPK cascade-induced p38 activation should not be affected, each polymorphism abolishes the T cell receptor (TCR)-mediated alternative activation pathway of p38.
Mapk14	012736	B6.Cg-Mapk14^tm1.1Dvb/J	Repository- Live
		These p38^AF mice harbor dominant-negative mutations of the activating phosphorylation sites of the p38MAPK gene that result in specifically attenuated p38MAPK signaling. These p38^AF mice may be useful in studying cell cycle inhibitors, cellular senescence, ageing, and cell proliferation/regeneration in response to stress.
Mapk14^tm1Jda	012566	B6.Cg-Mapk11^tm1Jda Mapk14^tm1Jda/J	Repository- Live
		These p38αβ^Y323F mice harbor two polymorphic mutations, a p38β^Y323F mutation of the Mapk11 gene and a p38α^Y323F mutation of the Mapk14 gene. While the canonical MAPK cascade-induced p38 activation should not be affected, each polymorphism abolishes the T cell receptor (TCR)-mediated alternative activation pathway of p38.
Met^tm1Sst	016974	FVB;129P2-Met^tm1Sst/J	Repository- Live
		These c-met^fl/fl floxed mutant mice possess loxP sites flanking exon 16 of the met proto-oncogene (Met) sequence. This strain may be useful for studying neuronal growth and development in neuropsychiatric diseases such as schizophrenia and autism.
Mir146^tm1.1Bal	016239	B6(FVB)-Mir146^tm1.1Bal/J	Repository- Live
		This B6/Mir-146a-/- targeted mutation mouse strain develops loss of peripheral T cell tolerance and may be useful in studies of autoimmune diseases, lymphoproliferative and myeloproliferative disease and cancer.
Mir21^tm1Yoli	016856	B6;129S6-Mir21^tm1Yoli/J	Under Development - Now Accepting Orders
		These miR-21 knockout mice are characterized by an increase in apoptotic cells found in the epidermal layer. Keratinocytes in particular exhibit increased apoptosis, elevated expression of several miR-21 target proteins (including Spry1, Pten, and Pdcd4), and attenuated Ras signaling/inhibition of Ras effector pathways.
Mirc30^tm1.1Rdf	017641	B6.129S-Mirc30^tm1.1Rdf/J	Under Development - Now Accepting Orders
		These floxed miR-15a/16-1^fl/fl mutant mice have applications in studies related to tumorigenesis and therapeutic management of chronic lymphocytic leukemia.
Mirc5^tm1Jae	017337	B6;129S4-Mirc5^tm1Jae/J	Repository- Live
		These mir-290-295^-/- mice exhibit an incomplete homozygous lethal phenotype. Surviving homozygous females are sterile, with reduced oocyte number. Embryonic primordial germ cell migration is mislocalized.
Mov10l1^tm1.1Eno	014179	STOCK Mov10l1^tm1.1Eno/J	Repository- Live
		These Mov10l1^fl floxed mutant mice may be useful in generating conditional mutations for studying Piwi-interacting RNAs (piRNAs), retrotransposon silencing and spermatogenesis.
Msh2^tm2.1Rak	016231	B6.Cg-Msh2^tm2.1Rak/J	Repository- Live
		Mice harboring the Msh2^LoxP allele have loxP sites flanking exon 12 of the mutS homolog 2 (E. coli) [Msh2] gene. When bred to mice that express Cre recombinase, the resulting offspring will have the sequences encoding a portion of the essential ATPase domain of MSH2 protein deleted in the cre-expressing tissues.
Mtpn	017319	FVB-Tg(Myh6-Mtpn)4Ssen/J	Repository- Live
		This Myo-Tg mutant mouse strain overexpresses myotrophin in the heart resulting in cardiac hypertrophy, which progresses to heart failure.
Myc	011001	B6;129S4-Col1a1^{tm1(tetO-Pou5f1,-Klf4,-Sox2,-Myc)Hoch}/J	Repository- Live
		Col1a1-tetO-OKSM mice have expression of the OKSM cassette (four mouse reprogramming genes Oct4 [Pou5f1], Klf4, Sox2, and c-Myc [Myc]) under the control of the bi-directional tet-responsive element (tetO; also called tetracycline operator, tet-operator, or tetracycline-responsive element [TRE]) with CMV minimal enhancer-less promoter. When bred with another mouse expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA), expression of the OKSM cassette can be regulated with the tetracycline analog doxycycline (dox) in the resulting double mutant offspring. Somatic expression of the OKSM reprogramming factors allows multiple somatic cell types to be directly reprogrammed to generate induced pluripotent stem cells (iPSCs).
Myd88^tm1Defr	012622	NOD.Cg-Myd88^tm1Defr/J	Repository- Live
		These Myd88^fl mice have loxP sites flanking exon 3 of the myeloid differentiation primary response gene 88 (Myd88). These mutant mice may be useful for Cre-lox studying signal transduction, Toll-like receptor signaling and natural killer cells.
Mylk	017755	STOCK Tg(tetO-GCAMP2)12iRyu/J	Under Development - Now Accepting Orders
		These inducible calcium sensing GCaMP2 transgenic mice allow transcranial imaging of neurons in live animals.
Ncor1^tm1Anh	017632	STOCK Ncor1^tm1Anh/J	Under Development - Now Accepting Orders
		These NCoR^lox mutant mice possess loxP sites flanking exons 37-40 of the nuclear receptor co-repressor 1 (Ncor1) gene. This strain may be useful for studying the role of NCOR1 on regulation of nuclear receptor signaling.
Nf1^tm1Par	017530	STOCK Tg(ACTB-tdTomato,-EGFP)11Luo Trp53^tm1Tyj Nf1^tm1Par/J	Under Development - Now Accepting Orders
		The MADM-TG,p53KO,NF1-flox strain may be used as a genetic mosaicism model for different types of cancers when bred to the companion MADAM strain (Stock No. 013749), and to a Cre recombinase expressing strain.
Nlgn3^tm2Sud	015835	STOCK Nlgn3^tm2Sud/J	Repository- Live
		This Nlgn3 (neuroligin 3) strain carries a hypomorphic mutation that reduces expression to approximately 10% that of wildtype levels in brain tissue.
Nog	016117	STOCK Nog^tm1.1Rmh/J	Repository- Live
		In this strain loxP sites flank the coding region of the Noggin gene. This strain may have applications in studying BMP-signaling during embryonic development and in postnatal tissues.
Nr1d1	016181	C57BL/6-Tg(tetO-Nr1d1)1Schb/J	Repository- Live
		These transgenic mice express the wildtype allele of the mouse Nr1d1 (nuclear receptor subfamily 1, group D, member 1) gene under the control of a tetracycline-responsive promoter element (TRE; tetO).
Nrxn3^tm4.1Sud	016194	B6;129-Nrxn3^tm4.1Sud/J	Repository- Live
		These NS4 mutant mice possess loxP sites flanking exon 20 (alternative splice site 4) of the neurexin III (Nrxn3) gene, and a mutated exon 20 splice acceptor sequence. This strain may be useful for studying neuronal synapses related to alcoholism, dependence, and addiction behaviors.
Nts^tm1(cre)Mgmj	017525	B6;129-Nts^tm1(cre)Mgmj/J	Under Development - Now Accepting Orders
		These mutant mice feature a nondisruptive cre recombinase knock-in at the endogenous Neurotensin locus. They may be useful for generating conditional mutations in studys related to metabolism and energy homeostasis.
ORF61^tm1.1Itl	016574	B6;129-ORF61^tm1.1Itl/J	Repository- Live
		These LoxP membralin mice possess loxP sites on either side of exons 2 through 4 of the ORF61 (open reading frame 61) gene and and have applications in studies related to spinal muscular atrophy and motor neuron diseases.
Pawr^tm1Rang	015823	C57BL/6N-Pawr^tm1Rang/J	Repository- Live
		These mice contain loxP sites flanking exon 2 of the targeted PRKC, apoptosis, WT1, regulator (Pawr or Par-4) gene. These mutant mice may be useful in generating conditional mutations for studying tumor development and treatment.
Pdgfb^tm2Cbet	017622	B6.129P2-Pdgfb^tm2Cbet/J	Under Development - Now Accepting Orders
		These platelet-derived growth factor (Pdgfb) floxed mice may be useful in generating conditional knockouts to study multiple systems including cardiovascular, renal, hematological development, as well as the role of pericyte recruitment and function in development and adult physiology.
Pdha1^tm1Ptl	017443	B6.129P2-Pdha1^tm1Ptl/J	Repository- Live
		These Pdha1^flox8 mutant mice possess loxP sites flanking exon 8 of the pyruvate dehydrogenase E1 alpha 1 (Pdha1) gene. This strain may be useful for studying lipid metabolism, glucose metabolism, and insulin sensitivity.
