Strains Newly Available
Hematological Research
Note: This list only includes strains that have become available within the last six months.
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| Allele Symbol | Stock Number | Strain Name Description |
Standard Supply |
| Abcg5trac | 001830 | A/J-Abcg5trac/J | Cryopreserved - Ready for recovery |
| Bmi1tm1Ilw | 017351 | BKa.Cg-Ptprcb Bmi1tm1Ilw Thy1a/J | Under Development - Now Accepting Orders |
| The Bmi-1GFP knock-in/knockout allele was designed to both abolish (Bmi1) gene function and express EGFP from the Bmi1 promoter/enhancer elements. Of note, these mice also harbor the CD45.2 (Ptprcb) and Thy1.1 leukocyte alloantigen (Thy1a) alleles to allow tracking of hematopoietic donor derived or transferred cells. | |||
| CR1 | 016911 | B6.Cg-Tg(Gata1-CR1)1Rwf/J | Repository- Live |
| These transgenic mice express human complement receptor 1, CR1, on erythrocytes. Erythrocytes from transgenic mice will adhere to beads coated with human or mouse serum complement, an attribute that may prove useful in studies of immune adherence and pathogen clearance. | |||
| Ccl7tm1Ifc | 017638 | B6.129S4-Ccl7tm1Ifc/J | Under Development - Now Accepting Orders |
| This knockout strain lacks the entire coding region of the Ccl7 gene. These mice may be useful for studying the role of MCP-3 during monocyte recruitment and homeostasis. | |||
| Eif2c2tm1.1Tara | 016520 | B6.129P2(129S4)-Eif2c2tm1.1Tara/J | Repository- Live |
| These mice carry a floxed allele that enables conditional inactivation of the Eif2c2 (eukaryotic translation initiation factor 2C, 2) gene. This strain may be useful in studies further characterizing the gene and its involvement with hematopoiesis and the microRNA (miRNA) pathway. | |||
| Eif2c2tm3.1Ghan | 014151 | STOCK Eif2c2tm3.1Ghan/J | Repository- Live |
| This mutant strain lacks Eif2c2 catalytic activity and may be useful in studies of microRNA biogenesis and erythropoiesis. | |||
| F8 | 017706 | STOCK F8tm1Kaz Tg(Alb-F8*R593C)T4Mcal/J | Under Development - Now Accepting Orders |
| These mice contain a huFVIII-R593C transgene, designed with the murine albumin (Alb) promoter driving expression of a mutated human coagulation factor VIII (F8) cDNA, and are deficient of endogenous F8. | |||
| F8tm1Kaz | 017706 | STOCK F8tm1Kaz Tg(Alb-F8*R593C)T4Mcal/J | Under Development - Now Accepting Orders |
| These mice contain a huFVIII-R593C transgene, designed with the murine albumin (Alb) promoter driving expression of a mutated human coagulation factor VIII (F8) cDNA, and are deficient of endogenous F8. | |||
| FCGRT | 016919 | B6.Cg-Rag1tm1Mom Fcgrttm1Dcr Tg(CAG-FCGRT)276Dcr/DcrJ | Repository- Live |
| These Rag1-/- FcRn-/- hFcRn (276) Tg mice express a human FCGRT molecule in lieu of the endogenous mouse Fcgrt. The absence of Rag1 makes the mice immunodeficient and therefore permits the engraftment of tissues and cell lines, making these mice well-suited for applications associated with the study of the pharmacokinetics and efficacy of therapeutic monoclonal antibody and FC fusion protein treatment. Further, these mice are suitable for the evaluation of immunogenic compounds. | |||
| Fcgrttm1Dcr | 017700 | B6.129-Rag1tm1Mom Fcgrttm1Dcr/DcrJ | Repository- Live |
| Rag1-/- mFcRn-/- mice are immunodeficient. This strain serves as a control strain for 016919 | |||
| Fcgrttm1Dcr | 016919 | B6.Cg-Rag1tm1Mom Fcgrttm1Dcr Tg(CAG-FCGRT)276Dcr/DcrJ | Repository- Live |
