Strains Newly Available
Mouse/Human Gene Homologs
Note: This list only includes strains that have become available within the last six months.
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| Allele Symbol | Stock Number | Strain Name Description |
Standard Supply |
| Apbb1tm1Her | 012865 | B6;129S6-Apbb1tm1Her/J | Repository- Live |
| The FE65 knockout allele has a nuclear localized-lacZ replacing exon 2 of the Apbb1 gene. These FE65 mutant mice, along with FE65L1 mutant mice, may be useful in studying brain development (neuronal positioning and establishment of axonal projections) and abnormal brain morphology (Cobblestone Lissencephaly, marginal zone heterotopias, and pial basement membrane integrity); as well as the function of FE65 family proteins in amyloid precursor protein (APP) processing, Alzheimer's disease, and neuronal protein trafficking. | |||
| Apbb2tm1Her | 012869 | B6;129S6-Apbb2tm1Her/J | Repository- Live |
| These FE65L1 mutant mice, along with FE65 mutant mice, may be useful in studying brain development (neuronal positioning and establishment of axonal projections) and abnormal brain morphology (Cobblestone Lissencephaly, marginal zone heterotopias, and pial basement membrane integrity); as well as the function of FE65 family proteins in amyloid precursor protein (APP) processing, Alzheimer's disease, and neuronal protein trafficking. | |||
| Apoetm1Unc | 013719 | D2.Cg-Apoetm1Unc Ins2Akita/J | Cryopreserved - Ready for recovery |
| Double mutant, Apoe-null, Akita heterozygous, mice may be useful in studies of diabetes, metabolism, hyperglycemia, atherosclerosis, hypercholesterolemia, and diabetes-related macrovascular complications. | |||
| Arl6tm1Vcs | 014606 | 129S.129(B6)-Arl6tm1Vcs/J | Repository- Live |
| In this strain a targeted mutation alters the sequence of the splice acceptor and splice donor sites (AG -> AC and GT -> CT respectively) of exon 8 of the Arl6 gene. These mice may be useful for studying retinal function and organization. | |||
| Cacna1ftm1Sdie | 017760 | B6(Cg)-Cacna1ftm1Sdie/J | Under Development for Cryo |
| These I756T+neo mice carry the I756T point mutation in exon 17 of the Cacna1f, calcium channel, voltage-dependent, alpha 1F subunit, (756 is the mouse equivalent to residue 745 in human CACNA1F) as well as a FRT flanked NEO selection cassette and loxP sites flanking exons 14 through 17. This mutant mouse strain may be useful in studies of calcium channelopathies, incomplete congenital stationary night blindness, photoreceptor electrophysiology, and the role of the Cav1.4 channel in survival of naive T cells. | |||
| Cntnap2tm1Pele | 017482 | B6.129(Cg)-Cntnap2tm1Pele/J | Under Development - Now Accepting Orders |
| These Cntnap2 knockout mice mice exhibit hyperactivity, social and communication behavioral impairment, spontaneous seizures, abnormal cortical neuron migration, and abnormal neural synchrony. They may be useful in studies related to Cortical Dysplasia-Focal Epilepsy Syndrome and autism spectrum disorders. | |||
| Dmdmdx | 016622 | STOCK Utrntm1Jrs Dmdmdx/J | Under Development - Now Accepting Orders |
| Mice homozygous for the Utrntm1Jrs and Dmdmdx exhibit an onset of skeletal muscle dystrophy as early as 4 weeks of age and are a model for Duchenne Type Muscular Dystrophy. | |||
| Fig4plt1 | 017800 | B6.Cg-Fig4plt1/MmJ | Under Development - Now Accepting Orders |
| The pale tremor (plt) allele is a spontaneous retrotransposon insertion in the Fig4 gene and is associated with Charcot-Marie-Tooth disease type 4J (CMT4J). Homozygous mice exhibit neuronal degeneration, juvenile lethality and diluted pigmentation. | |||
| Fig4plt1 | 017801 | C3Fe.Cg-Fig4plt1/MmJ | Under Development - Now Accepting Orders |
| The pale tremor (plt) allele is a spontaneous retrotransposon insertion in the Fig4 gene and is associated with Charcot-Marie-Tooth disease type 4J (CMT4J). Homozygous mice exhibit neuronal degeneration, juvenile lethality and diluted pigmentation. | |||
| GFP | 017530 | STOCK Tg(ACTB-tdTomato,-EGFP)11Luo Trp53tm1Tyj Nf1tm1Par/J | Under Development - Now Accepting Orders |
| The MADM-TG,p53KO,NF1-flox strain may be used as a genetic mosaicism model for different types of cancers when bred to the companion MADAM strain (Stock No. 013749), and to a Cre recombinase expressing strain. | |||
