Strains Newly Available

Sensorineural Research

Note: This list only includes strains that have become available within the last six months.


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Allele Symbol Stock Number Strain Name
 
Description		 Standard Supply
COP4 014546 B6.Cg-Tg(Chat-COP4*H134R/EYFP)6Gfng/J
Repository- Live
ChAT-mhChR2-YFP BAC transgenic mice express an improved channelrhodopsin-2/EYFP fusion protein (mhChR2::YFP) directed to cholinergic neuronal populations by the mouse choline acetyltransferase (Chat or ChAT) promoter/enhancer regions on the BAC transgene. Illuminating mhChR2-expressing neurons with blue light (450-490 nm) leads to rapid and reversible photostimulation of action potential firing/neural activity in these cells. These transgenic mice can be used in optogenetic studies for in vivo control of motor behavior by addition or removal of blue light.
COP4 014548 B6.Cg-Tg(Slc32a1-COP4*H134R/EYFP)8Gfng/J
Repository- Live
VGAT-mhChR2-YFP BAC transgenic mice express an improved channelrhodopsin-2/EYFP fusion protein (mhChR2::YFP) directed to GABAergic interneuronal populations by the mouse vesicular GABA transporter (VGAT or Slc32a1) promoter/enhancer regions on the BAC transgene. Illuminating mhChR2-expressing neurons with blue light (450-490 nm) leads to rapid and reversible photostimulation of action potential firing/neural activity in these cells. These transgenic mice can be used in optogenetic studies for in vivo control of motor behavior by addition or removal of blue light.
Cacna1ftm1.2Sdie 017762 B6(Cg)-Cacna1ftm1.2Sdie/J
Under Development for Cryo
These mice carry the I756T point mutation in exon 17, and loxP sites flanking exons 14 through 17, of the Cacna1f (calcium channel, voltage-dependent, alpha 1F subunit). This mutant mouse strain may be useful in studies of calcium channelopathies, an inherited retinal disorder, photoreceptor electrophysiology, and the role of the Cav1.4 channel in survival of naive T cells.
Cacna1ftm1Sdie 017760 B6(Cg)-Cacna1ftm1Sdie/J
Under Development for Cryo
These I756T+neo mice carry the I756T point mutation in exon 17 of the Cacna1f, calcium channel, voltage-dependent, alpha 1F subunit, (756 is the mouse equivalent to residue 745 in human CACNA1F) as well as a FRT flanked NEO selection cassette and loxP sites flanking exons 14 through 17. This mutant mouse strain may be useful in studies of calcium channelopathies, incomplete congenital stationary night blindness, photoreceptor electrophysiology, and the role of the Cav1.4 channel in survival of naive T cells.
Cdc14btm1.2Pzg 016896 B6.129P2(Cg)-Cdc14btm1.2Pzg/J
Under Development - Now Accepting Orders
These Cdc14bdeltaE2 mutant mice are deficient in Cdc14b and exhibit premature aging and impaired DNA damage repair.
Cep290rd16 012283 B6.Cg-Cep290rd16/Boc
Research Strain
Degeneration of outer segments and decreased thickness of the outer nuclear layer of the retina is found in homozygotes as early as 19 days of age, but other cellular layers do not appear to be involved. White retinal vessels appear at one month of age and large pigment patches are found at two months of age.
Dmdmdx 016622 STOCK Utrntm1Jrs Dmdmdx/J
Under Development - Now Accepting Orders
Mice homozygous for the Utrntm1Jrs and Dmdmdx exhibit an onset of skeletal muscle dystrophy as early as 4 weeks of age and are a model for Duchenne Type Muscular Dystrophy.
Epha7tm1Ud 017445 STOCK Epha7tm1Ud/J
Repository- Live
In this strain, exon 1 of the Eph receptor A7 (Epha7) gene is deleted, abolishing gene expression. These mice may be useful for studying the development of retinocollicular projection.
Fgfr1Eask 005412 BALB/cByJ-Fgfr1Eask/GrsrJ
Repository- Live
The ear askew mutation is homozygous embryonic lethal. Heterozygotes have unilateral or bilateral low-set ears and malformed pinna. There is variable expressivity. Heterozygotes are viable and fertile, but auditory brainstem response assessment shows severe hearing loss at 6 months of age.
Fgfr3m1J 014182 CByJ.Cg-Fgfr3m1J/GrsrJ
Repository- Live
Mice homozygous for the recessive Fgfr3m1J allele have skeletal deformities that result in kyphosis, scoliosis, and a bent tail, which is often found to exit the pelvis at an abnormal angle. ABR threshold assessment shows hearing loss to the point of deafness at 3 to 4 weeks of age, the earliest age assessed. Male homozygotes display infertility, but females do breed and rear pups. Homozygotes have not been found to have a reduced lifespan, distinct from the reduced lifespan or prenatal lethality found in homozygotes for targeted deletions of this gene.
Gfi1b 016163 B6.129-Gfi1tm3(Gfib1)Tmo/J
Repository- Live
These Gfi1:Gfi1b knock-in mice express mouse Gfi1b (growth factor independent 1B) from the endogenous Gfi1 (growth factor independent 1) locus and may be useful in studies of deafness, hematopoiesis, and lymphopoiesis.
Omptm1(tTA)Gogo 017754 B6;129-Omptm1(tTA)Gogo/J
Under Development - Now Accepting Orders