| These Rag1-/- FcRn-/- hFcRn (276) Tg mice express a human FCGRT molecule in lieu of the endogenous mouse Fcgrt. The absence of Rag1 makes the mice immunodeficient and therefore permits the engraftment of tissues and cell lines, making these mice well-suited for applications associated with the study of the pharmacokinetics and efficacy of therapeutic monoclonal antibody and FC fusion protein treatment. Further, these mice are suitable for the evaluation of immunogenic compounds. | |||
| GFP | 016836 | B6;129S4-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm7(tetO-HIST1H2BJ/GFP)Jae/J | Repository- Live |
| These H2B-GFP (histone 2B, HIST1H2BJ) doxycycline-inducible compound mutant mice may be used for cell labeling studies. | |||
| GFP | 016617 | C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J | Repository- Live |
| Mice harboring the Nur77-GFPCre BAC transgene express an enhanced green fluorescent protein/codon-optimized "humanized" Cre recombinase fusion protein under control of the Nr4a1 promoter/enhancer regions within the BAC transgene. GFP expression level correlates to the strength of antigen receptor signaling. | |||
| GFP | 017592 | B6;129S-Sox2tm2Hoch/J | Under Development - Now Accepting Orders |
| The Sox2 open reading frame is replaced by EGFP in this knockin/knockout line. Strong EGFP expression is detected in blastocysts, neural progenitor cells and in many adult epithelial tissues. | |||
| Gfi1b | 016163 | B6.129-Gfi1tm3(Gfib1)Tmo/J | Repository- Live |
| These Gfi1:Gfi1b knock-in mice express mouse Gfi1b (growth factor independent 1B) from the endogenous Gfi1 (growth factor independent 1) locus and may be useful in studies of deafness, hematopoiesis, and lymphopoiesis. | |||
| Gmnntm1Tjm | 016913 | B6;129P2-Gmnntm1Tjm/J | Under Development - Now Accepting Orders |
| These mice possess loxP sites flanking exons 5-7 of the geminin (Gmnn) gene and have applications in studies related to hematopoietic stem cell growth and differentiation. | |||
| HIST1H2BJ | 016836 | B6;129S4-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm7(tetO-HIST1H2BJ/GFP)Jae/J | Repository- Live |
| These H2B-GFP (histone 2B, HIST1H2BJ) doxycycline-inducible compound mutant mice may be used for cell labeling studies. | |||
| Hfetm2Nca | 017784 | B6.129S6-Hfetm2Nca/J | Under Development for Cryo |
| These mice carry a targeted mutation of Hfe, hemochromatosis, exhibit iron loading, and have applications in studies of hereditary hemochromatosis, iron homeostasis and innate immune response. | |||
| Il2rgtm1.1Flv | 014594 | C;129S4-Rag2tm1.1Flv Thpotm1.1(TPO)Flv Il2rgtm1.1Flv/J | Repository- Live |
| This immunodeficient strain carrying humanized Thpo (thrombopoietin) may be useful for transplantation studies, particularly those involving hematopoiesis. | |||
| Il2rgtm1.1Flv | 017707 | C;129S4-Rag2tm1.1Flv Il2rgtm1.1Flv Tg(SIRPA)1Flv/J | Under Development - Now Accepting Orders |
| This humanized SIRPA (signal-regulatory protein alpha), Rag2, Il2rg, compound mutant strain is a useful immunodeficient model for improved human hematopoietic cell engraftment with potential utility in human vaccine development. | |||
| Il2rgtm1Wjl | 014568 | NOD.Cg-Rag1tm1Mom Ins2Akita Il2rgtm1Wjl/SzJ | Repository- Live |
| These NRG-Akita mutant mice are immunodeficient and spontaneously develop hyperglycemia. The strain may be useful as a diabetic host for human islet cells. | |||
| Ins2Akita | 014568 | NOD.Cg-Rag1tm1Mom Ins2Akita Il2rgtm1Wjl/SzJ | Repository- Live |