| HTT | 017485 | FVB-Tg(HTT*)1Xwy/J | Under Development - Now Accepting Orders |
| BAC SA transgenic mice express a mutant human HTT (huntingtin) gene that produces a protein that is phosphoresistant at the NT17 domain and has a 97 polyQ repeat expansion. | |||
| HTT | 017486 | FVB-Tg(HTT*)BXwy/J | Under Development - Now Accepting Orders |
| BAC SD (line B) transgenic mice express a mutant human HTT (huntingtin) gene that produces a protein that is phosphomimetic at the NT17 domain and has a 97 polyQ repeat expansion. | |||
| HTT | 017487 | FVB-Tg(HTT*97Q)LXwy/J | Under Development - Now Accepting Orders |
| BACHD-L transgenic mice express a mutant human HTT (huntingtin) gene that produces a pathogenic protein with a 97 polyQ repeat expansion. | |||
| Hfetm2Nca | 017784 | B6.129S6-Hfetm2Nca/J | Under Development for Cryo |
| These mice carry a targeted mutation of Hfe, hemochromatosis, exhibit iron loading, and have applications in studies of hereditary hemochromatosis, iron homeostasis and innate immune response. | |||
| Htttm2Detl | 016522 | B6.129P2-Htttm2Detl/100J | Repository- Live |
| These HdhQ100 mice carry a mutant knock in allele with a 100 CAG/polyQ repeat mutation, and exhibit no discernable abnormality compared to the HdhQ150 strain (STOCK no. 4595), from which it was derived. This mutant strain may be useful in studies related to Huntington's disease. | |||
| Htttm2Detl | 016523 | B6.129P2-Htttm2Detl/200J | Repository- Live |
| These HdhQ200 mice carry a mutant knock in allele with a 200 CAG/polyQ repeat mutation, and exhibit a more aggressive and earlier onset of the behavioral and neurological phenotype as compared to the HdhQ150 strain (STOCK no. 4595) with progressive motor deficits starting at 50 weeks of age. This mutant strain may be useful in studies related to Huntington's disease. | |||
| Htttm2Detl | 016524 | B6.129P2-Htttm2Detl/250J | Repository- Live |
| These HdhQ250 mice carry a mutant knock in allele with a 250 CAG/polyQ repeat mutation, and exhibit an earlier onset of phenotype as compared to the HdhQ150 strain (STOCK no. 4595). This mutant strain may be useful in studies related to Huntington's disease. | |||
| Htttm2Detl | 016525 | B6.129P2-Htttm2Detl/315J | Repository- Live |
| These HdhQ315 mice carry a mutant knock in allele with a 315 CAG/polyQ repeat mutation, and exhibit an earlier onset of phenotype as compared to the HdhQ150 strain (STOCK no. 4595). This mutant strain may be useful in studies related to Huntington's disease. | |||
| Htttm2Detl | 016521 | B6.129P2-Htttm2Detl/50J | Repository- Live |
| These HdhQ50 mice carry a mutant knock in allele with a 50 CAG/polyQ repeat mutation, and exhibit no discernable abnormality when compared to the HdhQ150 strain (STOCK no. 4595), from which it was derived. This mutant strain may be useful in studies related to Huntington's disease. | |||
| Ins2Akita | 013719 | D2.Cg-Apoetm1Unc Ins2Akita/J | Cryopreserved - Ready for recovery |
| Double mutant, Apoe-null, Akita heterozygous, mice may be useful in studies of diabetes, metabolism, hyperglycemia, atherosclerosis, hypercholesterolemia, and diabetes-related macrovascular complications. | |||
| Itgb2tm2Bay | 016897 | NOD.129S7(B6)-Itgb2tm2Bay/CgkJ | Cryopreserved - Ready for recovery |
| This diabetes resistant congenic NOD.Itgb2 deficient mutant may be useful for in vivo analysis of leukocyte integrin-dependent adhesion in inflammatory disease models, specifically Type 1 Diabetes. | |||
| Ncor1tm1Anh | 017632 | STOCK Ncor1tm1Anh/J | Under Development - Now Accepting Orders |
| These NCoRlox mutant mice possess loxP sites flanking exons 37-40 of the nuclear receptor co-repressor 1 (Ncor1) gene. This strain may be useful for studying the role of NCOR1 on regulation of nuclear receptor signaling. | |||
| Nf1tm1Par | 017530 | STOCK Tg(ACTB-tdTomato,-EGFP)11Luo Trp53tm1Tyj Nf1tm1Par/J | Under Development - Now Accepting Orders |
| The MADM-TG,p53KO,NF1-flox strain may be used as a genetic mosaicism model for different types of cancers when bred to the companion MADAM strain (Stock No. 013749), and to a Cre recombinase expressing strain. | |||
| Prnp | 016144 | STOCK Tg(Prnp-TARDBP)4Jlel/J | Repository- Live |