Per1	016187	B6.BTBR-Tg(Per1-luc,Per1)1Jt/J	Repository- Live
		This compound transgenic strain was created by co-injecting a BAC clone encoding the entire mouse Per1 locus and a transgenic vector in which the Per1 promoter drives expression of luciferase (Per1:luc). Unlike most Per1:luc transgenic mice, expression of Per1:luc oscillates in the suprachiasmatic nuclei (SCN) as well as peripheral tissues in ex vivo cultures. This strain may be useful in studies of circadian rhythm.
Pglyrp1^tm1.1Lky	015861	B6.129S4-Pglyrp1^tm1.1Lky/J	Repository- Live
		These PGRP-S mice contain an EYFP gene placed immediately downstream from the initiation sequence of the Pglyrp1 gene, abolishing gene expression. These mice may be useful for visualizing PGRP-S expressing cells and for studying the role of peptidoglycan recognition proteins in immune function.
Pik3ca	016977	FVB.129S6-Gt(ROSA)26Sor^{tm1(Pik3caH1047R)Egan}*/J	Under Development - Now Accepting Orders
		This strain carries a conditionally expressed H1047R mutant allele of Pik3ca within the Gt(ROSA)26Sor gene. When crossed with an MMTV-Cre strain, progeny develop mammary tumors as well as lymphoid and skin malignancies.
Pkd2^tm1.1Tjwt	017292	B6.129X1(Cg)-Pkd2^tm1.1Tjwt/J	Repository- Live
		These Pkd2^cond mutant mice possess loxP sites flanking exons 11-13 of the polycystic kidney disease 2 (Pkd2) gene. This strain may be useful for studying renal development in autosomal dominant polycystic kidney disease.
Plk1s1^tm1Cpl	016240	129-Plk1s1^tm1Cpl/J	Repository- Live
		These Gm114^loxP mutant mice may be useful in generating conditional mutations for studies of germ cell biology and stem cell renewal and differentiation.
Polr2a^{tm1(cre/ERT2)Bbd}	017569	STOCK Polr2a^{tm1(cre/ERT2)Bbd} E4f1^tm1.1Llca/J	Under Development - Now Accepting Orders
		These E4F1^-/flox;RERT double mutant mice may be useful in studies of epidermal stem cells and skin homeostasis.
Pou5f1	011001	B6;129S4-Col1a1^{tm1(tetO-Pou5f1,-Klf4,-Sox2,-Myc)Hoch}/J	Repository- Live
		Col1a1-tetO-OKSM mice have expression of the OKSM cassette (four mouse reprogramming genes Oct4 [Pou5f1], Klf4, Sox2, and c-Myc [Myc]) under the control of the bi-directional tet-responsive element (tetO; also called tetracycline operator, tet-operator, or tetracycline-responsive element [TRE]) with CMV minimal enhancer-less promoter. When bred with another mouse expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA), expression of the OKSM cassette can be regulated with the tetracycline analog doxycycline (dox) in the resulting double mutant offspring. Somatic expression of the OKSM reprogramming factors allows multiple somatic cell types to be directly reprogrammed to generate induced pluripotent stem cells (iPSCs).
Ppargc1b	008737	FVB-Tg(Ckm-Ppargc1b)T37Brsp/J	Cryopreserved - Ready for recovery
		These MCK-PGC1beta transgenic mice (founder line T37) express mouse peroxisome proliferative activated receptor, gamma, coactivator 1 beta under the direction of the mouse muscle creatine kinase promoter. Transgenic mice have an increased number of mitochondria in muscle fibers, increased fast-twitch oxidative type IIX fibers and are able to sustain physical activity longer than wildtype controls. This mutant mouse strain may be useful in studies of muscle physiology and disease, exercise and oxidative capacity, and metabolic homeostasis.
Ppp3r1^tm2Grc	017692	B6;129S-Ppp3r1^tm2Grc/J	Under Development - Now Accepting Orders
		This strain carries a floxed allele of the Ppp3r1 gene. Cre excision disrupts calcineurin enzymatic activity in non-germline cell types. These mice have been useful in studies of T cell development/selection.
Prkaa1^tm1.1Sjm	014141	STOCK Prkaa1^tm1.1Sjm/J	Repository- Live
		These Prkaa1 mutant mice possess loxP sites flanking exon 3 of the protein kinase, AMP-activated, alpha 1 catalytic subunit (Prkaa1) gene. This strain may be useful for studying cell growth and energy expenditure.
Prkaa2^tm1.1Sjm	014142	B6(Cg)-Prkaa2^tm1.1Sjm/J	Repository- Live
		These Prkaa2 mutant mice possess loxP sites flanking exon 2 of the protein kinase, AMP-activated, alpha 2 catalytic subunit (Prkaa2) gene. This strain may be useful for studying cell growth and energy expenditure.
Prkd1^tm1Eno	014181	B6;129S-Prkd1^tm1Eno/J	Repository- Live
		These PKD1^loxP/loxP floxed mutation mice may be useful in generating conditional mutations for studying cardiac response and remodeling due to pathological stress.
Prkd2^tm1.1Daca	017285	C57BL/6-Prkd2^tm1.1Daca/J	Repository- Live
		This PKD2(S707A/S711A) knock-in strain expressing a functionally diminished enzyme may be useful in studies of T-cell-dependent antibody responses and TCR signaling.
Prkdc^scid	012480	NOD.Cg-Prkdc^scid Il2rg^tm1Wjl Hprt^b-m3/EshJ	Repository- Live
		These mutant mice combine the immunological characteristics of the NOD/ShiLtJ background, the severe combined immune deficiency mutation (scid), IL2 receptor gamma chain deficiency and a hypoxanthine phosphoribosyl transferase (Hprt^b-m3) null allele. This mutant mouse strain may be useful for xenotransplantation and drug screening.
Prkdc^scid	017637	NOD.Cg-Prkdc^scid Il2rg^tm1Wjl H2-Ab1^tm1Gru Tg(HLA-DRB1)31Dmz/SzJ	Under Development - Now Accepting Orders
		These NSG-Ab^o DR4 mice lack expression of the murine Prkdc gene, the X-linked Il2rg gene, and MHC class II, but express the human leukocyte antigen DR4 gene. These mice may be useful for targeting human CD4⁺ T cells in transplantation studies in the absence of xeno-GVHD.
Prkdc^scid	017830	NOD.Cg-Prkdc^scid Il2rg^tm1Wjl Tg(PGK1-KITLG*220)441Daw/SzJ	Under Development - Now Accepting Orders
		These NSG-Tg(hu-mSCF) mice provide a supportive microenvironment that is conducive to engraftment of human hematopoietic stem cells and would be useful in studies of human mast cell development and allergic responses.
Prkdc^scid	017619	NOD.Cg-Prkdc^scid Tg(CAG-EGFP)1Osb/KupwJ	Under Development - Now Accepting Orders
		This compound mutant strain combines the immunodeficiency features of the Prkdc^scid mutation and widespread fluorescent cell labeling capabilities of CAG-EGFP on the NOD genetic background. These mice are effective recipients of allogeneic and xenogenic grafts, and are an excellent source of fluorescent-labeled cells for transfer experiments.
Ptpn5^tm1Pjlo	016556	B6N.129-Ptpn5^tm1Pjlo/J	Repository- Live
		In this STEP KO strain, a neo cassette replaces the catalytic site of the protein tyrosine phosphatase, non-receptor type 5 (Ptpn5) gene, abolishing gene expression. These mice may be useful for studying the role of STEP in regulating synaptic plasticity in Alzheimer's Disease.
Ptprc^b	017351	BKa.Cg-Ptprc^b Bmi1^tm1Ilw Thy1^a/J	Under Development - Now Accepting Orders
		The Bmi-1^GFP knock-in/knockout allele was designed to both abolish (Bmi1) gene function and express EGFP from the Bmi1 promoter/enhancer elements. Of note, these mice also harbor the CD45.2 (Ptprc^b) and Thy1.1 leukocyte alloantigen (Thy1^a) alleles to allow tracking of hematopoietic donor derived or transferred cells.
Ptprc^ltng	016091	C57BL/6-Ptprc^ltng/J	Repository- Live
		These lightning mice possess an ENU-induced point mutation (F503S) in the Ptprc gene and may be useful in studying the differential regulation of TCR signaling by altered CD45 expression levels.
RBM45	017637	NOD.Cg-Prkdc^scid Il2rg^tm1Wjl H2-Ab1^tm1Gru Tg(HLA-DRB1)31Dmz/SzJ	Under Development - Now Accepting Orders
		These NSG-Ab^o DR4 mice lack expression of the murine Prkdc gene, the X-linked Il2rg gene, and MHC class II, but express the human leukocyte antigen DR4 gene. These mice may be useful for targeting human CD4⁺ T cells in transplantation studies in the absence of xeno-GVHD.
RFP	017456	B6(C)-Tg(CAG-mCherry,-GAL4)769Gsn/J	Repository- Live
		These transgenic mice carry both an mCherry fluorescent gene flanked by loxP sites and the yeast transcription activator protein GAL4 under the control of a cytomegalovirus enhancer/beta actin promoter (CAG). This strain may be effectively used as a component of the GAL4-UAS (Upstream Activation Sequence) system to activate gene transcription.