| These NRG-Akita mutant mice are immunodeficient and spontaneously develop hyperglycemia. The strain may be useful as a diabetic host for human islet cells. | |||
| Itgaltm1Bll | 016898 | NOD.129S7(B6)-Itgaltm1Bll/CgkJ | Repository- Live |
| This diabetes resistant congenic NOD.Itgal deficient mutant may be useful to further study the role of leukocyte intergrins in inflammatory disease models, specifically Type 1 Diabetes. | |||
| L3mbtl1tm1.1Haho | 016835 | B6;129S4-L3mbtl1tm1.1Haho/J | Repository- Live |
| This L3mbtl1 knockout strain may be useful in further characterization of this gene and its possible role in oncogene suppression and hematopoieis. | |||
| Mapk11tm1Jda | 012566 | B6.Cg-Mapk11tm1Jda Mapk14tm1Jda/J | Repository- Live |
| These p38αβY323F mice harbor two polymorphic mutations, a p38βY323F mutation of the Mapk11 gene and a p38αY323F mutation of the Mapk14 gene. While the canonical MAPK cascade-induced p38 activation should not be affected, each polymorphism abolishes the T cell receptor (TCR)-mediated alternative activation pathway of p38. | |||
| Mapk14tm1Jda | 012566 | B6.Cg-Mapk11tm1Jda Mapk14tm1Jda/J | Repository- Live |
| These p38αβY323F mice harbor two polymorphic mutations, a p38βY323F mutation of the Mapk11 gene and a p38αY323F mutation of the Mapk14 gene. While the canonical MAPK cascade-induced p38 activation should not be affected, each polymorphism abolishes the T cell receptor (TCR)-mediated alternative activation pathway of p38. | |||
| Mir223tm1Fcam | 013198 | B6.Cg-Ptprca Mir223tm1Fcam/J | Repository- Live |
| In this strain, the allele replaces the entire coding region of the microRNA-223 (Mir223) gene with a frt-flanked neomycin (neo) resistance cassette, abolishing gene function. These mice also harbor the CD45.1 (Ly5.1 or Ptprca) allele rather than the CD45.2 (Ly5.2 or Ptprcb) allele normally present in C57BL/6 mice. These mice may be useful for studying granulocyte production and inflammatory response. | |||
| Pglyrp1tm1.1Lky | 015861 | B6.129S4-Pglyrp1tm1.1Lky/J | Repository- Live |
| These PGRP-S mice contain an EYFP gene placed immediately downstream from the initiation sequence of the Pglyrp1 gene, abolishing gene expression. These mice may be useful for visualizing PGRP-S expressing cells and for studying the role of peptidoglycan recognition proteins in immune function. | |||
| Ptprca | 013198 | B6.Cg-Ptprca Mir223tm1Fcam/J | Repository- Live |
| In this strain, the allele replaces the entire coding region of the microRNA-223 (Mir223) gene with a frt-flanked neomycin (neo) resistance cassette, abolishing gene function. These mice also harbor the CD45.1 (Ly5.1 or Ptprca) allele rather than the CD45.2 (Ly5.2 or Ptprcb) allele normally present in C57BL/6 mice. These mice may be useful for studying granulocyte production and inflammatory response. | |||
| Ptprcb | 017351 | BKa.Cg-Ptprcb Bmi1tm1Ilw Thy1a/J | Under Development - Now Accepting Orders |
| The Bmi-1GFP knock-in/knockout allele was designed to both abolish (Bmi1) gene function and express EGFP from the Bmi1 promoter/enhancer elements. Of note, these mice also harbor the CD45.2 (Ptprcb) and Thy1.1 leukocyte alloantigen (Thy1a) alleles to allow tracking of hematopoietic donor derived or transferred cells. | |||
| Ptprcltng | 016091 | C57BL/6-Ptprcltng/J | Repository- Live |
| These lightning mice possess an ENU-induced point mutation (F503S) in the Ptprc gene and may be useful in studying the differential regulation of TCR signaling by altered CD45 expression levels. | |||
