Strains Newly Available
Metabolism Research
Strains Under Development for all Metabolism Research models.
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| Allele Symbol | Stock Number | Strain Name Description |
Standard Supply |
| Akt2tm1.1Mbb | 006952 | B6.Cg-Akt2tm1.1Mbb Ldlrtm1Her/J | Repository- Live |
| These C57BL/6J Akt2+/- LDLR-/- mice harbor targeted mutations in both the Akt2 (thymoma viral proto-oncogene 2) and Ldlr (low density lipoprotein receptor) loci. Independently, homozygous Akt2 mutant mice develop insulin resistance and diabetes, while LDLR homozygotes are predisposed to atherosclerosis. When these C57BL/6J Akt2+/- LDLR-/- double mutant mice are heterozygous for the Akt2 mutation and homozygous for the LDLR mutation they are viable and fertile and may be useful to study diabetes, metabolism, hyperglycemia, and atherosclerosis. | |||
| Bchetm1Loc | 008087 | B6.129S1-Bchetm1Loc/J | Repository- Live |
| These BChE (butyrylcholinesterase) mutant mice are a model for human butyrylcholinesterase deficiency and may be useful for studying metabolic effects of organophosphorus toxicants or nerve agents, neurotransmitter function, and anti-Alzheimer's drug therapies. | |||
| Cav1tm1Mls | 007083 | B6.Cg-Cav1tm1Mls/J | Repository- Live |
| Mice that are homozygous for this caveolin, caveolae protein 1 (Cav1) targeted mutation exhibit exercise intolerance when challenged, resistant to diet-induced obesity and are slightly hyperphagic. This mutant mouse strain may be useful in studies of vesicular and cholesterol trafficking, signal transduction and tumorigenesis. | |||
| Dldtm1Ptl | 008333 | B6;129P2-Dldtm1Ptl/J | Repository- Live |
| These Dld (dihydrolipoamide dehydrogenase or E3 component) mutant mice may be useful to study early murine embryonic metabolism, including glucose and mitochondrial metabolism during the early postimplantation period. As altered energy metabolism and reductions in alpha-ketoacid dehydrogenase complexes have also been associated with many neurodegenerative disorders, these mice may also be useful in studies related to Parkinson's disease, Huntington's disease, and/or Alzheimer's disease. Because the metabolic disturbances associated with E3 deficiency (Dld deficiency) cause a variant of Maple Syrup Urine Disease (MSUD) in which there is an accompanying lactic acidosis due to concomitant deficiency of pyruvate dehydrogenase complex, these mice may be useful in such studies or in conjunction with iMSUD mice (Stock No. 006999). | |||
| Gusbtm3Sly | 005644 | B6.129X-Gusbtm3Sly/J | Repository- Live |
| Homozygous mice for this targeted mutation in beta glucuronidase (Gusb) exhibit growth retardation, shortened extremities, and facial dysmorphism. This model has increased urinary glycosaminoglycan and secondary elevation of other lysosomal storage enzymes. This strain represents a model of human GUS deficiency characterized by the most prevalent human mutation, L176F, and is associated with mild Mucopolysaccharidosis type VII (MPS VII or Sly Syndrome). | |||
| Hmox1tm1Poss | 008311 | FVB.129S2(B6)-Hmox1tm1Poss/J | Repository- Live |
| Mice that are homozygous for this Hmox1 (heme oxygenase (decycling) 1) targeted mutation develop anemia with diminished serum iron, increased serum ferritin, iron accumulation in kidney and liver and progressive chronic inflammatory disease. Homozygotes occur at a lower than expected frequency, or are not produced, from heterozygous crosses and have decreased postnatal survival. This mutant mouse strain may be useful in studies of hemochromatosis, inflammation and iron metabolism. | |||