RFP	016204	B6.Cg-Tg(Drd1a-tdTomato)6Calak/J	Repository- Live
		These transgenic BAC Drd1a-tdTomato mice contain a mouse Drd1a promoter directing the expression of a modified DsRed fluorescent protein, tdTomato. These mice may be useful for specific visualization of striatonigral projection neurons and for studying dopamine-sensitive behaviors.
RFP	017496	B6;D-Tg(Lfng-TagRFP/cre/ERT2)8Amc/J	Repository- Live
		These Lfng-nuc-Tag-RFP-T-IRES-CE transgenic mice utilize a tamoxifen inducible Cre-mediated recombination system and may be useful in studies of genitourinary system development.
RFP	015853	B6;DBA-Tg(Cited1-TagRFP)26Amc/J	Repository- Live
		This Cited1-nuc-TagRFP-T transgenic strain expresses Red Fluorescent Protein in the developing kidney cap mesenchyme and male reproductive systems and may be useful in studies of genitourinary development.
RFP	016921	STOCK Tg(Myh2-DsRed2)1Jrs/J	Repository- Live
		These MyIIA-RFP transgenic mice express DsRed2 Fluorescent Protein specifically in Type IIA muscle fibers. This strain may be used to visualize Type IIA muscle fibers, and for studies of muscle development, architecture, plasticity and innervation.
RFP	016981	STOCK Tg(Uchl1-HIST2H2BE/mCherry/EGFP*)FSout/J	Repository- Live
		This Uchl1-mCherry/GFPgpi transgenic strain expresses a dual fluorescent protein reporter in the developing enteric nervous system and urogenital tract.
RFP	017457	B6(C)-Tg(CAG-mCherry,-GAL4)774Gsn/J	Under Development - Now Accepting Orders
		These transgenic mice carry both an mCherry fluorescent gene flanked by loxP sites and the yeast transcription activator protein GAL4 under the control of a cytomegalovirus enhancer/beta actin promoter (CAG). This strain may be effectively used as a component of the GAL4-UAS (Upstream Activation Sequence) system to activate gene transcription.
RFP	017614	B6(Cg)-Tyr^c-2J Tg(UBC-mCherry)1Phbs/J	Under Development - Now Accepting Orders
		These transgenic mice express monomeric red fluorescent protein (mCherry) under the direction of the human ubiqutin C promoter. Expression is observed in almost all tissues examined and may be useful as a bright and photostable means for visualizing morphogenesis and tissue rearrangements alone or in combination with mice expressing eGFP.
RFP	017923	STOCK Tg(ACTB-EGFP*,-tdTomato)10Luo/J	Under Development - Now Accepting Orders
		The Miya10^GT (M10^GT) transgene has the CMV enhancer/chicken beta-actin core promoter upstream of a frt-flanked "MADM GT" cassette, all inserted into an intergenic region on chromosome 10 (~21 Mbp; between the Ahi1 and Myb loci). These mutant mice are designed for MADM-10 (mosaic analysis with double markers on chromosome 10), and provide a tool to generate genetic mosaics in which an individual organism contains somatic cells of different genotypes. This allows Cre recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation and mitosis.
RFP	017530	STOCK Tg(ACTB-tdTomato,-EGFP)11Luo Trp53^tm1Tyj Nf1^tm1Par/J	Under Development - Now Accepting Orders
		The MADM-TG,p53KO,NF1-flox strain may be used as a genetic mosaicism model for different types of cancers when bred to the companion MADAM strain (Stock No. 013749), and to a Cre recombinase expressing strain.
Rag1^tm1Mom	017700	B6.129-Rag1^tm1Mom Fcgrt^tm1Dcr/DcrJ	Repository- Live
		Rag1-/- mFcRn-/- mice are immunodeficient. This strain serves as a control strain for 016919
Rag1^tm1Mom	016919	B6.Cg-Rag1^tm1Mom Fcgrt^tm1Dcr Tg(CAG-FCGRT)276Dcr/DcrJ	Repository- Live
		These Rag1-/- FcRn-/- hFcRn (276) Tg mice express a human FCGRT molecule in lieu of the endogenous mouse Fcgrt. The absence of Rag1 makes the mice immunodeficient and therefore permits the engraftment of tissues and cell lines, making these mice well-suited for applications associated with the study of the pharmacokinetics and efficacy of therapeutic monoclonal antibody and FC fusion protein treatment. Further, these mice are suitable for the evaluation of immunogenic compounds.
Rag1^tm1Mom	014568	NOD.Cg-Rag1^tm1Mom Ins2^Akita Il2rg^tm1Wjl/SzJ	Repository- Live
		These NRG-Akita mutant mice are immunodeficient and spontaneously develop hyperglycemia. The strain may be useful as a diabetic host for human islet cells.
Rag2^tm1.1Flv	014595	C;129S4-Rag2^tm1.1Flv Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Il2rg^tm1.1Flv/J	Repository- Live
		This immunodeficient strain carrying humanized IL3 and CSF2 (GM-CSF) cytokines may be useful for studies of lung disease and infection.
Rag2^tm1.1Flv	014593	C;129S4-Rag2^tm1.1Flv Il2rg^tm1.1Flv/J	Repository- Live
		These Rag2/Il2rg compound mutant mice (also called Rag2^-/- γc^-/- mice) exhibit T cell, B cell and NK cell immunodeficiencies that make them effective transplant hosts for human immune cells.
Rag2^tm1.1Flv	014594	C;129S4-Rag2^tm1.1Flv Thpo^{tm1.1(TPO)Flv} Il2rg^tm1.1Flv/J	Repository- Live
		This immunodeficient strain carrying humanized Thpo (thrombopoietin) may be useful for transplantation studies, particularly those involving hematopoiesis.
Rag2^tm1.1Flv	017707	C;129S4-Rag2^tm1.1Flv Il2rg^tm1.1Flv Tg(SIRPA)1Flv/J	Under Development - Now Accepting Orders
		This humanized SIRPA (signal-regulatory protein alpha), Rag2, Il2rg, compound mutant strain is a useful immunodeficient model for improved human hematopoietic cell engraftment with potential utility in human vaccine development.
Rbl2^tm2Tyj	008177	B6;129S4-Rbl2^tm2Tyj/J	Repository- Live
		These mice possess loxP sites on either side of exon 2 of the retinoblastoma-like 2 (Rbl) gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When bred to Cre transgenic strains, the loxP-flanked exon is excised to produce a null allele. Homozygous null mice made in this fashion show no expression of the protein coded by this gene and have no gross phenotype.
Rbp7^tm1Vgl	016238	B6.129S6-Rbp7^tm1Vgl/J	Repository- Live
		This CRBP-III knockout strain displays abnormal lipid homeostasis while fed a high fat diet and may be useful in studies of retinol and lipid metabolism.
Rims2^tm1.1Sud	015833	STOCK Rims2^tm1.1Sud/J	Repository- Live
		This floxed Rims2 (regulating synaptic membrane exocytosis 2) mutation strain enables cre-mediated excision of the α, β, and γ isoforms of the gene and may be useful in studies of synaptic neurotransmission.
SIRPA	017707	C;129S4-Rag2^tm1.1Flv Il2rg^tm1.1Flv Tg(SIRPA)1Flv/J	Under Development - Now Accepting Orders
		This humanized SIRPA (signal-regulatory protein alpha), Rag2, Il2rg, compound mutant strain is a useful immunodeficient model for improved human hematopoietic cell engraftment with potential utility in human vaccine development.
SNCA	010710	FVB;129S6-Snca^tm1Nbm Tg(SNCA)1Nbm/J	Repository- Live
		These PAC-Tg(SNCA^WT);Snca^-/- mice harbor a Snca knockout allele and a transgene encoding the human α-synuclein. PAC-Tg(SNCA^WT);Snca^-/- mice are the experimental control for strains that model the very early gastrointestinal dysfunction in the absence of major central nervous system pathology seen in human Parkinson's disease (Stock No. 010788 and Stock No. 010799).
SOD1	017458	B6(C)-Tg(UAS-EGFP,-SOD1*G37R)135Gsn/J	Repository- Live
		EGFP and the human SOD1 G37R mutation are driven by an inducible upstream activation sequence (UAS) promoter in this transgenic strain. These mice may be crossed with a GAL4 strain to activate gene expression in studies of familial amyotrophic lateral sclerosis (ALS) and motor neuron disease.
SOD1	017460	B6(C)-Tg(UAS-EGFP,-SOD1*G37R)677Gsn/J	Repository- Live
		EGFP and the human SOD1 G37R mutation are driven by an inducible upstream activation sequence (UAS) promoter in this transgenic strain. These mice may be crossed with a GAL4 strain to activate gene expression in studies of familial amyotrophic lateral sclerosis (ALS) and motor neuron disease.