| Rag1tm1Mom | 017700 | B6.129-Rag1tm1Mom Fcgrttm1Dcr/DcrJ | Repository- Live |
| Rag1-/- mFcRn-/- mice are immunodeficient. This strain serves as a control strain for 016919 | |||
| Rag1tm1Mom | 016919 | B6.Cg-Rag1tm1Mom Fcgrttm1Dcr Tg(CAG-FCGRT)276Dcr/DcrJ | Repository- Live |
| These Rag1-/- FcRn-/- hFcRn (276) Tg mice express a human FCGRT molecule in lieu of the endogenous mouse Fcgrt. The absence of Rag1 makes the mice immunodeficient and therefore permits the engraftment of tissues and cell lines, making these mice well-suited for applications associated with the study of the pharmacokinetics and efficacy of therapeutic monoclonal antibody and FC fusion protein treatment. Further, these mice are suitable for the evaluation of immunogenic compounds. | |||
| Rag1tm1Mom | 014568 | NOD.Cg-Rag1tm1Mom Ins2Akita Il2rgtm1Wjl/SzJ | Repository- Live |
| These NRG-Akita mutant mice are immunodeficient and spontaneously develop hyperglycemia. The strain may be useful as a diabetic host for human islet cells. | |||
| Rag2tm1.1Flv | 014594 | C;129S4-Rag2tm1.1Flv Thpotm1.1(TPO)Flv Il2rgtm1.1Flv/J | Repository- Live |
| This immunodeficient strain carrying humanized Thpo (thrombopoietin) may be useful for transplantation studies, particularly those involving hematopoiesis. | |||
| Rag2tm1.1Flv | 017707 | C;129S4-Rag2tm1.1Flv Il2rgtm1.1Flv Tg(SIRPA)1Flv/J | Under Development - Now Accepting Orders |
| This humanized SIRPA (signal-regulatory protein alpha), Rag2, Il2rg, compound mutant strain is a useful immunodeficient model for improved human hematopoietic cell engraftment with potential utility in human vaccine development. | |||
| SIRPA | 017707 | C;129S4-Rag2tm1.1Flv Il2rgtm1.1Flv Tg(SIRPA)1Flv/J | Under Development - Now Accepting Orders |
| This humanized SIRPA (signal-regulatory protein alpha), Rag2, Il2rg, compound mutant strain is a useful immunodeficient model for improved human hematopoietic cell engraftment with potential utility in human vaccine development. | |||
| Spnb1ja | 000452 | WB.129-Spnb1ja/J | Cryopreserved - Ready for recovery |
| Mice homozygous for the jaundiced mutation are very pale but not jaundiced at birth, but develop severe jaundice within hours of being born. They have severe microcytic hemolytic anemia, and most die by 4 days of age, even on a mixed background, but a single blood transfusion in the first days of life can foster survival of homozygotes. On a mixed C57BL/6J x WB/Re background transfused homozygotes generally survive to adulthood and are reported to have a mean life expectancy of 3.7 months. The hemolytic anemia phenotype of these adults includes decreased hematocrit, very low red blood cell count, reticulocytosis, microcytosis, bilirubinemia, extensive iron accumulation in the kidney, elevated blood urea nitrogen, hydronephrosis, hepatomegaly, splenomegaly of predominantly red pulp, and cardiomegaly, but less severe thrombosis than is found in mice homozygous for the mutation spherocytosis (Spna1sph). The erythrocytes are extremely fragile and have a very short lifespan and there is extramedullary hematopoiesis. Heterozygotes have a mild, well compensated anemia and the erythrocytes have a higher concentration of protoporphyrin, increased osmotic fragility, and a slightly reduced lifespan. | |||
| TPO | 014594 | C;129S4-Rag2tm1.1Flv Thpotm1.1(TPO)Flv Il2rgtm1.1Flv/J | Repository- Live |