The olfactory marker protein gene drives expression of a tetracycline-regulated transactivator in these mice, allowing the inducible expression of genes in the neurons of the olfactory bulb. They may have applications in studying the formation and organization of olfactory and other sensory maps.
Pkd1l3tm1.1Abek 016850 B6.Cg-Pkd1l3tm1.1Abek/J
Repository- Live
These PKD1L3-knockout mice may be useful in studies of taste perception.
Pkd2l1tm1.1Yuni 016853 B6.Cg-Pkd2l1tm1.1Yuni/J
Repository- Live
These PKD2L1-knockout mice may be useful in studies of taste perception.
RFP 017614 B6(Cg)-Tyrc-2J Tg(UBC-mCherry)1Phbs/J
Under Development - Now Accepting Orders
These transgenic mice express monomeric red fluorescent protein (mCherry) under the direction of the human ubiqutin C promoter. Expression is observed in almost all tissues examined and may be useful as a bright and photostable means for visualizing morphogenesis and tissue rearrangements alone or in combination with mice expressing eGFP.
Rd9 003391 C57BL/6J-Rd9/Boc
Research Strain
This semidominant X-linked mutation causes a blond appearance to the fundus in homozygous females and hemizygous males, while heterozygous females develop diffuse white spots covering the retina beginning at 6 weeks of age.
Rr13tm3Mom 016609 C57BL/6-Rr13tm3Mom/MomJ
Cryopreserved - Ready for recovery
Rr13 (regulatory region 13), shown to alter the selection for expression of specific olfactory receptor genes, has been deleted in these targeted mutant mice.
Rr16Tn(sb-Tyr)1HCeb 017609 FVB/N-Rr16Tn(sb-Tyr)1HCebOve/J
Under Development - Now Accepting Orders
These BART6-TP1H mice harbor a transposition-induced mutation near the bone morphogenetic protein 4 locus (Bmp4) on mouse chromosome 14; resulting in altered BMP4 expression. These mice may be useful for studying cleft palate, congenital absence of both eyes (anophthalmia), lens induction, and the optic vesicle.
Tas2r105tm2Csz 013067 B6;129-Tas2r105tm2Csz/J
Repository- Live
This strain carries a targeted mutation of the Tas2r105 (taste receptor, type 2, member 105; also known as T2R5) gene which encodes a cycloheximide-specific G-protein coupled receptor associated with bitter taste sensing. Homozygotes selectively lack electrophysiological responses to the taste of cycloheximide. This strain may be useful in studies of taste and chemosensation.
Trpv1tm1(cre)Bbm 017769 B6.129-Trpv1tm1(cre)Bbm/J
Under Development - Now Accepting Orders
These TRPV1Cre mice express Cre recombinase from the endogenous Trpv1 locus and may be useful for generating conditional mutations to study heat and capsaicin nociception or fate mapping of TRPV1 expression during development.
Trpv1tm2Bbm 017623 B6.129-Trpv1tm2Bbm/J
Under Development - Now Accepting Orders
These TRPV1PLAP-nlacZ mice express beta-galactosidase and alkaline phosphatase phosphatase from the from the endogenous Trpv1 locus, without disruption of the Trpv1 coding sequence. They may be useful for studying heat and capsaicin nociception or fate mapping of TRPV1 expression.
Tyrc-2J 017614 B6(Cg)-Tyrc-2J Tg(UBC-mCherry)1Phbs/J
Under Development - Now Accepting Orders
These transgenic mice express monomeric red fluorescent protein (mCherry) under the direction of the human ubiqutin C promoter. Expression is observed in almost all tissues examined and may be useful as a bright and photostable means for visualizing morphogenesis and tissue rearrangements alone or in combination with mice expressing eGFP.
Utrntm1Jrs 016622 STOCK Utrntm1Jrs Dmdmdx/J
Under Development - Now Accepting Orders
Mice homozygous for the Utrntm1Jrs and Dmdmdx exhibit an onset of skeletal muscle dystrophy as early as 4 weeks of age and are a model for Duchenne Type Muscular Dystrophy.
YFP 014546 B6.Cg-Tg(Chat-COP4*H134R/EYFP)6Gfng/J
Repository- Live
ChAT-mhChR2-YFP BAC transgenic mice express an improved channelrhodopsin-2/EYFP fusion protein (mhChR2::YFP) directed to cholinergic neuronal populations by the mouse choline acetyltransferase (Chat or ChAT) promoter/enhancer regions on the BAC transgene. Illuminating mhChR2-expressing neurons with blue light (450-490 nm) leads to rapid and reversible photostimulation of action potential firing/neural activity in these cells. These transgenic mice can be used in optogenetic studies for in vivo control of motor behavior by addition or removal of blue light.
YFP 014548 B6.Cg-Tg(Slc32a1-COP4*H134R/EYFP)8Gfng/J
Repository- Live
VGAT-mhChR2-YFP BAC transgenic mice express an improved channelrhodopsin-2/EYFP fusion protein (mhChR2::YFP) directed to GABAergic interneuronal populations by the mouse vesicular GABA transporter (VGAT or Slc32a1) promoter/enhancer regions on the BAC transgene. Illuminating mhChR2-expressing neurons with blue light (450-490 nm) leads to rapid and reversible photostimulation of action potential firing/neural activity in these cells. These transgenic mice can be used in optogenetic studies for in vivo control of motor behavior by addition or removal of blue light.

(25 stocks)

 

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