Sec61a1^m1Gek	016131	C57BL/6J-Sec61a1^m1Gek/J	Repository- Live
		The Sec61a1^Y344H mutation is an ENU-induced missense histidine to tyrosine substitution at amino acid 344 of the Sec61 alpha 1 subunit (S. cerevisiae) gene that renders mice diabetic. These Sec61a1^Y344H mutant mice may be useful in studying diabetes, ER protein trafficking/processing/secretion, ER stress, obesity, fat metabolism, and other high-fat diet-associated disorders.
Sema3a^m808Ddg	014646	C3.B6-Sema3a^m808Ddg/J	Under Development - Now Accepting Orders
		Mice homozygous for this ENU-induced mutation contain a loss-of-function mutation in exon 3 of the Sema3a gene and may be useful in studying proper patterning connectivity and guidance of neurons of the peripheral nervous system.
Sirt6^tm1.1Cxd	017334	FVB.129S6(Cg)-Sirt6^tm1.1Cxd/J	Repository- Live
		These Sirt6^Co floxed mutant mice possess loxP sites flanking exons 2-3 of the sirtuin 6 (Sirt6) targeted gene. This strain may be useful for studying glycoloysis, lipid metabolism, and glucose homeostasis.
Slc17a9^tm1.1Rpa	014604	B6.129-Slc17a9^tm1.1Rpa/J	Repository- Live
		Mice homozygous for this Slc17a9^flox allele are viable and fertile, with loxP sites flanking exons 2-3 of the solute carrier family 17, member 9 (Slc17a9) gene. These mutant mice may be useful in generating conditional mutations for studying the role of Slc17a9 in vesicular storage and ATP exocytosis.
Snca^tm1Nbm	010710	FVB;129S6-Snca^tm1Nbm Tg(SNCA)1Nbm/J	Repository- Live
		These PAC-Tg(SNCA^WT);Snca^-/- mice harbor a Snca knockout allele and a transgene encoding the human α-synuclein. PAC-Tg(SNCA^WT);Snca^-/- mice are the experimental control for strains that model the very early gastrointestinal dysfunction in the absence of major central nervous system pathology seen in human Parkinson's disease (Stock No. 010788 and Stock No. 010799).
Sox2	011001	B6;129S4-Col1a1^{tm1(tetO-Pou5f1,-Klf4,-Sox2,-Myc)Hoch}/J	Repository- Live
		Col1a1-tetO-OKSM mice have expression of the OKSM cassette (four mouse reprogramming genes Oct4 [Pou5f1], Klf4, Sox2, and c-Myc [Myc]) under the control of the bi-directional tet-responsive element (tetO; also called tetracycline operator, tet-operator, or tetracycline-responsive element [TRE]) with CMV minimal enhancer-less promoter. When bred with another mouse expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA), expression of the OKSM cassette can be regulated with the tetracycline analog doxycycline (dox) in the resulting double mutant offspring. Somatic expression of the OKSM reprogramming factors allows multiple somatic cell types to be directly reprogrammed to generate induced pluripotent stem cells (iPSCs).
Srsf1^tm1Xdfu	018020	B6;129S4-Srsf1^tm1Xdfu/J	Under Development - Now Accepting Orders
		These targeted mutation mice carry a floxed allele of the Srsf1 (serine/arginine-rich splicing factor 1) gene. When crossed with a cre strain, tissue specific excision of exons 2-4 can be accomplished.
Srsf2^tm1Xdfu	018019	B6;129S4-Srsf2^tm1Xdfu/J	Under Development - Now Accepting Orders
		These mutant Srsf2 mice possess loxP sites flanking exons 1-2. When crossed with a cre strain, the floxed sequence is excised in cre-expressing tissues of the offspring.
Stat3^tm1Xyfu	016923	B6.129S1-Stat3^tm1Xyfu/J	Repository- Live
		These Stat3^flox mutant mice may be useful in generating conditional mutations for studying liver regeneration and cardiac injury.
Stk11^tm1.1Sjm	014143	STOCK Stk11^tm1.1Sjm/J	Repository- Live
		These Stk11 mutant mice possess loxP sites flanking exons 3-6 of the serine/threonine kinase 11 (Stk11) gene. This strain may be useful for studying cell growth and tumor suppression.
Syk^tm1.2Tara	017309	B6.129P2-Syk^tm1.2Tara/J	Repository- Live
		This strain carries a conditional floxed allele of the Sykb (spleen tyrosine kinase) gene. When crossed with a Cre strain tissue/cell specific excision may be helpful with studies the immune, cardiovascular or skeletal systems.
T⁺	016926	BTBR T⁺ tf-Fbxl3^Ovtm/J	Repository- Live
		Ovtm ENU-induced mutants contain an A to G transition at nucleotide in exon 5 of the F-box and leucine-rich repeat protein 3 (Fbxl3) gene that defines an amino acid change from isoleucine to threonine at residue 364. These mice may be useful for studying circadian rhythm modulation.
TARDBP	016608	C57BL/6-Tg(Prnp-TARDBP)3cPtrc/J	Repository- Live
		TDP-43_PrP transgenic mice express a full length wild type human TARDBP cDNA under control of a Prnp promoter. These transgenic mice may be useful in studying neuromuscular and neurodegenerative disorders such as ALS (Lou Gehrig's Disease).
TARDBP	016841	B6;C3-Tg(tetO-TARDBP)12Vle/J	Under Development - Now Accepting Orders
		This tetO-hTDP-43-WT transgenic strain can be used to generate bitransgenic mice with spatio-temporal specific inducible overexpression of human TARDBP, which may be useful for studies of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD).
TARDBP	017604	C57BL/6-Tg(Prnp-TARDBP*M337V)4Ptrc/J	Under Development - Now Accepting Orders
		These hTDP-43_M337V transgenic mice express mutant human TARDBP protein under direction of the mouse prion protein (Prnp) promoter. They may be useful in studying neuromuscular and neurodegenerative disorders such as ALS (Lou Gehrig's Disease).
TPO	014594	C;129S4-Rag2^tm1.1Flv Thpo^{tm1.1(TPO)Flv} Il2rg^tm1.1Flv/J	Repository- Live
		This immunodeficient strain carrying humanized Thpo (thrombopoietin) may be useful for transplantation studies, particularly those involving hematopoiesis.
Terf1^tm2.1Tdl	012336	B6;129P2-Terf1^tm2.1Tdl/J	Repository- Live
		Mice homozygous for this TRF1^F allele are viable and fertile, with loxP sites flanking exon 1 of the targeted gene. When bred to mice that express Cre recombinase, the resulting offspring will have the sequences encoding the endogenous translation start site deleted in the cre-expressing tissues.
Terf2ip^tm1.1Tdl	012346	B6;129-Terf2ip^tm1.1Tdl/J	Repository- Live
		These Rap1^F mice harbor loxP sites flanking exon 2 (encoding the TRF2 binding domain) of the mouse Rap1 locus (also called mRap1, TRF2-interacting factor, Terf2ip, or telomeric repeat binding factor 2 interacting protein). Telomeres serve a dual role in protecting the chromosome ends from degradation/repair activities and in intracellular signaling for regulating cell proliferation. Mammalian telomeres are formed by tandem TTAGGG sequence repeats bound by a specialized complex of six telomere-associated proteins called the shelterin complex. As Rap1 is one of the components of shelterin, these Rap1^F mutant mice may be useful in generating conditional mutations for studying the shelterin complex of telomeres, telomere maintenance, chromosomal stability, cancer, and aging.
Tet1^tm1.1Jae	017358	B6;129S4-Tet1^tm1.1Jae/J	Under Development - Now Accepting Orders
		These Tet1 knockout mice may be useful in studies of embryonic cell pluripotency and development.
Tfpi	017602	C57BL/6-Tg(Tagln-Tfpi)1661Rdsi/J	Under Development - Now Accepting Orders
		These SM22α-mTFPI transgenic mice have vascular smooth muscle cell-directed overexpression of a mouse tissue factor pathway inhibitor cDNA sequence encoding the TFPIα isoform (TFPIα is the predominant TFPI protein isoform in humans). These mice may be useful in studying the role of vascular TFPI expression in intravascular thrombosis, the tissue factor pathway in vascular disease, coagulation, innate immunity, angiogenesis, and lipid metabolism.
Tfpi^tm1.1Rdsi	017603	B6.129S6(129S4)-Tfpi^tm1.1Rdsi/J	Under Development - Now Accepting Orders
		These mice contain a TFPI^Flox allele with loxP sites flanking exon 4 of the Tfpi gene. When bred to mice that express Cre recombinase, the resulting offspring will have the sequences encoding the Kunitz 1 domain of the TFPI protein deleted in cre-expressing tissues. As the TFPI-K1 domain is necessary for TFPI-inhibition of the tissue factor coagulation pathway, these mice may be useful in generating tissue-specific TFPI deletions for such studies, as well as innate immunity, angiogenesis, and lipid metabolism.