| TDP43 transgenic mice express a full-length human TAR DNA binding protein (TARDBP) cDNA under the control of mouse prion protien promoter. These transgenic mice may be useful in studying neuromuscular and neurodegenerative disorders such as ALS (Lou Gehrig's Disease) and frontotemporal lobar degeneration with ubiquitin aggregates. | |||
| Ptpn5tm1Pjlo | 016556 | B6N.129-Ptpn5tm1Pjlo/J | Repository- Live |
| In this STEP KO strain, a neo cassette replaces the catalytic site of the protein tyrosine phosphatase, non-receptor type 5 (Ptpn5) gene, abolishing gene expression. These mice may be useful for studying the role of STEP in regulating synaptic plasticity in Alzheimer's Disease. | |||
| RFP | 017614 | B6(Cg)-Tyrc-2J Tg(UBC-mCherry)1Phbs/J | Under Development - Now Accepting Orders |
| These transgenic mice express monomeric red fluorescent protein (mCherry) under the direction of the human ubiqutin C promoter. Expression is observed in almost all tissues examined and may be useful as a bright and photostable means for visualizing morphogenesis and tissue rearrangements alone or in combination with mice expressing eGFP. | |||
| RFP | 017530 | STOCK Tg(ACTB-tdTomato,-EGFP)11Luo Trp53tm1Tyj Nf1tm1Par/J | Under Development - Now Accepting Orders |
| The MADM-TG,p53KO,NF1-flox strain may be used as a genetic mosaicism model for different types of cancers when bred to the companion MADAM strain (Stock No. 013749), and to a Cre recombinase expressing strain. | |||
| Scn8a8J | 012945 | B6(C3Fe)-Scn8a8J/Frk | Cryopreserved - Ready for recovery |
| Scn8a is a voltage-gated, type VIII sodium channel involved in electrical signaling between cells. The 8J allele is a point mutation located in the pore region of domain 2. On a mixed C57BL/6J and C3HeB/FeJ background, mice homozygous for the mutation exhibit a high incidence of spike wave discharges (SWD), impaired motor function, unsteady gait, and small size. SWD burst frequency is recorded at 4-5 Hz. Homozygous mice die by 21 days of age, although with ground pellets some may live to 7 weeks. In mixed background heterozygotes, the SWD burst frequency is 7-9 Hz. SWD are characterized by high amplitude, significant duration and high frequency and occur between periods of locomotor activity. Severity of the SWD phenotype is dependent on genetic background. Homozygosity for C3HeB/FeJ alleles increases severity, while homozygosity for C57BL/6J alleles decreases severity. This mutant mouse strain may be useful in studies of human absence epilepsy.
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available. | |||
| TARDBP | 016608 | C57BL/6-Tg(Prnp-TARDBP)3cPtrc/J | Repository- Live |
| TDP-43PrP transgenic mice express a full length wild type human TARDBP cDNA under control of a Prnp promoter. These transgenic mice may be useful in studying neuromuscular and neurodegenerative disorders such as ALS (Lou Gehrig's Disease). | |||
| TARDBP | 016144 | STOCK Tg(Prnp-TARDBP)4Jlel/J | Repository- Live |
| TDP43 transgenic mice express a full-length human TAR DNA binding protein (TARDBP) cDNA under the control of mouse prion protien promoter. These transgenic mice may be useful in studying neuromuscular and neurodegenerative disorders such as ALS (Lou Gehrig's Disease) and frontotemporal lobar degeneration with ubiquitin aggregates. | |||
| TARDBP | 017604 | C57BL/6-Tg(Prnp-TARDBP*M337V)4Ptrc/J | Under Development - Now Accepting Orders |
| These hTDP-43M337V transgenic mice express mutant human TARDBP protein under direction of the mouse prion protein (Prnp) promoter. They may be useful in studying neuromuscular and neurodegenerative disorders such as ALS (Lou Gehrig's Disease). | |||
| Trp53tm1Tyj | 017530 | STOCK Tg(ACTB-tdTomato,-EGFP)11Luo Trp53tm1Tyj Nf1tm1Par/J | Under Development - Now Accepting Orders |
| The MADM-TG,p53KO,NF1-flox strain may be used as a genetic mosaicism model for different types of cancers when bred to the companion MADAM strain (Stock No. 013749), and to a Cre recombinase expressing strain. | |||
| Tyrc-2J | 017614 | B6(Cg)-Tyrc-2J Tg(UBC-mCherry)1Phbs/J | Under Development - Now Accepting Orders |
| These transgenic mice express monomeric red fluorescent protein (mCherry) under the direction of the human ubiqutin C promoter. Expression is observed in almost all tissues examined and may be useful as a bright and photostable means for visualizing morphogenesis and tissue rearrangements alone or in combination with mice expressing eGFP. | |||