| Ins2Akita | 006580 | B6.Cg-Ins2Akita Ldlrtm1Her/J | Repository- Live |
| Ldlrtm1Her | 006952 | B6.Cg-Akt2tm1.1Mbb Ldlrtm1Her/J | Repository- Live |
| These C57BL/6J Akt2+/- LDLR-/- mice harbor targeted mutations in both the Akt2 (thymoma viral proto-oncogene 2) and Ldlr (low density lipoprotein receptor) loci. Independently, homozygous Akt2 mutant mice develop insulin resistance and diabetes, while LDLR homozygotes are predisposed to atherosclerosis. When these C57BL/6J Akt2+/- LDLR-/- double mutant mice are heterozygous for the Akt2 mutation and homozygous for the LDLR mutation they are viable and fertile and may be useful to study diabetes, metabolism, hyperglycemia, and atherosclerosis. | |||
| Ldlrtm1Her | 006580 | B6.Cg-Ins2Akita Ldlrtm1Her/J | Repository- Live |
| Ldlrtm1Her | 006877 | B6.Cg-Ldlrtm1Her Tg(H2-K-AKR1B1)1Tj/J | Repository- Live |
| Ldlrtm1Her | 006906 | B6.Cg-Lepob Ldlrtm1Her/J | Repository- Live |
| The mice may be useful in studies of diabetes, metabolism, hyperglycemia, atherosclerosis, and hypercholesterolemia. | |||
| Lepob | 006906 | B6.Cg-Lepob Ldlrtm1Her/J | Repository- Live |
| The mice may be useful in studies of diabetes, metabolism, hyperglycemia, atherosclerosis, and hypercholesterolemia. | |||
| Nr1h4tm1Gonz | 007214 | B6.129X1(FVB)-Nr1h4tm1Gonz/J | Repository- Live |
| Mice homozygous for this targeted mutant allele display a proatherogenic serum lipoprotein profile characterized by elevated levels of serum and hepatic cholesterol and triglycerides. This mutant mouse strain represents a model that may be useful in studies related to bile acid and lipid homeostasis. | |||
| Pparatm1Gonz | 008154 | B6.129S4-Pparatm1Gonz/J | Repository- Live |
| Ppara deficient mutant mice exhibit increased gonadal adipose tissue stores, abnormal epidermal development and delayed wound healing. This mutant mouse strain may be useful in studies of lipid metabolism, cell proliferation, diabetes, obesity, and wound healing. | |||
| Snord116tm1.1Uta | 008149 | B6(Cg)-Snord116tm1.1Uta/J | Repository- Live |
| These Snord116del mice may be useful in studying growth and feeding regulation, mechanisms of obesity, and pathophysiology of Prader-Willi syndrome. Of note, mice harboring a loxP-flanked Snord116 cluster are also available (see Stock No. 008118). | |||
| Tg(APOE-DGAT2)24Far | 007744 | C57BL/6-Tg(APOE-DGAT2)24Far/J | Repository- Live |
| These Liv-DGAT2-low transgenic mice may be useful in studying hepatic steatosis, lipid, glucose, and insulin metabolism, as well as obesity and diabetes. | |||
| Tg(Ckm-DGAT2)10Far | 006781 | C57BL/6-Tg(Ckm-DGAT2)10Far/J | Repository- Live |
| These MCK-DGAT2 transgenic mice may be useful in studying lipid accumulation in skeletal muscle, insulin and glucose metabolism, obesity, and type 2 diabetes. | |||
| Tg(H2-K-AKR1B1)1Tj | 006877 | B6.Cg-Ldlrtm1Her Tg(H2-K-AKR1B1)1Tj/J | Repository- Live |
| Tg(IGFBP1)2Miel | 008221 | B6.Cg-Tg(IGFBP1)2Miel/J | Repository- Live |
| These hIGFBP-1 (insulin-like growth factor binding protein 1, human) transgenic mice may be useful in studying metabolic and vascular homeostasis, diabetes, and the role of insulin-like growth factor binding protein in placentation and preeclampsia. | |||
(19 stocks)
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