Thy1^a	017351	BKa.Cg-Ptprc^b Bmi1^tm1Ilw Thy1^a/J	Under Development - Now Accepting Orders
		The Bmi-1^GFP knock-in/knockout allele was designed to both abolish (Bmi1) gene function and express EGFP from the Bmi1 promoter/enhancer elements. Of note, these mice also harbor the CD45.2 (Ptprc^b) and Thy1.1 leukocyte alloantigen (Thy1^a) alleles to allow tracking of hematopoietic donor derived or transferred cells.
Trp53^tm1.1Dgk	017767	B6;129-Trp53^tm1.1Dgk/J	Under Development - Now Accepting Orders
		Exons 2-6 of the pro-apoptotic transformation related protein 53 (Trp53) gene are flanked by Frt-sites, allowing for disruption of gene expression.
Trp53^tm1Tyj	017530	STOCK Tg(ACTB-tdTomato,-EGFP)11Luo Trp53^tm1Tyj Nf1^tm1Par/J	Under Development - Now Accepting Orders
		The MADM-TG,p53KO,NF1-flox strain may be used as a genetic mosaicism model for different types of cancers when bred to the companion MADAM strain (Stock No. 013749), and to a Cre recombinase expressing strain.
Trpv1^tm1(cre)Bbm	017769	B6.129-Trpv1^tm1(cre)Bbm/J	Under Development - Now Accepting Orders
		These TRPV1^Cre mice express Cre recombinase from the endogenous Trpv1 locus and may be useful for generating conditional mutations to study heat and capsaicin nociception or fate mapping of TRPV1 expression during development.
Trpv1^tm2Bbm	017623	B6.129-Trpv1^tm2Bbm/J	Under Development - Now Accepting Orders
		These TRPV1^PLAP-nlacZ mice express beta-galactosidase and alkaline phosphatase phosphatase from the from the endogenous Trpv1 locus, without disruption of the Trpv1 coding sequence. They may be useful for studying heat and capsaicin nociception or fate mapping of TRPV1 expression.
Tsc2	014564	C57BL/6-Tg(CMV-Tsc2*)1Arbi/KlanJ	Repository- Live
		This Tsc2-DN transgenic mouse strain expresses a dominant negative mutant mouse Tsc2 (tuberous sclerosis 2) may be useful in studies of tuberous sclerosis.
Txnip^tm1Rlee	016847	B6;129-Txnip^tm1Rlee/J	Under Development - Now Accepting Orders
		These Txnip (thioredoxin interacting protein) floxed mice may be useful for generating tissue-specific knockouts used in studies of metabolism, angiogenesis, and cancer.
Tyr^c-2J	017614	B6(Cg)-Tyr^c-2J Tg(UBC-mCherry)1Phbs/J	Under Development - Now Accepting Orders
		These transgenic mice express monomeric red fluorescent protein (mCherry) under the direction of the human ubiqutin C promoter. Expression is observed in almost all tissues examined and may be useful as a bright and photostable means for visualizing morphogenesis and tissue rearrangements alone or in combination with mice expressing eGFP.
UGT1A1	014170	B6N.Cg-Tg(UGT1A1*28)1Rhtu/J	Repository- Live
		Transgenic UGT1A128* mice carry the entire human uridine diphosphate (UDP) glucuronosyltransferase 1 (UGT1) locus, and includes a mutant form of the human UGT1 polypeptide A1 (UGT1A1) promoter. These mice may be useful for studying the regulatory and functional properties of glucuronidation, and may also serve as a model for pharmacological studies associated with Gilbert's syndrome.
Ubb^tm2Nat	011077	B6;129-Ubb^tm2Nat/J	Repository- Live
		A targeted insertion of the Ubb ubiquitin b gene gives constitutive expression of a nuclear-localized beta-galactosidase/neomycin resistance protein reporter (NLS-beta-geo) in the absence of Cre-mediated recombination. Following cre-mediated recombination, the NLS-beta-geo coding region is excised and two downstream open reading frame codes two proteins - Norrin (NDP), and GFP with 6xMyc epitope are expressed.
Ubb^tm3Nat	012587	B6;129-Ubb^tm3Nat/J	Repository- Live
		A CMV/beta actin (Z/AP) promoter located 2 kb 5' of the Ubb (ubiquitin B) gene drives constitutive expression of a nuclear-localized beta-galactosidase/neomycin resistance protein reporter (NLS-beta-geo) in the absence of Cre-mediated recombination. When Cre-mediated recombination occurs in neurons, the amino terminal piece (tdTomato/TEVP, a 6xMyc epitope, a TEVP cleavage site) labels all axon and dendrites, and the carboxy-terminal portion (PSD95, GFP, 3xHA epitope) labels presynaptic structures.
Ube3a^tm1Alb	016590	B6.129S7-Ube3a^tm1Alb/J	Repository- Live
		These E6-AP mutant mice carry a maternally imprinted Ube3a (ubiquitin protein ligase E3A) knockout mutation and may be useful in studies studies of Angelman syndrome.
Ube3a^tm2.1Alb	017765	B6.129S7(Cg)-Ube3a^tm2.1Alb/J	Under Development - Now Accepting Orders
		These E6-AP:YFP mutant mice carry a maternally imprinted Ube3a (ubiquitin protein ligase E3A) knockin fluorescent reporter and may be useful in imaging studies of Angelman syndrome.
Ucp1^tm1Kz	003124	B6.129-Ucp1^tm1Kz/J	Repository- Live
		These Ucp knockout mice are sensitive to cold temperatures, exhibit altered metabolism and are resistant to diet induced obesity when maintained at 20°C. This mutant mouse strain may be useful in studies of obesity, metabolic homeostasis, and adaptive thermogenesis.
Utrn^tm1Jrs	016622	STOCK Utrn^tm1Jrs Dmd^mdx/J	Under Development - Now Accepting Orders
		Mice homozygous for the Utrn^tm1Jrs and Dmd^mdx exhibit an onset of skeletal muscle dystrophy as early as 4 weeks of age and are a model for Duchenne Type Muscular Dystrophy.
Vamp2	015814	B6;CBA-Tg(Thy1-spH)64Vnmu/FrkJ	Repository- Live
		These spH64 transgenic mice express the fluorescent indicator synaptopHluorin in many regions of the brain and may be useful in studies of synaptic vesicle recycling.
WGA	017524	B6;129-Tg(CMV-Bgeo,-WGA,-ALPP)1Mgmj/J	Under Development - Now Accepting Orders
		These iZ/WAP mice express a Cre recombinase-inducible wheat germ agglutinin in cre-expressing neurons, and have applications as a trans-synaptic tracer or marker.
YFP	014546	B6.Cg-Tg(Chat-COP4*H134R/EYFP)6Gfng/J	Repository- Live
		ChAT-mhChR2-YFP BAC transgenic mice express an improved channelrhodopsin-2/EYFP fusion protein (mhChR2::YFP) directed to cholinergic neuronal populations by the mouse choline acetyltransferase (Chat or ChAT) promoter/enhancer regions on the BAC transgene. Illuminating mhChR2-expressing neurons with blue light (450-490 nm) leads to rapid and reversible photostimulation of action potential firing/neural activity in these cells. These transgenic mice can be used in optogenetic studies for in vivo control of motor behavior by addition or removal of blue light.
YFP	014548	B6.Cg-Tg(Slc32a1-COP4*H134R/EYFP)8Gfng/J	Repository- Live
		VGAT-mhChR2-YFP BAC transgenic mice express an improved channelrhodopsin-2/EYFP fusion protein (mhChR2::YFP) directed to GABAergic interneuronal populations by the mouse vesicular GABA transporter (VGAT or Slc32a1) promoter/enhancer regions on the BAC transgene. Illuminating mhChR2-expressing neurons with blue light (450-490 nm) leads to rapid and reversible photostimulation of action potential firing/neural activity in these cells. These transgenic mice can be used in optogenetic studies for in vivo control of motor behavior by addition or removal of blue light.
YFP	016252	STOCK Tg(Hoxb7-Venus*)17Cos/J	Repository- Live
		Hoxb7-myr-Venus transgenic mice express a myristoylated yellow fluorescent protein, myr-Venus under the direction of a homeobox B7 promoter/enhancer. These mice may be useful for visualizing individual cells in the membranes of the Wolffian duct and branching ureteric bud of the kidney.
YFP	017578	B6.129S4-Mcpt8^tm1(cre)Lky/J	Under Development - Now Accepting Orders
		YFP and Cre are expressed from the basophil-specific Mcpt8 (mast cell protease 8; also known as Basoph8) promoter in this targeted mutation strain. This strain is useful for labeling, sorting and deleting basophil cell populations.
