Strains Newly Available

Endocrine Deficiency Research


Strains Under Development for all Endocrine Deficiency Research models.
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Allele Symbol Stock Number Strain Name
 
Description		 Standard Supply
Bdkrb2tm1Jfh 006860 B6.129-Ins2Akita Bdkrb2tm1Jfh/SmiJ
Repository- Live
Mice homozygous for this targeted mutation of the bradykinin receptor, beta 2 (Bdkrb2) gene and heterozygous for the Akita spontaneous mutation of the insulin 2 (Ins2) gene (Ins2Akita) are viable and fertile. They are extremely diabetic, underweight, hyperphagic, polyuric, and have severe kidney, skeletal, and testicular defects. essentially no subcutaneous fat, and a significantly reduced lifespan. This strain may be used to research the kallikrein-kinin system, specifically the role of bradykinin B2 receptor in diabetes, oxidative stress, mitochondrial DNA damage, apoptosis, kidney morphology and function, and other senescence-associated phenotypes.
Cyp4a14tm1Jhc 007175 129S-Cyp4a14tm1Jhc/J
Repository- Live
These "Cyp 4a14" mutant mice may be useful studying kidney function and metabolism, cardiovascular physiology, hypertension, and the relationships between blood pressure, sex hormones, and p450 w-hydroxylases.
Ins2Akita 006860 B6.129-Ins2Akita Bdkrb2tm1Jfh/SmiJ
Repository- Live
Mice homozygous for this targeted mutation of the bradykinin receptor, beta 2 (Bdkrb2) gene and heterozygous for the Akita spontaneous mutation of the insulin 2 (Ins2) gene (Ins2Akita) are viable and fertile. They are extremely diabetic, underweight, hyperphagic, polyuric, and have severe kidney, skeletal, and testicular defects. essentially no subcutaneous fat, and a significantly reduced lifespan. This strain may be used to research the kallikrein-kinin system, specifically the role of bradykinin B2 receptor in diabetes, oxidative stress, mitochondrial DNA damage, apoptosis, kidney morphology and function, and other senescence-associated phenotypes.
Ins2Akita 006580 B6.Cg-Ins2Akita Ldlrtm1Her/J
Repository- Live
Ins2Akita 007562 D2.B6-Ins2Akita/MatbJ
Repository- Live
Whereas congenic DBA/2J mice homozygous for the Akita spontaneous mutation of the insulin 2 gene (Ins2Akita) rarely survive beyond 12 weeks of age, heterozygotes are viable and fertile, developing hyperglycemia, hypoinsulinemia, polydipsia, and polyuria, which is more severe in the male mutants than female mutants. Obesity and insulitis do not accompany diabetes. This strain responds to exogenously administered insulin, and is an excellent substitute for mice made insulin-dependent diabetic with alloxan or streptozotocin. It is also ideally suited to allogeneic or xenogeneic islet transplantation. These mice are useful for studying diabetic complications specifically nephropathy.
Ldlrtm1Her 006580 B6.Cg-Ins2Akita Ldlrtm1Her/J
Repository- Live
Ldlrtm1Her 006906 B6.Cg-Lepob Ldlrtm1Her/J
Repository- Live
The mice may be useful in studies of diabetes, metabolism, hyperglycemia, atherosclerosis, and hypercholesterolemia.
Lepob 006906 B6.Cg-Lepob Ldlrtm1Her/J
Repository- Live
The mice may be useful in studies of diabetes, metabolism, hyperglycemia, atherosclerosis, and hypercholesterolemia.
Pomctm2Ute 008115 B6.129X1-Pomctm2Ute/J
Repository- Live
These mutant mice lack pro-opiomelanocortin-alpha (POMC) and all POMC-derived peptides. Homozygotes are twice the weight of wild-type controls and have no detectable serum adrenocorticotropic hormone (ACTH), corticosterone, or aldosterone. This mutant mouse strain may be useful in studies of obesity, energy homeostasis and endocrinology.
Sirt1tm1Ygu 008041 B6;129-Sirt1tm1Ygu/J
Repository- Live
These SirT1co/co mice may be useful in generating conditional mutations for studying the role of estrogen, insulin growth factor-1 (IGF-1), and transcription factors (including NF-kappaB) in mammary gland development, breast cancer, apoptosis, and metabolic diseases.
Tg(Sim1-cre)1Lowl 006451 B6.FVB(129X1)-Tg(Sim1-cre)1Lowl/J
Repository- Live
When these Sim1-Cre mice are bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in deletion of the flanked sequences in Sim1-expressing tissues (including hypothalamus). As such, Sim1-Cre transgenic mice may be useful in studying body weight homeostasis, obesity, leptin metabolism, or as a reporter strain for Sim1-transcription factor activity.

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