| UGT1A1 | 014170 | B6N.Cg-Tg(UGT1A1*28)1Rhtu/J | Repository- Live |
| Transgenic UGT1A1*28 mice carry the entire human uridine diphosphate (UDP) glucuronosyltransferase 1 (UGT1) locus, and includes a mutant form of the human UGT1 polypeptide A1 (UGT1A1) promoter. These mice may be useful for studying the regulatory and functional properties of glucuronidation, and may also serve as a model for pharmacological studies associated with Gilbert's syndrome. | |||
| Utrntm1Jrs | 016622 | STOCK Utrntm1Jrs Dmdmdx/J | Under Development - Now Accepting Orders |
| Mice homozygous for the Utrntm1Jrs and Dmdmdx exhibit an onset of skeletal muscle dystrophy as early as 4 weeks of age and are a model for Duchenne Type Muscular Dystrophy. | |||
| cre | 016223 | B6(Cg)-Tg(Phox2b-cre)3Jke/J | Repository- Live |
| Phox2b-Cre BAC transgenic mice from founder line 3 have Cre recombinase expression directed primarily to the hindbrain (dorsal motor nucleus of the vagus (DMV) in parasympathetic visceral and branchial motor neurons, nodose sensory ganglia, and nucleus of the solitary tract (NTS) cells) by the Phox2b promoter/enhancer regions within the BAC transgene. These Phox2b-Cre BAC transgenic mice may be used to generate conditional mutations for studying neuronal cell types expressing/depending on the Phox2b transcription factor for energy balance, glucose homeostasis, and autonomic breathing/respiration. Specifically, these mice may be useful for studying human respiratory disease, central chemoreceptive neurons in the retrotrapezoid nucleus, respiratory rhythmogenesis, and autonomic nervous system dysregulation (such as congenital central hypoventilation syndrome (CCHS) or Ondine-Hirschsprung disease). | |||
| rtTA | 016146 | STOCK Tg(SFTPC-rtTA)2Jaw/J | Under Development - Now Accepting Orders |
| These transgenic mice express the rtTA protein under the control of the human SFTPC promoter. This strain provides an improved Tet-On tool that allows the inducible expression of genes in the developing and adult lung and respiratory epithelium.
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| rtTA | 016145 | STOCK Tg(Scgb1a1-rtTA)2Jaw/J | Under Development - Now Accepting Orders |
| These CCSP-rtTA transgenic mice express the rtTA protein under the control of the rat Scgb1a1 gene promoter and provides an improved "Tet-On" tool that allows the inducible expression of genes in the developing and adult lung and respiratory epithelium. | |||
| Del(7Slx1b-Sept1)4Aam | 013128 | B6129S-Del(7Slx1b-Sept1)4Aam/J | Repository- Live |
| These mutant mice possess an engineered deletion spanning approximately 0.39 Mb on mouse Chromosome 7, a region that shares conserved synteny with the Autism spectrum disorders critical interval on human Chromosome 16. This mutant mouse may be useful in studying Autism and other associated disorders. | |||
| Del(7Slx1b-Sept1)4Aam | 016914 | B6.129S7-Del(7Slx1b-Sept1)4Aam/J | Under Development - Now Accepting Orders |
| These mutant mice possess an engineered deletion spanning approximately 0.39 Mb on mouse Chromosome 7, a region that shares conserved synteny with the Autism spectrum disorders critical interval on human Chromosome 16. This mutant mouse may be useful in studying Autism and other associated disorders. | |||
| Dp(7Slx1b-Sept1)5Aam | 013129 | B6129S-Dp(7Slx1b-Sept1)5Aam/J | Repository- Live |
| These mutant mice possess an engineered duplication of approximately 0.39 Mb of mouse Chromosome 7, a region that shares conserved synteny with the Autism spectrum disorders critical interval on human Chromosome 16. This mutant mouse may be useful in studying Autism and other associated disorders. | |||
| Dp(7Slx1b-Sept1)5Aam | 016915 | B6.127S7-Dp(7Slx1b-Sept1)5Aam/J | Under Development - Now Accepting Orders |
| These mutant mice possess an engineered duplication of approximately 0.39 Mb of mouse Chromosome 7, a region that shares conserved synteny with the Autism spectrum disorders critical interval on human Chromosome 16. This mutant mouse may be useful in studying Autism and other associated disorders. | |||
(42 stocks)
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