YFP	017582	C.129S4(B6)-Mcpt8^tm1(cre)Lky/J	Under Development - Now Accepting Orders
		YFP and Cre are expressed from the basophil-specific Mcpt8 (mast cell protease 8; also known as Basoph8) promoter in this targeted mutation strain. This strain is useful for labeling, sorting and deleting basophil cell populations.
cre/ER	017496	B6;D-Tg(Lfng-TagRFP/cre/ERT2)8Amc/J	Repository- Live
		These Lfng-nuc-Tag-RFP-T-IRES-CE transgenic mice utilize a tamoxifen inducible Cre-mediated recombination system and may be useful in studies of genitourinary system development.
cre	013730	B6(Cg)-Calb2^{tm2.1(cre/ERT2)Zjh}/J	Repository- Live
		The CR-CreERT2 knock-in allele was designed to both abolish Calb2 (calbindin 2; also called calretinin or CR) gene function and direct CreER^T2 fusion protein expression to calretinin positive interneurons in the brain by the endogenous Calb2 promoter/enhancer elements. Cre-ERT2 fusion gene activity is inducible by tamoxifen administration.
cre	012710	B6(Cg)-Cck^{tm2.1(cre/ERT2)Zjh}/J	Repository- Live
		The Cck-CreER (or Cck-CreERT2) knock-in allele both abolishes cholecystokinin (Cck) gene function and expresses the CreER^T2 fusion protein in cholecystokinin positive cortical neurons (both interneurons and pyramidal neurons) as directed by the endogenous Cck promoter/enhancer elements. Cre-ERT2 fusion gene activity is inducible by the administration of tamoxifen.
cre	016223	B6(Cg)-Tg(Phox2b-cre)3Jke/J	Repository- Live
		Phox2b-Cre BAC transgenic mice from founder line 3 have Cre recombinase expression directed primarily to the hindbrain (dorsal motor nucleus of the vagus (DMV) in parasympathetic visceral and branchial motor neurons, nodose sensory ganglia, and nucleus of the solitary tract (NTS) cells) by the Phox2b promoter/enhancer regions within the BAC transgene. These Phox2b-Cre BAC transgenic mice may be used to generate conditional mutations for studying neuronal cell types expressing/depending on the Phox2b transcription factor for energy balance, glucose homeostasis, and autonomic breathing/respiration. Specifically, these mice may be useful for studying human respiratory disease, central chemoreceptive neurons in the retrotrapezoid nucleus, respiratory rhythmogenesis, and autonomic nervous system dysregulation (such as congenital central hypoventilation syndrome (CCHS) or Ondine-Hirschsprung disease).
cre	011104	B6.Cg-Tg(Atoh1-cre)1Bfri/J	Repository- Live
		In this strain, mouse Atoh1 (atonal homolog 1 (Drosophila)) regulatory sequences drive expression of cre primarily in precursors of granule cell neurons of the cerebellum and dorsal hindbrain/spinal cord in the dp1 domain.
cre	016241	B6.Cg-Tg(Col1a1-cre/ERT2)1Crm/J	Repository- Live
		This Col1a1-CreERT2 mutant mouse strain carries a transgene with tamoxifen inducible Cre recombinase and may be useful for generating osteoblast and odontoblast specific targeted mutants for studies of bone physiology and homeostasis.
cre	016237	B6.Cg-Tg(Col1a2-cre/ERT)7Cpd/J	Repository- Live
		This Col1a2 Cre-ER mutant mouse strain carries a transgene with tamoxifen inducible Cre recombinase and may be useful for generating fibroblast specific targeted mutants for studies of fibrotic diseases, wound healing and connective tissue physiology, as well as fibroblast lineage fate mapping.
cre	017491	B6.Cg-Tg(Tagln-cre)1Her/J	Repository- Live
		These transgenic mice express Cre recombinase under the control of the mouse transgelin (smooth muscle protein 22-alpha) promoter. This strain represents an effective tool for generating tissue specific-targeted mutants that would be useful in studies of vascular diseases such as atherosclerosis.
cre	014643	B6.FVB-Tg(CMA1-cre)6Thhe/J	Repository- Live
		These Chm:Cre transgenic mice express cre under the control of the baboon CMA1, chymase 1, mast cell, promoter and may be useful for generating conditional mutations for studying gain/loss of function or fate mapping in resident mast cell lineages of the colon and lung.
cre	015854	B6;129P2-Foxl2^{tm1(GFP/cre/ERT2)Pzg}/J	Repository- Live
		These Fox L2-GCE mutant knock in mice utilize a tamoxifen inducible Cre-mediated recombination system and may be useful in studies of genitourinary system development.
cre	014647	B6;CBA-Tg(Pdx1-cre)6Cvw/J	Repository- Live
		These Pdx-Cre transgenic mice express Cre recombinase under the control of the mouse Pdx1 promoter and may be useful for generating pancreas-specific conditional mutations.
cre	017494	B6;D-Tg(Tshz3-GFP/cre)43Amc/J	Repository- Live
		These Tshz3-GC transgenic mice utilize a tamoxifen inducible Cre-mediated recombination system and may be useful in studies of genitourinary system development.
cre	015855	B6;DBA-Tg(Upk3a-GFP/cre/ERT2)26Amc/J	Repository- Live
		This Upk3a-GCE transgenic strain expresses GFP and tamoxifen inducible Cre recombinase in developing bladder urothelium and ureters and may be useful in studies of genitourinary development.
cre	017310	B6N.Cg-Tg(Hsd17b1-icre/ERT2)3Casa/J	Repository- Live
		Mice hemizygous for the BAC Hsd17b1-icreER^T2 transgene are viable, fertile, and normal in size with iCre-ER^T2 expression directed by the hydroxysteroid (17-beta) dehydrogenase 1 (Hsd17b1) promoter/enhancer regions within the BAC transgene. These mice may be useful for studying gene function in ovarian granulose cells.
cre	016097	C57BL/6-Tg(Car1-cre)5Flt/J	Repository- Live
		This CAC5 transgenic mouse strain expresses Cre recombinase under the control of the mouse Car1 promoter and may be useful in generating large intestine specific-targeted mutants for colon disease research.
cre	016617	C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J	Repository- Live
		Mice harboring the Nur77-GFPCre BAC transgene express an enhanced green fluorescent protein/codon-optimized "humanized" Cre recombinase fusion protein under control of the Nr4a1 promoter/enhancer regions within the BAC transgene. GFP expression level correlates to the strength of antigen receptor signaling.
cre	016582	C57BL/6N-Tg(Slc32a1-icre/ERT2)3Gloss/J	Repository- Live
		These VGAT-iCreER transgenic mice express a tamoxifen-inducible Cre recombinase under the control of the mouse Slc32a1 promoter region and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping throughout the brain in neurons that structurally resemble interneurons.
cre	016583	C57BL/6N-Tg(Slc6a3-icre/ERT2)2Gloss/J	Repository- Live
		These DAT-iCreER transgenic mice express a tamoxifen-inducible Cre recombinase under the control of the mouse Slc6a3 promoter region and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping of dopaminergic cells in the substantia nigra and locus coeruleus.
cre	016833	FVB(Cg)-Tg(Alb1-cre)1Dlr/J	Repository- Live
		The Alb1-cre transgene was designed with a Cre recombinase gene under control of Alb promoter/enhancer elements. These mice may be useful for studying the liver specific deletion of target genes.
cre	013251	NOD.FVB-Tg(EIIa-cre)C5379Lmgd/J	Repository- Live
		These EIIa-Cre transgenic mice express Cre recombinase under the control of the adenovirus EIIa promoter . When crossed with a strain containing loxP site-flanked sequences, Cre-mediated recombination occurs in a wide range of tissues, including germ cells that transmit the genetic alteration to progeny.
cre	011103	STOCK Olig2^{tm2(TVA,cre)Rth}/J	Repository- Live
		In this targeted mutation strain, the mouse Olig2 (oligodendrocyte transcription factor 2) locus drives expression of cre and tva (an avian-specific retroviral receptor). This strain may be useful in studies of neurodevelopment.
cre	014600	STOCK Tg(I12b-cre/ERT2,-ALPP)37Fsh/J	Repository- Live
		These transgenic mice express a tamoxifen-inducible Cre recombinase under the control of the mouse Dlx1/2 enhancer/ promoter and may be useful for generating temporal conditional mutations for studying gain or loss of function and/or fate mapping in Dlx1/2-expressing forebrain tissues, including interneurons of the olfactory bulb and neocortex.
cre	012452	STOCK Tg(Rr5-GFP/cre)1Sapc/J	Repository- Live
		Hoxb4-ENE-GFPCre transgenic mice have expression of a GFP/Cre fusion protein directed primarily to developing spinal cord and hindbrain by the mouse homeobox B4 early neuronal enhancer (ENE) region and heat shock protein 1B minimal promoter. These Hoxb4-ENE-GFPCre transgenic mice may be useful as a Cre-lox or fluorescent tool for the fate-mapping/lineage-tracing of Hoxb4-expressing neurons in the developing neural tube.
cre	016236	STOCK Tg(TCF/Lef1-cre/ERT2)1Dje/J	Repository- Live
		TopCreERT2 transgenic mice express a CreER^T2 fusion protein under the control of three copies of a T cell specific transcription factor/lymphoid enhancer-binding factor 1 (TCF/Lef1) response element and a c-fos minimal promoter. This strain may useful for studying the Wnt signaling pathway.