| This immunodeficient strain carrying humanized Thpo (thrombopoietin) may be useful for transplantation studies, particularly those involving hematopoiesis. | |||
| Tapt1TgTn(sb-cHS4,Tyr)2508GOve | 017436 | FVB/N-Tapt1TgTn(sb-cHS4,Tyr)2508GOve/J | Repository- Live |
| These OVE2508G mice harbor a mutation created by random insertion of the SB-cHS4core-SB-Tyro-WPRE-FUGW lentiposon transgene (LV2229). Using inverse PCR analysis, the transgene integration site was identified in intron 11 of the transmembrane anterior posterior transformation 1 gene (Tapt1) on chromosome 5. The donating investigator reports the phenotype of homozygous mice as: cleft palate, possible anemia. | |||
| Tfpitm1.1Rdsi | 017603 | B6.129S6(129S4)-Tfpitm1.1Rdsi/J | Under Development - Now Accepting Orders |
| These mice contain a TFPIFlox allele with loxP sites flanking exon 4 of the Tfpi gene. When bred to mice that express Cre recombinase, the resulting offspring will have the sequences encoding the Kunitz 1 domain of the TFPI protein deleted in cre-expressing tissues. As the TFPI-K1 domain is necessary for TFPI-inhibition of the tissue factor coagulation pathway, these mice may be useful in generating tissue-specific TFPI deletions for such studies, as well as innate immunity, angiogenesis, and lipid metabolism. | |||
| Thy1a | 017351 | BKa.Cg-Ptprcb Bmi1tm1Ilw Thy1a/J | Under Development - Now Accepting Orders |
| The Bmi-1GFP knock-in/knockout allele was designed to both abolish (Bmi1) gene function and express EGFP from the Bmi1 promoter/enhancer elements. Of note, these mice also harbor the CD45.2 (Ptprcb) and Thy1.1 leukocyte alloantigen (Thy1a) alleles to allow tracking of hematopoietic donor derived or transferred cells. | |||
| UGT1A1 | 014170 | B6N.Cg-Tg(UGT1A1*28)1Rhtu/J | Repository- Live |
| Transgenic UGT1A1*28 mice carry the entire human uridine diphosphate (UDP) glucuronosyltransferase 1 (UGT1) locus, and includes a mutant form of the human UGT1 polypeptide A1 (UGT1A1) promoter. These mice may be useful for studying the regulatory and functional properties of glucuronidation, and may also serve as a model for pharmacological studies associated with Gilbert's syndrome. | |||
| cre | 016617 | C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J | Repository- Live |
| Mice harboring the Nur77-GFPCre BAC transgene express an enhanced green fluorescent protein/codon-optimized "humanized" Cre recombinase fusion protein under control of the Nr4a1 promoter/enhancer regions within the BAC transgene. GFP expression level correlates to the strength of antigen receptor signaling. | |||
| cre | 017593 | B6;129S-Sox2tm1(cre/ERT2)Hoch/J | Under Development - Now Accepting Orders |
| These Sox2-CreER knockin mice have the Sox2 open reading frame replaced with a CreERT2 fusion gene. These mice may be useful for inducible Cre recombinase expression/floxed gene deletion in blastocysts, neural progenitor cells and in many adult epithelial tissues. | |||
| rtTA | 016836 | B6;129S4-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm7(tetO-HIST1H2BJ/GFP)Jae/J | Repository- Live |
| These H2B-GFP (histone 2B, HIST1H2BJ) doxycycline-inducible compound mutant mice may be used for cell labeling studies. | |||
| tetO | 016836 | B6;129S4-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm7(tetO-HIST1H2BJ/GFP)Jae/J | Repository- Live |
| These H2B-GFP (histone 2B, HIST1H2BJ) doxycycline-inducible compound mutant mice may be used for cell labeling studies. | |||
(47 stocks)
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