cre	017578	B6.129S4-Mcpt8^tm1(cre)Lky/J	Under Development - Now Accepting Orders
		YFP and Cre are expressed from the basophil-specific Mcpt8 (mast cell protease 8; also known as Basoph8) promoter in this targeted mutation strain. This strain is useful for labeling, sorting and deleting basophil cell populations.
cre	017336	B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ	Under Development - Now Accepting Orders
		CD4-Cre transgenic mice contain CD4 enhancer, promoter and silencer sequences driving the expression of a Cre recombinase gene. These mice may be useful for studying CD4 T cell maturation and proliferation.
cre	012849	B6.Cg-Tg(GFAP-cre/ERT2)505Fmv/J	Under Development - Now Accepting Orders
		These GCE transgenic mice have a human glial fibrillary acidic protein (hGFAP) promoter sequence directing expression of a Cre-estrogen receptor (Cre-ERT2) fusion protein. When these transgenic mice are bred with mice containing a loxP-flanked sequence, tamoxifen-inducible Cre-mediated recombination is expected to result in deletion of the floxed sequences in the Cre recombinase-expressing tissues of the offspring.
cre	016832	B6.FVB(129)-Tg(Alb1-cre)1Dlr/J	Under Development - Now Accepting Orders
		The Alb1-cre transgene was designed with a Cre recombinase gene under control of Alb promoter/enhancer elements. These mice may be useful for studying the liver specific deletion of target genes.
cre	017593	B6;129S-Sox2^{tm1(cre/ERT2)Hoch}/J	Under Development - Now Accepting Orders
		These Sox2-CreER knockin mice have the Sox2 open reading frame replaced with a CreER^T2 fusion gene. These mice may be useful for inducible Cre recombinase expression/floxed gene deletion in blastocysts, neural progenitor cells and in many adult epithelial tissues.
cre	017582	C.129S4(B6)-Mcpt8^tm1(cre)Lky/J	Under Development - Now Accepting Orders
		YFP and Cre are expressed from the basophil-specific Mcpt8 (mast cell protease 8; also known as Basoph8) promoter in this targeted mutation strain. This strain is useful for labeling, sorting and deleting basophil cell populations.
cre	016261	C57BL/6-Tg(Nes-cre/ERT2)KEisc/J	Under Development - Now Accepting Orders
		Nestin-Cre/ERT2 transgenic mice express a CreER^T2 fusion protein under the control of the rat nestin (Nes) promoter. This strain has proven useful for studying the lineage of nestin expressing cells and the effect of gene deletion from nestin expressing cells in both the adult and developing mouse brain.
cre	017928	FVB/N-Tg(Mpz-cre)26Mes/J	Under Development - Now Accepting Orders
		These transgenic mice contain the myelin protein zero (P₀) (Mpz) promoter driving expression of Cre recombinase in Schwann cell. These mice may be useful for studying the myelination of peripheral nerve cells.
cre	016879	STOCK Il17a^{tm1.1(icre)Stck}/J	Under Development - Now Accepting Orders
		These Il17a^Cre mutant mice express a codon improved Cre-Recombinase knocked in at the endogenous Il17a gene. This targeted mutation abolishes Il17a expression. These mice may be useful for fate mapping IL17A secretion during T helper cell activation.
cre	016963	STOCK Slc17a6^tm2(cre)Lowl/J	Under Development - Now Accepting Orders
		These Vglut2-ires-cre mutant mice express Cre recombinase from the endogenous Slc17a6 promoter. This mutant strain may be useful for generating conditional mutations in excitatory glutamatergic, VGLUT2 positive, neuron cell bodies.
cre	016962	STOCK Slc32a1^tm2(cre)Lowl/J	Under Development - Now Accepting Orders
		These Vgat-ires-cre knock-in mice express Cre recombinase from the endogenous Slc32a1 promoter. This strain may be useful for generating conditional mutations in inhibitory GABAergic neuron cell bodies.
cre	008852	STOCK Tg(En2-cre)22Alj/J	Under Development - Now Accepting Orders
		These En2-cre line 22 transgenic mice (also called En2cre-22, En2cre line Tg22, or En2-cre tg-22) have the mouse engrailed 2 (En2) promoter/enhancer elements directing expression of Cre recombinase to a subset of En2-expressing cells; including the embryonic midbrain-hindbrain (mesencephalon-metencephalon) constriction region of the developing brain that gives rise to the posterior midbrain and medial cerebellum.
cre	017981	STOCK Tg(Hoxb6-cre)Mku/J	Under Development - Now Accepting Orders
		These mice express cre recombinase under the direction of Hoxb6 and are useful for studying gene function during the early stages of limb development.
cre	008851	STOCK Tg(Wnt1-cre/ERT)1Alj/J	Under Development - Now Accepting Orders
		These Wnt1-CreER^T transgenic mice have expression of tamoxifen-inducible Cre recombinase directed by the wingless-related MMTV integration site 1 (Wnt1) promoter/regulatory sequences. When Wnt1-CreER^T transgenic mice are bred to mice containing loxP site-flanked sequences, tamoxifen-inducible cre-mediated recombination results in deletion of the floxed sequences in the Wnt1-expressing cells; including midbrain, developing neural tube, migrating neural crest cells and dopaminergic neuron populations.
luc	016187	B6.BTBR-Tg(Per1-luc,Per1)1Jt/J	Repository- Live
		This compound transgenic strain was created by co-injecting a BAC clone encoding the entire mouse Per1 locus and a transgenic vector in which the Per1 promoter drives expression of luciferase (Per1:luc). Unlike most Per1:luc transgenic mice, expression of Per1:luc oscillates in the suprachiasmatic nuclei (SCN) as well as peripheral tissues in ex vivo cultures. This strain may be useful in studies of circadian rhythm.
luc	013781	B6;FVB-Tg(Myh6/NFAT-luc)1Jmol/J	Repository- Live
		The NFAT-luc transgene has luciferase expression directed by a Myh6/NFAT hybrid promoter (composed of a minimal mouse alpha myosin heavy chain cardiac promoter [Myh6] with upstream copies of the nuclear factor of activated T cell binding site sequence [NFAT; from the mouse interleukin 4 (Il4) promoter]). In the hearts of adult NFAT-luc transgenic mice, NFAT-luc activity is upregulated during pathological cardiac hypertrophy induced by pressure-overload; more dramatically following myocardial infarction-induced heart failure. These NFAT-luc transgenic mice are a reporter of calcineurin-NFAT signaling, and may be useful in studying cardiac hypertrophy and calcineurin/NFAT coupling.
luc	010545	C.FVB-Tg(CAG-luc,-GFP)L2G85Chco/FathJ	Repository- Live
		These L2G85.BALB/c mice harbor the CAG-luc-eGFP L2G85 transgene, exhibit widespread expression of firefly luciferase directed by the CAG promoter, and may be useful in studies of transplantation, noninvasive lineage mapping, in vivo bioluminescence imaging and technology development.
luc	013116	NOD.B6-Tg(Ins2-luc/EGFP/TK)300Kauf/J	Repository- Live
		These NOD.MIP-TF mice harbor the tri-fusion transgene of three imaging reporters, luciferase/EGFP/thymidine kinase, under the control of mouse insulin promoter. Longitudinal noninvasive imaging of beta cells in the same transgenic animal by CCD and microPET, and the identification of beta cells at the cellular level by fluorescent microscopy is possible. This transgenic model provides a new tool for monitoring beta cells from the single cell level to non-invasive longitudinal assessments of beta cells in animal models of type 1 diabetes.
neo	012940	STOCK Snta1^tm1Scf/J	Repository- Live
		In this strain, the allele replaces exon 1 of the endogenous mouse syntrophin, acidic 1 (Snta1) gene with a neo cassette, abolishing gene function. These mice may be useful for studying synapse formation and maintenance, and the organization of utrophin, acetylcholine receptor, and acetylcholinesterase at neuromuscular junctions, and water homeostasis in the brain.
rtTA	016567	129S.Cg-Tg(Hoxb7-rtTA*M2)2Cos/J	Repository- Live
		RS-HTA2 transgenic mice have the homeobox B7 promoter/enhancer sequences driving expression of an optimized form of the reverse tetracycline-controlled transactivator (rtTA*M2) protein. These mice may be useful for the inducible expression of genes throughout the Wolffian duct, ureteric bud (UB) epithelium, and developing kidney.
rtTA	016997	B6.Cg-Tg(Axin2-rtTA2S*M2)7Cos/J	Repository- Live
		These Axin2-rtTA transgenic mice express the optimized reverse tetracycline-controlled transactivator (rtTA2^S-M2) protein directed by the mouse Axin2 promoter. These mice are a Tet-On tool that allows conditional, dox-inducible expression of genes in Axin2 expressing cells and may be useful for studying craniofacial, skeletal and early neural development.
rtTA	016836	B6;129S4-Gt(ROSA)26Sor^{tm1(rtTAM2)Jae} Col1a1^{tm7(tetO-HIST1H2BJ/GFP)Jae}*/J	Repository- Live
		These H2B-GFP (histone 2B, HIST1H2BJ) doxycycline-inducible compound mutant mice may be used for cell labeling studies.
rtTA	017519	FVB/N-Tg(KRT5-rtTA)T2D6Sgkd/J	Repository- Live
		These K5-rtTA transgenic mice have the bovine keratin 5 (KRT5) promoter directing expression of a nuclear localized reverse tetracycline transactivator gene (rtTA-nls). These K5-rtTA mice provide a Tet-On tool that allows the inducible expression of genes in the epithelium.
rtTA	016116	STOCK Wap^tm2(rtTA)Kuw/J	Repository- Live
		These mice contain a reverse tetracycline-controlled transactivator (rtTA) protein in the 5' untranslated region of the whey acidic protein gene. Theses Wap-rtTA mice are useful in regulating the expression of proteins (including oncoproteins) in mammary epithelium.
rtTA	014602	B6.Cg-Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}* Col1a1^{tm1(tetO-mCherry)Eggn}/J	Under Development - Now Accepting Orders
		These double mutant Rosa26-rtTA::Col1a1-tetO-H2B-mCherry mice harbor the Rosa26-rtTA targeted mutation (an optimized form of reverse tetracycline controlled transactivator (rtTA-M2) downstream of the Gt(ROSA)26Sor promoter) and the Col1a1-tetO-H2B-mcherry targeted mutation (a tet-responsive element (tetO) and a histone H2B-mCherry fusion protein, targeted to the collagen, type I, alpha 1 (Col1a1) locus). These Rosa26-rtTA::Col1a1-tetO-H2B-mCherry mice may be useful for doxycycline-inducible studies which utilize the rtTA/tet-O (tet-on/TRE) system for visualizing pluripotent cells.
rtTA	016146	STOCK Tg(SFTPC-rtTA)2Jaw/J	Under Development - Now Accepting Orders
		These transgenic mice express the rtTA protein under the control of the human SFTPC promoter. This strain provides an improved Tet-On tool that allows the inducible expression of genes in the developing and adult lung and respiratory epithelium.
rtTA	016145	STOCK Tg(Scgb1a1-rtTA)2Jaw/J	Under Development - Now Accepting Orders
		These CCSP-rtTA transgenic mice express the rtTA protein under the control of the rat Scgb1a1 gene promoter and provides an improved "Tet-On" tool that allows the inducible expression of genes in the developing and adult lung and respiratory epithelium.
tTA	016198	129S6.Cg-Tg(Camk2a-tTA)1Mmay/JlwsJ	Repository- Live
		These transgenic mice express the tetracycline-controlled transactivator protein (tTA) under regulatory control of the forebrain-specific calcium-calmodulin-dependent kinase II (Camk2a) promoter. These mice are a "Tet-Off" tool that allow the inducible expression of genes in forebrain neurons, and may be useful in studying brain disorders such as Alzheimer's disease, Parkinson's disease, or other neurodegenerative diseases.
tTA	015838	STOCK Tg(Camk2a-tTA)1Mmay Tg(tetO-ABL1P242EP249E)CPdav/J	Repository- Live
		These AblPP/tTA double mutant mice allow the forebrain-specific expression of a constitutively active form of c-Abl (AblPP) to be regulated with tetracycline or its analog doxycycline (dox). AblPP/tTA mice need to be maintained on a doxycycline diet to prevent the neurological phenotype. When maintained without dox, AblPP/tTA mice develop early reactive gliosis and astrocyctosis that continues to a severe, progressive neurodegeneration in the CA1 region of the hippocampus, and early death. These AblPP/tTA mice may be useful for studying tau phosphorylation and the pathogenesis of neurodegeneration/neuroinflammation associated with Alzheimer's disease.
tTA	017770	B6.Cg-Tg(Myh6-tTA)6Smbf/JpobJ	Under Development - Now Accepting Orders
		These C57BL/6 Myh6-tTA transgenic mice are part of a "Tet-Off" system that allows the inducible expression of genes in cardiac myocytes. In contrast to the phenotype observed when this transgene is on a FVB inbred background, no hypertrophy, dilation, nor cardiac disfunction is observed.
tTA	017722	B6.Cg-Tg(Tal1-tTA)19Dgt/J	Under Development - Now Accepting Orders
		Hemizygotes are viable, fertile, normal in size, and do not display any behavioral abnormalities. Hemizygotes express tetracycline-controlled transactivator protein (tTA) in bone marrow hematopoietic stem cells (HSC) and in common myeloid progenitors (CMP)). tTA activity also is detected in lung. Little to no tTA activity is detected in thymus, lymph node, intestine or spleen. When bred to other transgenic mice carrying a gene of interest coupled to a tetracycline-responsive promoter element (TRE; tetO), expression of the target gene in the bitransgenic offspring can be induced by withdrawal of tetracycline or doxycycline. This strain represents an effective tool for generating bitrangenic animals to study inducible gene expression in blood stem and progenitor cells. In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
tf	016926	BTBR T⁺ tf-Fbxl3^Ovtm/J	Repository- Live
		Ovtm ENU-induced mutants contain an A to G transition at nucleotide in exon 5 of the F-box and leucine-rich repeat protein 3 (Fbxl3) gene that defines an amino acid change from isoleucine to threonine at residue 364. These mice may be useful for studying circadian rhythm modulation.
GAL4	017456	B6(C)-Tg(CAG-mCherry,-GAL4)769Gsn/J	Repository- Live
		These transgenic mice carry both an mCherry fluorescent gene flanked by loxP sites and the yeast transcription activator protein GAL4 under the control of a cytomegalovirus enhancer/beta actin promoter (CAG). This strain may be effectively used as a component of the GAL4-UAS (Upstream Activation Sequence) system to activate gene transcription.
GAL4	017457	B6(C)-Tg(CAG-mCherry,-GAL4)774Gsn/J	Under Development - Now Accepting Orders
		These transgenic mice carry both an mCherry fluorescent gene flanked by loxP sites and the yeast transcription activator protein GAL4 under the control of a cytomegalovirus enhancer/beta actin promoter (CAG). This strain may be effectively used as a component of the GAL4-UAS (Upstream Activation Sequence) system to activate gene transcription.
Is(14)2Rdf	017642	B6.129S1-Is(14)2Rdf/J	Under Development - Now Accepting Orders
		These 14qC3-MDR mice carry a floxed region that encompases a region corresponding to a minimal deleted region involved in most common B cell chronic lymphocytic leukemias in humans. They have applications in studies related to tumorigenesis and therapeutic management of chronic lymphocytic leukemia.
Is(14)5Rdf	017643	B6.129S1-Is(14C3)3Rdf/J	Under Development - Now Accepting Orders
		These 14qC3-CDR^fl mice carry a floxed segment that encompasses sequence corresponding to a common deleted region (CDR) involved in most common B cell chronic lymphocytic leukemias in humans. They have applications in studies related to tumorigenesis and therapeutic management of chronic lymphocytic leukemia.
TVA	011103	STOCK Olig2^{tm2(TVA,cre)Rth}/J	Repository- Live
		In this targeted mutation strain, the mouse Olig2 (oligodendrocyte transcription factor 2) locus drives expression of cre and tva (an avian-specific retroviral receptor). This strain may be useful in studies of neurodevelopment.
Yeae^B10	016840	SJL/J-Chr Y^B10/TeuJ	Repository- Live
		This Y chromosome consomic was created by substituting the SJL/J Y chromosome with the Y chromosome from B10.S-H2^s/SgMcdJ. Following immunization to induce experimental allergic encephalomyelitis (EAE), young consomic males develop a significant increase in incidence and severity suggesting that a Y chromosome polymorphism is capable of modifying EAE susceptibility. This mouse strain may be useful in studies of EAE and other autoimmune diseases.
tetO	011001	B6;129S4-Col1a1^{tm1(tetO-Pou5f1,-Klf4,-Sox2,-Myc)Hoch}/J	Repository- Live
		Col1a1-tetO-OKSM mice have expression of the OKSM cassette (four mouse reprogramming genes Oct4 [Pou5f1], Klf4, Sox2, and c-Myc [Myc]) under the control of the bi-directional tet-responsive element (tetO; also called tetracycline operator, tet-operator, or tetracycline-responsive element [TRE]) with CMV minimal enhancer-less promoter. When bred with another mouse expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA), expression of the OKSM cassette can be regulated with the tetracycline analog doxycycline (dox) in the resulting double mutant offspring. Somatic expression of the OKSM reprogramming factors allows multiple somatic cell types to be directly reprogrammed to generate induced pluripotent stem cells (iPSCs).
tetO	016836	B6;129S4-Gt(ROSA)26Sor^{tm1(rtTAM2)Jae} Col1a1^{tm7(tetO-HIST1H2BJ/GFP)Jae}*/J	Repository- Live
		These H2B-GFP (histone 2B, HIST1H2BJ) doxycycline-inducible compound mutant mice may be used for cell labeling studies.

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